메뉴 건너뛰기




Volumn 195, Issue 6, 2015, Pages 2657-2665

1,25(OH)2D3 promotes the efficacy of CD28 costimulation blockade by abatacept

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; CALCITRIOL; CD28 ANTIGEN; CD3 ANTIGEN; CYCLOSPORIN A; T LYMPHOCYTE RECEPTOR; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84941755607     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1500306     Document Type: Article
Times cited : (20)

References (61)
  • 1
    • 84855957129 scopus 로고    scopus 로고
    • How the TCR balances sensitivity and specificity for the recognition of self and pathogens
    • Morris, G. P., and P. M. Allen. 2012. How the TCR balances sensitivity and specificity for the recognition of self and pathogens. Nat. Immunol. 13: 121-128.
    • (2012) Nat. Immunol. , vol.13 , pp. 121-128
    • Morris, G.P.1    Allen, P.M.2
  • 2
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen, L., and D. B. Flies. 2013. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat. Rev. Immunol. 13: 227-242.
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 3
    • 0030057218 scopus 로고    scopus 로고
    • T cell activation determined by T cell receptor number and tunable thresholds
    • Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273: 104-106.
    • (1996) Science , vol.273 , pp. 104-106
    • Viola, A.1    Lanzavecchia, A.2
  • 4
    • 0030006733 scopus 로고    scopus 로고
    • CD28 costimulation prevents cell death during primary T cell activation
    • Noel, P. J., L. H. Boise, J. M. Green, and C. B. Thompson. 1996. CD28 costimulation prevents cell death during primary T cell activation. J. Immunol. 157: 636-642.
    • (1996) J. Immunol. , vol.157 , pp. 636-642
    • Noel, P.J.1    Boise, L.H.2    Green, J.M.3    Thompson, C.B.4
  • 8
    • 82255192901 scopus 로고    scopus 로고
    • The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses
    • Walker, L. S. K., and D. M. Sansom. 2011. The emerging role of CTLA4 as a cell-extrinsic regulator of T cell responses. Nat. Rev. Immunol. 11: 852-863.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 852-863
    • Walker, L.S.K.1    Sansom, D.M.2
  • 9
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone, and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3: 541-547.
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 11
    • 0033579816 scopus 로고    scopus 로고
    • B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
    • Mandelbrot, D. A., A. J. McAdam, and A. H. Sharpe. 1999. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J. Exp. Med. 189: 435-440.
    • (1999) J. Exp. Med. , vol.189 , pp. 435-440
    • Mandelbrot, D.A.1    McAdam, A.J.2    Sharpe, A.H.3
  • 12
    • 65349185047 scopus 로고    scopus 로고
    • The clinical utility of inhibiting CD28-mediated costimulation
    • Linsley, P. S., and S. G. Nadler. 2009. The clinical utility of inhibiting CD28-mediated costimulation. Immunol. Rev. 229: 307-321.
    • (2009) Immunol. Rev. , vol.229 , pp. 307-321
    • Linsley, P.S.1    Nadler, S.G.2
  • 13
    • 54049120250 scopus 로고    scopus 로고
    • Abatacept in the treatment of rheumatoid arthritis
    • Buch, M. H., E. M. Vital, and P. Emery. 2008. Abatacept in the treatment of rheumatoid arthritis. Arthritis Res. Ther. 10 (Suppl. 1): S5.
    • (2008) Arthritis Res. Ther. , vol.10 , pp. S5
    • Buch, M.H.1    Vital, E.M.2    Emery, P.3
  • 17
    • 84874644839 scopus 로고    scopus 로고
    • Costimulation blockade: Current perspectives and implications for therapy
    • Kinnear, G., N. D. Jones, and K. J. Wood. 2013. Costimulation blockade: current perspectives and implications for therapy. Transplantation 95: 527-535.
    • (2013) Transplantation , vol.95 , pp. 527-535
    • Kinnear, G.1    Jones, N.D.2    Wood, K.J.3
  • 18
    • 84885643356 scopus 로고    scopus 로고
    • T-cell co-stimulatory blockade in transplantation: Two steps forward one step back! Expert Opin
    • Riella, L. V., and M. H. Sayegh. 2013. T-cell co-stimulatory blockade in transplantation: two steps forward one step back! Expert Opin. Biol. Ther. 13: 1557-1568.
    • (2013) Biol. Ther. , vol.13 , pp. 1557-1568
    • Riella, L.V.1    Sayegh, M.H.2
  • 19
    • 84869815306 scopus 로고    scopus 로고
    • Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses
    • Jeffery, L. E., A. M. Wood, O. S. Qureshi, T. Z. Hou, D. Gardner, Z. Briggs, S. Kaur, K. Raza, and D. M. Sansom. 2012. Availability of 25-hydroxyvitamin D(3) to APCs controls the balance between regulatory and inflammatory T cell responses. J. Immunol. 189: 5155-5164.
    • (2012) J. Immunol. , vol.189 , pp. 5155-5164
    • Jeffery, L.E.1    Wood, A.M.2    Qureshi, O.S.3    Hou, T.Z.4    Gardner, D.5    Briggs, Z.6    Kaur, S.7    Raza, K.8    Sansom, D.M.9
  • 20
    • 33845949937 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells
    • Penna, G., S. Amuchastegui, N. Giarratana, K. C. Daniel, M. Vulcano, S. Sozzani, and L. Adorini. 2007. 1,25-Dihydroxyvitamin D3 selectively modulates tolerogenic properties in myeloid but not plasmacytoid dendritic cells. J. Immunol. 178: 145-153.
    • (2007) J. Immunol. , vol.178 , pp. 145-153
    • Penna, G.1    Amuchastegui, S.2    Giarratana, N.3    Daniel, K.C.4    Vulcano, M.5    Sozzani, S.6    Adorini, L.7
  • 21
    • 78651407519 scopus 로고    scopus 로고
    • Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells
    • Palmer, M. T., Y. K. Lee, C. L. Maynard, J. R. Oliver, D. D. Bikle, A. M. Jetten, and C. T. Weaver. 2011. Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells. J. Biol. Chem. 286: 997-1004.
    • (2011) J. Biol. Chem. , vol.286 , pp. 997-1004
    • Palmer, M.T.1    Lee, Y.K.2    Maynard, C.L.3    Oliver, J.R.4    Bikle, D.D.5    Jetten, A.M.6    Weaver, C.T.7
  • 22
    • 0028903933 scopus 로고
    • Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo
    • Zamzami, N., P. Marchetti, M. Castedo, C. Zanin, J. L. Vayssière, P. X. Petit, and G. Kroemer. 1995. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. J. Exp. Med. 181: 1661-1672.
    • (1995) J. Exp. Med. , vol.181 , pp. 1661-1672
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3    Zanin, C.4    Vayssière, J.L.5    Petit, P.X.6    Kroemer, G.7
  • 23
    • 0033997963 scopus 로고    scopus 로고
    • CD28 and LFA-1 contribute to cyclosporin A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways
    • Geginat, J., B. Clissi, M. Moro, P. Dellabona, J. R. Bender, and R. Pardi. 2000. CD28 and LFA-1 contribute to cyclosporin A-resistant T cell growth by stabilizing the IL-2 mRNA through distinct signaling pathways. Eur. J. Immunol. 30: 1136-1144.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1136-1144
    • Geginat, J.1    Clissi, B.2    Moro, M.3    Dellabona, P.4    Bender, J.R.5    Pardi, R.6
  • 26
    • 0033008083 scopus 로고    scopus 로고
    • The structural basis of T cell activation by superantigens
    • Li, H., A. Llera, E. L. Malchiodi, and R. A. Mariuzza. 1999. The structural basis of T cell activation by superantigens. Annu. Rev. Immunol. 17: 435-466.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 435-466
    • Li, H.1    Llera, A.2    Malchiodi, E.L.3    Mariuzza, R.A.4
  • 28
    • 0347505003 scopus 로고    scopus 로고
    • CD28-mediated co-stimulation: A quantitative support for TCR signalling
    • Acuto, O., and F. Michel. 2003. CD28-mediated co-stimulation: a quantitative support for TCR signalling. Nat. Rev. Immunol. 3: 939-951.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 939-951
    • Acuto, O.1    Michel, F.2
  • 30
    • 0035693742 scopus 로고    scopus 로고
    • CD28 as a molecular amplifier extending TCR ligation and signaling capabilities
    • Michel, F., G. Attal-Bonnefoy, G. Mangino, S. Mise-Omata, and O. Acuto. 2001. CD28 as a molecular amplifier extending TCR ligation and signaling capabilities. Immunity 15: 935-945.
    • (2001) Immunity , vol.15 , pp. 935-945
    • Michel, F.1    Attal-Bonnefoy, G.2    Mangino, G.3    Mise-Omata, S.4    Acuto, O.5
  • 31
    • 0036195934 scopus 로고    scopus 로고
    • Regulation of Lck activity by CD4 and CD28 in the immunological synapse
    • Holdorf, A. D., K.-H. Lee, W. R. Burack, P. M. Allen, and A. S. Shaw. 2002. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat. Immunol. 3: 259-264.
    • (2002) Nat. Immunol. , vol.3 , pp. 259-264
    • Holdorf, A.D.1    Lee, K.-H.2    Burack, W.R.3    Allen, P.M.4    Shaw, A.S.5
  • 33
    • 0037015038 scopus 로고    scopus 로고
    • Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. [Published erratum appears in 2002 Proc Natl. Acad. Sci. USA. 23: 15245.]
    • Diehn, M., A. A. Alizadeh, O. J. Rando, C. L. Liu, K. Stankunas, D. Botstein, G. R. Crabtree, and P. O. Brown. 2002. Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. [Published erratum appears in 2002 Proc Natl. Acad. Sci. USA. 23: 15245.] Proc. Natl. Acad. Sci. USA 99: 11796-11801.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 11796-11801
    • Diehn, M.1    Alizadeh, A.A.2    Rando, O.J.3    Liu, C.L.4    Stankunas, K.5    Botstein, D.6    Crabtree, G.R.7    Brown, P.O.8
  • 34
    • 84872551703 scopus 로고    scopus 로고
    • Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells
    • Wakamatsu, E., D. Mathis, and C. Benoist. 2013. Convergent and divergent effects of costimulatory molecules in conventional and regulatory CD4+ T cells. Proc. Natl. Acad. Sci. USA 110: 1023-1028.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 1023-1028
    • Wakamatsu, E.1    Mathis, D.2    Benoist, C.3
  • 38
    • 33746114879 scopus 로고    scopus 로고
    • The kinetic-segregation model: TCR triggering and beyond
    • Davis, S. J., and P. A. van der Merwe. 2006. The kinetic-segregation model: TCR triggering and beyond. Nat. Immunol. 7: 803-809.
    • (2006) Nat. Immunol. , vol.7 , pp. 803-809
    • Davis, S.J.1    Merwe Der Van, P.A.2
  • 39
    • 0031585887 scopus 로고    scopus 로고
    • CD28-mediated activation of resting human T cells without costimulation of the CD3/TCR complex
    • Siefken, R., R. Kurrle, and R. Schwinzer. 1997. CD28-mediated activation of resting human T cells without costimulation of the CD3/TCR complex. Cell. Immunol. 176: 59-65.
    • (1997) Cell. Immunol. , vol.176 , pp. 59-65
    • Siefken, R.1    Kurrle, R.2    Schwinzer, R.3
  • 40
    • 0031034123 scopus 로고    scopus 로고
    • CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28
    • Tacke, M., G. Hanke, T. Hanke, and T. Hünig. 1997. CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28. Eur. J. Immunol. 27: 239-247.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 239-247
    • Tacke, M.1    Hanke, G.2    Hanke, T.3    Hünig, T.4
  • 42
    • 27444442536 scopus 로고    scopus 로고
    • Superagonistic anti-CD28 antibodies: Potent activators of regulatory T cells for the therapy of autoimmune diseases
    • Beyersdorf, N., T. Hanke, T. Kerkau, and T. Hünig. 2005. Superagonistic anti-CD28 antibodies: potent activators of regulatory T cells for the therapy of autoimmune diseases. Ann. Rheum. Dis. 64(Suppl. 4): iv91-iv95.
    • (2005) Ann. Rheum. Dis. , vol.64 , pp. iv91-iv95
    • Beyersdorf, N.1    Hanke, T.2    Kerkau, T.3    Hünig, T.4
  • 43
    • 0023637951 scopus 로고
    • T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
    • June, C. H., J. A. Ledbetter, M. M. Gillespie, T. Lindsten, and C. B. Thompson. 1987. T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell. Biol. 7: 4472-4481.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 4472-4481
    • June, C.H.1    Ledbetter, J.A.2    Gillespie, M.M.3    Lindsten, T.4    Thompson, C.B.5
  • 44
    • 0028093312 scopus 로고
    • The effect of combination cyclosporine and CTLA4-Ig therapy on cardiac allograft survival
    • Bolling, S. F., H. Lin, R.-Q. Wei, P. Linsley, and L. A. Turka. 1994. The effect of combination cyclosporine and CTLA4-Ig therapy on cardiac allograft survival. J. Surg. Res. 57: 60-64.
    • (1994) J. Surg. Res. , vol.57 , pp. 60-64
    • Bolling, S.F.1    Lin, H.2    Wei, R.-Q.3    Linsley, P.4    Turka, L.A.5
  • 45
    • 0028069695 scopus 로고
    • Synergy between cyclosporin A and a monoclonal antibody to B7 in blocking alloantigen-induced T-cell activation
    • Van Gool, S. W., J. L. Ceuppens, H. Walter, and M. de Boer. 1994. Synergy between cyclosporin A and a monoclonal antibody to B7 in blocking alloantigen-induced T-cell activation. Blood 83: 176-183.
    • (1994) Blood , vol.83 , pp. 176-183
    • Van Gool, S.W.1    Ceuppens, J.L.2    Walter, H.3    De Boer, M.4
  • 46
    • 0028950692 scopus 로고
    • Toward novel antirejection strategies: In vivo immunosuppressive properties of CTLA4Ig
    • Perico, N., O. Imberti, M. Bontempelli, and G. Remuzzi. 1995. Toward novel antirejection strategies: in vivo immunosuppressive properties of CTLA4Ig. Kidney Int. 47: 241-246.
    • (1995) Kidney Int. , vol.47 , pp. 241-246
    • Perico, N.1    Imberti, O.2    Bontempelli, M.3    Remuzzi, G.4
  • 48
    • 33846948640 scopus 로고    scopus 로고
    • T cell-directed therapies: Lessons learned and future prospects
    • Liu, E. H., R. M. Siegel, D. M. Harlan, and J. J. O'Shea. 2007. T cell-directed therapies: lessons learned and future prospects. Nat. Immunol. 8: 25-30.
    • (2007) Nat. Immunol. , vol.8 , pp. 25-30
    • Liu, E.H.1    Siegel, R.M.2    Harlan, D.M.3    O'Shea, J.J.4
  • 49
    • 52649155487 scopus 로고    scopus 로고
    • Vitamin D's role in cell proliferation and differentiation
    • Samuel, S., and M. D. Sitrin. 2008. Vitamin D's role in cell proliferation and differentiation. Nutr. Rev. 66(Suppl. 2): S116-S124.
    • (2008) Nutr. Rev. , vol.66 , pp. S116-S124
    • Samuel, S.1    Sitrin, M.D.2
  • 50
    • 0021678081 scopus 로고
    • Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol)
    • Rigby, W. F., T. Stacy, and M. W. Fanger. 1984. Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J. Clin. Invest. 74: 1451-1455.
    • (1984) J. Clin. Invest. , vol.74 , pp. 1451-1455
    • Rigby, W.F.1    Stacy, T.2    Fanger, M.W.3
  • 51
    • 0021271732 scopus 로고
    • 1,25-dihydroxyvitamin D3: A novel immunoregulatory hormone
    • Tsoukas, C. D., D. M. Provvedini, and S. C. Manolagas. 1984. 1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone. Science 224: 1438-1440.
    • (1984) Science , vol.224 , pp. 1438-1440
    • Tsoukas, C.D.1    Provvedini, D.M.2    Manolagas, S.C.3
  • 52
    • 0024409043 scopus 로고
    • T lymphocytes and their CD4 subset are direct targets for the inhibitory effect of calcitriol
    • Vanham, G., J. L. Ceuppens, and R. Bouillon. 1989. T lymphocytes and their CD4 subset are direct targets for the inhibitory effect of calcitriol. Cell. Immunol. 124: 320-333.
    • (1989) Cell. Immunol. , vol.124 , pp. 320-333
    • Vanham, G.1    Ceuppens, J.L.2    Bouillon, R.3
  • 53
    • 0039761218 scopus 로고
    • 1 a,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes
    • Reichel, H., H. P. Koeffler, A. Tobler, and A. W. Norman. 1987. 1 a,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes. Proc. Natl. Acad. Sci. USA 84: 3385-3389.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 3385-3389
    • Reichel, H.1    Koeffler, H.P.2    Tobler, A.3    Norman, A.W.4
  • 54
    • 0029018309 scopus 로고
    • Immunosuppressive actions of 1,25-dihydroxyvitamin D3: Preferential inhibition of Th1 functions
    • Lemire, J. M., D. C. Archer, L. Beck, and H. L. Spiegelberg. 1995. Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J. Nutr. 125: 1704S-1708S.
    • (1995) J. Nutr. , vol.125 , pp. 1704S-1708S
    • Lemire, J.M.1    Archer, D.C.2    Beck, L.3    Spiegelberg, H.L.4
  • 55
    • 77951253745 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3
    • Jeffery, L. E., F. Burke, M. Mura, Y. Zheng, O. S. Qureshi, M. Hewison, L. S. K. Walker, D. A. Lammas, K. Raza, and D. M. Sansom. 2009. 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J. Immunol. 183: 5458-5467.
    • (2009) J. Immunol. , vol.183 , pp. 5458-5467
    • Jeffery, L.E.1    Burke, F.2    Mura, M.3    Zheng, Y.4    Qureshi, O.S.5    Hewison, M.6    Walker, L.S.K.7    Lammas, D.A.8    Raza, K.9    Sansom, D.M.10
  • 57
    • 0035497752 scopus 로고    scopus 로고
    • 1a,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells
    • Boonstra, A., F. J. Barrat, C. Crain, V. L. Heath, H. F. Savelkoul, and A. O'Garra. 2001. 1a,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J. Immunol. 167: 4974-4980.
    • (2001) J. Immunol. , vol.167 , pp. 4974-4980
    • Boonstra, A.1    Barrat, F.J.2    Crain, C.3    Heath, V.L.4    Savelkoul, H.F.5    O'Garra, A.6
  • 58
    • 0031573660 scopus 로고    scopus 로고
    • Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation
    • Tao, X., S. Constant, P. Jorritsma, and K. Bottomly. 1997. Strength of TCR signal determines the costimulatory requirements for Th1 and Th2 CD4+ T cell differentiation. J. Immunol. 159: 5956-5963.
    • (1997) J. Immunol. , vol.159 , pp. 5956-5963
    • Tao, X.1    Constant, S.2    Jorritsma, P.3    Bottomly, K.4
  • 59
    • 79952931627 scopus 로고    scopus 로고
    • Integrated T-cell receptor and costimulatory signals determine TGF-b-dependent differentiation and maintenance of Foxp3+ regulatory T cells
    • Gabrysová, L., J. R. Christensen, X. Wu, A. Kissenpfennig, B. Malissen, and A. O'Garra. 2011. Integrated T-cell receptor and costimulatory signals determine TGF-b-dependent differentiation and maintenance of Foxp3+ regulatory T cells. Eur. J. Immunol. 41: 1242-1248.
    • (2011) Eur. J. Immunol. , vol.41 , pp. 1242-1248
    • Gabrysová, L.1    Christensen, J.R.2    Wu, X.3    Kissenpfennig, A.4    Malissen, B.5    O'Garra, A.6
  • 60
    • 84872458497 scopus 로고    scopus 로고
    • CD28 costimulation: Walking the immunological tightrope
    • Sansom, D. M., and L. S. K. Walker. 2013. CD28 costimulation: walking the immunological tightrope. Eur. J. Immunol. 43: 42-45.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 42-45
    • Sansom, D.M.1    Walker, L.S.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.