Hesperidin inhibits glutamate release and exerts neuroprotection against excitotoxicity induced by kainic acid in the hippocampus of rats

NeuroToxicology

Volumn 50, Issue , 2015, Pages 157-169

  Chang, Chia Ying ^a,b   Lin, Tzu Yu ^a,d   Lu, Cheng Wei ^a,d   Huang, Shu Kuei ^a   Wang, Ying Chou ^b   Chou, Shang Shing Peter ^b   Wang, Su Jane ^b,c  

^a FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^d YUAN ZE UNIVERSITY   (Taiwan)

Author keywords

Glutamate release; Hesperidin; Hippocampus; Kainic acid; Neuroprotection; SEPSCs

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL CAV 2 1; CALCIUM CHANNEL CAV 2 2; CALCIUM ION; GLUTAMIC ACID; HESPERIDIN; PROTEIN KINASE C; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR STIMULATING AGENT; CALCIUM; EGTAZIC ACID; ENZYME INHIBITOR; FAMPRIDINE; KAINIC ACID; NEUROPROTECTIVE AGENT; POTASSIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; EVOKED RESPONSE; EXCITOTOXICITY; EXTRACELLULAR SPACE; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; POSTSYNAPTIC MEMBRANE; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; SYNAPTOSOME; WHOLE CELL PATCH CLAMP; ANIMAL; DISEASE MODEL; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; MEMBRANE POTENTIAL; METABOLISM; NEUROTOXICITY SYNDROMES; PATHOLOGY; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

4-AMINOPYRIDINE; ANIMALS; CALCIUM; DISEASE MODELS, ANIMAL; EGTAZIC ACID; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLUTAMIC ACID; HESPERIDIN; HIPPOCAMPUS; KAINIC ACID; MALE; MEMBRANE POTENTIALS; NEUROPROTECTIVE AGENTS; NEUROTOXICITY SYNDROMES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SYNAPTOSOMES; TETRODOTOXIN;

EID: 84941786997     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2015.08.014     Document Type: Article

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