JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats

European Journal of Pharmacology

Volumn 668, Issue 1-2, 2011, Pages 331-336

  Kimura, Shuichi ^a   Nakagawa, Takashi ^a   Matsuo, Yushi ^a   Ishida, Yuji ^a   Okamoto, Yoshihisa ^a   Hayashi, Mikio ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

Antagonist; Bone formation; Bone mineral density; Calcium sensing receptor; Parathyroid hormone

Indexed keywords

ANABOLIC AGENT; CALCIUM SENSING RECEPTOR ANTAGONIST; JTT 305; PARATHYROID HORMONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DENSITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG POTENCY; FEMALE; IN VITRO STUDY; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OVARIECTOMY; PARATHYROID HORMONE BLOOD LEVEL; PARATHYROID HORMONE RELEASE; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT; TIBIA; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, ORAL; ANIMALS; BENZOIC ACIDS; CERCOPITHECUS AETHIOPS; COS CELLS; FEMALE; HUMANS; OSTEOGENESIS; OVARIECTOMY; PARATHYROID HORMONE; PROPANOLAMINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCIUM-SENSING; RECOMBINANT PROTEINS;

EID: 80052058754     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.07.015     Document Type: Article

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