Selective histone deacetylase-6 inhibition attenuates stress responses and prevents immune organ atrophy in a lethal septic model

Surgery (United States)

Volumn 156, Issue 2, 2014, Pages 235-242

  Zhao, Ting ^a   Li, Yongqing ^b   Bronson, Roderick T ^c   Liu, Baoling ^b   Velmahos, George C ^a   Alam, Hasan B ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MICHIGAN HOSPITALS   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CORTICOSTERONE; CORTICOTROPIN; DIMETHYL SULFOXIDE; EOSIN; HEMATOXYLIN; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE INHIBITOR; TUBASTATIN A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BONE MARROW DEPRESSION; C57BL 6 MOUSE; CONFERENCE PAPER; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; FEMUR; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPSIS; SPLEEN; STRESS; THYMOCYTE; THYMUS; THYMUS ATROPHY; TIBIA;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; APOPTOSIS; ATROPHY; BONE MARROW; CORTICOSTERONE; DISEASE MODELS, ANIMAL; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; INDOLES; MALE; MICE; MICE, INBRED C57BL; SEPSIS; SPLEEN; STRESS, PHYSIOLOGICAL; THYMUS GLAND;

EID: 84904257388     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2014.03.033     Document Type: Conference Paper

References (35)

1. J.S. Boomer, K. To, K.C. Chang, O. Takasu, D.F. Osborne, and A.H. Walton et al. Immunosuppression in patients who die of sepsis and multiple organ failure JAMA 306 2011 2594 2605
2. G.P. Chrousos The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation N Engl J Med 332 1995 1351 1362
3. W. Savino, and M. Dardenne Neuroendocrine control of thymus physiology Endocr Rev 21 2000 412 443
4. M. Hiramatsu, R.S. Hotchkiss, I.E. Karl, and T.G. Buchman Cecal ligation and puncture (CLP) induces apoptosis in thymus, spleen, lung, and gut by an endotoxin and TNF-independent pathway Shock 7 1997 247 253
5. K. Tokoyoda, T. Egawa, T. Sugiyama, B.I. Choi, and T. Nagasawa Cellular niches controlling B lymphocyte behavior within bone marrow during development Immunity 20 2004 707 718
6. V. Maxime, S. Siami, and D. Annane Metabolism modulators in sepsis: the abnormal pituitary response Crit Care Med 35 2007 S596 S601
7. R.A. Schwartzman, and J.A. Cidlowski Glucocorticoid-induced apoptosis of lymphoid cells Int Arch Allergy Immunol 105 1994 347 354
8. H. Zou, Y. Wu, M. Navre, and B.C. Sang Characterization of the two catalytic domains in histone deacetylase 6 Biochem Biophys Res Commun 341 2006 45 50
9. G.I. Aldana-Masangkay, and K.M. Sakamoto The role of HDAC6 in cancer J Biomed Biotechnol 2011 2011 875824
10. M.A. Rivieccio, C. Brochier, D.E. Willis, B.A. Walker, M.A. D'Annibale, and K. McLaughlin et al. HDAC6 is a target for protection and regeneration following injury in the nervous system Proc Natl Acad Sci U S A 106 2009 19599 19604
11. K.V. Butler, J. Kalin, C. Brochier, G. Vistoli, B. Langley, and A.P. Kozikowski Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A J Am Chem Soc 132 2010 10842 10846
12. D. Rittirsch, M.S. Huber-Lang, M.A. Flierl, and P.A. Ward Immunodesign of experimental sepsis by cecal ligation and puncture Nat Protoc 4 2009 31 36
13. M.J. Billard, A.L. Gruver, and G.D. Sempowski Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses PLoS One 6 2011 e17940
14. K.W. Tinsley, M.H. Grayson, P.E. Swanson, A.M. Drewry, K.C. Chang, and I.E. Karl et al. Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells J Immunol 171 2003 909 914
15. T. Zhao, Y. Li, B. Liu, Z. Liu, W. Chong, and X. Duan et al. Novel pharmacologic treatment attenuates septic shock and improves long-term survival Surgery 154 2013 206 213
16. Y. Li, and H.B. Alam Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock Adv Exp Med Biol 710 2012 107 133
17. A.M. Imam, G. Jin, M. Duggan, M. Sillesen, J.O. Hwabejire, and C.H. Jepsen et al. Synergistic effects of fresh frozen plasma and valproic acid treatment in a combined model of traumatic brain injury and hemorrhagic shock Surgery 154 2013 388 396
18. Y. Li, B. Liu, E.Y. Fukudome, A.R. Kochanek, R.A. Finkelstein, and W. Chong et al. Surviving lethal septic shock without fluid resuscitation in a rodent model Surgery 148 2010 246 254
19. A. Valenzuela-Fernandez, J.R. Cabrero, J.M. Serrador, and F. Sanchez-Madrid HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions Trends Cell Biol 18 2008 291 297
20. J.L. Meakins, J.B. Pietsch, O. Bubenick, R. Kelly, H. Rode, and J. Gordon et al. Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma Ann Surg 186 1977 241 250
21. R.S. Hotchkiss, P.E. Swanson, B.D. Freeman, K.W. Tinsley, J.P. Cobb, and G.M. Matuschak et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction Crit Care Med 27 1999 1230 1251
22. W. Ertel, J.P. Kremer, J. Kenney, U. Steckholzer, D. Jarrar, and O. Trentz et al. Downregulation of proinflammatory cytokine release in whole blood from septic patients Blood 85 1995 1341 1347
23. W.D. Docke, F. Randow, U. Syrbe, D. Krausch, K. Asadullah, and P. Reinke et al. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment Nat Med 3 1997 678 681
24. O. Lesur, J.F. Roussy, F. Chagnon, N. Gallo-Payet, R. Dumaine, and P. Sarret et al. Proven infection-related sepsis induces a differential stress response early after ICU admission Crit Care 14 2010 R131
25. W. Kanczkowski, V.I. Alexaki, N. Tran, S. Grossklaus, K. Zacharowski, and A. Martinez et al. Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation Proc Natl Acad Sci U S A 110 2013 14801 14806
26. P.M. Rothwell, Z.F. Udwadia, and P.G. Lawler Cortisol response to corticotropin and survival in septic shock Lancet 337 1991 582 583
27. D. Annane, V. Sebille, G. Troche, J.C. Raphael, P. Gajdos, and E. Bellissant A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin JAMA 283 2000 1038 1045
28. L. Miller, C.D. Foradori, A.S. Lalmansingh, D. Sharma, R.J. Handa, and R.M. Uht Histone deacetylase 1 (HDAC1) participates in the down-regulation of corticotropin releasing hormone gene (crh) expression Physiol Behav 104 2011 312 320
29. L. Jason, M. Sorenson, K. Sebally, D. Alkazemi, A. Lerch, and N. Porter et al. Increased HDAC in association with decreased plasma cortisol in older adults with chronic fatigue syndrome Brain Behav Immun 25 2011 1544 1547
30. G. Migliorati, C. Pagliacci, R. Moraca, F. Crocicchio, I. Nicoletti, and C. Riccardi Glucocorticoid-induced apoptosis of natural killer cells and cytotoxic T lymphocytes Pharmacol Res 26 Suppl 2 1992 26 27
31. A. Ayala, C.D. Herdon, D.L. Lehman, C.M. DeMaso, C.A. Ayala, and I.H. Chaudry The induction of accelerated thymic programmed cell death during polymicrobial sepsis: control by corticosteroids but not tumor necrosis factor Shock 3 1995 259 267
32. J.D. Ashwell, F.W. Lu, and M.S. Vacchio Glucocorticoids in T cell development and function* Annu Rev Immunol 18 2000 309 345
33. S.D. Wang, K.J. Huang, Y.S. Lin, and H.Y. Lei Sepsis-induced apoptosis of the thymocytes in mice J Immunol 152 1994 5014 5021
34. S. Chatterjee, O. Lardinois, S. Bhattacharjee, J. Tucker, J. Corbett, and L. Deterding et al. Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis Free Radic Biol Med 50 2011 988 999
35. A. Ayala, C.D. Herdon, D.L. Lehman, C.A. Ayala, and I.H. Chaudry Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators Blood 87 1996 4261 4275