Impaired insulin secretion by diphenyleneiodium associated with perturbation of cytosolic Ca2+ dynamics in pancreatic β-cells

Endocrinology

Volumn 149, Issue 11, 2008, Pages 5391-5400

  Imoto, Hirofumi ^a   Sasaki, Nobuhiro ^a   Iwase, Masanori ^a   Nakamura, Udai ^a   Oku, Miwako ^a   Sonoki, Kazuo ^a   Uchizono, Yuji ^a   Iida, Mitsuo ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; CARBACHOL; DIPHENYLIODONIUM SALT; GLUCOSE; INSULIN; NADPH OXIDASE INHIBITOR; NIFEDIPINE; PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THAPSIGARGIN; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; CYTOSOLIC FRACTION; DOSE RESPONSE; GLUCOSE OXIDATION; INSULIN DEFICIENCY; INSULIN METABOLISM; MALE; MEMBRANE DEPOLARIZATION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM SIGNALING; CELLS, CULTURED; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GLUCOSE; HYDROGEN PEROXIDE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MALE; ONIUM COMPOUNDS; OXIDATION-REDUCTION; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; WASP VENOMS;

EID: 54349114273     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-0186     Document Type: Article

References (39)

1. Stewart GA, Hanley T 1969 In: Campbell GD, ed. Oral hypoglycaemic agents. New York: Academic Press; 347-407
2. Holland PC, Clark MG, Bloxham DP, Lardy HA 1973 Mechanism of action of the hypoglycemic agent diphenyleneiodonium. J Biol Chem 248:6050-6056
3. Ragan IC, Bloxham PD 1977 Specific labeling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamide-adenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium. Biochem J 163:605-615
4. Cross AR, Jones OT 1986 The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Specific labelling of a component polypeptide of the oxidase. Biochem J 237:111-116
5. O'Donnell VB, Smith GC, Jones OT 1994 Involvement of phenyl radicals in iodonium inhibition of flavoenzymes. Mol Pharmacol 46:778-785
6. Bedard K, Krause KH 2007 The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev: 87:245-313
7. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I 2004 Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114:1753-1761
8. Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K, Kawata S 2005 NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology 41:1272-1281
9. Nagel S, Genius J, Heiland S, Horstmann S, Gardner H, Wagner S 2007 Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat. Brain Res 1132:210-217
10. Yu JH, Kim HK, Kim GD, Kim H 2007 Diphenyleneiodonium suppresses apoptosis in cerulein-stimulated pancreatic acinar cells. Int J Biochem Cell Biol 39:2063-2075
11. Hutchinson DS, Csikasz IR, Yamamoto LD, Shabalina GI, Wikstrom P, Wilcke M, Bengtsson T 2007 Diphenylene iodonium stimulates glucose uptake in skeletal muscle cells through mitochondrial complex I inhibition and activation of AMP-activated protein kinase. Cell Signal 19:1610-1620
12. Oliveira HR, Verlengia R, Carvalho CR, Britto LR, Curi R, Carpinelli AR 2003 Pancreatic β-cells express phagocyte-like NAD(P)H oxidase. Diabetes 52:1457-1463
13. Uchizono Y, Takeya R, Iwase M, Sasaki N, Oku M, Imoto H, Iida M, Sumimoto H 2006 Expression of isoforms of NADPH oxidase components in rat pancreatic islets. Life Sci 80:133-139
14. Uchizono Y, Iwase M, Nakamura U, Sasaki N, Goto D, Iida M 2004 Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling. Endocrinology 145:2264-2272
15. Sasaki N, Iwase M, Uchizono Y, Nakamura U, Imoto H, Abe S, Iida M 2007 The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets. Diabetologia 49:2930-2938
16. 2+-independent late site in stimulus-secretion coupling. Studies with the RINm5F β-cell line. J Biol Chem 268:23297-23306
17. D'Autreaux B, Toledano MB 2007 ROS as signalling molecules. Mechanism that generate specificity in ROS homeostasis. Nat Rev Mol Cell Biol 8:813-824
18. Morgan D, Oliveira-Emiliol HR, Keane D, Hirata AE, Santos da Rocha M, Bordin S, Curi1 R, Newsholme P, Carpinellil ARC 2007 Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal β-cell line. Diabetologia 50:359-369
19. Maechler P, Jornot L, Wollheim CB 1999 Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic β-cells. J Biol Chem 274:27905-27913
20. 2+ homeostasis in rat pancreatic β cells. Cell Struct Funct 25:187-193
21. Guay C, Madiraju SR, Aumais A, Joly E, Prentki M 2007 A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced insulin secretion. J Biol Chem 282:35657-35665
22. Barford D 2004 The role of cysteine residues as redox-sensitive regulatory switches. Curr Opin Struct Biol 14:679-686
23. Takeishi Y, Jalili T, Ball NA, Walsh RA 1999 Responses of cardiac protein kinase C isoforms to distinct pathological stimuli are differentially regulated. Circ Res 85:264-271
24. 2+ channel α1C subunits by redox agents and hypoxia. J Physiol (Lond) 514:629-637
25. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S 2007 Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes 56:1783-1791
26. Stuehr JD, Fasehun AO, Kwon SN, Gross SS, Gonzalez AJ, Levi R, Nathan FC 1991 Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs. FASEB J 5:98-103
27. Doussiere J, Vignais VP 1992 Diphenylene iodonium as an inhibitor of the NADPH oxidase complex of bovine neutrophils. Factors controlling the inhibitory potency of diphenylene iodonium in a cell-free system of oxidase activation. Eur J Biochem 208:61-71
28. Tew GD 1993 Inhibition of cytochrome P450 reductase by the diphenyliodonium cation. Kinetic analysis and covalent modifications. Biochemistry 32:10209-10215
29. Pfeiffer DR, Gudz TI, Novgorodov SA, Erdahl WL 1995 The peptide mastoparan is a potent facilitator of the mitochondrial permeability transition. J Biol Chem 270:4923-4932
30. 2+ currents in type I cells isolated from the neonatal rat carotid body. Neurosci Lett 172:63-66
31. Weir EK, Wyatt CN, Reeve HL, Huang J, Archer SL, Peers C 1994 Diphenyleneiodonium inhibits both potassium and calcium currents in isolated pulmonary artery smooth muscle cells. J Appl Physiol 76:2611-2615
32. Rada BK, Geiszt M, Van Bruggen R, Nemet K, Roos D, Ligeti E 2003 Calcium signaling is altered in myeloid cells with a deficiency in NADPH oxidase activity. Clin Exp Immunol 132:53-60
33. 2+ channel function during acute hypoxia. Cardiovasc Res 67:624-635
34. Heinonen E, Akerman KE, Kaila K 1984 Depolarization of the mitochondrial membrane potential increases free cytosolic calcium in synaptosomes. Neurosci Lett 49:33-37
35. 2+ molecular determinants and functional consequences. Physiol Rev 86:369-408
36. Li N, Ragheb K, Lawler G, Sturgis J, Rajwa B, Melendez JA, Robinson JP 2003 DPI induces mitochondrial superoxide-mediated apoptosis. Free Radic Biol Med 34:465-477
37. Balcerczyk A, Soszynski M, Rybaczek D, Przygodzki T, Karowicz-Bilinska A, Maszewski J, Bartosz G 2005 Induction of apoptosis and modulation of production of reactive oxygen species in human endothelial cells by diphenyleneiodonium. Biochem Pharmacol 69:1263-1273
38. Park SE, Song JD, Kim KM, Park YM, Kim ND, Yoo YH, Park YC 2007 Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells. FEBS Lett 581:180-186
39. 2 and alloxan in pancreatic β cells. Free Radic Biol Med 40:2047-2055