Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis

Journal of Trauma and Acute Care Surgery

Volumn 77, Issue 6, 2014, Pages 913-919

  Zhao, Ting ^a   Li, Yongqing ^b   Liu, Baoling ^b   Bronson, Roderick T ^c   Halaweish, Ihab ^b   Alam, Hasan B ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Cytokines; EX 527; Mice; Sepsis; SIRT1; Survival

Indexed keywords

CYTOKINE; EX 527; FIBRIN; HISTONE DEACETYLASE INHIBITOR; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; SIRTUIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE; CARBAZOLE DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ATROPHY; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; BONE MARROW ATROPHY; BONE MARROW DISEASE; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME INHIBITION; FEMUR; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PERITONEAL FLUID LEVEL; PROTEIN BLOOD LEVEL; PROTEIN CROSS LINKING; SEPSIS; SPLEEN CELL; SURVIVAL; SURVIVAL RATE; THROMBOCYTE FUNCTION; THROMBOELASTOGRAPHY; TIBIA; TREATMENT OUTCOME; ANIMAL; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; MORTALITY; PATHOLOGY; PHYSIOLOGY;

ANIMALS; BLOOD COAGULATION; CARBAZOLES; DISEASE MODELS, ANIMAL; FEMUR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; INTERLEUKIN-6; MALE; MICE, INBRED C57BL; SEPSIS; THROMBELASTOGRAPHY; TIBIA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84918557424     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000347     Document Type: Conference Paper

References (34)

1. Suliman BA, Xu D, Williams BR. HDACI: molecular mechanisms and therapeutic implications in the innate immune system. Immunol Cell Biol. 2012;90:23-32.
2. Xu WS, Parmigiani RB, Marks PA. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007;26:5541-5552.
3. Martin M, Kettmann R, Dequiedt F. Class IIa histone deacetylases: regulating the regulators. Oncogene. 2007;26:5450-5467. Research support, non-US government review.
4. Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP,Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, et al. SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor alpha in breast cancer. Cancer Res. 2011;71:6654-6664.
5. Wang YZ, Huang YN, Sun KY, Qi JH, Xiang L. Leptin gene transfer regulates fibromuscular development and lipid deposition in muscles via SIRT1, FOXO3a and PGC-1alpha in mice in vivo. Int J Mol Med. 2011; 28:617-623.
6. Aquilano K, Vigilanza P, Baldelli S, Pagliei B, Rotilio G, Ciriolo MR. Peroxisome proliferator-Activated receptor gamma co-Activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside inmitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem. 2010;285:21590-21599.
7. Gao J, Wang WY, Mao YW, Graff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH.Anovel pathway regulatesmemory and plasticity via SIRT1 and miR-134. Nature. 2010;466:1105-1109.
8. Zhao T, Li Y, Liu B, Liu Z, Chong W, Duan X, Deperalta DK, Velmahos GC, Alam HB. Novel pharmacologic treatment attenuates septic shock and improves long-term survival. Surgery. 2013;154:206-213.
9. Bradner JE,West N, Grachan ML, Greenberg EF, Haggarty SJ,Warnow T, Mazitschek R. Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010;6:238-243.
10. Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, et al. Innate response activator B cells protect against microbial sepsis. Science. 2012;335:597-601.
11. Liu G, Friggeri A, Yang Y, Park Y-J, Tsuruta Y, Abraham E. miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murinemacrophage inflammatory responses. Proc Natl Acad SciUSA. 2009; 106:15819-15824.
12. Chong W, Li Y, Liu B, Zhao T, Fukudome EY, Liu Z, Smith WM, Velmahos GC, deMoya MA, Alam HB. Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages. J Surg Res. 2012; 178:851-859.
13. Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4:31-36.
14. Waters JH, Anthony DG, Gottlieb A, Sprung J. Bleeding in a patient receiving platelet aggregation inhibitors. Anesth Analg. 2001;93:878-882, table of contents. Case reports.
15. Billard MJ, Gruver AL, Sempowski GD. Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses. PLoS One. 2011;6:e17940.
16. Michishita E, Park JY, Burneskis JM, Barrett JC, Horikawa I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol Biol Cell. 2005;16:4623-4635.
17. Tanno M, Sakamoto J, Miura T, Shimamoto K, Horio Y. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. J Biol Chem. 2007;282:6823-6832.
18. Yuan H, Su L, Chen WY. The emerging and diverse roles of sirtuins in cancer: a clinical perspective. Onco Targets Ther. 2013;6:1399-1416.
19. Yeung F,Hoberg JE,RamseyCS,KellerMD, JonesDR, FryeRA,MayoMW. Modulation of NF-kappaBYdependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004;23:2369-2380.
20. Rajendran R, Garva R, Krstic-Demonacos M, Demonacos C. Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. J Biomed Biotechnol. 2010;2011:368276.
21. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol. 2008;8:776-787. Research support,NIH, extramural review.
22. KarinM, Lin A. NF-kappaB at the crossroads of life and death. Nat Immunol. 2002;3:221-227.
23. Fulda S, Debatin KM. Sensitization for tumor necrosis factorYrelated apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrol. Cancer Res. 2004;64:337-346.
24. Levi M, Schultz M, van der Poll T. Disseminated intravascular coagulation in infectious disease. Semin Thromb Hemost. 2010;36:367-377.
25. Semeraro N, Ammollo CT, Semeraro F, Colucci M. Sepsis-Associated disseminated intravascular coagulation and thromboembolic disease. Mediterr J Hematol Infect Dis. 2010;2:e2010024.
26. Levi M. The coagulant response in sepsis. Clin Chest Med. 2008;29: 627-642, viii.
27. Cinel I, Opal SM. Molecular biology of inflammation and sepsis: a primer. Crit Care Med. 2009;37:291-304.
28. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F, Esmon CT. Extracellular histones are major mediators of death in sepsis. Nat Med. 2009;15:1318-1321.
29. Tokoyoda K, Egawa T, Sugiyama T, Choi BI, Nagasawa T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity. 2004;20:707-718.
30. TobonGJ, Izquierdo JH, Canas CA. B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus. Autoimmune Dis. 2013;2013:827254.
31. Liu H, Zhou J, Cheng P, Ramachandran I, Nefedova Y, Gabrilovich DI. Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis. J Immunol. 2013;191:1916-1926.
32. Ayala A, Herdon CD, Lehman DL, Ayala CA, Chaudry IH. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. Blood. 1996;87:4261-4275.
33. Peled T, Shoham H, Aschengrau D, Yackoubov D, Frei G, Rosenheimer GN, Lerrer B, Cohen HY, Nagler A, Fibach E, et al. Nicotinamide, a SIRT1 inhibitor, inhibits differentiation and facilitates expansion of hematopoietic progenitor cells with enhanced bone marrow homing and engraftment. Exp Hematol. 2012;40:342-55 e1.
34. Narala SR, Allsopp RC,Wells TB, Zhang G, Prasad P, Coussens MJ, Rossi DJ, Weissman IL, Vaziri H. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Mol Biol Cell. 2008;19:1210-1219.