Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease

Journal of Hepatology

Volumn 63, Issue 4, 2015, Pages 962-970

  Machado, Mariana Verdelho ^a,b   Michelotti, Gregory Alexander ^a   Pereira, Thiago Almeida ^a   Xie, Guanhua ^a   Premont, Richard ^a   Cortez Pinto, Helena ^b   Diehl, Anna Mae ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b HOSPITAL DE SANTA MARIA   (Portugal)

Author keywords

Ductular reaction; Fibrosis; Non alcoholic steatohepatitis; Regeneration; YAP

Indexed keywords

OSTEOPONTIN; SONIC HEDGEHOG PROTEIN; STEM CELL FACTOR; UNCLASSIFIED DRUG; YAP PROTEIN; MESSENGER RNA; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; YAP PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FIBROSIS; HEPATOMEGALY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL DAMAGE; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; METABOLISM; MOUSE; MYOFIBROBLAST; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; ANIMAL; BIOPSY; BIOSYNTHESIS; C57BL MOUSE; DISEASE COURSE; EXPERIMENTAL LIVER CIRRHOSIS; GENE EXPRESSION REGULATION; GENETICS; INTRAHEPATIC BILE DUCT; LIVER CELL; PATHOLOGY; WESTERN BLOTTING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; ANIMALS; BILE DUCTS, INTRAHEPATIC; BIOPSY; BLOTTING, WESTERN; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICE; MICE, INBRED C57BL; NON-ALCOHOLIC FATTY LIVER DISEASE; PHOSPHOPROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84941935061     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2015.05.031     Document Type: Article

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