The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice

Free Radical Research

Volumn 49, Issue 11, 2015, Pages 1308-1318

  Anvari, E ^a   Wikstrom P ^b   Walum, E ^b   Welsh, N ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b Glucox Biotech AB   (Sweden)

Author keywords

beta cell death; glucose intolerance; human islet; insulin release; NADPH oxidase; NOX inhibitor; reactive oxygen radical

Indexed keywords

ANTIDIABETIC AGENT; ETHYL 2 [[2 [4 (FURAN 2 CARBONYL)PIPERAZIN 1 YL]ACETYL]AMINO] 5,6 DIHYDRO 4H CYCLOPENTA [B]THIOPHENE 3 CARBOXYLATE; INSULIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; UNCLASSIFIED DRUG; ENZYME INHIBITOR; NOX4 PROTEIN, MOUSE; PIPERAZINE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOPHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL/6N MOUSE; DRUG SELECTIVITY; ENZYME INHIBITION; GLUCOSE INTOLERANCE; HUMAN; HUMAN CELL; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID DIET; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; METABOLISM; PRECLINICAL STUDY;

ANIMALS; DIET, HIGH-FAT; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GLUCOSE INTOLERANCE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYPERGLYCEMIA; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; PIPERAZINES; REACTIVE OXYGEN SPECIES; THIOPHENES;

EID: 84942501536     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715762.2015.1067697     Document Type: Article

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