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Bioorganic and Medicinal Chemistry

Volumn 23, Issue 19, 2015, Pages 6520-6527

Kinase hinge binding scaffolds and their hydrogen bond patterns

(4) Xing, Li a Klug Mcleod, Jacquelyn a Rai, Brajesh a Lunney, Elizabeth A a

a PFIZER INC (United States)

Author keywords

Crystal structure database; Hinge scaffolds; Hydrogen bonds; Kinase hinge; Potency and selectivity; Protein kinase

Indexed keywords

PROTEIN KINASE; SCAFFOLD PROTEIN; PROTEIN BINDING; PROTEIN KINASE INHIBITOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG SCREENING; ENZYME ACTIVITY; HUMAN; HYDROGEN BOND; LIGAND BINDING; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; CHEMISTRY; METABOLISM; PROTEIN DATABASE; PROTEIN TERTIARY STRUCTURE;

BINDING SITES; DATABASES, PROTEIN; HUMANS; HYDROGEN BONDING; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY;

EID: 84942199772 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2015.08.006 Document Type: Article

Times cited : (123)

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