Sequence and structural determinants of human APOBEC3H deaminase and anti-HIV-1 activities

Retrovirology

Volumn 12, Issue 1, 2015, Pages

  Mitra, Mithun ^a,e   Singer, Dustin ^a   Mano, Yu ^b   Hritz, Jozef ^c,f   Nam, Gabriel ^a   Gorelick, Robert J ^d   Byeon, In Ja L ^c   Gronenborn, Angela M ^c   Iwatani, Yasumasa ^b   Levin, Judith G ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b NATIONAL HOSPITAL ORGANIZATION NAGOYA MEDICAL CENTER   (Japan)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Antiviral activity; APOBEC3H; Deaminase activity; Deaminase independent restriction; HIV 1; Homology model; Reverse transcription

Indexed keywords

APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3A; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3C; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3F; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3H; CAPSID PROTEIN; CYTIDINE DEAMINASE; OLIGONUCLEOTIDE; RIBONUCLEASE A; UNCLASSIFIED DRUG; APOBEC3H PROTEIN, HUMAN; HYDROLASE;

5' UNTRANSLATED REGION; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ENZYME SUBSTRATE COMPLEX; GENE FUNCTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTAGENESIS; NONHUMAN; PROTEIN FUNCTION; PROTEIN NUCLEIC ACID INTERACTION; PROTEIN RNA BINDING; REVERSE TRANSCRIPTION; SEQUENCE ALIGNMENT; SEQUENCE GUIDED MUTAGENESIS; STRUCTURE ANALYSIS; STRUCTURE GUIDED MUTAGENESIS; VIRUS INFECTIVITY; VIRUS INHIBITION; ZINC FINGER MOTIF; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; AMINOHYDROLASES; DNA MUTATIONAL ANALYSIS; HIV-1; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; VIRUS REPLICATION;

EID: 84924281644     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/s12977-014-0130-8     Document Type: Article

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