Phosphodiesterase 4D: An enzyme to remember

British Journal of Pharmacology

Volumn 172, Issue 20, 2015, Pages 4785-4789

  Ricciarelli, Roberta ^a   Fedele, Ernesto ^a  

^a UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APREMILAST; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC NUCLEOTIDE GATED CHANNEL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; PHOSPHODIESTERASE I; PHOSPHODIESTERASE IV; PHOSPHOLIPASE D; ROFLUMILAST; ROLIPRAM;

ALZHEIMER DISEASE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONFORMATIONAL TRANSITION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME STRUCTURE; ENZYME SYNTHESIS; HIPPOCAMPAL CA1 REGION; HUMAN; LONG TERM MEMORY; LONG TERM POTENTIATION; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; PSORIATIC ARTHRITIS; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; METABOLISM; PHYSIOLOGY;

ANIMALS; CYCLIC AMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; HUMANS; MEMORY; SIGNAL TRANSDUCTION;

EID: 84942281913     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13257     Document Type: Review

References (59)

1. Abel T, Nguyen PV, Barad M, Deuel TA, Kandel ER, Bourtchouladze R, (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell 88: 615-626.
2. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, et al. (2013a). The concise guide to pharmacology 2013/14: ion channels. Br J Pharmacol 170: 1607-1651.
3. Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, et al. (2013b). The concise guide to pharmacology 2013/14: enzymes. Br J Pharmacol 170: 1797-1867.
4. Akkerman S, Blokland A, Prickaerts J, (2014). Mind the gap: delayed manifestation of long-term object memory improvement by phosphodiesterase inhibitors. Neurobiol Learn Mem 109: 139-143.
5. Barco A, Alarcon JM, Kandel ER, (2002). Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 108: 689-703.
6. Bliss TV, Collingridge GL, (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361: 31-39.
7. Bliss TV, Lømo T, (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant pathway. J Physiol 232: 331-356.
8. Bollen E, Puzzo D, Rutten K, Privitera L, De Vry J, Vanmierlo T, et al., (2014). Improved long-term memory via enhancing cGMP-PKG signaling requires cAMP-PKA signaling. Neuropsychopharmacology 39: 2497-2505.
9. Bruno O, Fedele E, Prickaerts J, Parker LA, Canepa E, Brullo C, et al., (2011). GEBR-7b, a novel PDE4D selective inhibitor that improves memory in rodents at non-emetic doses. Br J Pharmacol 164: 2054-2063.
10. Bruno O, Ricciarelli R, Prickaerts J, Parker LA, Fedele E, (2014). PDE4D inhibitors: a potential strategy for the treatment of memory impairment? Neuropharmacology 85: 290-292.
11. Burgin AB, Magusson OT, Singh J, Witte P, Staker BL, Bjornsson JM, et al., (2010). Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety. Nat Biotechnol 28: 63-70.
12. Chern Y, (2000). Regulation of adenylyl cyclase in the central nervous system. Cell Signal 12: 195-204.
13. Cherry JA, Davis RL, (1999). Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect. J Comp Neurol 407: 287-301.
14. Conti M, Beavo J, (2007). Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem 76: 481-511.
15. Corbin JD, Krebs EG, (1969). A cyclic AMP-stimulated protein kinase in adipose tissue. Biochem Biophys Res Commun 36: 328-336.
16. De Rooij J, Zwartkruis FJ, Verheijen MH, Cool RH, Nijman SM, Wittinghofer A, et al., (1998). Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396: 474-477.
17. Frey U, Krug M, Reymann KG, Matthies H, (1988). Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro. Brain Res 452: 57-65.
18. Frey U, Huang YY, Kandel ER, (1993). Effects of cAMP simulate a late stage of LTP in hippocampal neurons. Science 260: 1661-1664.
19. Gelinas JN, Banko JL, Peters MM, Klann E, Weeber WJ, Nguyen PV, (2008). Activation of exchange protein activated by cyclic-AMP enhances long-lasting synaptic potentiation in the hippocampus. Learn Mem 15: 403-411.
20. Gonzalez GA, Yamamoto KK, Fischer WH, Karr D, Menzel P, Biggs W, (1989). A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence. Nature 337: 749-752.
21. Gurney ME, D'Amato EC, Burgin AB, (2015). Phosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's disease. Neurotherapeutics 12: 49-56.
22. Hansen RT III, Zhang HT, (2015). Phosphodiesterase-4 modulation as potential therapeutic for cognitive loss in pathological and non-pathological aging: possibilities and pitfalls. Curr Pharm Des 21: 291-302.
23. Heckman PR, Blokland A, Ramaekers J, Prickaerts J, (2015). Phosphodiesterase inhibitors as a target for cognition enhancement in aging and Alzheimer's disease: a translational overview. Curr Pharm Des 21: 317-331.
24. Huang EP, (1998). Synaptic plasticity: going through phases with LTP. Neuron 8: R350-352.
25. Huang YY, Kandel ER, (1994). Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. Learn Mem 1: 74-82.
26. Kandel ER, (2012). The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain 5: 14.
27. Kaupp UB, Seifert R, (2002). Cyclic nucleotide-gated ion channels. Physiol Rev 82: 769-824.
28. Kawasaki H, Springett GM, Mochizucki N, Toki S, Nakaya M, Matsuda M, et al., (1998). A family of cAMP-binding proteins that directly activate Rap1. Science 282: 2275-2279.
29. Kida S, (2012). A functional role for CREB as a positive regulator of memory formation and LTP. Exp Neurobiol 21: 136-140.
30. Koh MT, Thiele TE, Bernstein IL, (2002). Inhibition of protein kinase A activity interferes with lon-term, but not short-term, memory of conditioned taste aversions. Behav Neurosci 116: 1070-1074.
31. Krug M, Lössner B, Ott T, (1984). Anisomycin blocks the late phase of long-term potentiation in the dentate gyrus of freely moving rats. Brain Res Bull 13: 39-42.
32. Lamontagne S, Meadows E, Luke P, Normandin D, Muise E, Boulet L, et al., (2001). Localization of phosphodiesterases-4 isoforms in the medulla and nodose ganglion of the squirrel monkey. Brain Res 920: 84-96.
33. Lee YS, Bailey CH, Kandel ER, Kaang BK, (2008). Transcrptional regulation of long-term memory in the marine snail Aplysia. Mol Brain 1: 3.
34. Li YF, Cheng YF, Huang Y, Conti M, Wilson SP, O'Donnel JM, et al., (2011). Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling. J Neurosci 31: 172-183.
35. Ma N, Abel T, Hernadez PJ, (2009). Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A. Learn Mem 16: 367-370.
36. Matthies H, Frey U, Reymann KG, Krug M, Jork R, Schroeder H, (1990). Different mechanisms and multiple stages of LTP. Adv Exp Med Biol 268: 359-368.
37. Montminy MR, Sevarino KA, Wagner JA, Mandel G, Goodman RH, (1986). Identification of a cyclic AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci U S A 83: 6682-6686.
38. Mori F, Perez-Torres S, De Caro R, Porzionato A, Macchi V, Beleta J, et al., (2010). The human area postrema and other nuclei related to the emetic reflex express cAMP phosphodiesterases 4B and 4D. J Chem Neuroanat 40: 36-42.
39. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, Davenport AP, McGrath JC, Peters JA, Southan C, Spedding M, Yu W, Harmar AJ,; NC-IUPHAR. (2014) The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucl. Acids Res. 42 (Database Issue): D1098-106.
40. 3H]rolipram binding autoradiography: comparison with monkey and rat brain. J Chem Neuroanat 20: 349-374.
41. Pittenger C, Huang YY, Paletzki RF, Bourtchouladze R, Scanlin H, Vronskaya S, et al., (2002). Reversible inhibition of CREB/ATF transcription factors in region CA1 of the dorsal hippocampus disrupts hippocampus-dependent spatial memory. Neuron 34: 447-462.
42. Podda MV, Grassi C, (2014). New perspective in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channles. Pflugers Arch-Eur J Physiol 466: 1241-1257.
43. Poser S, Storm DR, (2001). Role of Ca2+-stimulated adenylyl cyclase in LTP and memory formation. Int J Dev Neurosci 19: 387-94.
44. Reymann KG, Frey JU, (2007). The late maintenance of hippocampal LTP: requirements, phases, 'synaptic tagging', 'late-associativity' and implications. Neuropharmacology 52: 24-40.
45. Richter W, Menniti FS, Zhang HT, Conti M, (2013). PDE4 as target for cognition enhancement. Expert Opin Ther Targets 17: 1011-1027.
46. Robichaud A, Stamatiou PB, Lin SL, Lachance N, MacDonald D, Laliberté F, et al., (2002). Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest 110: 1045-1052.
47. Roscioni SS, Elzinga CR, Schmidt M, (2008). Epac: effectors and biological functions. Naunyn Schmiedebergs Arch Pharmacol 377: 345-357.
48. -/-) mice. Eur J Neurosci 28: 625-632.
49. Sierksma AS, van den Hove DL, Pfau F, Philippens M, Bruno O, Fedele E, et al., (2014). Improvement of spatial memory function in APPswe/PS1dE9 mice after chronic inhibition of phosphodiesterase type 4D. Neuropharmacology 77: 120-130.
50. Steegborn C, (2014). Structure, mechanism, and regulation of soluble adenylyl cyclase- similarities and differences to transmembrane adenylyl cyclase. Biochim Biophys Acta 1842: 2535-2547.
51. Sutcliffe JS, Beaumont V, Watson JM, Chew CS, Beconi M, Hutcheson DM, et al., (2014). Efficacy of selective PDE4D negative allosteric modulators in the object retrieval task in female cynomolgus monkeys (Macaca fascicularis). PLoS One 9: e102449.
52. Suzuki A, Fukushima H, Mukawa T, Toyoda H, Wu LJ, Zhao MG, et al., (2011). Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci 31: 8786-8802.
53. Wang H, Ferguson GD, Pineda VV, Cundiff PE, Storm DR, (2004). Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. Nat Neurosci 7: 635-642.
54. Wang ZZ, Zhang Y, Liu YQ, Zhao N, Zhang YZ, Yuan L, et al., (2013). RNA interference-mediated phosphodiesterase-4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects. Br J Pharmacol 168: 1001-1014.
55. Wong ST, Athos J, Figueroa XA, Pineda VV, Schaefer ML, Chavkin CC, et al., (1999). Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron 23: 787-798.
56. Young JZ, Isiegas C, Abel T, Nguyen PV, (2006). Metaplasticity of the late phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging. Eur J Neurosci 23: 1784-1794.
57. Zhang C, Cheng Y, Wang H, Wang C, Wilson SP, Xu J, et al., (2014). RNA interference-mediated knockdown of long-form phosphodiesterase-4D (PDE4D) enzyme reverses amyloid-β42-induced memory deficits in mice. J Alzheimers Dis 38: 269-280.
58. Zhang HT, Huang Y, Jin SLC, Frith S, Suvarna N, Conti M, et al., (2002). Antidepressant-like profile and reduced sensitivity to rolipram in mice deficient in the PDE4D phosphodiesterase enzyme. Neuropsychopharmcology 27: 587-595.
59. Zhang M, Wang H, (2013). Mice overexpressing type 1 adenylyl cyclase show enhanced spatial memory flexibility in the absence of intact synaptic long-term depression. Learn Mem 20: 352-367.