SCOPUS 정보 검색 플랫폼

Volumn 25, Issue 11, 2015, Pages 2372-2376

Current kinase inhibitors cover a tiny fraction of fragment space

Author keywords

Chemical space; Fragment based drug discovery; Fragmentation; Kinase; Tricyclic ring systems

Indexed keywords

MOLECULAR LIBRARY; PROTEIN KINASE INHIBITOR;

CHEMICAL DATABASE; CHEMISTRY; CLASSIFICATION; MOLECULAR LIBRARY; STRUCTURE ACTIVITY RELATION;

DATABASES, CHEMICAL; PROTEIN KINASE INHIBITORS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84937764242 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.04.005 Document Type: Article

Times cited : (21)

References (26)

1
- 57749188299
- J. Zhang, P.L. Yang, and N.S. Gray Nat. Rev. Cancer 9 2009 28
- (2009) Nat. Rev. Cancer , vol.9 , pp. 28
- Zhang, J.¹ Yang, P.L.² Gray, N.S.³

2
- 33745298429
- Y. Liu, and N.S. Gray Nat. Chem. Biol. 2 2006 358
- (2006) Nat. Chem. Biol. , vol.2 , pp. 358
- Liu, Y.¹ Gray, N.S.²

3
- 77950573400
- F. Zuccotto, E. Ardini, E. Casale, and M. Angiolini J. Med. Chem. 53 2010 2681
- (2010) J. Med. Chem. , vol.53 , pp. 2681
- Zuccotto, F.¹ Ardini, E.² Casale, E.³ Angiolini, M.⁴

4
- 84871730931
- L.K. Gavrin, and E. Saiah Medchemcomm 4 2013 41
- (2013) Medchemcomm , vol.4 , pp. 41
- Gavrin, L.K.¹ Saiah, E.²

5
- 84862869077
- D.E. Scott, A.G. Coyne, S.A. Hudson, and C. Abell Biochemistry 51 2012 4990
- (2012) Biochemistry , vol.51 , pp. 4990
- Scott, D.E.¹ Coyne, A.G.² Hudson, S.A.³ Abell, C.⁴

6
- 84867352362
- H.T. Zhao, J. Dong, K. Lafleur, C. Nevado, and A. Caflisch ACS Med. Chem. Lett. 3 2012 834
- (2012) ACS Med. Chem. Lett. , vol.3 , pp. 834
- Zhao, H.T.¹ Dong, J.² Lafleur, K.³ Nevado, C.⁴ Caflisch, A.⁵

7
- 50849118847
- P. Kolb, C.B. Kipouros, D. Huang, and A. Caflisch Proteins 73 2008 11
- (2008) Proteins , vol.73 , pp. 11
- Kolb, P.¹ Kipouros, C.B.² Huang, D.³ Caflisch, A.⁴

8
- 84899934825
- H. Zhao, L. Gartenmann, J. Dong, D. Spiliotopoulos, and A. Caflisch Bioorg. Med. Chem. Lett. 24 2014 2493
- (2014) Bioorg. Med. Chem. Lett. , vol.24 , pp. 2493
- Zhao, H.¹ Gartenmann, L.² Dong, J.³ Spiliotopoulos, D.⁴ Caflisch, A.⁵

9
- 84921532261
- H. Zhao, and A. Caflisch Eur. J. Med. Chem. 91 2015 4
- (2015) Eur. J. Med. Chem. , vol.91 , pp. 4
- Zhao, H.¹ Caflisch, A.²

10
- 70350072332
- K. Lafleur, D. Huang, T. Zhou, A. Caflisch, and C. Nevado J. Med. Chem. 52 2009 6433
- (2009) J. Med. Chem. , vol.52 , pp. 6433
- Lafleur, K.¹ Huang, D.² Zhou, T.³ Caflisch, A.⁴ Nevado, C.⁵

11
- 84872309000
- K. Lafleur, J. Dong, D. Huang, A. Caflisch, and C. Nevado J. Med. Chem. 56 2013 84
- (2013) J. Med. Chem. , vol.56 , pp. 84
- Lafleur, K.¹ Dong, J.² Huang, D.³ Caflisch, A.⁴ Nevado, C.⁵

12
- 0029894013
- G.W. Bemis, and M.A. Murcko J. Med. Chem. 39 1996 2887
- (1996) J. Med. Chem. , vol.39 , pp. 2887
- Bemis, G.W.¹ Murcko, M.A.²

13
- 84898721607
- R.D. Taylor, M. MacCoss, and A.D. Lawson J. Med. Chem. 57 2014 5845
- (2014) J. Med. Chem. , vol.57 , pp. 5845
- Taylor, R.D.¹ Maccoss, M.² Lawson, A.D.³

14
- 13844312649
- J.J. Irwin, and B.K. Shoichet J. Chem. Inf. Model. 45 2005 177
- (2005) J. Chem. Inf. Model. , vol.45 , pp. 177
- Irwin, J.J.¹ Shoichet, B.K.²

15
- 84906088551
- A. Unzue, J. Dong, K. Lafleur, H. Zhao, E. Frugier, A. Caflisch, and C. Nevado J. Med. Chem. 57 2014 6834
- (2014) J. Med. Chem. , vol.57 , pp. 6834
- Unzue, A.¹ Dong, J.² Lafleur, K.³ Zhao, H.⁴ Frugier, E.⁵ Caflisch, A.⁶ Nevado, C.⁷

16
- 77953631827
- C. Bissantz, B. Kuhn, and M. Stahl J. Med. Chem. 53 2010 5061
- (2010) J. Med. Chem. , vol.53 , pp. 5061
- Bissantz, C.¹ Kuhn, B.² Stahl, M.³

17
- 84867343363
- H. Zhao, D. Huang, and A. Caflisch ChemMedChem 7 2012 1983
- (2012) ChemMedChem , vol.7 , pp. 1983
- Zhao, H.¹ Huang, D.² Caflisch, A.³

18
- 84874632186
- R. Wilcken, M.O. Zimmermann, A. Lange, A.C. Joerger, and F.M. Boeckler J. Med. Chem. 56 2013 1363
- (2013) J. Med. Chem. , vol.56 , pp. 1363
- Wilcken, R.¹ Zimmermann, M.O.² Lange, A.³ Joerger, A.C.⁴ Boeckler, F.M.⁵

19
- 79251579303
- O. Fedorov, K. Huber, A. Eisenreich, P. Filippakopoulos, O. King, A.N. Bullock, D. Szklarczyk, L.J. Jensen, D. Fabbro, J. Trappe, U. Rauch, F. Bracher, and S. Knapp Chem. Biol. 18 2011 67
- (2011) Chem. Biol. , vol.18 , pp. 67
- Fedorov, O.¹ Huber, K.² Eisenreich, A.³ Filippakopoulos, P.⁴ King, O.⁵ Bullock, A.N.⁶ Szklarczyk, D.⁷ Jensen, L.J.⁸ Fabbro, D.⁹ Trappe, J.¹⁰ Rauch, U.¹¹ Bracher, F.¹² Knapp, S.¹³

20
- 0035289779
- C.A. Lipinski, F. Lombardo, B.W. Dominy, and P.J. Feeney Adv. Drug Deliv. Rev. 46 2001 3
- (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 3
- Lipinski, C.A.¹ Lombardo, F.² Dominy, B.W.³ Feeney, P.J.⁴

21
- 79851514554
- T.J. Ritchie, S.J. Macdonald, R.J. Young, and S.D. Pickett Drug Discovery Today 16 2011 164
- (2011) Drug Discovery Today , vol.16 , pp. 164
- Ritchie, T.J.¹ Macdonald, S.J.² Young, R.J.³ Pickett, S.D.⁴

22
- 79251561193
- C.Y. Chen PLoS ONE 6 2011 e15939
- (2011) PLoS ONE , vol.6
- Chen, C.Y.¹

23
- 84896728348
- L. Xing, B. Rai, and E.A. Lunney J. Comput. Aided Mol. Des. 28 2014 13
- (2014) J. Comput. Aided Mol. Des. , vol.28 , pp. 13
- Xing, L.¹ Rai, B.² Lunney, E.A.³

24
- 70350072342
- J. Wagner, P. von Matt, R. Sedrani, R. Albert, N. Cooke, C. Ehrhardt, M. Geiser, G. Rummel, W. Stark, A. Strauss, S.W. Cowan-Jacob, C. Beerli, G. Weckbecker, J.P. Evenou, G. Zenke, and S. Cottens J. Med. Chem. 52 2009 6193
- (2009) J. Med. Chem. , vol.52 , pp. 6193
- Wagner, J.¹ Von Matt, P.² Sedrani, R.³ Albert, R.⁴ Cooke, N.⁵ Ehrhardt, C.⁶ Geiser, M.⁷ Rummel, G.⁸ Stark, W.⁹ Strauss, A.¹⁰ Cowan-Jacob, S.W.¹¹ Beerli, C.¹² Weckbecker, G.¹³ Evenou, J.P.¹⁴ Zenke, G.¹⁵ Cottens, S.¹⁶

25
- 84903208494
- Z. Zhao, H. Wu, L. Wang, Y. Liu, S. Knapp, Q. Liu, and N.S. Gray ACS Chem. Biol. 9 2014 1230
- (2014) ACS Chem. Biol. , vol.9 , pp. 1230
- Zhao, Z.¹ Wu, H.² Wang, L.³ Liu, Y.⁴ Knapp, S.⁵ Liu, Q.⁶ Gray, N.S.⁷

26
- 79959222106
- H. Zhao, and D. Huang PLoS ONE 6 2011 e19923
- (2011) PLoS ONE , vol.6
- Zhao, H.¹ Huang, D.²

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