DNA Nanostructures as Smart Drug-Delivery Vehicles and Molecular Devices

Trends in Biotechnology

Volumn 33, Issue 10, 2015, Pages 586-594

  Linko, Veikko ^a   Ora, Ari ^a   Kostiainen, Mauri A ^a  

^a AALTO UNIVERSITY   (Finland)

Author keywords

Biocomputing; Biosensing; Cell uptake; DNA nanotechnology; DNA origami; Drug delivery; Enzymatic payloads; Immunostimulation; Self assembly

Indexed keywords

CELLS; CONTROLLED DRUG DELIVERY; CYTOLOGY; DNA; DRUG DELIVERY; NANOSTRUCTURED MATERIALS; NANOSTRUCTURES; SELF ASSEMBLY; VEHICLES;

BIO-COMPUTING; BIOSENSING; CELL UPTAKE; DNA NANOTECHNOLOGY; DNA ORIGAMIS; ENZYMATIC PAYLOADS; IMMUNOSTIMULATION;

TARGETED DRUG DELIVERY;

DNA; MESSENGER RNA; NANOMATERIAL; PRODRUG; SMALL INTERFERING RNA;

BIOCOMPATIBILITY; BIODEGRADABILITY; CANCER THERAPY; CONFORMATIONAL TRANSITION; DNA STRUCTURE; DNA TEMPLATE; DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; ENZYME REPLACEMENT; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; IN VITRO STUDY; LIPID MEMBRANE; MEMBRANE BINDING; NANODEVICE; NANOTECHNOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SPATIAL ORIENTATION; VIRUS PARTICLE; BASE PAIRING; CHEMISTRY; CONFORMATION; DEVICES; METABOLISM; NEOPLASMS; PATHOLOGY; PROCEDURES; SIGNAL TRANSDUCTION; SPHINGOLIPIDOSES;

BASE PAIRING; DNA; DRUG DELIVERY SYSTEMS; ENZYME REPLACEMENT THERAPY; HUMANS; NANOSTRUCTURES; NANOTECHNOLOGY; NEOPLASMS; NUCLEIC ACID CONFORMATION; SIGNAL TRANSDUCTION; SPHINGOLIPIDOSES;

EID: 84942111117     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2015.08.001     Document Type: Review

References (68)

1. Seeman N.C. Nucleic acid junctions and lattices. J. Theor. Biol. 1982, 99:237-247.
2. Watson J.D., Crick F.H.C. Molecular structure of nucleic acids. Nature 1953, 171:737-738.
3. Linko V., Dietz H. The enabled state of DNA nanotechnology. Curr. Opin. Biotechnol. 2013, 24:555-561.
4. Rothemund P.W.K. Folding DNA to create nanoscale shapes and patterns. Nature 2006, 440:297-302.
5. Ke Y., et al. Scaffolded DNA origami of a DNA tetrahedron molecular container. Nano Lett. 2009, 9:2445-2447.
6. Andersen E.S., et al. Self-assembly of a nanoscale DNA box with a controllable lid. Nature 2009, 459:73-76.
7. Kuzuya A., Komiyama M. Design and construction of a box-shaped 3D-DNA origami. Chem. Commun. 2009, 4182-4184.
8. Douglas S.M., et al. Self-assembly of DNA into nanoscale three-dimensional shapes. Nature 2009, 459:414-418.
9. Ke Y., et al. Multilayer DNA origami packed on a square lattice. J. Am. Chem. Soc. 2009, 131:15903-15908.
10. Ke Y., et al. Multilayer DNA origami packed on hexagonal and hybrid lattices. J. Am. Chem. Soc. 2012, 134:1770-1774.
11. Dietz H., et al. Folding DNA into twisted and curved nanoscale shapes. Science 2009, 325:725-730.
12. Han D., et al. DNA origami with complex curvatures in three-dimensional space. Science 2011, 332:342-346.
13. Wei B., et al. Complex shapes self-assembled from single-stranded DNA tiles. Nature 2012, 485:623-626.
14. Ke Y., et al. Three-dimensional structures self-assembled from DNA bricks. Science 2012, 338:1177-1183.
15. Han D., et al. DNA gridiron nanostructures based on four-arm junctions. Science 2013, 339:1412-1415.
16. Zhang F., et al. Complex wireframe DNA origami nanostructures with multi-arm junction vertices. Nat. Nanotech. 2015, Published online July 20, 2015. 10.1038/nnano.2015.162.
17. Benson E., et al. DNA rendering of polyhedral meshes at the nanoscale. Nature 2015, 523:441-444.
18. Gerling T., et al. Dynamic DNA devices and assemblies formed by shape-complementary, non-base pairing 3D components. Science 2015, 347:1446-1452.
19. Douglas S.M., et al. Rapid prototyping of 3D DNA-origami shapes with caDNAno. Nucleic Acids Res. 2009, 37:5001-5006.
20. Castro C.E., et al. A primer to scaffolded DNA origami. Nat. Methods 2011, 8:221-229.
21. Pan K., et al. Lattice-free prediction of three-dimensional structure of programmed DNA assemblies. Nat. Commun. 2014, 5:5578.
22. Mei Q., et al. Stability of DNA origami nanoarrays in cell lysate. Nano Lett. 2011, 11:1477-1482.
23. McLaughlin C.K., et al. Three-dimensional organization of block copolymers on 'DNA-minimal' scaffolds. J. Am. Chem. Soc. 2012, 134:4280-4286.
24. Conway J.W., et al. DNA nanostructure serum stability: greater than the sum of its parts. Chem. Commun. 2013, 49:1172-1174.
25. Krishnan Y., Simmel F.C. Nucleic acid based molecular devices. Angew. Chem. Int. Ed. 2011, 50:3124-3156.
26. Saccà B., Niemeyer C.M. Functionalization of DNA nanostructures with proteins. Chem. Soc. Rev. 2011, 40:5910-5921.
27. Ko S-H., et al. DNA nanotubes as combinatorial vehicles for cellular delivery. Biomacromolecules 2008, 9:3039-3043.
28. Sellner S., et al. DNA nanotubes as intracellular delivery vehicles in vivo. Biomaterials 2015, 53:453-463.
29. Walsh A.S., et al. DNA cage delivery to mammalian cells. ACS Nano 2011, 5:5427-5432.
30. Bujold K.E., et al. Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles. Chem. Sci. 2014, 5:2449-2455.
31. Jiang Q., et al. DNA origami as a carrier for circumvention of drug resistance. J. Am. Chem. Soc. 2012, 134:13396-13403.
32. Zhang Q., et al. DNA origami as an in vivo drug delivery vehicle for cancer therapy. ACS Nano 2014, 8:6633-6643.
33. Zhao Y-X., et al. DNA origami delivery system for cancer therapy with tunable release properties. ACS Nano 2012, 6:8684-8691.
34. Bhatia D., et al. A synthetic icosahedral DNA-based host-cargo complex for functional in vivo imaging. Nat. Commun. 2011, 2:339.
35. Keum J-W., et al. Design, assembly, and activity of antisense DNA nanostructures. Small 2011, 7:3529-3535.
36. Kocabey S., et al. Cellular uptake of tile-assembled DNA nanotubes. Nanomaterials 2014, 5:47-60.
37. Lee H., et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nat. Nanotech. 2012, 7:389-393.
38. Shaw A., et al. Spatial control of membrane receptor function using ligand nanocalipers. Nat. Methods 2014, 11:841-846.
39. Schüller V.J., et al. Cellular immunostimulation by CpG-sequence-coated DNA origami structures. ACS Nano 2011, 5:9696-9702.
40. Li J., et al. Self-assembled multivalent DNA nanostructures for noninvasive intracellular delivery of immunostimulatory CpG oligonucleotides. ACS Nano 2011, 5:8783-8789.
41. Mohri K., et al. Design and development of nanosized DNA assemblies in polypod-like structures as efficient vehicles for immunostimulatory CpG motifs to immune cells. ACS Nano 2012, 6:5931-5940.
42. Mohri K., et al. Self-assembling DNA dendrimer for effective delivery of immunostimulatory CpG DNA to immune cells. Biomacromolecules 2015, 16:1095-1101.
43. Douglas S.M., et al. A logic-gated nanorobot for targeted transport of molecular payloads. Science 2012, 335:831-834.
44. Okholm A.H., et al. Quantification of cellular uptake of DNA nanostructures by qPCR. Methods 2014, 67:193-197.
45. Brglez J., et al. Designed intercalators for modification of DNA origami surface properties. Chem. Eur. J. 2015, 21:9440-9446.
46. Ma Y., et al. Virus-based nanocarriers for drug delivery. Adv. Drug Deliv. Rev. 2012, 64:811-825.
47. Mikkilä J., et al. Virus-encapsulated DNA origami nanostructures for cellular delivery. Nano Lett. 2014, 14:2196-2200.
48. Perrault S.D., Shih W.M. Virus-inspired membrane encapsulation of DNA nanostructures to achieve in vivo stability. ACS Nano 2014, 8:5132-5140.
49. Wu C., et al. Building a multifunctional aptamer-based DNA nanoassembly for targeted cancer therapy. J. Am. Chem. Soc. 2013, 135:18644-18650.
50. Charoenphol P., Bermudez H. Aptamer-targeted DNA nanostructures for therapeutic delivery. Mol. Pharm. 2014, 11:1721-1725.
51. Cho Y., et al. Controlled release of an anti-cancer drug from DNA structured nano-films. Sci. Rep. 2014, 4:4078.
52. Simmel F.C. DNA-based assembly lines and nanofactories. Curr. Opin. Biotechnol. 2012, 23:516-521.
53. Delebecque C.J., et al. Organization of intracellular reactions with rationally designed RNA assemblies. Science 2011, 333:470-474.
54. Wilner O.I., et al. Enzyme cascades activated on topologically programmed DNA scaffolds. Nat. Nanotech. 2009, 4:249-254.
55. Voigt N.V., et al. Single-molecule chemical reactions on DNA origami. Nat. Nanotech. 2010, 5:200-203.
56. Fu J., et al. Interenzyme substrate diffusion for an enzyme cascade organized on spatially addressable DNA nanostructures. J. Am. Chem. Soc. 2012, 134:5516-5519.
57. Liu M., et al. A DNA tweezer-actuated enzyme nanoreactor. Nat. Commun. 2013, 4:2127.
58. Fu J., et al. Multi-enzyme complexes on DNA scaffolds capable of substrate channeling with an artificial swinging arm. Nat. Nanotech. 2014, 9:531-536.
59. Linko V., et al. A modular DNA origami-based enzyme cascade nanoreactor. Chem. Commun. 2015, 51:5351-5354.
60. Derr N.D., et al. Tug-of-war in motor protein ensembles revealed with a programmable DNA origami scaffold. Science 2012, 338:662-665.
61. Langecker M., et al. Synthetic lipid membrane channels formed by designed DNA nanostructures. Science 2012, 338:932-936.
62. Burns J.R., et al. Membrane-spanning DNA nanopores with cytotoxic effect. Angew. Chem. Int. Ed. 2014, 53:12466-12470.
63. Amir Y., et al. Universal computing by DNA origami robots in a living animal. Nat. Nanotech. 2014, 9:353-357.
64. Pinheiro A.V., et al. Challenges and opportunities for structural DNA nanotechnology. Nat. Nanotech. 2011, 6:763-772.
65. Sobczak J-P.J., et al. Rapid folding of DNA into nanoscale shapes at constant temperature. Science 2012, 338:1458-1461.
66. Lin C., et al. Purification of DNA-origami nanostructures by rate-zonal centrifugation. Nucleic Acids Res. 2013, 41:e40.
67. Stahl E., et al. Facile and scalable preparation of pure and dense DNA origami solutions. Angew. Chem. Int. Ed. 2014, 53:12735-12740.
68. Kick B., et al. Efficient production of single-stranded phage DNA as scaffolds for DNA origami. Nano Lett. 2015, 15:4672-4676.