Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups

Annals of the Rheumatic Diseases

Volumn 75, Issue 8, 2016, Pages 1558-1566

  Rothwell, Simon ^a   Cooper, Robert G ^b   Lundberg, Ingrid E ^c   Miller, Frederick W ^d   Gregersen, Peter K ^e   Bowes, John ^a   Vencovsky, Jiri ^f   Danko, Katalin ^g   Limaye, Vidya ^h   Selva O'Callaghan, Albert ⁱ   Hanna, Michael G ^j   Machado, Pedro M ^j   Pachman, Lauren M ^k   Reed, Ann M ^l   Rider, Lisa G ^d   Cobb, Joanna ^a   Platt, Hazel ^a   Molberg, Øyvind ^m   Benveniste, Olivier ⁿ   Mathiesen, Pernille ^o   Radstake, Timothy ^p   Doria, Andrea ^q   De Bleecker, Jan ^r   De Paepe, Boel ^r   Maurer, Britta ^s   Ollier, William E ^a   Padyukov, Leonid ^c   O'Hanlon, Terrance P ^d   Lee, Annette ^e   Amos, Christopher I ^t   Gieger, Christian ^u   Meitinger, Thomas ^u,v   Winkelmann, Juliane ^u,w   Wedderburn, Lucy R ^x   Chinoy, Hector ^a   Lamb, Janine A ^a   more..

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^f CHARLES UNIVERSITY   (Czech Republic)

^g UNIVERSITY OF DEBRECEN   (Hungary)

^h ROYAL ADELAIDE HOSPITAL   (Australia)

ⁱ HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^j UNIVERSITY COLLEGE LONDON   (United Kingdom)

^k NORTHWESTERN UNIVERSITY   (United States)

^l DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^m OSLO UNIVERSITY HOSPITAL   (Norway)

ⁿ PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^o NAESTVED HOSPITAL   (Denmark)

^p UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^q UNIVERSITY OF PADOVA   (Italy)

^r GHENT UNIVERSITY HOSPITAL   (Belgium)

^s UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^t DARTMOUTH MEDICAL SCHOOL   (United States)

^u INSTITUTE OF EPIDEMIOLOGY   (Germany)

^v TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^w TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^x UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; HLA ANTIGEN; HLA B ANTIGEN; HLA DQB1 ANTIGEN; HLA DRB1 ANTIGEN; INTERLEUKIN 18 RECEPTOR ALPHA; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; STAT4 PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; PTPN22 PROTEIN, HUMAN;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CAUCASIAN; CD28 GENE; COHORT ANALYSIS; CONTROLLED STUDY; DERMATOMYOSITIS; DISEASE ASSOCIATION; GENE; GENE LOCUS; GENETIC BACKGROUND; GENETIC RISK; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GSDMB GENE; HAPLOTYPE; HLA B GENE; HLA DQB1 GENE; HLA DRB1 GENE; HLA SYSTEM; HUMAN; IL18R1 GENE; JUVENILE DERMATOMYOSITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; MYOSITIS; POLYMYOSITIS; PRIORITY JOURNAL; PTPN22 GENE; RGS1 GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STAT4 GENE; TRAF6 GENE; UBE2L3 GENE; YDJC GENE; AUTOIMMUNITY; CASE CONTROL STUDY; CLINICAL TRIAL; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MULTICENTER STUDY; QUANTITATIVE TRAIT LOCUS;

ALLELES; AUTOIMMUNITY; CASE-CONTROL STUDIES; DERMATOMYOSITIS; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HLA ANTIGENS; HUMANS; MYOSITIS; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYMYOSITIS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; QUANTITATIVE TRAIT LOCI; RISK FACTORS;

EID: 84941695475     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2015-208119     Document Type: Article

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