The role of GW182 proteins in miRNA-mediated gene silencing

Advances in Experimental Medicine and Biology

Volumn 768, Issue , 2013, Pages 147-163

  Braun, Joerg E ^a   Huntzinger, Eric ^a   Izaurralde, Elisa ^a  

^a MAX PLANCK INSTITUTE FOR DEVELOPMENTAL BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GW182 PROTEIN; MICRORNA; MULTIPROTEIN COMPLEX; POLYADENYLIC ACID BINDING PROTEIN; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; GENE SILENCING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

EID: 84873541811     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-5107-5_9     Document Type: Article

References (65)

1. Baillat D, Shiekhattar R (2009) Functional dissection of the human TNRC6 (GW182-related) family of proteins. Mol Cell Biol 29:4144-41555
2. Bartel PD (2009) MicroRNAs: Target recognition and regulatory functions. Cell 136:215-2333
3. Bazzini AA, Lee MT, Giraldez AJ (2012) Ribosome profiling shows that miR-430 reduces translation before causing mRNA decay in Zebrafish. Science 336:233-2377
4. Behm-Ansmant I, Rehwinkel J, Doerks T et al (2006a) mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes. Genes Dev 20:1885-18988
5. Behm-Ansmant I, Rehwinkel J, Izaurralde E (2006b) MicroRNAs silence gene expression by repressing protein expression and/or by promoting mRNA decay. Cold Spring Harb Symp Quant Biol 71:523-5300
6. Béthune J, Artus-Revel CG, Filipowicz W (2012) Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells. EMBO Rep 13(8):716-7233
7. Bies-Etheve N, Pontier D, Lahmy S et al (2009) RNA-directed DNA methylation requires an AGO4-interacting member of the SPT5 elongation factor family. EMBO Rep 10:649-6544
8. Braun JE, Huntzinger E, Fauser M, Izaurralde E (2011) GW182 proteins recruit cytoplasmic deadenylase complexes to miRNA targets. Mol Cell 44:120-1333
9. Buchberger A (2002) From UBA to UBX: New words in the ubiquitin vocabulary. Trends Cell Biol 12:216-2211
10. Chekulaeva M, Filipowicz W, Parker R (2009) Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila. RNA 15:794-8033
11. Chekulaeva M, Parker R, Filipowicz W (2010) The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression. Nucleic Acids Res 38:6673-66833
12. Chekulaeva M, Mathys H, Zipprich JT, Attig J, Colic M, Parker R, Filipowicz W (2011) miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs. Nat Struct Mol Biol 18:1218-12266
13. Chen CY, Zheng D, Xia Z et al (2009) Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps. Nat Struct Mol Biol 16:1160-11666
14. Chu CY, Rana TM (2006) Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54. PLoS Biol 4:e2100
15. Cooke A, Prigge A, Wickens M (2010) Translational repression by deadenylases. J Biol Chem 285:28506-285133
16. Derry MC, Yanagiya A, Martineau Y et al (2006) Regulation of poly(A)-binding protein through PABP-interacting proteins. Cold Spring Harb Symp Quant Biol 71:537-5433
17. Ding XC, Großhans H (2009) Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins. EMBO J 28:213-2222
18. Ding L, Han M (2007) GW182 family proteins are crucial for microRNA-mediated gene silencing. Trends Cell Biol 17:411-4166
19. Ding L, Spencer A, Morita K et al (2005) The developmental timing regulator AIN-1 interacts with miRISCs and may target the argonaute protein ALG-1 to cytoplasmic P bodies in C. elegans. Mol Cell 19:437-4477
20. Djuranovic S, Nahvi A, Green A (2012) miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay. Science 336:237-2400
21. El-Shami M, Pontier D, Lahmy S, Braun L, Picart C, Vega D, Hakimi MA, Jacobsen SE, Cooke R, Lagrange T. (2007) Reiterated WG/GW motifs form functionally and evolutionarily conserved ARGONAUTE-binding platforms in RNAi-related components. Genes Dev. 21:2539-25444
22. Eulalio A, Rehwinkel J, Stricker M et al (2007a) Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing. Genes Dev 21:2558-25700
23. Eulalio A, Behm-Ansmant I, Schweizer D et al (2007b) P-body formation is a consequence, not the cause of RNA-mediated gene silencing. Mol Cell Biol 27:3970-39811
24. Eulalio A, Huntzinger E, Izaurralde E (2008) GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol 15:346-3533
25. Eulalio A, Tritschler F, Izaurralde E (2009a) The GW182 protein family in animal cells: New insights into domains required for miRNA mediated gene silencing. RNA 15:1433-14422
26. Eulalio A, Huntzinger E, Nishihara T et al (2009b) Deadenylation is a widespread effect of miRNA regulation. RNA 15:21-322
27. Eulalio A, Helms S, Fritzsch C et al (2009c) A C-terminal silencing domain in GW182 is essential for miRNA function. RNA 15:1067-10777
28. Eulalio A, Tritschler F, Buettner R et al (2009d) The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing. Nucleic Acids Res 37:2974-29833
29. Eystathioy T, Chan EK, Tenenbaum SA et al (2002) A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. Mol Biol Cell 13:1338-13511
30. Fabian MR, Sonenberg N (2012) The mechanics of miRNA-mediated gene silencing: A look under the hood of miRISC. Nat Struct Mol Biol 19:586-5933
31. Fabian MR, Mathonnet G, Sundermeier T et al (2009) Mammalian miRNA RISC recruits CAF11 and PABP to affect PABP-dependent deadenylation Mol Cell 35:868-8800
32. Fabian MR, Cieplak MK, Frank F et al (2011) miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nat Struct Mol Biol 18:1211-12177
33. Fukaya T, Tomari Y (2011) PABP is not essential for microRNA-mediated translational repression and deadenylation in vitro. EMBO J 30:4998-50099
34. Giraldez AJ, Mishima Y, Rihel J et al (2006) Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs. Science 312:75-799
35. Huntzinger E, Izaurralde E (2011) Gene silencing by microRNAs: Contributions of translational repression and mRNA decay. Nat Rev Genet 12:99-1100
36. Huntzinger E, Braun EJ, Heimstädt S et al (2010) Two PABP-binding sites in GW182 proteins promote miRNA-mediated gene silencing. EMBO J 29:4146-41600
37. Iwasaki S, Kawamata T, Tomari Y (2009) Drosophila Argonaute1 and Argonaute2 employ distinct mechanisms for translational repression. Mol Cell 34:58-677
38. Jakymiw A, Lian S, Eystathioy T et al (2005) Disruption of GW bodies impairs mammalian RNA interference. Nat Cell Biol 7:1267-12744
39. Jinek M, Doudna JA (2009) A three-dimensional view of the molecular machinery of RNA interference. Nature 457:405-4122
40. Jinek M, Fabian MR, Coyle SM et al (2010) Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nat Struct Mol Biol 17:238-2400
41. Kozlov G, Safaee N, Rosenauer A et al (2010) Structural basis of binding of P-body associated protein GW182 and Ataxin-2 by the MLLE domain of poly(A)-binding protein. J Biol Chem 285:13599-136066
42. Kuzuoglu-Öztürk D, Huntzinger E, Schmidt S, Izaurralde E (2012) The Caenorhabditis elegans GW182 protein AIN-1 interacts with PAB-1 and subunits of the PAN2-PAN3 and CCR4-NOT deadenylase complexes. Nucleic Acids Res 40:5651-56655
43. Landthaler M, Gaidatzis D, Rothballer A et al (2008) Molecular characterization of human Argonaute-containing ribonucleoprotein complexes and their bound target mRNAs. RNA 14:2580-25966
44. Lazzaretti D, Tournier I, Izaurralde E (2009) The C-terminal domains of human TNRC6A, B and C silence bound transcripts independently of the Argonaute proteins. RNA 15:1059-10666
45. Li S, Lian SL, Moser JJ et al (2008) Identification of GW182 and its novel isoform TNGW1 as translational repressors in Ago2-mediated silencing. J Cell Sci 121:4134-41444
46. Lian SL, Li S, Abadal GX et al (2009) The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing. RNA 15:804-8133
47. Liu J, Rivas FV, Wohlschlegel J et al (2005) A role for the P-body component GW182 in microRNA function. Nat Cell Biol 7:1261-12666
48. Meister G, Landthaler M, Peters L et al (2005) Identification of novel argonaute-associated proteins. Curr Biol 15:2149-21555
49. Mishima Y, Fukao A, Kishimoto T, Sakamoto H, Fujiwara T, Inoue K (2012) Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish. Proc Natl Acad Sci USA 109:1104-11099
50. Miyoshi K, Okada TN, Siomi H et al (2009) Characterization of miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway. RNA 15:1282-12911
51. Moretti F, Kaiser C, Zdanowicz-Specht A, Hentze MW (2012) PABP and the poly(A) tail augment microRNA repression by facilitated miRISC binding. Nat Struct Mol Biol 19:603-6088
52. Partridge JF, DeBeauchamp JL, Kosinski AM et al (2007) Functional separation of the requirements for establishment and maintenance of centromeric heterochromatin. Mol Cell 26:593-6022
53. Piao X, Zhang X, Wu L et al (2010) CCR4-NOT deadenylates mRNA associated with RNAinduced silencing complexes in human cells. Mol Cell Biol 30:1486-14944
54. Rehwinkel J, Behm-Ansmant I, Gatfield D et al (2005) A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing. RNA 11:1640-16477
55. Takimoto K, Wakiyama M, Yokoyama S (2009) Mammalian GW182 contains multiple Argonaute binding sites and functions in microRNA-mediated translational repression. RNA 15:1078-10899
56. Till S, Lejeune E, Thermann R et al (2007) A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Nat Struct Mol Biol 14:897-9033
57. Wakiyama M, Takimoto K, Ohara O et al (2007) Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system. Genes Dev 21:1857-18622
58. Walters RW, Bradrick SS, Gromeier M (2010) Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. RNA 16:239-2500
59. Wu L, Fan J, Belasco JG (2006) MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci USA 103:4034-40399
60. Wu E, Thivierge C, Flamand M et al (2010) Pervasive and cooperative deadenylation of 3 ¢ UTRs by embryonic MicroRNA families. Mol Cell 40:558-5700
61. Yao B, Li S, Jung HM et al (2011) Divergent GW182 functional domains in the regulation of translational silencing. Nucleic Acids Res 39:2534-25477
62. Zdanowicz A, Thermann R, Kowalska J et al (2009) Drosophila miR2 primarily targets the m7GpppN cap structure for translational repression. Mol Cell 35:881-8888
63. Zekri L, Huntzinger E, Heimstädt S et al (2009) The silencing domain of GW182 interacts with PABP to promote translational repression and degradation of miRNA targets and is required for target release. Mol Cell Biol 29:6220-62311
64. Zhang L, Ding L, Cheung TH et al (2007) Systematic identification of C. elegans miRISC proteins, miRNAs, and mRNA targets by their interactions with GW182 proteins AIN-1 and AIN-2. Mol Cell 28:598-6133
65. Zipprich JT, Bhattacharyya S, Mathys H et al (2009) Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression. RNA 15:781-7933