-
1
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi FS, O’Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. NEngl J Med. 2010; 363(8):711-723.
-
(2010)
Nengl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O’Day, S.J.2
McDermott, D.F.3
-
2
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. NEngl JMed. 2012;366(26): 2443-2454.
-
(2012)
Nengl Jmed
, vol.366
, Issue.26
, pp. 2443-2454
-
-
Topalian, S.L.1
Hodi, F.S.2
Brahmer, J.R.3
-
3
-
-
77954899030
-
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: Safety, clinical activity, pharmacodynamics, and immunologic correlates
-
Brahmer JR, Drake CG, Wollner I, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol. 2010;28(19):3167-3175.
-
(2010)
J Clin Oncol
, vol.28
, Issue.19
, pp. 3167-3175
-
-
Brahmer, J.R.1
Drake, C.G.2
Wollner, I.3
-
4
-
-
0036852241
-
Cancer immu- noediting: From immunosurveillance to tumor escape
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immu- noediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991-998.
-
(2002)
Nat Immunol
, vol.3
, Issue.11
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
6
-
-
0027087331
-
Costimulation of T lymphocytes: The role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy
-
Schwartz RH. Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7/BB1 in interleukin-2 production and immunotherapy. Cell. 1992;71(7):1065-1068.
-
(1992)
Cell
, vol.71
, Issue.7
, pp. 1065-1068
-
-
Schwartz, R.H.1
-
7
-
-
0027078670
-
Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4
-
Chen L, Ashe S, Brady WA, et al. Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4. Cell. 1992;71(7):1093-1102.
-
(1992)
Cell
, vol.71
, Issue.7
, pp. 1093-1102
-
-
Chen, L.1
Ashe, S.2
Brady, W.A.3
-
8
-
-
0027392843
-
Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells
-
Townsend SE, Allison JP. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science. 1993; 259(5093):368-370.
-
(1993)
Science
, vol.259
, Issue.5093
, pp. 368-370
-
-
Townsend, S.E.1
Allison, J.P.2
-
9
-
-
73949092850
-
Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer
-
Denkert C, Loibl S, Noske A, et al. Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer. J Clin Oncol. 2010;28(1):105-113.
-
(2010)
J Clin Oncol
, vol.28
, Issue.1
, pp. 105-113
-
-
Denkert, C.1
Loibl, S.2
Noske, A.3
-
10
-
-
84875722651
-
Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98
-
Loi S, Sirtaine N, Piette F, et al. Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98. J Clin Oncol. 2013;31(7):860-867.
-
(2013)
J Clin Oncol
, vol.31
, Issue.7
, pp. 860-867
-
-
Loi, S.1
Sirtaine, N.2
Piette, F.3
-
11
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon J, Costes A, Sanchez-Cabo F, et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science. 2006;313(5795):1960-1964.
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
-
12
-
-
84858800620
-
The immune contexture in human tumours: Impact on clinical outcome
-
Fridman WH, Pages F, Sautes-Fridman C, Galon J. The immune contexture in human tumours: impact on clinical outcome. Nat Rev Cancer. 2012;12(4):298-306.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.4
, pp. 298-306
-
-
Fridman, W.H.1
Pages, F.2
Sautes-Fridman, C.3
Galon, J.4
-
13
-
-
0037448353
-
Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
-
Zhang L, Conejo-Garcia JR, Katsaros D, et al. Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003;348(3):203-213.
-
(2003)
N Engl J Med
, vol.348
, Issue.3
, pp. 203-213
-
-
Zhang, L.1
Conejo-Garcia, J.R.2
Katsaros, D.3
-
14
-
-
84899748384
-
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
-
Gros A, Robbins PF, Yao X, et al. PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors. J Clin Invest. 2014;124(5):2246-2259.
-
(2014)
J Clin Invest
, vol.124
, Issue.5
, pp. 2246-2259
-
-
Gros, A.1
Robbins, P.F.2
Yao, X.3
-
15
-
-
0025830902
-
CTLA-4 is a second receptor for the B cell activation antigen B7
-
Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med. 1991;174(3):561-569.
-
(1991)
J Exp Med
, vol.174
, Issue.3
, pp. 561-569
-
-
Linsley, P.S.1
Brady, W.2
Urnes, M.3
Grosmaire, L.S.4
Damle, N.K.5
Ledbetter, J.A.6
-
16
-
-
84866537984
-
Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer
-
Salvi S, Fontana V, Boccardo S, et al. Evaluation of CTLA-4 expression and relevance as a novel prognostic factor in patients with non-small cell lung cancer. Cancer immunolImmunother. 2012;61(9):1463-1472.
-
(2012)
Cancer Immunolimmunother
, vol.61
, Issue.9
, pp. 1463-1472
-
-
Salvi, S.1
Fontana, V.2
Boccardo, S.3
-
17
-
-
0030694234
-
The emerging role of CTLA-4 as an immune attenuator
-
Thompson CB, Allison JP. The emerging role of CTLA-4 as an immune attenuator. Immunity. 1997;7(4):445-450.
-
(1997)
Immunity
, vol.7
, Issue.4
, pp. 445-450
-
-
Thompson, C.B.1
Allison, J.P.2
-
18
-
-
0028484545
-
CTLA-4 can function as a negative regulator of T cell activation
-
Walunas TL, Lenschow DJ, Bakker CY, et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994;1(5):405-413.
-
(1994)
Immunity
, vol.1
, Issue.5
, pp. 405-413
-
-
Walunas, T.L.1
Lenschow, D.J.2
Bakker, C.Y.3
-
19
-
-
0029100024
-
Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4
-
Kearney ER, Walunas TL, Karr RW, et al. Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4. JImmunol. 1995;155(3):1032-1036.
-
(1995)
Jimmunol
, vol.155
, Issue.3
, pp. 1032-1036
-
-
Kearney, E.R.1
Walunas, T.L.2
Karr, R.W.3
-
20
-
-
0029120245
-
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
-
Krummel MF, Allison JP. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J Exp Med. 1995;182(2): 459-465.
-
(1995)
J Exp Med
, vol.182
, Issue.2
, pp. 459-465
-
-
Krummel, M.F.1
Allison, J.P.2
-
21
-
-
0029960141
-
CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo
-
Krummel MF, Sullivan TJ, Allison JP. Superantigen responses and co-stimulation: CD28 and CTLA-4 have opposing effects on T cell expansion in vitro and in vivo. Int Immunol. 1996;8(4):519-523.
-
(1996)
Int Immunol
, vol.8
, Issue.4
, pp. 519-523
-
-
Krummel, M.F.1
Sullivan, T.J.2
Allison, J.P.3
-
22
-
-
0028867420
-
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
-
Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995;3(5):541-547.
-
(1995)
Immunity
, vol.3
, Issue.5
, pp. 541-547
-
-
Tivol, E.A.1
Borriello, F.2
Schweitzer, A.N.3
Lynch, W.P.4
Bluestone, J.A.5
Sharpe, A.H.6
-
23
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science. 1995;270(5238):985-988.
-
(1995)
Science
, vol.270
, Issue.5238
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
-
24
-
-
0031405867
-
Lymphoproliferation in CTLA- 4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells
-
Chambers CA, Sullivan TJ, Allison JP. Lymphoproliferation in CTLA- 4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells. Immunity. 1997;7(6):885-895.
-
(1997)
Immunity
, vol.7
, Issue.6
, pp. 885-895
-
-
Chambers, C.A.1
Sullivan, T.J.2
Allison, J.P.3
-
25
-
-
5644263642
-
Role of LAG-3 in regulatory T cells
-
Huang CT, Workman CJ, Flies D, et al. Role of LAG-3 in regulatory T cells. Immunity. 2004;21(4):503-513.
-
(2004)
Immunity
, vol.21
, Issue.4
, pp. 503-513
-
-
Huang, C.T.1
Workman, C.J.2
Flies, D.3
-
26
-
-
33749127585
-
Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients
-
Gandhi MK, Lambley E, Duraiswamy J, et al. Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. Blood. 2006;108(7):2280-2289.
-
(2006)
Blood
, vol.108
, Issue.7
, pp. 2280-2289
-
-
Gandhi, M.K.1
Lambley, E.2
Duraiswamy, J.3
-
27
-
-
30044434075
-
The TIM-3 ligand galectin-9 negatively regulates T helper type 1 immunity
-
Zhu C, Anderson AC, Schubart A, et al. The TIM-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005; 6(12):1245-1252.
-
(2005)
Nat Immunol
, vol.6
, Issue.12
, pp. 1245-1252
-
-
Zhu, C.1
Erson, A.C.2
Schubart, A.3
-
28
-
-
0242539820
-
Interaction of TIM-3 and TIM-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance
-
Sabatos CA, Chakravarti S, Cha E, et al. Interaction of TIM-3 and TIM-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003;4(11):1102-1110.
-
(2003)
Nat Immunol
, vol.4
, Issue.11
, pp. 1102-1110
-
-
Sabatos, C.A.1
Chakravarti, S.2
Cha, E.3
-
29
-
-
77957744369
-
Kuchroo VK,Anderson AC. Targeting TIM-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
-
Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK,Anderson AC. Targeting TIM-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med. 2010;207(10): 2187-2194.
-
(2010)
J Exp Med
, vol.207
, Issue.10
, pp. 2187-2194
-
-
Sakuishi, K.1
Apetoh, L.2
Sullivan, J.M.3
Blazar, B.R.4
-
30
-
-
84857159981
-
TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression
-
Gao X, Zhu Y, Li G, et al. TIM-3 expression characterizes regulatory T cells in tumor tissues and is associated with lung cancer progression. PLoS One. 2012;7(2):e30676.
-
(2012)
Plos One
, vol.7
, Issue.2
-
-
Gao, X.1
Zhu, Y.2
Li, G.3
-
31
-
-
84864214537
-
Ectopic expression of TIM-3 in lung cancers: A potential independent prognostic factor for patients with NSCLC
-
Zhuang X, Zhang X, Xia X, et al. Ectopic expression of TIM-3 in lung cancers: a potential independent prognostic factor for patients with NSCLC. Am J Clin Pathol. 2012;137(6):978-985.
-
(2012)
Am J Clin Pathol
, vol.137
, Issue.6
, pp. 978-985
-
-
Zhuang, X.1
Zhang, X.2
Xia, X.3
-
32
-
-
84893604594
-
In vivo discovery of immunotherapy targets in the tumour microenvironment
-
Zhou P, Shaffer DR, Alvarez Arias DA, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014; 506(7486):52-57.
-
(2014)
Nature
, vol.506
, Issue.7486
, pp. 52-57
-
-
Zhou, P.1
Shaffer, D.R.2
Alvarez Arias, D.A.3
-
33
-
-
84897429090
-
VISTA regulates the development of protective antitumor immunity
-
Le Mercier I, Chen W, Lines JL, et al. VISTA regulates the development of protective antitumor immunity. Cancer Res. 2014;74(7): 1933-1944.
-
(2014)
Cancer Res
, vol.74
, Issue.7
, pp. 1933-1944
-
-
Le Mercier, I.1
Chen, W.2
Lines, J.L.3
-
34
-
-
84891534246
-
Programmed death ligand-1 expression in non-small cell lung cancer
-
Velcheti V, Schalper KA, Carvajal DE, et al. Programmed death ligand-1 expression in non-small cell lung cancer. Lab Invest. 2014; 94(1):107-116.
-
(2014)
Lab Invest
, vol.94
, Issue.1
, pp. 107-116
-
-
Velcheti, V.1
Schalper, K.A.2
Carvajal, D.E.3
-
35
-
-
84885633682
-
Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients
-
Chen YY, Wang LB, Zhu HL, et al. Relationship between programmed death-ligand 1 and clinicopathological characteristics in non-small cell lung cancer patients. Chin MedSci J. 2013;28(3):147-151.
-
(2013)
Chin Medsci J
, vol.28
, Issue.3
, pp. 147-151
-
-
Chen, Y.Y.1
Wang, L.B.2
Zhu, H.L.3
-
36
-
-
84873666114
-
Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: A 5-year-follow-up study
-
Chen YB, Mu CY, Huang JA. Clinical significance of programmed death-1 ligand-1 expression in patients with non-small cell lung cancer: a 5-year-follow-up study. Tumori. 2012;98(6):751-755.
-
(2012)
Tumori
, vol.98
, Issue.6
, pp. 751-755
-
-
Chen, Y.B.1
Mu, C.Y.2
Huang, J.A.3
-
37
-
-
84858766182
-
The blockade of immune checkpoints in cancer immunotherapy
-
Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer. 2012;12(4):252-264.
-
(2012)
Nat Rev Cancer
, vol.12
, Issue.4
, pp. 252-264
-
-
Pardoll, D.M.1
-
38
-
-
18544380239
-
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med. 2002;8(8):793-800.
-
(2002)
Nat Med
, vol.8
, Issue.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
39
-
-
34447646310
-
Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
-
Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007;27(1):111-122.
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 111-122
-
-
Butte, M.J.1
Keir, M.E.2
Phamduy, T.B.3
Sharpe, A.H.4
Freeman, G.J.5
-
40
-
-
84904860154
-
Non-smallcell lung cancers: A heterogeneous set of diseases
-
Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK. Non-smallcell lung cancers: a heterogeneous set of diseases. Nat Rev Cancer. 2014;14(8):535-546.
-
(2014)
Nat Rev Cancer
, vol.14
, Issue.8
, pp. 535-546
-
-
Chen, Z.1
Fillmore, C.M.2
Hammerman, P.S.3
Kim, C.F.4
Wong, K.K.5
-
41
-
-
80053927917
-
PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells
-
Karwacz K, Bricogne C, MacDonald D, et al. PD-L1 co-stimulation contributes to ligand-induced T cell receptor down-modulation on CD8+ T cells. EMBO Mol Med. 2011;3(10):581-592.
-
(2011)
EMBO Mol Med
, vol.3
, Issue.10
, pp. 581-592
-
-
Karwacz, K.1
Bricogne, C.2
Macdonald, D.3
-
42
-
-
84881065928
-
Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment
-
Freire J, Ajona D, de Biurrun G, et al. Silica-induced chronic inflammation promotes lung carcinogenesis in the context of an immunosuppressive microenvironment. Neoplasia. 2013;15(8):913-924.
-
(2013)
Neoplasia
, vol.15
, Issue.8
, pp. 913-924
-
-
Freire, J.1
Ajona, D.2
De Biurrun, G.3
-
43
-
-
78650434229
-
The role of inflammation in the pathogenesis of non-small cell lung cancer
-
O’Callaghan DS, O’Donnell D, O’Connell F, O’Byrne KJ. The role of inflammation in the pathogenesis of non-small cell lung cancer. J Thorac Oncol. 2010;5(12):2024-2036.
-
(2010)
J Thorac Oncol
, vol.5
, Issue.12
, pp. 2024-2036
-
-
O’Callaghan, D.S.1
O’Donnell, D.2
O’Connell, F.3
O’Byrne, K.J.4
-
44
-
-
84863280130
-
Epithelial-mesenchymal transition induced by TNF-a requires NF-KB-mediated transcriptional upregulation of Twist1
-
Li CW, Xia W, Huo L, et al. Epithelial-mesenchymal transition induced by TNF-a requires NF-KB-mediated transcriptional upregulation of Twist1. Cancer Res. 2012;72(5):1290-1300.
-
(2012)
Cancer Res
, vol.72
, Issue.5
, pp. 1290-1300
-
-
Li, C.W.1
Xia, W.2
Huo, L.3
-
45
-
-
21344466748
-
Haplotype loss of HLA class I antigen as an escape mechanism from immune attack in lung cancer
-
So T, Takenoyama M, Mizukami M, et al. Haplotype loss of HLA class I antigen as an escape mechanism from immune attack in lung cancer. Cancer Res. 2005;65(13):5945-5952.
-
(2005)
Cancer Res
, vol.65
, Issue.13
, pp. 5945-5952
-
-
So, T.1
Takenoyama, M.2
Mizukami, M.3
-
46
-
-
77951877847
-
Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer
-
Shimizu K, Nakata M, Hirami Y, Yukawa T, Maeda A, Tanemoto K. Tumor-infiltrating Foxp3+ regulatory T cells are correlated with cyclooxygenase-2 expression and are associated with recurrence in resected non-small cell lung cancer. J Thorac Oncol. 2010;5(5): 585-590.
-
(2010)
J Thorac Oncol
, vol.5
, Issue.5
, pp. 585-590
-
-
Shimizu, K.1
Nakata, M.2
Hirami, Y.3
Yukawa, T.4
Maeda, A.5
Tanemoto, K.6
-
47
-
-
84863338694
-
Myeloid suppressor cells and immune modulation in lung cancer
-
Srivastava MK, Andersson A, Zhu L, et al. Myeloid suppressor cells and immune modulation in lung cancer. Immunotherapy. 2012;4(3): 291-304.
-
(2012)
Immunotherapy
, vol.4
, Issue.3
, pp. 291-304
-
-
Srivastava, M.K.1
Ersson, A.2
Zhu, L.3
-
48
-
-
84880715077
-
Survival and long-term follow-up of the phase I trial of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC)
-
Brahmer J, Horn L, Antonia S, et al. Survival and long-term follow-up of the phase I trial of nivolumab (Anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with previously treated advanced non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol. 2013.
-
(2013)
Proc am Soc Clin Oncol
-
-
Brahmer, J.1
Horn, L.2
Antonia, S.3
-
49
-
-
84937632027
-
Safety and response with nivolumab (Anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced non-small cell lung cancer (NSCLC)
-
Gettinger S, Chow LQ, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 2014;90(5):S34-S35.
-
(2014)
Int J Radiat Oncol Biol Phys
, vol.90
, Issue.5
, pp. 34-35
-
-
Gettinger, S.1
Chow, L.Q.2
Borghaei, H.3
-
50
-
-
84924901863
-
Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): A phase 2, single-arm trial
-
Rizvi NA, Mazieres J, Planchard D, et al. Activity and safety of nivolumab, an anti-PD-1 immune checkpoint inhibitor, for patients with advanced, refractory squamous non-small-cell lung cancer (CheckMate 063): a phase 2, single-arm trial. Lancet Oncol. 2015;16(3):257-265.
-
(2015)
Lancet Oncol
, vol.16
, Issue.3
, pp. 257-265
-
-
Rizvi, N.A.1
Mazieres, J.2
Planchard, D.3
-
51
-
-
84937630627
-
Nivolumab (Anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC)
-
Antonia SJ, Brahmer JR, Gettinger S, et al. Nivolumab (anti-PD-1; BMS-936558, ONO-4538) in combination with platinum-based doublet chemotherapy (PT-DC) in advanced non-small cell lung cancer (NSCLC). Int J Radiat Oncol Biol Phys. 2014;90(5):S2.
-
(2014)
Int J Radiat Oncol Biol Phys
, vol.90
, Issue.5
, pp. 2
-
-
Antonia, S.J.1
Brahmer, J.R.2
Gettinger, S.3
-
53
-
-
84924907300
-
Antitumor activity of pembroli- zumab (Pembro; MK-3475) and correlation with programmed death ligand 1 (PD-L1) expression in a pooled analysis of patients (pts) with advanced non-small cell lung carcinoma (NSCLC)
-
Garon EB, Gandhi L, Rizvi N, et al. Antitumor activity of pembroli- zumab (pembro; MK-3475) and correlation with programmed death ligand 1 (PD-L1) expression in a pooled analysis of patients (pts) with advanced non-small cell lung carcinoma (NSCLC). Ann Oncol. 2014; 25 (Supplement 5):v1-v41.
-
(2014)
Ann Oncol
, vol.25
, pp. 1-41
-
-
Garon, E.B.1
Gandhi, L.2
Rizvi, N.3
-
54
-
-
84862903106
-
Safety and activity of anti- PD-L1 antibody in patients with advanced cancer
-
Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti- PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455-2465.
-
(2012)
N Engl J Med
, vol.366
, Issue.26
, pp. 2455-2465
-
-
Brahmer, J.R.1
Tykodi, S.S.2
Chow, L.Q.3
-
56
-
-
84907532904
-
A phase 1 study of MEDI4736, an anti-PD-Ll antibody, in patients with advanced solid tumors
-
Lutzky J, Antonia SJ, Blake-Haskins A, et al. A phase 1 study of MEDI4736, an anti-PD-Ll antibody, in patients with advanced solid tumors. J Clin Oncol. 2014;32:5s(Suppl; abstr 3001).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Lutzky, J.1
Antonia, S.J.2
Blake-Haskins, A.3
-
57
-
-
84907521154
-
Preliminary data from a multiarm expansion study of MEDI4736, an anti-PD-L1 antibody
-
Segal NH, Antonia S, Brahmer J, et al. Preliminary data from a multiarm expansion study of MEDI4736, an anti-PD-L1 antibody. J Clin Oncol. 2014;32:5s(Suppl; abstr 3002).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Segal, N.H.1
Antonia, S.2
Brahmer, J.3
-
58
-
-
84880709088
-
Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC)
-
Spigel D, Gettinger S, Horn L, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol. 2013;31.
-
(2013)
Proc am Soc Clin Oncol
, pp. 31
-
-
Spigel, D.1
Gettinger, S.2
Horn, L.3
-
59
-
-
84942317642
-
-
Presented at: European Cancer Congress
-
Soria JC, Cruz C, Bahleda R, et al. Clinical activity, safety, and biomarkers of a PD-L1 blockade in non-small cell lung cancer (NSCLC9: additional analyses from a clinical study of the engineered antibody MPDL3280A (anti-PDL1)). Presented at: European Cancer Congress 2013;2013.
-
(2013)
Clinical Activity, Safety, and Biomarkers of a PD-L1 Blockade in Non-Small Cell Lung Cancer (NSCLC9: Additional Analyses from a Clinical Study of the Engineered Antibody MPDL3280A (Anti-Pdl1)
, pp. 2013
-
-
Soria, J.C.1
Cruz, C.2
Bahleda, R.3
-
61
-
-
84907651086
-
First-line nivolumab (Anti- PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: Safety, efficacy, and correlation of outcomes with PD-L1 status
-
Gettinger SN, Shepherd FA, Antonia SJ, et al. First-line nivolumab (anti- PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC: safety, efficacy, and correlation of outcomes with PD-L1 status. J Clin Oncol. 2014;32:5s(Suppl; abstr 8024).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Gettinger, S.N.1
Shepherd, F.A.2
Antonia, S.J.3
-
62
-
-
84920956735
-
Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients
-
Herbst RS, Soria JC, Kowanetz M, et al. Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients. Nature. 2014;515(7528):563-567.
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 563-567
-
-
Herbst, R.S.1
Soria, J.C.2
Kowanetz, M.3
-
63
-
-
84912130561
-
Nivolumab (Anti-PD-1, BMS- 936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): Survival and clinical activity by subgroup analysis
-
Brahmer JR, Horn L, Gandhi L, et al. Nivolumab (anti-PD-1, BMS- 936558, ONO-4538) in patients (pts) with advanced non-small-cell lung cancer (NSCLC): survival and clinical activity by subgroup analysis. JClin Oncol. 2014;32:5s(Suppl; abstr 8112).
-
(2014)
Jclin Oncol
, vol.5s
, pp. 32
-
-
Brahmer, J.R.1
Horn, L.2
Gandhi, L.3
-
64
-
-
84907651084
-
Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC
-
Brahmer JR, Rizvi NA, Lutzky J, et al. Clinical activity and biomarkers of MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. J Clin Oncol. 2014;32:5s(Suppl; abstr 8021).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Brahmer, J.R.1
Rizvi, N.A.2
Lutzky, J.3
-
65
-
-
84904856935
-
Preliminary clinical safety and activity of MK-3475 mono-therapy for the treatment of previously treated patients with non-small cell lung cancer
-
Garon E, Balmanoukian A, Hamid O, et al. Preliminary clinical safety and activity of MK-3475 mono-therapy for the treatment of previously treated patients with non-small cell lung cancer. lASLC 15th World Conference on Lung Cancer. 2013 Abstract MO18.02.
-
(2013)
Laslc 15Th World Conference on Lung Cancer
-
-
Garon, E.1
Balmanoukian, A.2
Hamid, O.3
-
66
-
-
84904024273
-
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
-
Taube JM, Klein A, Brahmer JR, et al. Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy. Clin Cancer Res. 2014;20(19): 5064-5074.
-
(2014)
Clin Cancer Res
, vol.20
, Issue.19
, pp. 5064-5074
-
-
Taube, J.M.1
Klein, A.2
Brahmer, J.R.3
-
67
-
-
84920956732
-
PD-1 blockade induces responses by inhibiting adaptive immune resistance
-
Tumeh PC, Harview CL, Yearley JH, et al. PD-1 blockade induces responses by inhibiting adaptive immune resistance. Nature. 2014; 515(7528):568-571.
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 568-571
-
-
Tumeh, P.C.1
Harview, C.L.2
Yearley, J.H.3
-
68
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder A, Makarov V, Merghoub T, et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med. 2014; 371(23):2189-2199.
-
(2014)
N Engl J Med
, vol.371
, Issue.23
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
69
-
-
0033591845
-
Tobacco smoke carcinogens and lung cancer
-
Hecht SS. Tobacco smoke carcinogens and lung cancer. J Natl Cancer Inst. 1999;91(14):1194-1210.
-
(1999)
J Natl Cancer Inst
, vol.91
, Issue.14
, pp. 1194-1210
-
-
Hecht, S.S.1
-
70
-
-
84937108473
-
Smoking history and response to nivolumab in patients with advanced NSCLCs
-
Hellmann MD, Creelan BC, Woo K, et al. Smoking history and response to nivolumab in patients with advanced NSCLCs. Ann Oncol. 2014;25(Supplement 4):IV426-IV470.
-
(2014)
Ann Oncol
, vol.25
, Issue.4
-
-
Hellmann, M.D.1
Creelan, B.C.2
Woo, K.3
-
71
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
-
Lynch TJ, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol. 2012;30(17):2046-2054.
-
(2012)
J Clin Oncol
, vol.30
, Issue.17
, pp. 2046-2054
-
-
Lynch, T.J.1
Bondarenko, I.2
Luft, A.3
-
72
-
-
84900393562
-
Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression
-
Xu C, Fillmore CM, Koyama S, et al. Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression. Cancer Cell. 2014;25(5):590-604.
-
(2014)
Cancer Cell
, vol.25
, Issue.5
, pp. 590-604
-
-
Xu, C.1
Fillmore, C.M.2
Koyama, S.3
-
73
-
-
84879465848
-
Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1)
-
Velcheti V, Rimm DL, Schalper KA. Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1). J Thorac Oncol. 2013;8(6):803-805.
-
(2013)
J Thorac Oncol
, vol.8
, Issue.6
, pp. 803-805
-
-
Velcheti, V.1
Rimm, D.L.2
Schalper, K.A.3
-
74
-
-
84871532643
-
Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease- small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
-
Reck M, Bondarenko I, Luft A, et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease- small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol. 2013;24(1):75-83.
-
(2013)
Ann Oncol
, vol.24
, Issue.1
, pp. 75-83
-
-
Reck, M.1
Bondarenko, I.2
Luft, A.3
-
75
-
-
84859128199
-
Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape
-
Taube JM, Anders RA, Young GD, et al. Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape. Sci Transl Med. 2012;4(127):127-137.
-
(2012)
Sci Transl Med
, vol.4
, Issue.127
, pp. 127-137
-
-
Taube, J.M.1
Ers, R.A.2
Young, G.D.3
-
76
-
-
84883863501
-
Up-regulation of PD-L1, IDO, and T(Regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells
-
Spranger S, Spaapen RM, Zha Y, et al. Up-regulation of PD-L1, IDO, and T(regs) in the melanoma tumor microenvironment is driven by CD8(+) T cells. Sci Transl Med. 2013;5(200):116-200.
-
(2013)
Sci Transl Med
, vol.5
, Issue.200
, pp. 116-200
-
-
Spranger, S.1
Spaapen, R.M.2
Zha, Y.3
-
77
-
-
84890020587
-
Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors
-
Akbay EA, Koyama S, Carretero J, et al. Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. Cancer Discov. 2013;3(12):1355-1363.
-
(2013)
Cancer Discov
, vol.3
, Issue.12
, pp. 1355-1363
-
-
Akbay, E.A.1
Koyama, S.2
Carretero, J.3
-
78
-
-
68149155982
-
Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies
-
Peggs KS, Quezada SA, Chambers CA, Korman AJ, Allison JP. Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti-CTLA-4 antibodies. J Exp Med. 2009;206(8):1717-1725.
-
(2009)
J Exp Med
, vol.206
, Issue.8
, pp. 1717-1725
-
-
Peggs, K.S.1
Quezada, S.A.2
Chambers, C.A.3
Korman, A.J.4
Allison, J.P.5
-
79
-
-
84983372582
-
Induction of T-cell immunity overcomes complete resistance to PD-1 and CTLA-4 blockade and improves survival in pancreatic carcinoma
-
Winograd R, Byrne KT, Evans RA, et al. Induction of T-cell immunity overcomes complete resistance to PD-1 and CTLA-4 blockade and improves survival in pancreatic carcinoma. Cancer Immunol Res. 2015;3(4):399-411.
-
(2015)
Cancer Immunol Res
, vol.3
, Issue.4
, pp. 399-411
-
-
Winograd, R.1
Byrne, K.T.2
Evans, R.A.3
-
80
-
-
84904038862
-
OX40 engagement depletes intratumoral Tregs via activating FcyRs, leading to antitumor efficacy
-
Bulliard Y, Jolicoeur R, Zhang J, Dranoff G, Wilson NS, Brogdon JL. OX40 engagement depletes intratumoral Tregs via activating FcyRs, leading to antitumor efficacy. Immunol Cell Biol. 2014;92(6): 475-480.
-
(2014)
Immunol Cell Biol
, vol.92
, Issue.6
, pp. 475-480
-
-
Bulliard, Y.1
Jolicoeur, R.2
Zhang, J.3
Dranoff, G.4
Wilson, N.S.5
Brogdon, J.L.6
-
81
-
-
53049104162
-
High expression of indoleamine 2,3-dioxygenase gene in prostate cancer
-
Feder-Mengus C, Wyler S, Hudolin T, et al. High expression of indoleamine 2,3-dioxygenase gene in prostate cancer. Eur J Cancer. 2008;44(15):2266-2275.
-
(2008)
Eur J Cancer
, vol.44
, Issue.15
, pp. 2266-2275
-
-
Feder-Mengus, C.1
Wyler, S.2
Hudolin, T.3
-
82
-
-
84890281217
-
Targeting CXCL12 from FAP- expressing carcinoma-associated fibroblasts synergizes with anti-PD- L1 immunotherapy in pancreatic cancer
-
Feig C, Jones JO, Kraman M, et al. Targeting CXCL12 from FAP- expressing carcinoma-associated fibroblasts synergizes with anti-PD- L1 immunotherapy in pancreatic cancer. Proc Natl Aca^ Sci U S A. 2013;110(50):20212-20217.
-
(2013)
Proc Natl Aca^ Sci U S A
, vol.110
, Issue.50
, pp. 20212-20217
-
-
Feig, C.1
Jones, J.O.2
Kraman, M.3
-
83
-
-
84907484156
-
CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models
-
Zhu Y, Knolhoff BL, Meyer MA, et al. CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models. Cancer Res. 2014;74(18):5057-5069.
-
(2014)
Cancer Res
, vol.74
, Issue.18
, pp. 5057-5069
-
-
Zhu, Y.1
Knolhoff, B.L.2
Meyer, M.A.3
-
84
-
-
84890378536
-
Cutting edge: Hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-p1
-
Hasmim M, Noman MZ, Messai Y, et al. Cutting edge: hypoxia-induced Nanog favors the intratumoral infiltration of regulatory T cells and macrophages via direct regulation of TGF-p1. J Immunol. 2013;191(12): 5802-5806.
-
(2013)
J Immunol
, vol.191
, Issue.12
, pp. 5802-5806
-
-
Hasmim, M.1
Noman, M.Z.2
Messai, Y.3
-
85
-
-
84928917822
-
Pooled analysis of long-term survival data from Phase II and Phase III trials of ipilimumab in unresectable or metastatic melanoma
-
Schadendorf D, Hodi FS, Robert C, et al. Pooled analysis of long-term survival data from Phase II and Phase III trials of ipilimumab in unresectable or metastatic melanoma. J Clin Oncol. Epub February 9, 2015.
-
(2015)
J Clin Oncol. Epub February
, pp. 9
-
-
Schadendorf, D.1
Hodi, F.S.2
Robert, C.3
-
86
-
-
84863115998
-
Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
-
Woo SR, Turnis ME, Goldberg MV, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res. 2012;72(4):917-927.
-
(2012)
Cancer Res
, vol.72
, Issue.4
, pp. 917-927
-
-
Woo, S.R.1
Turnis, M.E.2
Goldberg, M.V.3
-
87
-
-
77957723967
-
Upregulation of TIM-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients
-
Fourcade J, Sun Z, Benallaoua M, et al. Upregulation of TIM-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. JExp Med. 2010;207(10): 2175-2186.
-
(2010)
Jexp Med
, vol.207
, Issue.10
, pp. 2175-2186
-
-
Fourcade, J.1
Sun, Z.2
Benallaoua, M.3
-
88
-
-
84884561907
-
Molecular pathways: Coexpression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy
-
Nirschl CJ, Drake CG. Molecular pathways: coexpression of immune checkpoint molecules: signaling pathways and implications for cancer immunotherapy. Clin Cancer Res. 2013;19(18):4917-4924.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.18
, pp. 4917-4924
-
-
Nirschl, C.J.1
Drake, C.G.2
-
89
-
-
84894266990
-
PD-1 and TIM-3 regulate the expansion of tumor antigen-specific CD8+ T cells induced by melanoma vaccines
-
Fourcade J, Sun Z, Pagliano O, et al. PD-1 and TIM-3 regulate the expansion of tumor antigen-specific CD8+ T cells induced by melanoma vaccines. Cancer Res. 2014;74(4):1045-1055.
-
(2014)
Cancer Res
, vol.74
, Issue.4
, pp. 1045-1055
-
-
Fourcade, J.1
Sun, Z.2
Pagliano, O.3
-
90
-
-
79955977180
-
Coexpression of TIM-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
-
Zhou Q, Munger ME, Veenstra RG, et al. Coexpression of TIM-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood. 2011;117(17):4501-4510.
-
(2011)
Blood
, vol.117
, Issue.17
, pp. 4501-4510
-
-
Zhou, Q.1
Munger, M.E.2
Veenstra, R.G.3
-
91
-
-
79956103042
-
Anti-TIM-3 antibody promotes T cell IFN-y-mediated antitumor immunity and suppresses established tumors
-
Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM-3 antibody promotes T cell IFN-y-mediated antitumor immunity and suppresses established tumors. Cancer Res. 2011;71(10): 3540-3551.
-
(2011)
Cancer Res
, vol.71
, Issue.10
, pp. 3540-3551
-
-
Ngiow, S.F.1
Von Scheidt, B.2
Akiba, H.3
Yagita, H.4
Teng, M.W.5
Smyth, M.J.6
-
92
-
-
84904254163
-
Antimetastatic eJfects of blocking PD-1 and the adenosine A2A receptor
-
Mittal D, Young A, Stannard K, et al. Antimetastatic eJfects of blocking PD-1 and the adenosine A2A receptor. Cancer Res. 2014;74(14): 3652-3658.
-
(2014)
Cancer Res
, vol.74
, Issue.14
, pp. 3652-3658
-
-
Mittal, D.1
Young, A.2
Stannard, K.3
-
93
-
-
84913604670
-
Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model
-
lannone R, Miele L, Maiolino P, Pinto A, Morello S. Adenosine limits the therapeutic effectiveness of anti-CTLA4 mAb in a mouse melanoma model. Am J Cancer Res. 2014;4(2):172-181.
-
(2014)
Am J Cancer Res
, vol.4
, Issue.2
, pp. 172-181
-
-
Lannone, R.1
Miele, L.2
Maiolino, P.3
Pinto, A.4
Morello, S.5
-
94
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok JD, Kluger H, Callahan MK, et al. Nivolumab plus ipilimumab in advanced melanoma. N E^ngl J Med. 2013;369(2):122-133.
-
(2013)
N E^Ngl J Med
, vol.369
, Issue.2
, pp. 122-133
-
-
Wolchok, J.D.1
Kluger, H.2
Callahan, M.K.3
-
96
-
-
84874872137
-
BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma
-
Frederick DT, Piris A, Cogdill AP, et al. BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma. Clin Cancer Res. 2013;19(5):1225-1231.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.5
, pp. 1225-1231
-
-
Frederick, D.T.1
Piris, A.2
Cogdill, A.P.3
-
97
-
-
84873336707
-
The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition
-
Jiang X, Zhou J, Giobbie-Hurder A, Wargo J, Hodi FS. The activation of MAPK in melanoma cells resistant to BRAF inhibition promotes PD-L1 expression that is reversible by MEK and PI3K inhibition. Clin Cancer Res. 2013;19(3):598-609.
-
(2013)
Clin Cancer Res
, vol.19
, Issue.3
, pp. 598-609
-
-
Jiang, X.1
Zhou, J.2
Giobbie-Hurder, A.3
Wargo, J.4
Hodi, F.S.5
-
98
-
-
84903831602
-
Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma
-
Atefi M, Avramis E, Lassen A, et al. Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma. Cli^ Cancer Res. 2014;20(13):3446-3457.
-
(2014)
Cli^ Cancer Res
, vol.20
, Issue.13
, pp. 3446-3457
-
-
Atefi, M.1
Avramis, E.2
Lassen, A.3
-
99
-
-
84938892168
-
PD-L1 and PD-1 expression in molecularly selected non-small-cell lung cancer (NSCLC) patients
-
D’Incecco A, Andreozzi M, Ludovini V, et al. PD-L1 and PD-1 expression in molecularly selected non-small-cell lung cancer (NSCLC) patients. JThorac Oncol. 2014;9(Supplement 9):S7-S52.
-
(2014)
Jthorac Oncol
, vol.9
, Issue.9
, pp. 7-52
-
-
D’Incecco, A.1
Reozzi, M.2
Ludovini, V.3
-
100
-
-
33947236179
-
CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma
-
Ait-Tahar K, Barnardo MC, Pulford K. CD4 T-helper responses to the anaplastic lymphoma kinase (ALK) protein in patients with ALK-positive anaplastic large-cell lymphoma. Cancer Res. 2007;67(5):1898-1901.
-
(2007)
Cancer Res
, vol.67
, Issue.5
, pp. 1898-1901
-
-
Ait-Tahar, K.1
Barnardo, M.C.2
Pulford, K.3
-
101
-
-
84857789296
-
The secret ally: Immu- nostimulation by anticancer drugs
-
Galluzzi L, Senovilla L, Zitvogel L, Kroemer G. The secret ally: immu- nostimulation by anticancer drugs. Nat Rev Drug Discov. 2012;11(3): 215-233.
-
(2012)
Nat Rev Drug Discov
, vol.11
, Issue.3
, pp. 215-233
-
-
Galluzzi, L.1
Senovilla, L.2
Zitvogel, L.3
Kroemer, G.4
-
102
-
-
84862517728
-
Cancer stem cells: Current status and evolving complexities
-
Visvader JE, Lindeman GJ. Cancer stem cells: current status and evolving complexities. Cell Stem Cell. 2012;10(6):717-728.
-
(2012)
Cell Stem Cell
, vol.10
, Issue.6
, pp. 717-728
-
-
Visvader, J.E.1
Lindeman, G.J.2
-
103
-
-
84880023918
-
A rare population of CD24(+) ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal
-
Zheng Y, de la Cruz CC, Sayles LC, et al. A rare population of CD24(+) ITGB4(+)Notch(hi) cells drives tumor propagation in NSCLC and requires Notch3 for self-renewal. Cancer Cell. 2013;24(1):59-74.
-
(2013)
Cancer Cell
, vol.24
, Issue.1
, pp. 59-74
-
-
Zheng, Y.1
De La Cruz, C.C.2
Sayles, L.C.3
-
104
-
-
84907651085
-
Safety and response with nivolumab (Anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC
-
Rizvi N, Chow LQ, Borghaei H, et al. Safety and response with nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus erlotinib in patients (pts) with epidermal growth factor receptor mutant (EGFR MT) advanced NSCLC. J Clin Oncol. 2014;32:5s(Suppl; abstr 8022).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Rizvi, N.1
Chow, L.Q.2
Borghaei, H.3
-
105
-
-
84929365744
-
Association of epithelial-mesenchymal transition status with PD1/PDL1 expression and a distinct immunophe- notype in non-small cell lung cancer: Implications for immunotherapy biomarkers
-
Lou Y, Diao L, Byers LA, et al. Association of epithelial-mesenchymal transition status with PD1/PDL1 expression and a distinct immunophe- notype in non-small cell lung cancer: implications for immunotherapy biomarkers. J Clin Oncol. 2014;32:5s(Suppl; abstr 3018).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Lou, Y.1
Diao, L.2
Byers, L.A.3
-
106
-
-
79959908506
-
HIF induces human embryonic stem cell markers in cancer cells
-
Mathieu J, Zhang Z, Zhou W, et al. HIF induces human embryonic stem cell markers in cancer cells. Cancer Res. 2011;71(13):4640-4652.
-
(2011)
Cancer Res
, vol.71
, Issue.13
, pp. 4640-4652
-
-
Mathieu, J.1
Zhang, Z.2
Zhou, W.3
-
107
-
-
80054769985
-
Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells
-
Hasmim M, Noman MZ, Lauriol J, et al. Hypoxia-dependent inhibition of tumor cell susceptibility to CTL-mediated lysis involves NANOG induction in target cells. J Immunol. 2011;187(8):4031-4039.
-
(2011)
J Immunol
, vol.187
, Issue.8
, pp. 4031-4039
-
-
Hasmim, M.1
Noman, M.Z.2
Lauriol, J.3
-
108
-
-
84863955851
-
Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: An opportunity for novel interventions against lung cancer
-
Roselli M, Fernando RI, Guadagni F, et al. Brachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancer. Clin Cancer Res. 2012;18(14):3868-3879.
-
(2012)
Clin Cancer Res
, vol.18
, Issue.14
, pp. 3868-3879
-
-
Roselli, M.1
Fernando, R.I.2
Guadagni, F.3
-
109
-
-
84903945206
-
The FGFR/ MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival
-
Hu Y, Mintz A, Shah SR, Quinones-Hinojosa A, Hsu W. The FGFR/ MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival. Carcinogenesis. 2014;35(7):1491-1499.
-
(2014)
Carcinogenesis
, vol.35
, Issue.7
, pp. 1491-1499
-
-
Hu, Y.1
Mintz, A.2
Shah, S.R.3
Quinones-Hinojosa, A.4
Hsu, W.5
-
110
-
-
84871973263
-
Blockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-a leads to synergistic antitumor activity
-
Yuan Z, Syrkin G, Adem A, et al. Blockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-a leads to synergistic antitumor activity. Cancer Gene Ther. 2013;20(1):46-56.
-
(2013)
Cancer Gene Ther
, vol.20
, Issue.1
, pp. 46-56
-
-
Yuan, Z.1
Syrkin, G.2
Adem, A.3
-
111
-
-
84874115512
-
Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy
-
Knights AJ, Fucikova J, Pasam A, Koernig S, Cebon J. Inhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapy. Cancer Immunol Immunother. 2013;62(2): 321-335.
-
(2013)
Cancer Immunol Immunother
, vol.62
, Issue.2
, pp. 321-335
-
-
Knights, A.J.1
Fucikova, J.2
Pasam, A.3
Koernig, S.4
Cebon, J.5
-
112
-
-
84937639107
-
Long-term survival, clinical activity, and safety of nivolumab (Anti-PD-1; BMS-936558, ONO- 4538) in patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
Gettinger SN, Horn L, Gandhi L, et al. Long-term survival, clinical activity, and safety of nivolumab (anti-PD-1; BMS-936558, ONO- 4538) in patients (pts) with advanced non-small cell lung cancer (NSCLC). Int JRadiat Oncol Biol Phys. 2014;90(5):S34.
-
(2014)
Int Jradiat Oncol Biol Phys
, vol.90
, Issue.5
, pp. 34
-
-
Gettinger, S.N.1
Horn, L.2
Gandhi, L.3
-
113
-
-
84937518516
-
Phase II study of nivolumab (Anti-PD-1, BMS-936558, ONO-4538) in patients with advanced, refractory squamous non-small cell lung cancer
-
Ramalingam SS, Mazieres J, Planchard D, et al. Phase II study of nivolumab (anti-PD-1, BMS-936558, ONO-4538) in patients with advanced, refractory squamous non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2014;90(5):1266-1267.
-
(2014)
Int J Radiat Oncol Biol Phys
, vol.90
, Issue.5
, pp. 1266-1267
-
-
Ramalingam, S.S.1
Mazieres, J.2
Planchard, D.3
-
114
-
-
84937635597
-
First-Line monotherapy with nivolumab (Anti-PD-1; BMS-936558, ONO-4538) in advanced non-small cell lung cancer (NSCLC): Safety, efficacy, and correlation of outcomes with PD-L1 status
-
Rizvi NA, Shepherd FA, Antonia SJ, et al. First-Line monotherapy with nivolumab (anti-PD-1; BMS-936558, ONO-4538) in advanced non-small cell lung cancer (NSCLC): safety, efficacy, and correlation of outcomes with PD-L1 status. Int J Radiat Oncol Biol Phys. 2014;90(5):S31.
-
(2014)
Int J Radiat Oncol Biol Phys
, vol.90
, Issue.5
, pp. 31
-
-
Rizvi, N.A.1
Shepherd, F.A.2
Antonia, S.J.3
-
115
-
-
84907614647
-
Safety and clinical activity of MK-3475 as initial therapy in patients with advanced non-small cell lung cancer (NSCLC)
-
Rizvi NA, Garon EB, Patnaik A, et al. Safety and clinical activity of MK-3475 as initial therapy in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2014;32:5s(Suppl; abstr 8007).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Rizvi, N.A.1
Garon, E.B.2
Patnaik, A.3
-
116
-
-
84975033744
-
Development of MEDI4736, an anti-programmed cell death ligand 1 (PD-L1) antibody, as monotherapy or in combination with other therapies in the treatment of non-small cell lung cancer (NSCLC)
-
Brahmer J, Balmanoukian A, Goldberg S, et al. Development of MEDI4736, an anti-programmed cell death ligand 1 (PD-L1) antibody, as monotherapy or in combination with other therapies in the treatment of non-small cell lung cancer (NSCLC). J Immunother Cancer. 2014;2(Suppl 3):179.
-
(2014)
J Immunother Cancer
, vol.2
, pp. 179
-
-
Brahmer, J.1
Balmanoukian, A.2
Goldberg, S.3
-
117
-
-
76749084659
-
Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
Zatloukal P, Heo DS, Park K, et al. Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol. 2009;27:15s(Suppl; abstr 8071).
-
(2009)
J Clin Oncol
, vol.15s
, pp. 27
-
-
Zatloukal, P.1
Heo, D.S.2
Park, K.3
-
119
-
-
84907973066
-
Clinical efficacy and correlation with tumor PD-L1 expression in patients (Pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475
-
Kefford R, Ribas A, Hamid O, et al. Clinical efficacy and correlation with tumor PD-L1 expression in patients (pts) with melanoma (MEL) treated with the anti-PD-1 monoclonal antibody MK-3475. J Clin Oncol. 2014;32:5s(Suppl; abstr 3005).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Kefford, R.1
Ribas, A.2
Hamid, O.3
-
120
-
-
84907521155
-
A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer
-
Seiwert TY, Burtness B, Weiss J, et al. A phase Ib study of MK-3475 in patients with human papillomavirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer. J Clin Oncol. 2014;32:5s(Suppl; abstr 6011).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Seiwert, T.Y.1
Burtness, B.2
Weiss, J.3
-
121
-
-
84892866206
-
Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma
-
Weber JS, Kudchadkar RR, Yu B, et al. Safety, efficacy, and biomarkers of nivolumab with vaccine in ipilimumab-refractory or -naive melanoma. J Clin Oncol. 2013;31(34):4311-4318.
-
(2013)
J Clin Oncol
, vol.31
, Issue.34
, pp. 4311-4318
-
-
Weber, J.S.1
Kudchadkar, R.R.2
Yu, B.3
-
122
-
-
84929572937
-
Nivolumab for metastatic renal cell carcinoma: Results of a randomized Phase II trial
-
Motzer RJ, Rini BI, McDermott DF, et al. Nivolumab for metastatic renal cell carcinoma: results of a randomized Phase II trial. J Clin Oncol. 2015;33(13):1430-1437.
-
(2015)
J Clin Oncol
, vol.33
, Issue.13
, pp. 1430-1437
-
-
Motzer, R.J.1
Rini, B.I.2
McDermott, D.F.3
-
123
-
-
84880736969
-
Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (Pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538)
-
Grosso J, Horak CE, Inzunza D, et al. Association of tumor PD-L1 expression and immune biomarkers with clinical activity in patients (pts) with advanced solid tumors treated with nivolumab (anti-PD-1; BMS-936558; ONO-4538). J Clin Oncol. 2013;31(Suppl; abstr 3016).
-
(2013)
J Clin Oncol
, vol.31
-
-
Grosso, J.1
Horak, C.E.2
Inzunza, D.3
-
124
-
-
84907558390
-
Long-term survival of ipili- mumab-naive patients (Pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial
-
Hodi FS, Sznol M, Kluger HM, et al. Long-term survival of ipili- mumab-naive patients (pts) with advanced melanoma (MEL) treated with nivolumab (anti-PD-1, BMS-936558, ONO-4538) in a phase I trial. J Clin Oncol. 2014;32:5s(Suppl; abstr 9002).
-
(2014)
J Clin Oncol
, vol.5s
, pp. 32
-
-
Hodi, F.S.1
Sznol, M.2
Kluger, H.M.3
-
125
-
-
84925222119
-
Nivolumab in previously untreated melanoma without BRAF mutation
-
Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015;372(4): 320-330.
-
(2015)
N Engl J Med
, vol.372
, Issue.4
, pp. 320-330
-
-
Robert, C.1
Long, G.V.2
Brady, B.3
-
126
-
-
84923078390
-
MPDL3280A (Anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
-
Powles T, Eder JP, Fine GD, et al. MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer. Nature. 2014;515(7528):558-562.
-
(2014)
Nature
, vol.515
, Issue.7528
, pp. 558-562
-
-
Powles, T.1
Eder, J.P.2
Fine, G.D.3
-
127
-
-
84880277245
-
Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic melanoma (mM)
-
Hamid O, Sosman JA, Lawrence DP, et al. Clinical activity, safety, and biomarkers of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic melanoma (mM). J Clin Oncol. 2013;31(Suppl; abstr 9010).
-
(2013)
J Clin Oncol
, vol.31
-
-
Hamid, O.1
Sosman, J.A.2
Lawrence, D.P.3
|