Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs

Circulation

Volumn 123, Issue 6, 2011, Pages 621-630

  Chatzizisis, Yiannis S ^a,b   Baker, Aaron B ^a,b   Sukhova, Galina K ^a   Koskinas, Konstantinos C ^a,b   Papafaklis, Michail I ^a   Beigel, Roy ^a,b   Jonas, Michael ^a,b   Coskun, Ahmet U ^c   Stone, Benjamin V ^a,b   Maynard, Charles ^d   Shi, Guo Ping ^a   Libby, Peter ^a   Feldman, Charles L ^a   Edelman, Elazer R ^a,b   Stone, Peter H ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Northeastern University   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

atherosclerosis; endothelium; inflammation; proteases; shear stress

Indexed keywords

CATHEPSIN K; CATHEPSIN K INHIBITOR; CATHEPSIN S; CATHEPSIN S INHIBITOR; CYSTATIN C; DIPEPTIDYL PEPTIDASE I; GELATINASE A; GELATINASE B; MACROPHAGE ELASTASE; MESSENGER RNA; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTERY INTIMA; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CELL ACTIVATION; CELL INFILTRATION; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; CORONARY ARTERY; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME LOCALIZATION; IN VIVO STUDY; INFLAMMATORY CELL; INTRAVASCULAR ULTRASOUND; LIPID STORAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR STRESS; SWINE; THREE DIMENSIONAL IMAGING;

ANIMALS; CATHEPSIN K; CATHEPSINS; CORONARY ARTERY DISEASE; CORONARY VESSELS; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; ENDOTHELIUM, VASCULAR; ENZYME INDUCTION; EXTRACELLULAR MATRIX; MALE; MATRIX METALLOPROTEINASES; PLAQUE, ATHEROSCLEROTIC; SHEAR STRENGTH; STRESS, MECHANICAL; SWINE; TUNICA INTIMA;

EID: 79951682743     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.970038     Document Type: Article

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