Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 27753-27766

  Thielen, Beth K ^a   McNevin, John P ^b   McElrath, M Juliana ^a,b   Hunt, Brook Vander Stoep ^a   Klein, Kevin C ^a   Lingappa, Jaisri R ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; DNA; GENES; INTERFERONS; VIRUSES;

CYTIDINE; DINUCLEOTIDES; HOST DEFENSE; HYPER MUTATION; ISOFORMS; LOW LEVEL; MODEL SYSTEM; PERIPHERAL BLOOD MONONUCLEAR CELLS; PRIMARY CELLS; SPECIFIC ACTIVITY; TOLL-LIKE RECEPTORS; TRANSLATIONAL INITIATION;

THERMAL CONDUCTIVITY;

ALPHA INTERFERON; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3A; DEAMINASE; DNA GLYCOSYLTRANSFERASE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; APOBEC3A PROTEIN, HUMAN; APOBEC3G PROTEIN, HUMAN; CYTIDINE DEAMINASE; PROTEIN;

ADAPTIVE IMMUNITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEAMINATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HOST RESISTANCE; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSLATION INITIATION; AMINO ACID SEQUENCE; ANIMAL; BOVINAE; CELL LINE; CHEMISTRY; CYTOLOGY; DEFICIENCY; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE REPEAT; PROTEIN SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CATTLE; CELL LINE; CYTIDINE DEAMINASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNITY, INNATE; INTERFERON-ALPHA; MACROPHAGES; MOLECULAR SEQUENCE DATA; MONOCYTES; PROTEIN BIOSYNTHESIS; PROTEINS; REPETITIVE SEQUENCES, NUCLEIC ACID; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TOLL-LIKE RECEPTORS; TRANSCRIPTION, GENETIC;

EID: 77956261579     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.102822     Document Type: Article

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