Benzimidazoles: Novel mycobacterial gyrase inhibitors from scaffold morphing

ACS Medicinal Chemistry Letters

Volumn 5, Issue 7, 2014, Pages 820-825

  Hameed P, Shahul ^a   Raichurkar, Anandkumar ^a   Madhavapeddi, Prashanti ^a   Menasinakai, Sreenivasaiah ^a   Sharma, Sreevalli ^a   Kaur, Parvinder ^a   Nandishaiah, Radha ^a   Panduga, Vijender ^a   Reddy, Jitendar ^a   Sambandamurthy, Vasan K ^a   Sriram, D ^b  

^a ASTRAZENECA   (United Kingdom)

^b BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE   (India)

Author keywords

aminopiperidines; benzimidazoles; DNA gyrase; NBTIs; Tuberculosis; type II topoisomerases

Indexed keywords

ANTIMYCOBACTERIAL AGENT; BENZIMIDAZOLE DERIVATIVE; CIPROFLOXACIN; DNA TOPOISOMERASE INHIBITOR; GYRASE INHIBITOR; ISONIAZID; MOXIFLOXACIN; MYCOBACTERIAL GYRASE INHIBITOR; RIFAMPICIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HYDROGEN BOND; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUBERCULOSIS;

EID: 84904361498     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml5001728     Document Type: Article

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