Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation

International Journal of Cancer

Volumn 129, Issue 11, 2011, Pages 2744-2755

  Thaiparambil, Jose T ^a,b   Bender, Laura ^a,b   Ganesh, Thota ^a   Kline, Erik ^a,b   Patel, Pritty ^a,b   Liu, Yuan ^a   Tighiouart, Mourad ^a   Vertino, Paula M ^a,b   Harvey, R Donald ^a,b   Garcia, Anapatricia ^a,b   Marcus, Adam I ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

breast cancer; metastasis; motility; vimentin; Withaferin A

Indexed keywords

ANTINEOPLASTIC AGENT; SERINE; TG 3 180; TG 3 191; TG 3 192; UNCLASSIFIED DRUG; VIMENTIN; WITHAFERIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL CULTURE; CANCER INVASION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLYMERIZATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG MECHANISM; FEMALE; HUMAN; HUMAN CELL; LUNG METASTASIS; LUNG TOXICITY; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN PHOSPHORYLATION; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; NEOPLASM INVASIVENESS; PHOSPHORYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERINE; VIMENTIN; WITHANOLIDES;

EID: 80053309063     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.25938     Document Type: Article

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