Withaferin A induces cell death selectively in androgen-independent prostate cancer cells but not in normal fibroblast cells

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Nishikawa, Yukihiro ^a   Okuzaki, Daisuke ^a   Fukushima, Kohshiro ^a   Mukai, Satomi ^a   Ohno, Shouichi ^a   Ozaki, Yuki ^a   Yabuta, Norikazu ^a   Nojima, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FLICE INHIBITORY PROTEIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK TRANSCRIPTION FACTOR 1; MESSENGER RNA; PROTEIN HSPA6; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VIMENTIN; WITHAFERIN A; ANDROGEN; PROTEIN C FOS; SERUM-FREE MEDIUM; WITHANOLIDE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FIBROBLAST; GENE EXPRESSION; HEAT SHOCK TRANSCRIPTION FACTOR 1 GENE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; MALE; MICROARRAY ANALYSIS; ONCOGENE C FOS; PROSTATE CANCER CELL LINE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING; CELL DEATH; CELL FRACTIONATION; CYTOLOGY; DRUG EFFECTS; DRUG RESISTANCE; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; METABOLISM; MITOCHONDRION; PATHOLOGY; PROSTATE TUMOR; SERUM-FREE MEDIUM; TUMOR CELL LINE; UPREGULATION;

ANDROGENS; AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CULTURE MEDIA, SERUM-FREE; DRUG RESISTANCE, NEOPLASM; ENDOPLASMIC RETICULUM; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MITOCHONDRIA; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-FOS; SUBCELLULAR FRACTIONS; UP-REGULATION; VIMENTIN; WITHANOLIDES;

EID: 84942292096     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0134137     Document Type: Article

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