Selective inhibition of SIRT2 improves outcomes in a lethal septic model

Current Molecular Medicine

Volumn 15, Issue 7, 2015, Pages 634-641

  Zhao, T ^a   Alam, H B ^a   Liu, B ^a   Bronson, R T ^b   Nikolian, V C ^a   Wu, E ^c   Chong, W ^d   Li, Y ^a  

^a UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^d CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Bone marrow atrophy; Mouse; Septic shock; SIRT2 inhibitor; Survival

Indexed keywords

INTERLEUKIN 6; SELISISTAT; SIRTUIN 2; TUMOR NECROSIS FACTOR ALPHA; AGK2 COMPOUND; CYTOKINE; FURAN DERIVATIVE; HISTONE DEACETYLASE INHIBITOR; LIPOPOLYSACCHARIDE; QUINOLINE DERIVATIVE; SIRT2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOLOGY; MALE; MOUSE; NONHUMAN; SEPTIC SHOCK; SPLEEN CELL; THROMBOELASTOGRAPHY; TREATMENT OUTCOME; ANIMAL; ANTAGONISTS AND INHIBITORS; ATROPHY; BLOOD; BONE MARROW; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; IMMUNOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; PRECLINICAL STUDY; SHOCK, SEPTIC;

ANIMALS; ATROPHY; BONE MARROW; CELLS, CULTURED; CYTOKINES; DRUG EVALUATION, PRECLINICAL; FURANS; HISTONE DEACETYLASE INHIBITORS; INJECTIONS, INTRAPERITONEAL; LIPOPOLYSACCHARIDES; MALE; MICE, INBRED C57BL; QUINOLINES; SHOCK, SEPTIC; SIRTUIN 2;

EID: 84942081900     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652401507150903185852     Document Type: Article

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