Decreasing pfmdr1 copy number suggests that Plasmodium falciparum in Western Cambodia is regaining in vitro susceptibility to mefloquine

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 5, 2015, Pages 2934-2937

  Lim, Pharath ^a,b   Dek, Dalin ^b   Try, Vorleak ^b   Sreng, Sokunthea ^b   Suon, Seila ^b   Fairhurst, Rick M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b Entomology and Malaria Control   (Cambodia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTESUNATE; ATOVAQUONE; CHLOROQUINE; DNA; MEFLOQUINE; PFMDR1 PROTEIN; PIPERAQUINE; PROTEIN; PYRONARIDINE; QUININE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; MDR1 PROTEIN, PLASMODIUM FALCIPARUM; MULTIDRUG RESISTANCE PROTEIN; PROTOZOAL PROTEIN;

ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CAMBODIA; CONTROLLED STUDY; COPY NUMBER VARIATION; CROSS RESISTANCE; DRUG EFFICACY; DRUG MECHANISM; GENE AMPLIFICATION; GENETIC ASSOCIATION; GROWTH INHIBITION; HUMAN; IC50; IN VITRO STUDY; INFECTION RESISTANCE; INFECTION SENSITIVITY; MALARIA FALCIPARUM; PARASITE ISOLATION; PHENOTYPIC VARIATION; PLASMODIUM FALCIPARUM; PREVALENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SAMPLE; DRUG EFFECTS; DRUG SENSITIVITY; GENETICS;

ANTIMALARIALS; MEFLOQUINE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 84931275565     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.05163-14     Document Type: Article

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