-
1
-
-
38849147752
-
Ral GTPases and cancer: Linchpin support of the tumorigenic platform
-
Bodemann, B. O., and White, M. A. (2008) Ral GTPases and cancer: linchpin support of the tumorigenic platform. Nat. Rev. Cancer 8, 133-140
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 133-140
-
-
Bodemann, B.O.1
White, M.A.2
-
2
-
-
79960069763
-
The RalGEF-Ral effector signaling network: The road less traveled for anti-Ras drug discovery
-
Neel, N. F., Martin, T. D., Stratford, J. K., Zand, T. P., Reiner, D. J., and Der, C. J. (2011) The RalGEF-Ral effector signaling network: the road less traveled for anti-Ras drug discovery. Genes Cancer 2, 275-287
-
(2011)
Genes Cancer
, vol.2
, pp. 275-287
-
-
Neel, N.F.1
Martin, T.D.2
Stratford, J.K.3
Zand, T.P.4
Reiner, D.J.5
Der, C.J.6
-
3
-
-
84907494105
-
Ral small GTPase signaling and oncogenesis: More than just 15 minutes of fame
-
Gentry, L. R., Martin, T. D., Reiner, D. J., and Der, C. J. (2014) Ral small GTPase signaling and oncogenesis: more than just 15 minutes of fame. Biochim. Biophys. Acta 1843, 2976-2988
-
(2014)
Biochim. Biophys. Acta
, vol.1843
, pp. 2976-2988
-
-
Gentry, L.R.1
Martin, T.D.2
Reiner, D.J.3
Der, C.J.4
-
4
-
-
78049370949
-
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms
-
Vigil, D., Martin, T. D., Williams, F., Yeh, J. J., Campbell, S. L., and Der, C. J. (2010) Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms. J. Biol. Chem. 285, 34729-34740
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 34729-34740
-
-
Vigil, D.1
Martin, T.D.2
Williams, F.3
Yeh, J.J.4
Campbell, S.L.5
Der, C.J.6
-
5
-
-
73449083717
-
RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling
-
Balasubramanian, N., Meier, J. A., Scott, D. W., Norambuena, A., White, M. A., and Schwartz, M. A. (2010) RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Curr. Biol. 20, 75-79
-
(2010)
Curr. Biol.
, vol.20
, pp. 75-79
-
-
Balasubramanian, N.1
Meier, J.A.2
Scott, D.W.3
Norambuena, A.4
White, M.A.5
Schwartz, M.A.6
-
6
-
-
33846011880
-
RalA-exocystdependent recycling endosome trafficking is required for the completion of cytokinesis
-
Chen, X. W., Inoue, M., Hsu, S. C., and Saltiel, A. R. (2006) RalA-exocystdependent recycling endosome trafficking is required for the completion of cytokinesis. J. Biol. Chem. 281, 38609-38616
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38609-38616
-
-
Chen, X.W.1
Inoue, M.2
Hsu, S.C.3
Saltiel, A.R.4
-
7
-
-
2942711520
-
RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells
-
Shipitsin, M., and Feig, L. A. (2004) RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells. Mol. Cell. Biol. 24, 5746-5756
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 5746-5756
-
-
Shipitsin, M.1
Feig, L.A.2
-
8
-
-
80052514798
-
RALA and RALBP1 regulate mitochondrial fission at mitosis
-
Kashatus, D. F., Lim, K. H., Brady, D. C., Pershing, N. L., Cox, A. D., and Counter, C. M. (2011) RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat. Cell. Biol. 13, 1108-1115
-
(2011)
Nat. Cell. Biol.
, vol.13
, pp. 1108-1115
-
-
Kashatus, D.F.1
Lim, K.H.2
Brady, D.C.3
Pershing, N.L.4
Cox, A.D.5
Counter, C.M.6
-
9
-
-
84892853050
-
Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion
-
Martin, T. D., Chen, X. W., Kaplan, R. E., Saltiel, A. R., Walker, C. L., Reiner, D. J., and Der, C. J. (2014) Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion. Mol. Cell 53, 209-220
-
(2014)
Mol. Cell
, vol.53
, pp. 209-220
-
-
Martin, T.D.1
Chen, X.W.2
Kaplan, R.E.3
Saltiel, A.R.4
Walker, C.L.5
Reiner, D.J.6
Der, C.J.7
-
10
-
-
78651488777
-
RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly
-
Bodemann, B. O., Orvedahl, A., Cheng, T., Ram, R. R., Ou, Y. H., Formstecher, E., Maiti, M., Hazelett, C. C., Wauson, E. M., Balakireva, M., Camonis, J. H., Yeaman, C., Levine, B., and White, M. A. (2011) RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly. Cell 144, 253-267
-
(2011)
Cell
, vol.144
, pp. 253-267
-
-
Bodemann, B.O.1
Orvedahl, A.2
Cheng, T.3
Ram, R.R.4
Ou, Y.H.5
Formstecher, E.6
Maiti, M.7
Hazelett, C.C.8
Wauson, E.M.9
Balakireva, M.10
Camonis, J.H.11
Yeaman, C.12
Levine, B.13
White, M.A.14
-
11
-
-
0042353628
-
RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival
-
Chien, Y., and White, M. A. (2003) RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival. EMBO Rep. 4, 800-806
-
(2003)
EMBO Rep.
, vol.4
, pp. 800-806
-
-
Chien, Y.1
White, M.A.2
-
12
-
-
23844472876
-
RalA and RalB: Antagonistic relatives in cancer cell migration
-
Oxford, G., Owens, C. R., Titus, B. J., Foreman, T. L., Herlevsen, M. C., Smith, S. C., and Theodorescu, D. (2005) RalA and RalB: antagonistic relatives in cancer cell migration. Cancer Res. 65, 7111-7120
-
(2005)
Cancer Res.
, vol.65
, pp. 7111-7120
-
-
Oxford, G.1
Owens, C.R.2
Titus, B.J.3
Foreman, T.L.4
Herlevsen, M.C.5
Smith, S.C.6
Theodorescu, D.7
-
13
-
-
33845448647
-
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells
-
Lim, K. H., O'Hayer, K., Adam, S. J., Kendall, S. D., Campbell, P. M., Der, C. J., and Counter, C. M. (2006) Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. Curr. Biol. 16, 2385-2394
-
(2006)
Curr. Biol.
, vol.16
, pp. 2385-2394
-
-
Lim, K.H.1
O'Hayer, K.2
Adam, S.J.3
Kendall, S.D.4
Campbell, P.M.5
Der, C.J.6
Counter, C.M.7
-
14
-
-
78651380816
-
Activation and involvement of Ral GTPases in colorectal cancer
-
Martin, T. D., Samuel, J. C., Routh, E. D., Der, C. J., and Yeh, J. J. (2011) Activation and involvement of Ral GTPases in colorectal cancer. Cancer Res. 71, 206-215
-
(2011)
Cancer Res.
, vol.71
, pp. 206-215
-
-
Martin, T.D.1
Samuel, J.C.2
Routh, E.D.3
Der, C.J.4
Yeh, J.J.5
-
15
-
-
80054866000
-
Targeting protein prenylation for cancer therapy
-
Berndt, N., Hamilton, A. D., and Sebti, S. M. (2011) Targeting protein prenylation for cancer therapy. Nat. Rev. Cancer 11, 775-791
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 775-791
-
-
Berndt, N.1
Hamilton, A.D.2
Sebti, S.M.3
-
16
-
-
4644370323
-
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity
-
Reid, T. S., Terry, K. L., Casey, P. J., and Beese, L. S. (2004) Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity. J. Mol. Biol. 343, 417-433
-
(2004)
J. Mol. Biol.
, vol.343
, pp. 417-433
-
-
Reid, T.S.1
Terry, K.L.2
Casey, P.J.3
Beese, L.S.4
-
17
-
-
0025874249
-
Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA
-
Kinsella, B. T., Erdman, R. A., and Maltese, W. A. (1991) Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA. J. Biol. Chem. 266, 9786-9794
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 9786-9794
-
-
Kinsella, B.T.1
Erdman, R.A.2
Maltese, W.A.3
-
18
-
-
36048968159
-
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth
-
Falsetti, S. C., Wang, D. A., Peng, H., Carrico, D., Cox, A. D., Der, C. J., Hamilton, A. D., and Sebti, S. M. (2007) Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Mol. Cell. Biol. 27, 8003-8014
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 8003-8014
-
-
Falsetti, S.C.1
Wang, D.A.2
Peng, H.3
Carrico, D.4
Cox, A.D.5
Der, C.J.6
Hamilton, A.D.7
Sebti, S.M.8
-
19
-
-
18344394166
-
Post-prenylation-processing enzymes as new targets in oncogenesis
-
Winter-Vann, A. M., and Casey, P. J. (2005) Post-prenylation-processing enzymes as new targets in oncogenesis. Nat. Rev. Cancer 5, 405-412
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 405-412
-
-
Winter-Vann, A.M.1
Casey, P.J.2
-
20
-
-
20444410041
-
Activation of RalA is critical for Ras-induced tumorigenesis of human cells
-
Lim, K. H., Baines, A. T., Fiordalisi, J. J., Shipitsin, M., Feig, L. A., Cox, A. D., Der, C. J., and Counter, C. M. (2005) Activation of RalA is critical for Ras-induced tumorigenesis of human cells. Cancer Cell 7, 533-545
-
(2005)
Cancer Cell
, vol.7
, pp. 533-545
-
-
Lim, K.H.1
Baines, A.T.2
Fiordalisi, J.J.3
Shipitsin, M.4
Feig, L.A.5
Cox, A.D.6
Der, C.J.7
Counter, C.M.8
-
21
-
-
84862084695
-
Phosphorylation by protein kinase Calpha regulates RalB small GTPase protein activation, subcellular localization, and effector utilization
-
Martin, T. D., Mitin, N., Cox, A. D., Yeh, J. J., and Der, C. J. (2012) Phosphorylation by protein kinase Calpha regulates RalB small GTPase protein activation, subcellular localization, and effector utilization. J. Biol. Chem. 287, 14827-14836
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 14827-14836
-
-
Martin, T.D.1
Mitin, N.2
Cox, A.D.3
Yeh, J.J.4
Der, C.J.5
-
22
-
-
73549119929
-
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA
-
Lim, K. H., Brady, D. C., Kashatus, D. F., Ancrile, B. B., Der, C. J., Cox, A. D., and Counter, C. M. (2010) Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. Mol. Cell. Biol. 30, 508-523
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 508-523
-
-
Lim, K.H.1
Brady, D.C.2
Kashatus, D.F.3
Ancrile, B.B.4
Der, C.J.5
Cox, A.D.6
Counter, C.M.7
-
23
-
-
78449292864
-
Phosphorylation of RalB is important for bladder cancer cell growth and metastasis
-
Wang, H., Owens, C., Chandra, N., Conaway, M. R., Brautigan, D. L., and Theodorescu, D. (2010) Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res. 70, 8760-8769
-
(2010)
Cancer Res.
, vol.70
, pp. 8760-8769
-
-
Wang, H.1
Owens, C.2
Chandra, N.3
Conaway, M.R.4
Brautigan, D.L.5
Theodorescu, D.6
-
24
-
-
34249291096
-
The tumor suppressor PP2A Aβ regulates the RalA GTPase
-
Sablina, A. A., Chen, W., Arroyo, J. D., Corral, L., Hector, M., Bulmer, S. E., De Caprio, J. A., and Hahn, W. C. (2007) The tumor suppressor PP2A Aβ regulates the RalA GTPase. Cell 129, 969-982
-
(2007)
Cell
, vol.129
, pp. 969-982
-
-
Sablina, A.A.1
Chen, W.2
Arroyo, J.D.3
Corral, L.4
Hector, M.5
Bulmer, S.E.6
De Caprio, J.A.7
Hahn, W.C.8
-
25
-
-
20144373746
-
Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening
-
Wu, J. C., Chen, T. Y., Yu, C. T., Tsai, S. J., Hsu, J. M., Tang, M. J., Chou, C. K., Lin, W. J., Yuan, C. J., and Huang, C. Y. (2005) Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening. J. Biol. Chem. 280, 9013-9022
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9013-9022
-
-
Wu, J.C.1
Chen, T.Y.2
Yu, C.T.3
Tsai, S.J.4
Hsu, J.M.5
Tang, M.J.6
Chou, C.K.7
Lin, W.J.8
Yuan, C.J.9
Huang, C.Y.10
-
26
-
-
84875246715
-
Identification of a novel prenyl and palmitoyl modification at the CAAX motif of Cdc42 that regulates RhoGDI binding
-
Nishimura, A., and Linder, M. E. (2013) Identification of a novel prenyl and palmitoyl modification at the CAAX motif of Cdc42 that regulates RhoGDI binding. Mol. Cell. Biol. 33, 1417-1429
-
(2013)
Mol. Cell. Biol.
, vol.33
, pp. 1417-1429
-
-
Nishimura, A.1
Linder, M.E.2
-
27
-
-
0024412469
-
Coding sequences of human ralA and ralB cDNAs
-
Chardin, P., and Tavitian, A. (1989) Coding sequences of human ralA and ralB cDNAs. Nucleic Acids Res. 17, 4380
-
(1989)
Nucleic Acids Res.
, vol.17
, pp. 4380
-
-
Chardin, P.1
Tavitian, A.2
-
28
-
-
84908491115
-
Drugging the undruggable RAS: Mission possible?
-
Cox, A. D., Fesik, S. W., Kimmelman, A. C., Luo, J., and Der, C. J. (2014) Drugging the undruggable RAS: mission possible? Nat. Rev. Drug Discov. 13, 828-851
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 828-851
-
-
Cox, A.D.1
Fesik, S.W.2
Kimmelman, A.C.3
Luo, J.4
Der, C.J.5
-
29
-
-
0033605596
-
Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells
-
Kim, E., Ambroziak, P., Otto, J. C., Taylor, B., Ashby, M., Shannon, K., Casey, P. J., and Young, S. G. (1999) Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J. Biol. Chem. 274, 8383-8390
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8383-8390
-
-
Kim, E.1
Ambroziak, P.2
Otto, J.C.3
Taylor, B.4
Ashby, M.5
Shannon, K.6
Casey, P.J.7
Young, S.G.8
-
30
-
-
0035937112
-
Isoprenylcysteine carboxyl methyltransferase deficiency in mice
-
Bergo, M. O., Leung, G. K., Ambroziak, P., Otto, J. C., Casey, P. J., Gomes, A. Q., Seabra, M. C., and Young, S. G. (2001) Isoprenylcysteine carboxyl methyltransferase deficiency in mice. J. Biol. Chem. 276, 5841-5845
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5841-5845
-
-
Bergo, M.O.1
Leung, G.K.2
Ambroziak, P.3
Otto, J.C.4
Casey, P.J.5
Gomes, A.Q.6
Seabra, M.C.7
Young, S.G.8
-
31
-
-
84855884600
-
Posttranslational lipid modification of Rho family small GTPases
-
Mitin, N., Roberts, P. J., Chenette, E. J., and Der, C. J. (2012) Posttranslational lipid modification of Rho family small GTPases. Methods Mol. Biol. 827, 87-95
-
(2012)
Methods Mol. Biol.
, vol.827
, pp. 87-95
-
-
Mitin, N.1
Roberts, P.J.2
Chenette, E.J.3
Der, C.J.4
-
32
-
-
84893453773
-
CellGeo: A computational platform for the analysis of shape changes in cells with complex geometries
-
Tsygankov, D., Bilancia, C. G., Vitriol, E. A., Hahn, K. M., Peifer, M., and Elston, T. C. (2014) CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. J. Cell Biol. 204, 443-460
-
(2014)
J. Cell Biol.
, vol.204
, pp. 443-460
-
-
Tsygankov, D.1
Bilancia, C.G.2
Vitriol, E.A.3
Hahn, K.M.4
Peifer, M.5
Elston, T.C.6
-
33
-
-
16344396081
-
Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases
-
Michaelson, D., Ali, W., Chiu, V. K., Bergo, M., Silletti, J., Wright, L., Young, S. G., and Philips, M. (2005) Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Mol. Biol. Cell 16, 1606-1616
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 1606-1616
-
-
Michaelson, D.1
Ali, W.2
Chiu, V.K.3
Bergo, M.4
Silletti, J.5
Wright, L.6
Young, S.G.7
Philips, M.8
-
34
-
-
0032499175
-
Ras-dependent activation of the small GTPase Ral
-
Wolthuis, R. M., Zwartkruis, F., Moen, T. C., and Bos, J. L. (1998) Ras-dependent activation of the small GTPase Ral. Curr. Biol. 8, 471-474
-
(1998)
Curr. Biol.
, vol.8
, pp. 471-474
-
-
Wolthuis, R.M.1
Zwartkruis, F.2
Moen, T.C.3
Bos, J.L.4
-
35
-
-
69249109593
-
Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases
-
Shirakawa, R., Fukai, S., Kawato, M., Higashi, T., Kondo, H., Ikeda, T., Nakayama, E., Okawa, K., Nureki, O., Kimura, T., Kita, T., and Horiuchi, H. (2009) Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases. J. Biol. Chem. 284, 21580-21588
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 21580-21588
-
-
Shirakawa, R.1
Fukai, S.2
Kawato, M.3
Higashi, T.4
Kondo, H.5
Ikeda, T.6
Nakayama, E.7
Okawa, K.8
Nureki, O.9
Kimura, T.10
Kita, T.11
Horiuchi, H.12
-
36
-
-
1642326112
-
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf
-
Bergo, M. O., Gavino, B. J., Hong, C., Beigneux, A. P., McMahon, M., Casey, P. J., and Young, S. G. (2004) Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J. Clin. Invest. 113, 539-550
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 539-550
-
-
Bergo, M.O.1
Gavino, B.J.2
Hong, C.3
Beigneux, A.P.4
McMahon, M.5
Casey, P.J.6
Young, S.G.7
-
37
-
-
2042544816
-
Post-translational processing of RhoA: Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of RhoA
-
Backlund, P. S., Jr. (1997) Post-translational processing of RhoA: carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of RhoA. J. Biol. Chem. 272, 33175-33180
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 33175-33180
-
-
Backlund, P.S.1
-
38
-
-
84883234639
-
Ral GTPases in tumorigenesis: Emerging from the shadows
-
Kashatus, D. F. (2013) Ral GTPases in tumorigenesis: emerging from the shadows. Exp. Cell Res. 319, 2337-2342
-
(2013)
Exp. Cell Res.
, vol.319
, pp. 2337-2342
-
-
Kashatus, D.F.1
-
39
-
-
54449089270
-
Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification
-
Roberts, P. J., Mitin, N., Keller, P. J., Chenette, E. J., Madigan, J. P., Currin, R. O., Cox, A. D., Wilson, O., Kirschmeier, P., and Der, C. J. (2008) Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification. J. Biol. Chem. 283, 25150-25163
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25150-25163
-
-
Roberts, P.J.1
Mitin, N.2
Keller, P.J.3
Chenette, E.J.4
Madigan, J.P.5
Currin, R.O.6
Cox, A.D.7
Wilson, O.8
Kirschmeier, P.9
Der, C.J.10
-
40
-
-
34248222607
-
R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes
-
Takaya, A., Kamio, T., Masuda, M., Mochizuki, N., Sawa, H., Sato, M., Nagashima, K., Mizutani, A., Matsuno, A., Kiyokawa, E., and Matsuda, M. (2007) R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes. Mol. Biol. Cell 18, 1850-1860
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1850-1860
-
-
Takaya, A.1
Kamio, T.2
Masuda, M.3
Mochizuki, N.4
Sawa, H.5
Sato, M.6
Nagashima, K.7
Mizutani, A.8
Matsuno, A.9
Kiyokawa, E.10
Matsuda, M.11
-
41
-
-
84865465364
-
RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane
-
Neyraud, V., Aushev, V. N., Hatzoglou, A., Meunier, B., Cascone, I., and Camonis, J. (2012) RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane. J. Biol. Chem. 287, 29397-29405
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 29397-29405
-
-
Neyraud, V.1
Aushev, V.N.2
Hatzoglou, A.3
Meunier, B.4
Cascone, I.5
Camonis, J.6
-
42
-
-
0034731405
-
The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules
-
Chen, Z., Otto, J. C., Bergo, M. O., Young, S. G., and Casey, P. J. (2000) The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. J. Biol. Chem. 275, 41251-41257
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 41251-41257
-
-
Chen, Z.1
Otto, J.C.2
Bergo, M.O.3
Young, S.G.4
Casey, P.J.5
-
43
-
-
0027983602
-
Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction
-
Fukada, Y., Matsuda, T., Kokame, K., Takao, T., Shimonishi, Y., Akino, T., and Yoshizawa, T. (1994) Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction. J. Biol. Chem. 269, 5163-5170
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5163-5170
-
-
Fukada, Y.1
Matsuda, T.2
Kokame, K.3
Takao, T.4
Shimonishi, Y.5
Akino, T.6
Yoshizawa, T.7
-
44
-
-
0141530040
-
A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation
-
Maske, C. P., Hollinshead, M. S., Higbee, N. C., Bergo, M. O., Young, S. G., and Vaux, D. J. (2003) A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation. J. Cell Biol. 162, 1223-1232
-
(2003)
J. Cell Biol.
, vol.162
, pp. 1223-1232
-
-
Maske, C.P.1
Hollinshead, M.S.2
Higbee, N.C.3
Bergo, M.O.4
Young, S.G.5
Vaux, D.J.6
-
45
-
-
0029075550
-
Functional significance of βγ-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase
-
Parish, C. A., Smrcka, A. V., and Rando, R. R. (1995) Functional significance of βγ-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase. Biochemistry 34, 7722-7727
-
(1995)
Biochemistry
, vol.34
, pp. 7722-7727
-
-
Parish, C.A.1
Smrcka, A.V.2
Rando, R.R.3
-
46
-
-
0030968859
-
Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo
-
Rowell, C. A., Kowalczyk, J. J., Lewis, M. D., and Garcia, A. M. (1997) Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo. J. Biol. Chem. 272, 14093-14097
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14093-14097
-
-
Rowell, C.A.1
Kowalczyk, J.J.2
Lewis, M.D.3
Garcia, A.M.4
-
47
-
-
0030923192
-
K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors
-
Whyte, D. B., Kirschmeier, P., Hockenberry, T. N., Nunez-Oliva, I., James, L., Catino, J. J., Bishop, W. R., and Pai, J. K. (1997) K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors. J. Biol. Chem. 272, 14459-14464
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14459-14464
-
-
Whyte, D.B.1
Kirschmeier, P.2
Hockenberry, T.N.3
Nunez-Oliva, I.4
James, L.5
Catino, J.J.6
Bishop, W.R.7
Pai, J.K.8
-
48
-
-
84927620483
-
Targeting RAS membrane association: Back to the future for anti-RAS drug discovery?
-
Cox, A. D., Philips, M. R., and Der, C. J. (2015) Targeting RAS membrane association: back to the future for anti-RAS drug discovery? Clin. Cancer Res. 21, 1819-1827
-
(2015)
Clin. Cancer Res.
, vol.21
, pp. 1819-1827
-
-
Cox, A.D.1
Philips, M.R.2
Der, C.J.3
-
49
-
-
0036132907
-
Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation
-
Bergo, M. O., Ambroziak, P., Gregory, C., George, A., Otto, J. C., Kim, E., Nagase, H., Casey, P. J., Balmain, A., and Young, S. G. (2002) Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol. Cell. Biol. 22, 171-181
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 171-181
-
-
Bergo, M.O.1
Ambroziak, P.2
Gregory, C.3
George, A.4
Otto, J.C.5
Kim, E.6
Nagase, H.7
Casey, P.J.8
Balmain, A.9
Young, S.G.10
-
50
-
-
33846191877
-
Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease
-
Wahlstrom, A. M., Cutts, B. A., Karlsson, C., Andersson, K. M., Liu, M., Sjogren, A. K., Swolin, B., Young, S. G., and Bergo, M. O. (2007) Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease. Blood 109, 763-768
-
(2007)
Blood
, vol.109
, pp. 763-768
-
-
Wahlstrom, A.M.1
Cutts, B.A.2
Karlsson, C.3
Andersson, K.M.4
Liu, M.5
Sjogren, A.K.6
Swolin, B.7
Young, S.G.8
Bergo, M.O.9
-
51
-
-
51649099589
-
Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease
-
Wahlstrom, A. M., Cutts, B. A., Liu, M., Lindskog, A., Karlsson, C., Sjogren, A. K., Andersson, K. M., Young, S. G., and Bergo, M. O. (2008) Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease. Blood 112, 1357-1365
-
(2008)
Blood
, vol.112
, pp. 1357-1365
-
-
Wahlstrom, A.M.1
Cutts, B.A.2
Liu, M.3
Lindskog, A.4
Karlsson, C.5
Sjogren, A.K.6
Andersson, K.M.7
Young, S.G.8
Bergo, M.O.9
-
52
-
-
84887433950
-
Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression
-
Court, H., Amoyel, M., Hackman, M., Lee, K. E., Xu, R., Miller, G., Bar-Sagi, D., Bach, E. A., Bergö, M. O., and Philips, M. R. (2013) Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression. J. Clin. Invest. 123, 4681-4694
-
(2013)
J. Clin. Invest.
, vol.123
, pp. 4681-4694
-
-
Court, H.1
Amoyel, M.2
Hackman, M.3
Lee, K.E.4
Xu, R.5
Miller, G.6
Bar-Sagi, D.7
Bach, E.A.8
Bergö, M.O.9
Philips, M.R.10
-
53
-
-
0037354548
-
Epigenetic regulation of ARHI in breast and ovarian cancer cells
-
Yu, Y., Fujii, S., Yuan, J., Luo, R. Z., Wang, L., Bao, J., Kadota, M., Oshimura, M., Dent, S. R., Issa, J. P., and Bast, R. C., Jr. (2003) Epigenetic regulation of ARHI in breast and ovarian cancer cells. Ann. N. Y. Acad. Sci. 983, 268-277
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.983
, pp. 268-277
-
-
Yu, Y.1
Fujii, S.2
Yuan, J.3
Luo, R.Z.4
Wang, L.5
Bao, J.6
Kadota, M.7
Oshimura, M.8
Dent, S.R.9
Issa, J.P.10
Bast, R.C.11
|