Morphogen-related therapeutic targets for liver fibrosis

Clinics and Research in Hepatology and Gastroenterology

Volumn 39, Issue , 2015, Pages S69-S74

  Fung, Eileen ^a   Tsukamoto, Hidekazu ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA LIKE HOMOLOG 1; MORPHOGEN; NECDIN; NOTCH RECEPTOR; PROTEIN; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN; DLK1 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; SIGNAL PEPTIDE;

APOPTOSIS; CELL DIFFERENTIATION; CELL FATE; CELL FUNCTION; CELL PROLIFERATION; DISEASE COURSE; EMBRYO DEVELOPMENT; FIBROGENESIS; HUMAN; LIVER DEVELOPMENT; LIVER FIBROSIS; LIVER INJURY; LIVER REGENERATION; MYOFIBROBLAST; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SHORT SURVEY; SIGNAL TRANSDUCTION; STELLATE CELL; WOUND HEALING; CELL TRANSDIFFERENTIATION; HEPATIC STELLATE CELL; LIVER CIRRHOSIS; MORPHOGENESIS; PATHOPHYSIOLOGY; PHYSIOLOGY; WNT SIGNALING PATHWAY;

CELL TRANSDIFFERENTIATION; HEDGEHOG PROTEINS; HEPATIC STELLATE CELLS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER CIRRHOSIS; MEMBRANE PROTEINS; MORPHOGENESIS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

EID: 84942822765     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/j.clinre.2015.05.017     Document Type: Short Survey

References (49)

1. Michalopoulos G.K. Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. Am J Pathol 2010, 176(1):2-13.
2. Stanger B.Z. Cellular homeostasis and repair in the mammalian liver. Annu Rev Physiol 2015, 77:179-200.
3. Friedman S.L. Liver fibrosis - from bench to bedside. J Hepatol 2003, 38(Suppl. 1):S38-S53.
4. Friedman S.L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008, 88(1):125-172.
5. Tsukamoto H., She H., Hazra S., Cheng J., Wang J. Fat paradox of steatohepatitis. J Gastroenterol Hepatol 2008, 23(Suppl. 1):S104-S107.
6. Ito T., Shibasaki S. Electron microscopic study on the hepatic sinusoidal wall and the fat-storing cells in the normal human liver. Arch Histol Jpn 1968, 29(2):137-192.
7. Miyahara T., Schrum L., Rippe R., et al. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 2000, 275(46):35715-35722.
8. Hazra S., Xiong S., Wang J., et al. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 2004, 279(12):11392-11401.
9. Lecuit T., Goff L.L. Orchestrating size and shape during morphogenesis. Nature 2007, 450(7167):189-192.
10. Turing A.M. The chemical basis of morphogenesis. Philosophical Transactions 1952.
11. Wolpert L. Positional information and the spatial pattern of cellular differentiation. J Theor Biol 1969, 25(1):1-47.
12. Wessells N.K., Cohen J.H. Early pancreas organogenesis: morphogenesis, tissue interactions, and mass effects. Dev Biol 1967, 15(3):237-270.
13. Zaret K.S., Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008, 322(5907):1490-1494.
14. Lee C.S., Friedman J.R., Fulmer J.T., Kaestner K.H. The initiation of liver development is dependent on Foxa transcription factors. Nature 2005, 435(7044):944-947.
15. Rossi J.M., Dunn N.R., Hogan B.L., Zaret K.S. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 2001, 15(15):1998-2009.
16. Asahina K., Zhou B., Pu W.T., Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 2011, 53(3):983-995.
17. Macdonald R.A. "Lifespan" of liver cells. Autoradio-graphic study using tritiated thymidine in normal, cirrhotic, and partially hepatectomized rats. Arch Intern Med 1961, 107:335-343.
18. Maeda K., Kobayashi Y., Udagawa N., et al. Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis. Nat Med 2012, 18:405-412.
19. Naskar D., Maiti G., Chakraborty A., Roy A., Chattopadhyay D., Sen M. Wnt5a-Rac1-NF-κB homeostatic circuitry sustains innate immune functions in macrophages. J Immunol 2014, 192(9):4386-4397.
20. Schlessinger K., Hall A., Tolwinski N. Wnt signaling pathways meet Rho GTPases. Genes Dev 2009, 23(3):265-277.
21. Myung S.J., Yoon J.H., Gwak G.Y., et al. Wnt signaling enhances the activation and survival of human hepatic stellate cells. FEBS Lett 2007, 581(16):2954-2958.
22. Jiang F., Parsons C.J., Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 2006, 45(3):401-409.
23. Cheng J.H., She H., Han Y.P., et al. Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis. Am J Physiol Gastrointest Liver Physiol 2008, 294(1):G39-G49.
24. Bennett C.N., Ross S.E., Longo K.A., et al. Regulation of Wnt signaling during adipogenesis. J Biol Chem 2002, 277(34):30998-31004.
25. Ross S.E., Hemati N., Longo K.A., et al. Inhibition of adipogenesis by Wnt signaling. Science 2000, 289(5481):950-953.
26. Kordes C., Sawitza I., Haussinger D. Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun 2008, 367(1):116-123.
27. Barker P.A., Salehi A. The MAGE proteins: emerging roles in cell cycle progression, apoptosis, and neurogenetic disease. J Neurosci Res 2002, 67(6):705-712.
28. Kuwajima T., Taniura H., Nishimura I., Yoshikawa K. Necdin interacts with the Msx2 homeodomain protein via MAGE-D1 to promote myogenic differentiation of C2C12 cells. J Biol Chem 2004, 279(39):40484-40493.
29. Tseng Y.H., Butte A.J., Kokkotou E., et al. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol 2005, 7(6):601-611.
30. Zhu N.L., Wang J., Tsukamoto H. The Necdin-Wnt pathway causes epigenetic peroxisome proliferator-activated receptor gamma repression in hepatic stellate cells. J Biol Chem 2010, 285(40):30463-30471.
31. Zong Y., Panikkar A., Xu J., et al. Notch signaling controls liver development by regulating biliary differentiation. Development 2009, 136(10):1727-1739.
32. Tanimizu N., Miyajima A. Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors. J Cell Sci 2004, 117(Pt 15):3165-3174.
33. Sparks E.E., Perrien D.S., Huppert K.A., Peterson T.E., Huppert S.S. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech 2011, 4(3):359-367.
34. D'Souza B., Meloty-Kapella L., Weinmaster G. Canonical and non-canonical Notch ligands. Curr Top Dev Biol 2010, 92:73-129.
35. Kohler C., Bell A.W., Bowen W.C., Monga S.P., Fleig W., Michalopoulos G.K. Expression of Notch-1 and its ligand Jagged-1 in rat liver during liver regeneration. Hepatology 2004, 39(4):1056-1065.
36. Reister S., Kordes C., Sawitza I., Haussinger D. The epigenetic regulation of stem cell factors in hepatic stellate cells. Stem Cells Dev 2011, 20(10):1687-1699.
37. Furubo S., Sato Y., Harada K., Nakanuma Y. Roles of myofibroblasts and notch and hedgehog signaling pathways in the formation of intrahepatic bile duct lesions in polycystic kidney rats. Pediatr Dev Pathol 2013, 16(3):177-190.
38. Zhu N.L., Asahina K., Wang J., et al. Hepatic stellate cell-derived delta-like homolog 1 (DLK1) protein in liver regeneration. J Biol Chem 2012, 287(13):10355-10367.
39. Smas C.M., Sul H.S. Pref-1, a protein containing EGF-like repeats, inhibits adipocyte differentiation. Cell 1993, 73(4):725-734.
40. Tanimizu N., Nishikawa M., Saito H., Tsujimura T., Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003, 116(Pt 9):1775-1786.
41. Yanai H., Nakamura K., Hijioka S., et al. Dlk-1, a cell surface antigen on foetal hepatic stem/progenitor cells, is expressed in hepatocellular, colon, pancreas and breast carcinomas at a high frequency. J Biochem 2010, 148(1):85-92.
42. Kim Y., Lin Q., Zelterman D., Yun Z. Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res 2009, 69(24):9271-9280.
43. Nusslein-Volhard C., Wieschaus E. Mutations affecting segment number and polarity in Drosophila. Nature 1980, 287(5785):795-801.
44. Yang L., Wang Y., Mao H., et al. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 2008, 48(1):98-106.
45. Lin N., Tang Z., Deng M., et al. Hedgehog-mediated paracrine interaction between hepatic stellate cells and marrow-derived mesenchymal stem cells. Biochem Biophys Res Commun 2008, 372(1):260-265.
46. Omenetti A., Yang L., Li Y.X., et al. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest 2007, 87(5):499-514.
47. Qiu J., Zhou Q., Zhai X., Jia X., Zhou Y. Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell. Eur J Pharmacol 2014, 728:9-15.
48. Michelotti G.A., Xie G., Swiderska M., et al. Smoothened is a master regulator of adult liver repair. J Clin Invest 2013, 123(6):2380-2394.
49. Kisseleva T., Cong M., Paik Y., et al. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. Proc Natl Acad Sci U S A 2012, 109(24):9448-9453.