Characterization of the Catalytic Domain of Human APOBEC3B and the Critical Structural Role for a Conserved Methionine

Journal of Molecular Biology

Volumn 427, Issue 19, 2015, Pages 3042-3055

  Siriwardena, Sachini U ^a   Guruge, Thisari A ^a   Bhagwat, Ashok S ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

APOBEC3B multimerization; breast cancer; cancer mutational signatures; demethylation; kataegis

Indexed keywords

5 METHYLCYTOSINE; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3B; CYTOSINE DEAMINASE; METHIONINE; THYMINE; UNCLASSIFIED DRUG; APOBEC3A PROTEIN, HUMAN; CYTIDINE DEAMINASE; CYTOSINE; PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOCHEMICAL ANALYSIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DEAMINATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ESCHERICHIA COLI; KINETIC PARAMETERS; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FOLDING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SIZE EXCLUSION CHROMATOGRAPHY; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN MULTIMERIZATION;

5-METHYLCYTOSINE; AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CYTIDINE DEAMINASE; CYTOSINE; HUMANS; METHIONINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN MULTIMERIZATION; PROTEINS;

EID: 84941939841     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2015.08.006     Document Type: Article

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