Xenobiotics: Interaction with the intestinal microflora

ILAR Journal

Volumn 56, Issue 2, 2015, Pages 218-227

  Lu, Kun ^a   Mahbub, Ridwan ^a   Fox, James G ^b  

^a UNIVERSITY OF GEORGIA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Gut microbiome; Interaction; Xenobiotics

Indexed keywords

XENOBIOTIC AGENT;

ANIMAL; DRUG EFFECTS; HUMAN; INTESTINE FLORA; METABOLISM; PHYSIOLOGY;

ANIMALS; GASTROINTESTINAL MICROBIOME; HUMANS; XENOBIOTICS;

EID: 84941795860     PISSN: 10842020     EISSN: 19306180     Source Type: Journal    
DOI: 10.1093/ilar/ilv018     Document Type: Article

References (113)

1. Alava P, Tack F, Laing GD, van de Wiele T. 2013. Arsenic undergoes significant speciation changes upon incubation of contaminated rice with human colon micro biota. J Hazard Mater 262:1237-1244.
2. Alkhouri N, Cikach F, Eng K, Moses J, Patel N, Yan C, Hanouneh I, Grove D, Lopez R, Dweik R. 2014. Analysis of breath volatile organic compounds as a noninvasive tool to diagnose nonalcoholic fatty liver disease in children. Eur J Gastroenterol Hepatol 26:82-87.
3. Altieri L, Neri C, Sacco R, Curatolo P, Benvenuto A, Muratori F, Santocchi E, Bravaccio C, Lenti C, Saccani M, Rigardetto R, Gandione M, Urbani A, Persico AM. 2011. Urinary p-cresol is elevated in small children with severe autism spectrum disorder. Biomarkers 16:252-260.
4. Baker NA, Shoemaker R, English V, Larian N, Sunkara M, Morris AJ, Walker M, Yiannikouris F, Cassis LA. 2015. Effects of adipocyte aryl hydrocarbon receptor deficiency on PCB-induced disruption of glucose homeostasis in lean and obese mice. Environ Health Perspect [Epub ahead of print].
5. Barbosa SM, Farhat SC, Martins LC, Pereira LA, Saldiva PH, Zanobetti A, Braga AL. 2015. Air pollution and children's health: sickle cell disease. Cad Saude Publica 31:265-275.
6. Benach JL, Li E, McGovern MM. 2012. A microbial association with autism. MBio 3:e00019-12.
7. Bisanz JE, Enos MK, Mwanga JR, Changalucha J, Burton JP, Gloor GB, Reid G. 2014. Randomized open-label pilot study of the influence ofprobioticsand thegut microbiome on toxic metal levels in Tanzanian pregnant women and school children. MBio 5:e01580-14.
8. Bjorkholm B, Bok CM, Lundin A, Rafter J, Hibberd ML, Pettersson S. 2009. Intestinal microbiota regulate xenobiotic metabolism in the liver. PLoS One 4:e6958.
9. Brandt EB, Biagini Myers JM, Acciani TH, Ryan PH, Sivaprasad U, RuffB, LeMasters GK, Bernstein DI, Lockey JE, LeCras TD, Khurana Hershey GK. 2015. Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility. J Allergy Clin Immunol [Epub ahead of print].
10. Breton J, Daniel C, Dewulf J, Pothion S, Froux N, Sauty M, Thomas P, Pot B, Foligne B. 2013. Gut microbiota limits heavy metals burden caused by chronic oral exposure. Toxicol Lett 222:132-138.
11. Breton J, Massart S, Vandamme P, De Brandt E, Pot B, Foligne B. 2013. Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome. BMC Pharmacol Toxicol 14:62.
12. Carvalho BM, Saad MJ. 2013. Influence of gut microbiota on sub-clinical inflammation and insulin resistance. Mediators Inflamm 2013:986734.
13. Chan SH, Van Hee VC, Bergen S, Szpiro AA, DeRoo LA, London SJ, Marshall JD, Kaufman JD, Sandler DP. 2015. Long-term air pollution exposure and blood pressure in the sister study. Environ Health Perspect [Epub ahead of print].
14. Chen X, Zhou H, Li X, Wang Z, Zhu G, Jin T. 2015. Effects of lead and cadmium co-exposure on hemoglobin in a Chinese population. Environ Toxicol Pharmacol 39:758-763.
15. Choi JJ, Eum SY, Rampersaud E, Daunert S, Abreu MT, Toborek M. 2013. Exercise attenuates PCB-induced changes in the mouse gut microbiome. Environ Health Perspect 121:725-730.
16. Clarke SF, Murphy EF, O'Sullivan O, Lucey AJ, Humphreys M, Hogan A, Hayes P, O'Reilly M, Jeffery IB, Wood-Martin R, Kerins DM, Quigley E, Ross RP, O'Toole PW, Molloy MG, Falvey E, Shanahan F, Cotter PD. 2014. Exercise and associated dietary extremes impact on gut microbial diversity. Gut 63:1913-1920.
17. Conklin SD, Ackerman AH, Fricke MW, Creed PA, Creed JT, Kohan MC, Herbin-Davis K, Thomas DJ. 2006. In vitro bio-transformation of an arsenosugar by mouse anaerobic cecal microflora and cecal tissue as examined using IC-ICP-MS and LC-ESI-MS/MS. Analyst 131:648-655.
18. Coppé J-P, Desprez P-Y, Krtolica A, Campisi J. 2010. The senescence-associated secretory phenotype: The dark side of tumor suppression. Annual Review of Pathology 5:99-118.
19. D'Argenio V, Casaburi G, Precone V, Salvatore F. 2014. Comparative metagenomic analysis of human gut microbiome composition using two different bioinformatic pipelines. Biomed Res Int 2014:325340.
20. Dall'Erta A, Cirlini M, Dall'Asta M, Del Rio D, Galaverna G, Dall'Asta C. 2013. Masked mycotoxins are efficiently hydro-lyzed by human colonic microbiota releasing their aglycones. Chem Res Toxicol 26:305-312.
21. Davey KJ, Cotter PD, O'Sullivan O, Crispie F, Dinan TG, Cryan JF, O'Mahony SM. 2013. Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat. Transl Psychiatry 3:e309.
22. Davey KJ, O'Mahony SM, Schellekens H, O'Sullivan O, Bienenstock J, Cotter PD, Dinan TG, Cryan JF. 2012. Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters. Psychopharmacology (Berl) 221:155-169.
23. Debes F, Budtz-Jorgensen E, WeiheP, White RF, Grandjean P. 2006. Impact of prenatal methylmercury exposure on neuro-behavioral function at age 14 years. Neurotoxicol Teratol 28:536-547.
24. Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, Hauser R, Prins GS, Soto AM, Zoeller RT, Gore AC. 2009. Endocrine-disrupting chemicals: An endocrine society scientific statement. Endocrine Reviews 30:293-342.
25. Diaz-Bone RA, van de Wiele TR. 2009. Biovolatilization of metal (loid)s by intestinal microorganisms in the simulator of the human intestinal microbial ecosystem. Environ Sci Technol 43:5249-5256.
26. Dumas ME, Barton RH, Toye A, Cloarec O, Blancher C, Rothwell A, Fearnside J, Tatoud R, Blanc V, Lindon JC, Mitchell SC, Holmes E, McCarthy MI, Scott J, Gauguier D, Nicholson JK. 2006. Metabolic profiling reveals a contribution of gut micro-biota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci USA 103:12511-12516.
27. Everard A, Cani PD. 2013. Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol 27:73-83.
28. Foster JA, McVey Neufeld K-A. 2013. Gut-brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences 36:305-312.
29. Fu PP, Cerniglia CE, Richardson KE, Heflich RH. 1988. Nitroreduction of 6-nitrobenzo[a]pyrene: a potential activation pathway in humans. Mutat Res 209(3-4):123-129.
30. George SE, Walsh DB, Stead AG, Claxton LD. 1989. Effect of ampicillin-induced alterations in murine intestinal microbiota on the survival and competition of environmentally released pseudomonads. Toxicological Sciences 13:670-680.
31. Gratz SW, Duncan G, Richardson AJ. 2013. The human fecal microbiota metabolizes deoxynivalenol and deoxynivalenol-3-glucoside and may be responsible for urinary deep-oxy-deoxynivalenol. Appl Environ Microbiol 79:1821-1825.
32. Guo X, Liu S, Wang Z, Zhang XX, Li M, Wu B. 2014. Metagenomic profiles and antibiotic resistance genes in gut microbiota of mice exposed to arsenic and iron. Chemosphere 112:1-8.
33. Haiser HJ, Gootenberg DB, Chatman K, Sirasani G, Balskus EP, Turnbaugh PJ. 2013. Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta. Science 341:295-298.
34. Haiser HJ, Seim KL, Balskus EP, Turnbaugh PJ. 2014. Mechanistic insight into digoxin inactivation by Eggerthella lenta augments our understanding of its pharmacokinetics. Gut Microbes 5:233-238.
35. Hwang I, Park YJ, Kim YR, Kim YN, Ka S, Lee HY, Seong JK, Seok YJ, Kim JB. 2015. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. Faseb J 29:2397-2411.
36. Jacobson JL, Muckle G, Ayotte P, Dewailly E, Jacobson SW. 2015. Relation of prenatal methylmercury exposure from environmental sources to childhood IQ. Environ Health Perspect [Epub ahead of print].
37. Joly C, Gay-Queheillard J, Leke A, Chardon K, Delanaud S, Bach V, Khorsi-Cauet H. 2013. Impact of chronic exposure to low doses of chlorpyrifos on the intestinal microbiota in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and in the rat. Environ Sci Pollut Res Int 20:2726-2734.
38. Jung J, Heo A, Park YW, Kim YJ, Koh H, Park W. 2014. Gut microbiota of Tenebrio molitor and their response to environmental change. J Microbiol Biotechnol 24:888-897.
39. Kang MJ, Kim HG, Kim JS, Oh do G, Um YJ, Seo CS, Han JW, Cho HJ, Kim GH, Jeong TC, Jeong HG. 2013. The effects of gut microbiota on drug metabolism. Expert Opin Drug Metab Toxicol 9: 1295-1308.
40. Kataoka K, Kinouchi T, Akimoto S, Ohnishi Y. 1995. Bioactivation of cysteine conjugates of 1-nitropyrene oxides by cysteine conjugate beta-lyase purified from Peptostreptococcus magnus. Appl Environ Microbiol 61:3781-3787.
41. Keku TO, Dulal S, Deveaux A, Jovov B, Han X. 2015. The gastrointestinal microbiota and colorectal cancer. Am J Physiol Gastrointest Liver Physiol 308:G351-g363.
42. Kerman DH, Deshpande AR. 2014. Gut microbiota and inflamma-tory bowel disease: the role of antibiotics in disease management. Postgrad Med 126:7-19.
43. Kim BW, Kim BC, Cha JS, Pfeifer GP, Lee CS. 2008. Mutation spectra induced by 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide in the supF gene of human XP-A fibroblasts. BMB Rep 41:604-608.
44. Kinouchi T, Kataoka K, Miyanishi K, Akimoto S, Ohnishi Y. 1992. Role of intestinal microflora in metabolism of glutathione conjugates of 1-nitropyrene 4,5-oxide and 1-nitropyrene 9,10-oxide. Tohoku J Exp Med 168:119-122.
45. Kish L, Hotte N, Kaplan GG, Vincent R, Tso R, Ganzle M, Rioux KP, Thiesen A, Barkema HW, Madsen KL. 2013. Environmental particulate matter induces murine intestinal in-flammatory responses and alters the gut microbiome. PLoS One 8:e62220.
46. Koch-Weser D, De La Huerga J, Popper H. 1953. Effect of choline supplements on fatty metamorphosis and liver cell damage in choline and protein deficiency. J Nutr 49:443-452.
47. Kollarczik B, Gareis M, Hanelt M. 1994. In vitro transformation of the Fusarium mycotoxins deoxynivalenol and zearalenone by the normal gut microflora of pigs. Nat Toxins 2:105-110.
48. Konturek SJ, Konturek JW, Pawlik T, Brzozowki T. 2004. Brain-gut axis and its role in the control of food intake. Journal of Physiology and Pharmacology 55:137-154.
49. Kuroda K, Yoshida K, Yoshimura M, Endo Y, Wanibuchi H, Fukushima S, Endo G. 2004. Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic. Toxicol Appl Pharmacol 198:345-353.
50. Lapanje A, Zrimec A, Drobne D, Rupnik M. 2010. Long-term Hg pollution-induced structural shifts of bacterial community in the terrestrial isopod (Porcellio scaber) gut. Environ Pollut 158:3186-3193.
51. Laterza L, Ianiro G, Scoleri I, Landi R, Bruno G, Scaldaferri F, Gaetani E, Campanale M, Gasbarrini A. 2015. Rifaximin for the treatment of diarrhoea-predominant irritable bowel syndrome. Expert Opin Pharmacother 16:607-615.
52. Leffers L, Ebert F, Taleshi MS, Francesconi KA, Schwerdtle T. 2013. In vitro toxicological characterization of two arsenosugars and their metabolites. Mol Nutr Food Res 57:1270-1282.
53. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. 2005. Obesity alters gut microbial ecology. Proc Natl Acad Sci USA 102:11070-5.
54. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. 2006. Microbial ecology: human gut microbes associated with obesity. Nature 444: 1022-1023.
55. Li-Wan-Po A. 2013. The human genome: its modifications and interactions with those of the microbiome, and the practice of genomic medicine. Discov Med 15:283-290.
56. Li DY, Yang M, Edwards S, Ye SQ. 2013. Nonalcoholic fatty liver disease: for better or worse, blame the gut microbiota? JPEN J Parenter Enteral Nutr 37:787-793.
57. Li H, Jia W. 2013. Cometabolism of microbes and host: implications for drug metabolism and drug-induced toxicity. Clin Pharmacol Ther 94:574-581.
58. Liebert CA, Wireman J, Smith T, Summers AO. 1997. Phylogeny of mercury resistance (mer) operons of gram-negative bacteria isolated from the fecal flora of primates. Appl Environ Microbiol 63:1066-1076.
59. Lindenbaum J, Rund DG, Butler VP Jr., Tse-Eng D, Saha JR. 1981. Inactivation of digoxin by the gut flora: reversal by antibiotic therapy. N Engl J Med 305:789-794.
60. Liu Y, Li Y, Liu K, Shen J. 2014. Exposing to cadmium stress cause profound toxic effect on microbiota of the mice intestinal tract. PLoS One 9:e85323.
61. Louis P. 2012. Does the human gut microbiota contribute to the etiology of autism spectrum disorders? Dig Dis Sci 57:1987-1989.
62. Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, Swenberg JA, Tannenbaum SR, Fox JG. 2014. Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis. Environ Health Perspect 122:284-291.
63. Lu K, Cable PH, Abo RP, Ru H, Graffam ME, Schlieper KA, Parry NM, LevineS, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR. 2013. Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation. Chem Res Toxicol 26:1893-1903.
64. Lu K, Mahbub R, Cable PH, Ru H, Parry NM, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR. 2014. Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Chem Res Toxicol 27:172-174.
65. Maharshak N, Packey CD, Ellermann M, Manick S, Siddle JP, Huh EY, Plevy S, Sartor RB, Carroll IM. 2013. Altered enteric microbiota ecology in interleukin 10-deficient mice during development and progression of intestinal inflammation. Gut Microbes 4:316-324.
66. Maurice CF, Haiser HJ, Turnbaugh PJ. 2013. Xenobiotics shape the physiology and gene expression of the active human gut microbiome. Cell 152(1-2):39-50.
67. Mayer EA, Padua D, Tillisch K. 2014. Altered brain-gut axis in autism: comorbidity or causative mechanisms? Bioessays 36:933-939.
68. Meinl W, Sczesny S, Brigelius-Flohe R, Blaut M, Glatt H. 2009. Impact of gut microbiota on intestinal and hepatic levels of phase 2 xenobiotic-metabolizing enzymes in the rat. Drug Metab Dispos 37:1179-1186.
69. Michalke K, Schmidt A, Huber B, Meyer J, Sulkowski M, Hirner AV, Boertz J, Mosel F, Dammann P, Hilken G, et al. 2008. Role of intestinal microbiota in transformation of bismuth and other metals and metalloids into volatile methyl and hydride derivatives in humans and mice. Appl Environ Microbiol 74:3069-3075.
70. Mulle JG, Sharp WG, Cubells JF. 2013. The gut microbiome: a new frontier in autism research. Curr Psychiatry Rep 15:337.
71. Nakayama H, Kinouchi T, Kataoka K, Akimoto S, Matsuda Y, Ohnishi Y. 1997. Intestinal anaerobic bacteria hydrolyse sorivudine, producing the high blood concentration of 5-(E)-(2-bromovinyl)uracil that increases the level and toxicity of 5-fluorouracil. Pharmacogenetics 7:35-43.
72. Naranmandura H, Ibata K, Suzuki KT. 2007. Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells. Chem Res Toxicol 20:1120-1125.
73. National Institute for Occupational Safety and Health Division of Surveillance HE, and Field Studies (DSHEFS). PESTICIDE ILLNESS & INJURY SURVEILLANCE [Internet]. Available from: http://www.cdc.gov/niosh/topics/pesticides/.
74. Ohtani N. 2015. Microbiome and cancer. Semin Immunopathol 37:65-72.
75. Okuda H, Ogura K, Kato A, Takubo H, Watabe T. 1998. A possible mechanism of eighteen patient deaths caused by interactions of sorivudine, a new antiviral drug, with oral 5-fluorouracil prodrugs. J Pharmacol Exp Ther 287:791-799.
76. Parracho HM, Bingham MO, Gibson GR, McCartney AL. 2005. Differences between the gut microflora of children with autistic spectrum disorders and that of healthy children. Journal of Medical Microbiology 54:987-991.
77. Port RG, Anwar AR, Ku M, Carlson GC, Siegel SJ, Roberts TP. 2015. Prospective MEG Biomarkers in ASD: Pre-clinical evidence and clinical promise of electrophysiological signatures. Yale J Biol Med 88:25-36.
78. Ramakrishna BS. 2013. Role of the gut microbiota in human nutrition and metabolism. J Gastroenterol Hepatol 28 Suppl 4:9-17.
79. Rick Irvin T, Irgolic KJ. 1995. In-vitro prenatal toxicity of trimethylarsine, trimethylarsine oxide and trimethylarsine sulfide. Applied Organometallic Chemistry 9:315-321.
80. Robinson CJ, Young VB. 2010. Antibiotic administration alters the community structure of the gastrointestinal micobiota. Gut Microbes 1:279-284.
81. Ross AB, Pere-Trepat E, Montoliu I, Martin FP, Collino S, Moco S, Godin JP, Cleroux M, Guy PA, Breton I, Bibiloni R, Thorimbert A, Tavazzi I, Tornier L, Bebuis A, Bruce SJ, Beaumont M, Fay LB, Kochhar S. 2013. A whole-grain-rich diet reduces urinary excretion of markers of protein catabolism and gut microbiota metabolism in healthy men after one week. J Nutr 143:766-773.
82. Russell WR, Hoyles L, Flint HJ, Dumas ME. 2013. Colonic bacterial metabolites and human health. Curr Opin Microbiol 16:246-254.
83. Saha JR, Butler VP Jr., Neu HC, Lindenbaum J. 1983. Digoxin-inactivating bacteria: identification in human gut flora. Science 220:325-327.
84. Salim SY, Kaplan GG, Madsen KL. 2014. Air pollution effects on the gut microbiota: a link between exposure and inflammatory disease. Gut Microbes 5:215-219.
85. Shehata AA, Schrodl W, Aldin AA, Hafez HM, Kruger M. 2013. The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro. Curr Microbiol 66:350-358.
86. Shetty SA, Marathe NP, Shouche YS. 2013. Opportunities and challenges for gut microbiome studies in the Indian population. Microbiome 1:24.
87. Sommer F, Backhed F. 2013. The gut microbiota-masters of host development and physiology. Nat Rev Microbiol 11:227-238.
88. Sousa T, Paterson R, Moore V, Carlsson A, Abrahamsson B, Basit AW. 2008. The gastrointestinal microbiota as a site for the biotransformation of drugs. Int J Pharm 363(1-2):1-25.
89. Summers AO, Wireman J, Vimy MJ, Lorscheider FL, Marshall B, Levy SB, Bennett S, Billard L. 1993. Mercury released from dental "silver" fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates. Antimicrob Agents Chemother 37:825-834.
90. Sun J, Schnackenberg LK, Khare S, Yang X, Greenhaw J, Salminen W, Mendrick DL, Beger RD. 2013. Evaluating effects of penicillin treatment on the metabolome of rats. Journal of Chromatography B 932:134-143.
91. Sundstol Eriksen G, Pettersson H. 2003. Lack of de-epoxidation of type B trichothecenes in incubates with human faeces. Food Addit Contam 20:579-582.
92. Suzuki KT, Iwata K, Naranmandura H, Suzuki N. 2007. Metabolic differences between two dimethylthioarsenicals in rats. Toxicol Appl Pharmacol 218:166-173.
93. Tang WH, Wang Z, Levison BS, Koeth RA, Britt EB, Fu X, Wu Y, Hazen SL. 2013. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med 368:1575-1584.
94. Tilg H, Kaser A. 2011. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 121:2126-2132.
95. Tinkov AA, Ajsuvakova OP, Skalnaya MG, Popova EV, Sinitskii AI, Nemereshina ON, Gatiatulina ER, Nikonorov AA, Skalny AV. 2015. Mercury and metabolic syndrome: a review of experimental and clinical observations. Biometals 28:231-254.
96. Toh MC, Allen-Vercoe E. 2015. The human gut microbiota with reference to autism spectrum disorder: considering the whole as more than a sum of its parts. Microb Ecol Health Dis 26:26309.
97. Tremaroli V, Backhed F. 2012. Functional interactions between the gut microbiota and host metabolism. Nature 489:242-249.
98. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444:1027-1031.
99. van de Wiele T, Gallawa CM, Kubachka KM, Creed JT, Basta N, Dayton EA, Whitacre S, Du Laing G, Bradham K. 2010. Arsenic metabolism by human gut microbiota upon in vitro digestion of contaminated soils. Environ Health Perspect 118:1004-1009.
100. van de Wiele T, Vanhaecke L, Boeckaert C, Peru K, Headley J, Verstraete W, Siciliano S. 2005. Human colon microbiota transform polycyclic aromatic hydrocarbons to estrogenic metabolites. Environ Health Perspect 113:6-10.
101. Vrieze A, Van Nood E, Holleman F, Salojarvi J, Kootte RS, Bartelsman JF, Dallinga-Thie GM, Ackermans MT, Serlie MJ, Oozeer R, Derrien M, Druesne A, Van Hylckama Villeg JET, Bloks VW, Groen AK, Heilig HGHJ, Zoetendal EG, Stroes ES, de Vos WM, Hoekstra JBL, Nieuwdorp M. 2012. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 143:913-916.e7.
102. Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, Wu Y, Schauer P, Smith JD, Allayee H, Tang WHW, DiDonato JA, Lusis AJ, Hazen SL. 2011. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472:57-63.
103. Watabe T, Ogura K, Nishiyama T. 2002. [Molecular toxicological mechanism of the lethal interactions of the new antiviral drug, sorivudine, with 5-fluorouracil prodrugs and genetic de-ficiency of dihydropyrimidine dehydrogenase]. Yakugaku Zasshi 122:527-535.
104. Williams BL, Hornig M, Buie T, Bauman ML, Cho Paik M, Wick I, Bennett A, Jabado O, Hirschberg DL, Lipkin WI. 2011. Impaired Carbohydrate digestion and transport and mucosal dysbiosis in the intestines of children with autism and gastrointestinal disturbances. PLoS ONE 6:e24585.
105. Worrell NR, Mallett AK, Cook WM, Baldwin NC, Shepherd MJ. 1989. The role of gut micro-organisms in the metabolism of deoxynivalenol administered to rats. Xenobiotica 19:25-32.
106. Xiao S, Zhao L. 2014. Gut microbiota-based translational bio-markers to prevent metabolic syndrome via nutritional modulation. FEMS Microbiol Ecol 87:303-314.
107. Yang WS, Zhao H, Wang X, Deng Q, Fan WY, Wang L. 2015. An evidence-based assessment for the association between long-term exposure to outdoor air pollution and the risk of lung cancer. Eur J Cancer Prev [Epub ahead of print].
108. Yoshida K, Kuroda K, Zhou X, Inoue Y, Date Y, Wanibuchi H, Fukushima S, Endo G. 2003. Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats. Chem Res Toxicol 16:1124-1129.
109. Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, IwakuraY, Oshima K, Morita H, Hattori M, HondaK, Ishikawa Y, Hara E, Ohtani N. 2013. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:97-101.
110. Young VB, Schmidt TM. 2004. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. J Clin Microbiol 42:1203-1206.
111. Zeisel SH. 1992. Choline: an important nutrient in brain development, liver function and carcinogenesis. J Am Coll Nutr 11:473-481.
112. Zeisel SH, Wishnok JS, Blusztajn JK. 1983. Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp Ther 225:320-324.
113. Zimmerman MA, Singh N, Martin PM, Thangaraju M, Ganapathy V, Waller JL, ShiH, Robertson KD, Munn DH, Liu K. 2012. Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. Am J Physiol Gastrointest Liver Physiol 302:G1405-G1415.