Berberine inhibits Smad and non-Smad signaling cascades and enhances autophagy against pulmonary fibrosis

Journal of Molecular Medicine

Volumn 93, Issue 9, 2015, Pages 1015-1031

  Chitra, Palanivel ^a   Saiprasad, Gowrikumar ^a   Manikandan, Ramar ^a   Sudhandiran, Ganapasam ^a  

^a UNIVERSITY OF MADRAS   (India)

Author keywords

Autophagy; FAK; mTOR; PI3K; Pulmonary fibrosis; Smad

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BECLIN 1; BERBERINE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; FOCAL ADHESION KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; BLEOMYCIN; SMAD PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; EFFECTIVE DOSE (PHARMACOLOGY); ENZYME INHIBITION; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CHEMICALLY INDUCED; CONFOCAL MICROSCOPY; DRUG EFFECTS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; METABOLISM; PULMONARY FIBROSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WISTAR RAT;

ANIMALS; AUTOPHAGY; BERBERINE; BLEOMYCIN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PULMONARY FIBROSIS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD PROTEINS;

EID: 84942295210     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-015-1283-1     Document Type: Article

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