Inhibition of alveolar macrophage pyroptosis reduces lipopolysaccharide-induced acute lung injury in mice

Chinese Medical Journal

Volumn 128, Issue 19, 2015, Pages 2638-2645

  Wu, Dong Dong ^a   Pan, Pin Hua ^a   Liu, Ben ^a   Su, Xiao Li ^a   Zhang, Le Meng ^b   Tan, Hong Yi ^a   Cao, Zu ^a   Zhou, Zuo Ren ^a   Li, Hai Tao ^a   Li, Hao Si ^a   Huang, Li ^a   Li, Yuan Yuan ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Central South University   (China)

Author keywords

Acute lung injury acute respiratory distress syndrome; Alveolar macrophage; Caspase 1; Pyroptosis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; CRYOPYRIN; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; BENZOYLCARBONYL-ASPARTYL-GLUTAMYL-VALYL-ASPARTYL-FLUOROMETHYL KETONE; N-ACETYL-TYROSYL-VALYL-ALANYL-ASPARTYL CHLOROMETHYL KETONE; OLIGOPEPTIDE; PEPTIDE CHLOROMETHYL KETONE;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING, CELL DEGENERATION AND CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOLOGY; IMMUNOFLUORESCENCE TEST; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; LUNG EDEMA; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PYROPTOSIS; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; MALE;

ACUTE LUNG INJURY; AMINO ACID CHLOROMETHYL KETONES; ANIMALS; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES; PYROPTOSIS;

EID: 84942280179     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.4103/0366-6999.166039     Document Type: Article

References (36)

1. Modrykamien AM, Gupta P. The acute respiratory distress syndrome. Proc (Bayl Univ Med Cent) 2015;28:163-71.
2. Zambon M, Vincent JL. Mortality rates for patients with acute lung injury/ARDS have decreased over time. Chest 2008;133:1120-7.
3. Villar J, Blanco J, Añón JM, Santos-Bouza A, Blanch L, Ambrós A, et al. The ALIEN study: Incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med 2011;37:1932-41.
4. Matuschak GM, Lechner AJ. Acute lung injury and the acute respiratory distress syndrome: Pathophysiology and treatment. Mo Med 2010;107:252-8.
5. Z’graggen BR, Tornic J, Müller-Edenborn B, Reyes L, Booy C, Beck-Schimmer B. Acute lung injury: Apoptosis in effector and target cells of the upper and lower airway compartment. Clin Exp Immunol 2010;161:324-31.
6. Fink SL, Cookson BT. Pyroptosis and host cell death responses during Salmonella infection. Cell Microbiol 2007;9:2562-70.
7. Sangiuliano B, Pérez NM, Moreira DF, Belizário JE. Cell death-associated molecular-pattern molecules: Inflammatory signaling and control. Mediators Inflamm 2014;2014:821043.
8. Bergsbaken T, Fink SL, Cookson BT. Pyroptosis: Host cell death and inflammation. Nat Rev Microbiol 2009;7:99-109.
9. Fink SL, Cookson BT. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol 2006;8:1812-25.
10. Fink SL, Cookson BT. Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005;73:1907-16.
11. Miao EA, Rajan JV, Aderem A. Caspase-1-induced pyroptotic cell death. Immunol Rev 2011;243:206-14.
12. Yang HH, Jun HK, Jung YJ, Choi BK. Enterococcus faecalis activates caspase-1 leading to increased interleukin-1 beta secretion in macrophages. J Endod 2014;40:1587-92.
13. Dinarello CA. A clinical perspective of IL-16 as the gatekeeper of inflammation. Eur J Immunol 2011;41:1203-17.
14. Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, et al. Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism. PLoS One 2014;9:e85765.
15. Wree A, Eguchi A, McGeough MD, Pena CA, Johnson CD, Canbay A, et al. NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice. Hepatology 2014;59:898-910.
16. Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, et al. The NLRP3 inflammasome is required for the development of hypoxemia in LPS/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol 2014;50:270-80.
17. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, et al. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med 2012;185:1225-34.
18. Lamkanfi M, Sarkar A, Vande Walle L, Vitari AC, Amer AO, Wewers MD, et al. Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia. J Immunol 2010;185:4385-92.
19. Mathiak G, Grass G, Herzmann T, Luebke T, Zetina CC, Boehm SA, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol 2000;131:383-6.
20. Aggarwal NR, King LS, D’Alessio FR. Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol 2014;306:L709-25.
21. Zhang L, Cardinal JS, Bahar R, Evankovich J, Huang H, Nace G, et al. Interferon regulatory factor-1 regulates the autophagic response in LPS-stimulated macrophages through nitric oxide. Mol Med 2012;18:201-8.
22. Zhang C, Wang SH, Lasbury ME, Tschang D, Liao CP, Durant PJ, et al. Toll-like receptor 2 mediates alveolar macrophage response to Pneumocystis murina. Infect Immun 2006;74:1857-64.
23. McGuigan RM, Mullenix P, Norlund LL, Ward D, Walts M, Azarow K. Acute lung injury using oleic acid in the laboratory rat: Establishment of a working model and evidence against free radicals in the acute phase. Curr Surg 2003;60:412-7.
24. Broz P, Newton K, Lamkanfi M, Mariathasan S, Dixit VM, Monack DM. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J Exp Med 2010;207:1745-55.
25. Karmakar M, Katsnelson M, Malak HA, Greene NG, Howell SJ, Hise AG, et al. Neutrophil IL-16 processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux. J Immunol 2015;194:1763-75.
26. Miao EA, Leaf IA, Treuting PM, Mao DP, Dors M, Sarkar A, et al. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat Immunol 2010;11:1136-42.
27. Li B, Zeng M, He W, Huang X, Luo L, Zhang H, et al. Ghrelin protects alveolar macrophages against lipopolysaccharide-induced apoptosis through growth hormone secretagogue receptor 1a-dependent c-Jun N-terminal kinase and Wnt/6-catenin signaling and suppresses lung inflammation. Endocrinology 2015;156:203-17.
28. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995;267:2000-3.
29. Aziz M, Jacob A, Wang P. Revisiting caspases in sepsis. Cell Death Dis 2014;5:e1526.
30. Van de Veerdonk FL, Netea MG, Dinarello CA, Joosten LA. Inflammasome activation and IL-16 and IL-18 processing during infection. Trends Immunol 2011;32:110-6.
31. Compan V, Martín-Sánchez F, Baroja-Mazo A, López-Castejón G, Gomez AI, Verkhratsky A, et al. Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling. J Immunol 2015;194:1261-73.
32. Martinon F, Mayor A, Tschopp J. The inflammasomes: Guardians of the body. Annu Rev Immunol 2009;27:229-65.
33. Triantafilou K, Triantafilou M. Ion flux in the lung: Virus-induced inflammasome activation. Trends Microbiol 2014;22:580-8.
34. Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol 2013;13:397-411.
35. Goodman RB, Pugin J, Lee JS, Matthay MA. Cytokine-mediated inflammation in acute lung injury. Cytokine Growth Factor Rev 2003;14:523-35.
36. Kudo D, Toyama M, Aoyagi T, Akahori Y, Yamamoto H, Ishii K, et al. Involvement of high mobility group box 1 and the therapeutic effect of recombinant thrombomodulin in a mouse model of severe acute respiratory distress syndrome. Clin Exp Immunol 2013;173:276-87.