Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity

Journal of Medicinal Chemistry

Volumn 58, Issue 18, 2015, Pages 7273-7285

  Chandrasekera, N Susantha ^a   Alling, Torey ^a   Bailey, Mai A ^a   Files, Megan ^a   Early, Julie V ^a   Ollinger, Juliane ^a   Ovechkina, Yulia ^a   Masquelin, Thierry ^b   Desai, Prashant V ^b   Cramer, Jeffrey W ^b   Hipskind, Philip A ^b   Odingo, Joshua O ^a   Parish, Tanya ^a  

^a INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 1 (3 PHENOXYPROPYL) 1H BENZO[D]IMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; PHENOXYALKYLBENZIMIDAZOLE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ANTITUBERCULAR ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG METABOLISM; DRUG SYNTHESIS; HEPATIC CLEARANCE; HUMAN; HUMAN TISSUE; LIVER MICROSOME; LIVER MICROSOME METABOLISM; MDCK CELL LINE; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; RODENT; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS; ANIMAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; COMPUTER SIMULATION; DOG; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOUSE; PERMEABILITY; RAT; SYNTHESIS; VERO CELL LINE;

ANIMALS; ANTITUBERCULAR AGENTS; BENZIMIDAZOLES; CERCOPITHECUS AETHIOPS; COMPUTER SIMULATION; DOGS; HUMANS; MADIN DARBY CANINE KIDNEY CELLS; MICE; MICROBIAL SENSITIVITY TESTS; MICROSOMES, LIVER; MYCOBACTERIUM TUBERCULOSIS; PERMEABILITY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; VERO CELLS;

EID: 84942357986     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00546     Document Type: Article

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