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Volumn 69, Issue 24, 2009, Pages 9271-9280

Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CD133 ANTIGEN; CYCLINE; GENE PRODUCT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; NOTCH1 RECEPTOR; PROTEIN DLK1; SERINE; TYROSINE; UNCLASSIFIED DRUG;

EID: 73649094822     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1605     Document Type: Article
Times cited : (107)

References (44)
  • 1
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006;66:9339-44.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 2
    • 49249091689 scopus 로고    scopus 로고
    • Is tumor growth sustained by rare cancer stem cells or dominant clones?
    • Adams JM, Strasser A. Is tumor growth sustained by rare cancer stem cells or dominant clones? Cancer Res 2008;68:4018-21.
    • (2008) Cancer Res , vol.68 , pp. 4018-4021
    • Adams, J.M.1    Strasser, A.2
  • 3
    • 34547121206 scopus 로고    scopus 로고
    • Hypoxia in cancer: Significance and impact on clinical outcome
    • Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev 2007;26:225-39.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 225-239
    • Vaupel, P.1    Mayer, A.2
  • 4
    • 54249151684 scopus 로고    scopus 로고
    • Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction
    • Das B, Tsuchida R, Malkin D, Koren G, Baruchel S, Yeger H. Hypoxia enhances tumor stemness by increasing the invasive and tumorigenic side population fraction. Stem Cells 2008;26:1818-30.
    • (2008) Stem Cells , vol.26 , pp. 1818-1830
    • Das, B.1    Tsuchida, R.2    Malkin, D.3    Koren, G.4    Baruchel, S.5    Yeger, H.6
  • 5
    • 0037076385 scopus 로고    scopus 로고
    • Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype
    • Jogi A, Ora I, Nilsson H, et al. Hypoxia alters gene expression in human neuroblastoma cells toward an immature and neural crest-like phenotype. Proc Natl Acad Sci U S A 2002;99:7021-6.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 7021-7026
    • Jogi, A.1    Ora, I.2    Nilsson, H.3
  • 6
    • 19944434272 scopus 로고    scopus 로고
    • Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: Negative correlation of microvascular density and VEGF expression with tumour progression
    • Couvelard A, O'Toole D, Turley H, et al. Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. Br J Cancer 2005;92:94-101.
    • (2005) Br J Cancer , vol.92 , pp. 94-101
    • Couvelard, A.1    O'Toole, D.2    Turley, H.3
  • 7
    • 33750630119 scopus 로고    scopus 로고
    • Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype
    • Holmquist-Mengelbier L, Fredlund E, Lofstedt T, et al. Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype. Cancer Cell 2006; 10:413-23.
    • (2006) Cancer Cell , vol.10 , pp. 413-423
    • Holmquist-Mengelbier, L.1    Fredlund, E.2    Lofstedt, T.3
  • 8
    • 65749106405 scopus 로고    scopus 로고
    • Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells
    • Li Z, Bao S, Wu Q, et al. Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells. Cancer Cell 2009;15:501-13.
    • (2009) Cancer Cell , vol.15 , pp. 501-513
    • Li, Z.1    Bao, S.2    Wu, Q.3
  • 9
    • 16344380951 scopus 로고    scopus 로고
    • Low O2 tensions and the prevention of differentiation of hES cells
    • Ezashi T, Das P, Roberts RM. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci U S A 2005;102:4783-8.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4783-4788
    • Ezashi, T.1    Das, P.2    Roberts, R.M.3
  • 10
    • 27644561755 scopus 로고    scopus 로고
    • Hypoxia requires notch signaling to maintain the undifferentiated cell state
    • Gustafsson MV, Zheng X, Pereira T, et al. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005;9:617-28.
    • (2005) Dev Cell , vol.9 , pp. 617-628
    • Gustafsson, M.V.1    Zheng, X.2    Pereira, T.3
  • 11
    • 33750038847 scopus 로고    scopus 로고
    • Differentiation arrest by hypoxia
    • Lin Q, Lee YJ, Yun Z. Differentiation arrest by hypoxia. J Biol Chem 2006;281:30678-83.
    • (2006) J Biol Chem , vol.281 , pp. 30678-30683
    • Lin, Q.1    Lee, Y.J.2    Yun, Z.3
  • 12
    • 0036198010 scopus 로고    scopus 로고
    • Inhibition of PPARg2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
    • Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPARg2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2002;2:331-41.
    • (2002) Dev Cell , vol.2 , pp. 331-341
    • Yun, Z.1    Maecker, H.L.2    Johnson, R.S.3    Giaccia, A.J.4
  • 13
    • 0033885174 scopus 로고    scopus 로고
    • Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation
    • Floridon C, Jensen CH, Thorsen P, et al. Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 2000;66:49-59.
    • (2000) Differentiation , vol.66 , pp. 49-59
    • Floridon, C.1    Jensen, C.H.2    Thorsen, P.3
  • 14
    • 0028017528 scopus 로고
    • Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2
    • Jensen CH, Krogh TN, Hojrup P, et al. Protein structure of fetal antigen 1 (FA1). A novel circulating human epidermal-growth-factor-like protein expressed in neuroendocrine tumors and its relation to the gene products of dlk and pG2. Eur J Biochem 1994;225:83-92.
    • (1994) Eur J Biochem , vol.225 , pp. 83-92
    • Jensen, C.H.1    Krogh, T.N.2    Hojrup, P.3
  • 15
    • 0030457199 scopus 로고    scopus 로고
    • FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression
    • Tornehave D, Jensen CH, Teisner B, Larsson LI. FA1 immunoreactivity in endocrine tumours and during development of the human fetal pancreas; negative correlation with glucagon expression. Histochem Cell Biol 1996;106:535-42.
    • (1996) Histochem Cell Biol , vol.106 , pp. 535-542
    • Tornehave, D.1    Jensen, C.H.2    Teisner, B.3    Larsson, L.I.4
  • 16
    • 33645325623 scopus 로고    scopus 로고
    • DLK1: Increased expression in gliomas and associated with oncogenic activities
    • Yin D, Xie D, Sakajiri S, et al. DLK1: increased expression in gliomas and associated with oncogenic activities. Oncogene 2006;25:1852-61.
    • (2006) Oncogene , vol.25 , pp. 1852-1861
    • Yin, D.1    Xie, D.2    Sakajiri, S.3
  • 17
    • 23744486278 scopus 로고    scopus 로고
    • Dlk1 in normal and abnormal hematopoiesis
    • Sakajiri S, O'Kelly J, Yin D, et al. Dlk1 in normal and abnormal hematopoiesis. Leukemia 2005;19:1404-10.
    • (2005) Leukemia , vol.19 , pp. 1404-1410
    • Sakajiri, S.1    O'Kelly, J.2    Yin, D.3
  • 18
    • 0037457658 scopus 로고    scopus 로고
    • High ä-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type
    • Van Limpt VA, Chan AJ, Van Sluis PG, Caron HN, Van Noesel CJ, Versteeg R. High ä-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type. Int J Cancer 2003;105:61-9.
    • (2003) Int J Cancer , vol.105 , pp. 61-69
    • Van Limpt, V.A.1    Chan, A.J.2    Van Sluis, P.G.3    Caron, H.N.4    Van Noesel, C.J.5    Versteeg, R.6
  • 19
    • 21744438770 scopus 로고    scopus 로고
    • Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation
    • Li L, Forman SJ, Bhatia R. Expression of DLK1 in hematopoietic cells results in inhibition of differentiation and proliferation. Oncogene 2005;24:4472-6.
    • (2005) Oncogene , vol.24 , pp. 4472-4476
    • Li, L.1    Forman, S.J.2    Bhatia, R.3
  • 20
    • 16244406228 scopus 로고    scopus 로고
    • Adaptive myogenesis under hypoxia
    • Yun Z, Lin Q, Giaccia AJ. Adaptive myogenesis under hypoxia. Mol Cell Biol 2005;25:3040-55.
    • (2005) Mol Cell Biol , vol.25 , pp. 3040-3055
    • Yun, Z.1    Lin, Q.2    Giaccia, A.J.3
  • 21
    • 38049173572 scopus 로고    scopus 로고
    • A gain-of-function mutation in the HIF2A gene in familial erythrocytosis
    • Percy MJ, FurlowPW, Lucas GS, et al. A gain-of-function mutation in the HIF2A gene in familial erythrocytosis. N Engl J Med 2008;358:162-8.
    • (2008) N Engl J Med , vol.358 , pp. 162-168
    • Percy, M.J.1    Furlow, P.W.2    Lucas, G.S.3
  • 22
    • 10744229064 scopus 로고    scopus 로고
    • RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA
    • Katayama K, Wada K, Miyoshi H, et al. RNA interfering approach for clarifying the PPARγ pathway using lentiviral vector expressing short hairpin RNA. FEBS Lett 2004;560:178-82.
    • (2004) FEBS Lett , vol.560 , pp. 178-182
    • Katayama, K.1    Wada, K.2    Miyoshi, H.3
  • 23
    • 0142026839 scopus 로고    scopus 로고
    • Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth
    • Hirama M, Takahashi F, Takahashi K, et al. Osteopontin overproduced by tumor cells acts as a potent angiogenic factor contributing to tumor growth. Cancer Lett 2003;198: 107-17.
    • (2003) Cancer Lett , vol.198 , pp. 107-117
    • Hirama, M.1    Takahashi, F.2    Takahashi, K.3
  • 24
    • 0036875135 scopus 로고    scopus 로고
    • Pref-1 and ADSF/resistin: Two secreted factors inhibiting adipose tissue development
    • Villena JA, Kim KH, Sul HS. Pref-1 and ADSF/resistin: two secreted factors inhibiting adipose tissue development. Horm Metab Res 2002;34:664-70.
    • (2002) Horm Metab Res , vol.34 , pp. 664-670
    • Villena, J.A.1    Kim, K.H.2    Sul, H.S.3
  • 26
    • 34047112221 scopus 로고    scopus 로고
    • Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia
    • Bindra RS, Glazer PM. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene 2007;26:2048-57.
    • (2007) Oncogene , vol.26 , pp. 2048-2057
    • Bindra, R.S.1    Glazer, P.M.2
  • 27
    • 33646248422 scopus 로고    scopus 로고
    • Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 α (HIF-1α) and HIF-2α in stem cells
    • Hu CJ, Iyer S, Sataur A, Covello KL, Chodosh LA, Simon MC. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 α (HIF-1α) and HIF-2α in stem cells. Mol Cell Biol 2006;26:3514-26.
    • (2006) Mol Cell Biol , vol.26 , pp. 3514-3526
    • Hu, C.J.1    Iyer, S.2    Sataur, A.3    Covello, K.L.4    Chodosh, L.A.5    Simon, M.C.6
  • 28
    • 0037767937 scopus 로고    scopus 로고
    • A role for distinct cell types in determining malignancy in human neuroblastoma cell lines and tumors
    • Ross RA, Biedler JL, Spengler BA. A role for distinct cell types in determining malignancy in human neuroblastoma cell lines and tumors. Cancer Lett 2003;197:35-9.
    • (2003) Cancer Lett , vol.197 , pp. 35-39
    • Ross, R.A.1    Biedler, J.L.2    Spengler, B.A.3
  • 29
    • 4544230424 scopus 로고    scopus 로고
    • Characteristics of stem cells from human neuroblastoma cell lines and in tumors
    • Walton JD, Kattan DR, Thomas SK, et al. Characteristics of stem cells from human neuroblastoma cell lines and in tumors. Neoplasia 2004;6:838-45.
    • (2004) Neoplasia , vol.6 , pp. 838-845
    • Walton, J.D.1    Kattan, D.R.2    Thomas, S.K.3
  • 30
    • 0344735881 scopus 로고    scopus 로고
    • Cancerous stem cells can arise from pediatric brain tumors
    • Hemmati HD, Nakano I, Lazareff JA, et al. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci U S A 2003;100:15178-83.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15178-15183
    • Hemmati, H.D.1    Nakano, I.2    Lazareff, J.A.3
  • 31
    • 19044397160 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
    • Bachoo RM, Maher EA, Ligon KL, et al. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 2002;1:269-77.
    • (2002) Cancer Cell , vol.1 , pp. 269-277
    • Bachoo, R.M.1    Maher, E.A.2    Ligon, K.L.3
  • 32
    • 0345863393 scopus 로고    scopus 로고
    • Constitutive EGFR signaling confers a motile phenotype to neural stem cells
    • Boockvar JA, Kapitonov D, Kapoor G, et al. Constitutive EGFR signaling confers a motile phenotype to neural stem cells. Mol Cell Neurosci 2003;24:1116-30.
    • (2003) Mol Cell Neurosci , vol.24 , pp. 1116-1130
    • Boockvar, J.A.1    Kapitonov, D.2    Kapoor, G.3
  • 33
    • 38549132254 scopus 로고    scopus 로고
    • Constitutive EGFR signaling in oligodendrocyte progenitors leads to diffuse hyperplasia in postnatal white matter
    • Ivkovic S, Canoll P, Goldman JE. Constitutive EGFR signaling in oligodendrocyte progenitors leads to diffuse hyperplasia in postnatal white matter. J Neurosci 2008; 28:914-22.
    • (2008) J Neurosci , vol.28 , pp. 914-922
    • Ivkovic, S.1    Canoll, P.2    Goldman, J.E.3
  • 34
    • 33847194579 scopus 로고    scopus 로고
    • Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors
    • Maric D, Fiorio Pla A, Chang YH, Barker JL. Self-renewing and differentiating properties of cortical neural stem cells are selectively regulated by basic fibroblast growth factor (FGF) signaling via specific FGF receptors. J Neurosci 2007;27:1836-52.
    • (2007) J Neurosci , vol.27 , pp. 1836-1852
    • Maric, D.1    Fiorio Pla, A.2    Chang, Y.H.3    Barker, J.L.4
  • 35
    • 34547886139 scopus 로고    scopus 로고
    • Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain
    • Saarimaki-Vire J, Peltopuro P, Lahti L, et al. Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain. J Neurosci 2007;27:8581-92.
    • (2007) J Neurosci , vol.27 , pp. 8581-8592
    • Saarimaki-Vire, J.1    Peltopuro, P.2    Lahti, L.3
  • 37
    • 59649116008 scopus 로고    scopus 로고
    • Regulation of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation
    • Berwick DC, Calissano M, Corness JD, Cook SJ, Latchman DS. Regulation of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation. Brain Res 2009;1256:8-18.
    • (2009) Brain Res , vol.1256 , pp. 8-18
    • Berwick, D.C.1    Calissano, M.2    Corness, J.D.3    Cook, S.J.4    Latchman, D.S.5
  • 38
    • 37049033079 scopus 로고    scopus 로고
    • Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell
    • Hansford LM, McKee AE, Zhang L, et al. Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell. Cancer Res 2007;67:11234-43.
    • (2007) Cancer Res , vol.67 , pp. 11234-11243
    • Hansford, L.M.1    McKee, A.E.2    Zhang, L.3
  • 39
    • 42649112047 scopus 로고    scopus 로고
    • An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors
    • Ben-Porath I, Thomson MW, Carey VJ, et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet 2008;40:499-507.
    • (2008) Nat Genet , vol.40 , pp. 499-507
    • Ben-Porath, I.1    Thomson, M.W.2    Carey, V.J.3
  • 40
    • 33644820339 scopus 로고    scopus 로고
    • Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
    • Phillips HS, Kharbanda S, Chen R, et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 2006;9: 157-73.
    • (2006) Cancer Cell , vol.9 , pp. 157-173
    • Phillips, H.S.1    Kharbanda, S.2    Chen, R.3
  • 41
    • 0031813294 scopus 로고    scopus 로고
    • Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements
    • Bauer SR, Ruiz-Hidalgo MJ, Rudikoff EK, Goldstein J, Laborda J. Modulated expression of the epidermal growth factor-like homeotic protein dlk influences stromal-cell-pre-B-cell interactions, stromal cell adipogenesis, and pre-B-cell interleukin-7 requirements. Mol Cell Biol 1998;18:5247-55.
    • (1998) Mol Cell Biol , vol.18 , pp. 5247-5255
    • Bauer, S.R.1    Ruiz-Hidalgo, M.J.2    Rudikoff, E.K.3    Goldstein, J.4    Laborda, J.5
  • 43
    • 0027467416 scopus 로고    scopus 로고
    • Laborda J, Sausville EA, Hoffman T, Notario V. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 1993;268:3817-20.
    • Laborda J, Sausville EA, Hoffman T, Notario V. dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem 1993;268:3817-20.
  • 44
    • 40349088993 scopus 로고    scopus 로고
    • High levels of HIF-2α highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche
    • Pietras A, Gisselsson D, Ora I, et al. High levels of HIF-2α highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche. J Pathol 2008;214:482-8.
    • (2008) J Pathol , vol.214 , pp. 482-488
    • Pietras, A.1    Gisselsson, D.2    Ora, I.3


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