Gefitinib and erlotinib lead to phosphorylation of eukaryotic initiation factor 2 alpha independent of epidermal growth factor receptor in A549 cells

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Koyama, Satoshi ^a   Omura, Tomohiro ^a   Yonezawa, Atsushi ^a   Imai, Satoshi ^a   Nakagawa, Shunsaku ^a   Nakagawa, Takayuki ^a   Yano, Ikuko ^a   Matsubara, Kazuo ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; INITIATION FACTOR 2ALPHA; MESSENGER RNA; PROTEIN KINASE R; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TAUROURSODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR; UBIQUITIN PROTEIN LIGASE E3; ANTINEOPLASTIC AGENT; CCND1 PROTEIN, HUMAN; INITIATION FACTOR 2; QUINAZOLINE DERIVATIVE; TAUROCHENODEOXYCHOLIC ACID;

ARTICLE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM STRESS; GROWTH INHIBITION; HUMAN; INTERSTITIAL LUNG DISEASE; LUNG ALVEOLUS EPITHELIUM CELL; LUNG INJURY; NON SMALL CELL LUNG CANCER; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA ISOLATION; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICALLY INDUCED; DRUG EFFECTS; LUNG ALVEOLUS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; CELL LINE; CELL PROLIFERATION; CYCLIN D1; ENDOPLASMIC RETICULUM STRESS; ERLOTINIB HYDROCHLORIDE; EUKARYOTIC INITIATION FACTOR-2; HUMANS; LUNG DISEASES, INTERSTITIAL; PHOSPHORYLATION; PULMONARY ALVEOLI; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TAUROCHENODEOXYCHOLIC ACID;

EID: 84942474291     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0136176     Document Type: Article

References (48)

1. Inoue A, Saijo Y, Maemondo M, Gomi K, Tokue Y, Kimura Y, et al. (2003) Severe acute interstitial pneumonia and gefitinib. Lancet 361: 137-139. PMID: 12531582
2. Cersosimo RJ (2006) Gefitinib: an adverse effects profile. Expert Opin Drug Saf 5: 469-479. PMID: 16610973
3. Kudoh S, Kato H, Nishiwaki Y, Fukuoka M, Nakata K, Ichinose Y, et al. (2008) Interstitial lung disease in Japanese patients with lung cancer: a cohort and nested case-control study. Am J Respir Crit Care Med 177: 1348-1357. doi: 10.1164/rccm.200710-1501OC PMID: 18337594
4. Uhal BD (1997) Cell cycle kinetics in the alveolar epithelium. Am J Physiol 272: L1031-L1045. PMID: 9227501
5. Petty WJ, Dragnev KH, Memoli VA, Ma Y, Desai NB, Biddle A, et al. (2004) Epidermal growth factor receptor tyrosine kinase inhibition represses cyclin D1 in aerodigestive tract cancers. Clin Cancer Res 10: 7547-7554. PMID: 15569985
6. Orzáez M, Guevara T, Sancho M, Pérez-Payá E (2012) Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment. Cell Death Dis 3: e415. doi: 10.1038/cddis.2012.155 PMID: 23096116
7. Kalish LH, Kwong RA, Cole IE, Gallagher RM, Sutherland RL, Musgrove EA (2004) Deregulated cyclin D1 expression is associated with decreased efficacy of the selective epidermal growth factor receptor tyrosine kinase inhibitor gefitinib in head and neck squamous cell carcinoma cell lines. Clin Cancer Res 10: 7764-7774. PMID: 15570011
8. Raven JF, Baltzis D, Wang S, Mounir Z, Papadakis AI, Gao HQ, et al. (2008) PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2α phosphorylation. J Biol Chem 283: 3097-3108. PMID: 18063576
9. Hamanaka R, Bennett B, Cullinan S, Diehl J (2005) PERK and GCN2 contribute to eIF2α phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway. Mol Biol Cell 16: 5493-5501. PMID: 16176978
10. Rowlands AG, Panniers R, Henshaw EC (1988) The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2. J Biol Chem 263: 5526-5533. PMID: 3356695
11. Gebauer F, Hentze MW (2004) Molecular mechanisms of translational control. Nat Rev Mol Cell Biol 5: 827-835. PMID: 15459663
12. Namba T, Tanaka K, Hoshino T, Azuma A, Mizushima T (2011) Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis. PLoS One 6: e27296. doi: 10.1371/journal.pone.0027296 PMID: 22096546
13. Thomas AQ, Lane K, Phillips J, Prince M, Markin C, Speer M, et al. (2002) Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred. Am J Respir Crit Care Med 165: 1322-1328. PMID: 11991887
14. Lawson WE, Cheng D-S, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, et al. (2011) Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A 108: 10562-10567. doi: 10.1073/pnas.1107559108 PMID: 21670280
15. Jorgensen E, Stinson A, Shan L, Yang J, Gietl D, Albino AP (2008) Cigarette smoke induces endoplasmic reticulum stress and the unfolded protein response in normal and malignant human lung cells. BMC Cancer 8: 229. doi: 10.1186/1471-2407-8-229 PMID: 18694499
16. Omura T, Asari M, Yamamoto J, Oka K, Hoshina C, Maseda C, et al. (2013) Sodium tauroursodeoxycholate prevents paraquat-induced cell death by suppressing endoplasmic reticulum stress responses in human lung epithelial A549 cells. Biochem Biophys Res Commun 432: 689-694. doi: 10.1016/j.bbrc.2013.01.131 PMID: 23416354
17. Lin Y-C, Wu M-H, Wei T-T, Lin Y-C, Huang W-C, Huang L-Y, et al. (2014) Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress. Oncotarget 5: 298-308. PMID: 24457597
18. Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, et al. (2006) Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med 12: 908-916. PMID: 16862153
19. Rahmani M, Davis EM, Crabtree TR, Habibi JR, Nguyen TK, Dent P, et al. (2007) The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol 27: 5499-5513. PMID: 17548474
20. Imai Y, Soda M, Takahashi R (2000) Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 275: 35661-35664. PMID: 10973942
21. Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H, et al. (1998) CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 12: 982-995. PMID: 9531536
22. Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ (2008) Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. J Clin Invest 118: 3378-3389. doi: 10.1172/JCI34587 PMID: 18776938
23. Kaneko M, Ishiguro M, Niinuma Y, Uesugi M, Nomura Y (2002) Human HRD1 protects against ER stress-induced apoptosis through ER-associated degradation. FEBS Lett 532: 147-152. PMID: 12459480
24. Kaneko M, Nomura Y (2003) ER signaling in unfolded protein response. Life Sci 74: 199-205. PMID: 14607247
25. Yamaguchi H, Wang H-G (2004) CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem 279: 45495-45502. PMID: 15322075
26. Bouman L, Schlierf A, Lutz AK, Shan J, Deinlein A, Kast J, et al. (2011) Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress. Cell Death Differ 18: 769-782. doi: 10.1038/cdd.2010.142 PMID: 21113145
27. Bruhat A, Jousse C, Carraro V, Reimold AM, Ferrara M, Fafournoux P (2000) Amino acids control mammalian gene transcription: activating transcription factor 2 is essential for the amino acid responsiveness of the CHOP promoter. Mol Cell Biol 20: 7192-7204. PMID: 10982836
28. Cybulsky AV, Takano T, Papillon J, Bijian K (2005) Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury. J Biol Chem 280: 24396-24403. PMID: 15863508
29. Henkel AS, Dewey AM, Anderson KA, Olivares S, Green RM (2012) Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet. Am J Physiol Gastrointest Liver Physiol 303: G54-G59. doi: 10.1152/ajpgi.00052.2012 PMID: 22556147
30. Macedo B, Batista AR, Ferreira N, Almeida MR, Saraiva MJ (2008) Anti-apoptotic treatment reduces transthyretin deposition in a transgenic mouse model of Familial Amyloidotic Polyneuropathy. Biochim Biophys Acta 1782: 517-522. doi: 10.1016/j.bbadis.2008.05.005 PMID: 18572024
31. Higenbottam T, Kuwano K, Nemery B, Fujita Y (2004) Understanding the mechanisms of drug-associated interstitial lung disease. Br J Cancer 91: S31-S37. PMID: 15340376
32. Ware LB, Matthay MA (2000) The acute respiratory distress syndrome. N Engl J Med 342: 1334-1349. PMID: 10793167
33. Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, et al. (2000) ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 20: 6755-6767. PMID: 10958673
34. Lee A-H, Iwakoshi NN, Glimcher LH (2003) XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response. Mol Cell Biol 23: 7448-7459. PMID: 14559994
35. Harding HP, Zhang Y, Ron D (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274. PMID: 9930704
36. Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D (2000) Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5: 897-904. PMID: 10882126
37. Kaneko M, Yasui S, Niinuma Y, Arai K, Omura T, Okuma Y, et al. (2007) A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes. FEBS Lett 581: 5355-5360. PMID: 17967421
38. Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, et al. (2008) Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. J Biochem 144: 477-486. doi: 10.1093/jb/mvn091 PMID: 18664523
39. Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, et al. (2002) The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Mol Cell Biol 22: 6681-6688. PMID: 12215525
40. Barber GN (2005) The dsRNA-dependent protein kinase, PKR and cell death. Cell Death Differ 12: 563-570. PMID: 15846372
41. Chen J-J (2007) Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias. Blood 109: 2693-2699. PMID: 17110456
42. Palam LR, Baird TD, Wek RC (2011) Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem 286: 10939-10949. doi: 10.1074/jbc.M110.216093 PMID: 21285359
43. Gotoh T, Oyadomari S, Mori K, Mori M (2002) Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem 277: 12343-12350. PMID: 11805088
44. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, et al. (2001) Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol 3: 802-808. PMID: 11533659
45. Park OK, Schaefer TS, Nathans D (1996) In vitro activation of Stat3 by epidermal growth factor receptor kinase. Proc Natl Acad Sci U S A 93: 13704-13708. PMID: 8942998
46. Moriuchi A, Hirono S, Ido A, Ochiai T, Nakama T, Uto H, et al. (2001) Additive and inhibitory effects of simultaneous treatment with growth factors on DNA synthesis through MAPK pathway and G1 cyclins in rat hepatocytes. Biochem Biophys Res Commun 280: 368-373. PMID: 11162525
47. McGrath-Morrow S, Lauer T, Yee M, Neptune E, Podowski M, Thimmulappa RK, et al. (2009) Nrf2 increases survival and attenuates alveolar growth inhibition in neonatal mice exposed to hyperoxia. Am J Physiol Lung Cell Mol Physiol 296: L565-L573. doi: 10.1152/ajplung.90487.2008 PMID: 19151108
48. Marsh LM, Cakarova L, Kwapiszewska G, von Wulffen W, Herold S, Seeger W, et al. (2009) Surface expression of CD74 by type II alveolar epithelial cells: a potential mechanism for macrophage migration inhibitory factor-induced epithelial repair. Am J Physiol Lung Cell Mol Physiol 296: L442-L452. doi: 10.1152/ajplung.00525.2007 PMID: 19136583