Molecular mechanism of silver nanoparticles in human intestinal cells

Nanotoxicology

Volumn 9, Issue 7, 2015, Pages 852-860

  Böhmert, Linda ^a   Niemann, Birgit ^a   Lichtenstein, Dajana ^a   Juling, Sabine ^a   Lampen, Alfonso ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

Author keywords

Caco 2 cells; in vitro; microarray; oral; silver nanoparticles

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METAL ION; SILVER NANOPARTICLE; SURFACTANT; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2; METAL NANOPARTICLE; SILVER;

APOPTOSIS; ARTICLE; CACO 2 CELL LINE; CELL ADHESION; CELL CONTACT; CELL DEATH; CELL STRUCTURE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY TEST; DEPOLARIZATION; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IMPEDANCE; INTESTINE CELL; MATERIAL COATING; MICROARRAY ANALYSIS; MICROSCOPY; MOLECULAR MECHANICS; OXIDATIVE STRESS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIGHT JUNCTION; CACO-2 CELL LINE; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; INTESTINE; METABOLISM; ULTRASTRUCTURE;

APOPTOSIS; CACO-2 CELLS; CELL SURVIVAL; GENE EXPRESSION PROFILING; HUMANS; INTESTINES; METAL NANOPARTICLES; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; SILVER;

EID: 84942609975     PISSN: 17435390     EISSN: 17435404     Source Type: Journal    
DOI: 10.3109/17435390.2014.980760     Document Type: Article

References (48)

1. Ahamed M, Karns M, Goodson M, Rowe J, Hussain SM, Schlager JJ, Hong Y. 2008. DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells. Toxicol Appl Pharmacol 15: 404-10
2. Arora S, Jain J, Rajwade JM, Paknikar KM. 2009. Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells. Toxicol Appl Pharmacol 236: 310-8
3. BAM. 2013. Certified Reference Material BAM-N001: particle Size Parameters of Nano Silver. 11
4. Behrens I, Pena AIV, Alonso MJ, Kiessel T. 2002. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm Res 19: 1185-93
5. Böhmert L, Girod M, Hansen U, Maul R, Knappe P, Niemann B, et al. 2013. Analytically monitored digestion of silver nanoparticles and their toxicity for human intestinal cells. Nanotoxicology 42: 8959-64
6. Böhmert L, Niemann B, Thünemann AF, Lampen A. 2012. Cytotoxicity of peptide-coated silver nanoparticles on the human intestinal cell line Caco-2. Arch Toxicol 86: 1107-15
7. Bouwmeester H, Poortman J, Peters RJ, Kramer E, Makama S, Puspitaninganindita K, et al. 2011. Charakterisation of translocation of silver nanoparticles and effects on whole-genome gene expression using an in vitro intestinal epithelium coculture model. ACS Nano 5: 4091-103
8. Clark EA, Brugge JS. 1995. Integrins and signal transduction pathways: the road taken. Science 268: 233-9
9. Deng F, Olesen P, Foldbjerg R, Dang DA, Guo X, Autrup H. 2010. Silver nanoparticles up-regulate Connexin43 expression and increase gap junctional intercellular communication in human lung adenocarcinoma cell line A549. Nanotoxicology 4: 186-95
10. Eom H-J, Choi J. 2010. p38 MAPK Activation, DNA damage, cell cycle arrest and apoptosis as mechanisms of toxicity of silver nanoparticles in Jurkat T cells. Environ Sci Technol 44: 8337-42
11. Foldbjerg R, Irving ES, Hayashi Y, Sutherland DS, Thorsen K, Autrup H, Beer C. 2012. Global gene expression profiling of human lung epithelial cells after exposure to nanosilver. Toxicol Sci 130: 145-57
12. Gitrowski C, Al-Jubory AR, Handy RD. 2014. Uptake of different crystal structures of TiO2 nanoparticles by Caco-2 intestinal cells. Toxicol Lett 226: 264-76
13. Gopinath P, Gogoi SK, Sanpui P, Paul A, Chattopadhyay A, Ghosh SS. 2010. Signaling gene cascade in silver nanoparticle induced apoptosis. Colloids Surf B Biointerfaces 77: 240-5
14. Harris C, Hansen J. 2012. Oxidative stress, thiols, and redox profiles. Methods Mol Biol 889: 325-46
15. He B, Lin P, Jia Z, Du W, Qu W, Yuan L, et al. 2013. The transport mechanisms of polymer nanoparticles in Caco-2 epithelial cells. Biomaterials 34: 6082-98
16. Honore S, Pichard V, Penel C, Rigot V, Prev TC, Marvaldi J, et al. 2000. Outside-in regulation of integrin clustering processes by ECM components per se and their involvement in actin cytoskeleton organization in a colon adenocarcinoma cell line. Histochem Cell Biol 114: 323-35
17. Hsin Y-H, Chen C-F, Huang S, Shih T-S, Lai P-S, Chueh PJ. 2008. The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Lett 179: 130-9
18. Hubatsch I, Ragnarsson EGE, Artursson P. 2007. Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers. Nat Protocols 2: 2111-9
19. Imhoff BR, Hansen JM. 2009. Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species. Biochem J 424: 491-500
20. Kang M-I, Kobayashi A, Nobunao W, Kim S-G, Yamamoto M. 2004. Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes. Proc Natl Acad Sci 101: 2046-51
21. Kang SJ, Ryoo I-G, Lee YJ, Kwak M-K. 2012. Role of the Nrf2-heme oxygenase-1 pathway in silver nanoparticle-mediated cytotoxicity. Toxicol Appl Pharmacol 258: 89-98
22. Kawata K, Osawa M, Okabe S. 2009. In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells. Environ Sci Technol 43: 6046-51
23. Kim E, Chu YC, Han JY, Lee DH, Kim YJ, Kim H-C, et al. 2010. Proteomic analysis of silver nanoparticle toxicity in rat. Toxicol Environ Health Sci 2: 251-62
24. Kim S, Ryu D-Y. 2013. Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissues. J Appl Toxicol 33: 78-89
25. Klein CL, Comero S, Stahlmecke B, Romazanov J, Kuhlbusch TAJ, Van Doren E, et al. 2011. NM-Series of representative manufactured nanomaterials: NM-300 silver characterisation, stability, homogeneity. In: EUR 24693 EN-2011. Luxembourg: Publications Office of the European Union
26. Lampen A, Ebert B, Stumkat L, Jacob J, Seidel A. 2004. Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells. Biochimica et Biophysica Acta (BBA)-Gene Struct Expr 1681: 38-46
27. Lee YS, Kim DW, Lee YH, Oh JH, Yoon S, Choi MS, et al. 2011. Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells. Arch Toxicol 85: 1529-40
28. Lindeque JZ, Levanets O, Louw R, Van Der Westhuizen FH. 2010. The involvement of metallothioneins in mitochondrial function and disease. Curr Protein Peptide Sci 11: 292-309
29. Liu W, Wu Y, Wang C, Li HC, Wang T, Liao CY, et al. 2010. Impact of silver nanoparticles on human cells: effect of particle size. Nanotoxicology 4: 319-30
30. Miethling-Graff R, Rumpker R, Richter M, Verano-Braga T, Kjeldsen F, Brewer J, et al. 2014. Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells. Toxicol in Vitro 28: 1280-9
31. Miura N, Shinohara Y. 2009. Cytotoxic effect and apoptosis induction by silver nanoparticles in HeLa cells. Biochem Biophys Res Commun 390: 733-7
32. Moriarty-Craige SE, Jones DP. 2004. Extracellular thiols and thiol/disulfide redox in metabolism. Annu Rev Nutr 24: 481-509
33. Nanotechproject.Org. 2014. Available at: http://www.nanotechproject.org/. Accessed on 12 May 2014
34. Nkabyo YS, Ziegler TR, Gu LH, Watson WH, Johnes DP. 2002. Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells. Am J Physiol Gastrointest Liver Physiol 283: 1352-9
35. Nowrouzi A, Meghrazi K, Golmohammadi T, Golestani A, Ahmadian S, Shafiezadeh M, et al. 2010. Cytotoxicity od subtoxic AgNP in human hepatoma cell line (HepG2) after long-term exposure. Iran Biomed J 14: 23-32
36. O'donnell MA, Legarda-Addison D, Skountzos P, Yeh WC, Ting AT. 2007. Ubiquitination of RIP1 Regulates an NF-B-Independent Cell-Death Switch in TNF Signaling. Curr Biol 17: 418-24
37. Park E-J, Yi J, Kim Y, Choi K, Park K. 2010. Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism. Toxicol in Vitro 24: 872-8
38. Piao MJ, Kang KA, Lee IK, Kim HS, Kim S, Choi JY, et al. 2011. Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Toxicol Lett 201: 92-100
39. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. 2010. Oxidative stress, inflammation, and cancer: how are they linked? Free Radical Biol Med 49: 1603-16
40. Satapathy SR, Mohapatra P, Preet R, Das D, Sarkar B, Choudhuri T, et al. 2013. Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53. Nanomedicine 8: 1307-22
41. Shen B, Delaney MK, Du X. 2012. Inside-out, outside-in, and inside-outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction. Curr Opinion Cell Biol 24: 600-6
42. Simmons SO, Fan C-Y, Yeoman K, Wakefield J, Ramabhadran R. 2011. NRF2 oxidative stress induced by heavy metals is cell type dependent. Curr Chem Genomics 5: 1-12
43. Stępkowski TM, Brzóska K, Kruszewski M. 2014. Silver nanoparticles induced changes in the expression of NF-B related genes are cell type specific and related to the basal activity of NF-B. Toxicol in Vitro 28: 473-8
44. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-Biol Interactions 160: 1-40
45. Walczak AP, Fokkink R, Peters R, Tromp P, Herrera Rivera ZE, Rietjens IMCM, et al. 2013. Behaviour of silver nanoparticles and silver ions in an in vitro human gastrointestinal digestion model. Nanotoxicology 7: 1198-210
46. Whitmarsh AJ, Davis RJ. 1996. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74: 589-607
47. Wijnhoven SWP, Peijnenburg WJGM, Herberts CA, Hagens WI, Oomen AG, Heugens EHW, et al. 2009. Nano-silver-a review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology 3: 109-38
48. Yu S-H, Tang D-W, Hsieh H-Y, Wu W-S, Lin B-X, Chuang E-Y, et al. 2013. Nanoparticle-induced tight-junction opening for the transport of an anti-angiogenic sulfated polysaccharide across Caco-2 cell monolayers. Acta Biomaterialia 9: 7449-59