An enriched structural kinase database to enable kinome-wide structure-based analyses and drug discovery

Protein Science

Volumn 19, Issue 4, 2010, Pages 763-774

  Brooijmans, Natasja ^a   Chang, Yu Wei ^a   Mobilio, Dominick ^a   Denny, Rajiah A ^b   Humblet, Christine ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

Binding sites; Catalytic domain; Crystallography: X ray; Databases: protein; Protein binding; Protein conformation; Protein kinases; Sequence analysis: protein; Structural informatics; Structure based drug design

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLYCINE; HELIX LOOP HELIX PROTEIN; PHOSPHOTRANSFERASE;

ARTICLE; AUTOANALYSIS; BINDING SITE; CLASSIFICATION; CRYSTAL STRUCTURE; DATA ANALYSIS; DATA BASE; DNA HELIX; ENZYME ANALYSIS; ENZYME STRUCTURE; GENOME; HYDROGEN BOND; INFORMATION PROCESSING; KINASE KNOWLEDGE BASE; KINOME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DATA BANK; PROTEIN DOMAIN; SEQUENCE ANALYSIS;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; DRUG DISCOVERY; HUMANS; HYDROGEN BONDING; LIGANDS; MODELS, MOLECULAR; PHOSPHOTRANSFERASES; PROTEIN CONFORMATION; PROTEIN FOLDING;

EID: 77950271944     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.355     Document Type: Article

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