Acute perioperative-stress-induced increase of atherosclerotic plaque volume and vulnerability to rupture in apolipoprotein-Edeficient mice is amenable to statin treatment and IL-6 inhibition

DMM Disease Models and Mechanisms

Volumn 8, Issue 9, 2015, Pages 1071-1080

  Janssen, Henrike ^a,b   Wagner, Christian S ^a   Demmer, Philipp ^a   Callies, Simone ^a   Sölter, Gesine ^a   Loghmani Khouzani, Houra ^a   Hu, Niandan ^a   Schuett, Harald ^c   Tietge, Uwe J F ^d   Warnecke, Gregor ^a,e   Larmann, Jan ^a,b   Theilmeier, Gregor ^a,f  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY HOSPITAL MARBURG   (Germany)

^d UNIVERSITY OF GRONINGEN   (Netherlands)

^e German Center for Lung Research   (Germany)

^f UNIVERSITY OF OLDENBURG   (Germany)

Author keywords

Atherosclerosis; Mouse model; Perioperative stress

Indexed keywords

APOLIPOPROTEIN E; ATORVASTATIN; CHOLESTEROL; FC RECEPTOR; GLYCOPROTEIN GP 130; GLYCOPROTEIN GP 130 FC RECEPTOR FUSION PROTEIN; HYBRID PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; SERUM AMYLOID A; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN-6, MOUSE; LIPOPROTEIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD VOLUME; BRACHIOCEPHALIC TRUNK; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; FEMALE; HEMODYNAMICS; LAPAROTOMY; MACROPHAGE; MALE; MOUSE; NONHUMAN; OPERATIVE BLOOD LOSS; PERIOPERATIVE PERIOD; POSTOPERATIVE CARE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SHORT COURSE THERAPY; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SURGICAL STRESS; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DISEASE MODEL; GENETICS; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; RUPTURE; SMOOTH MUSCLE CELL; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOLIPOPROTEINS E; ATORVASTATIN CALCIUM; CHOLESTEROL; DISEASE MODELS, ANIMAL; FEMALE; HEMODYNAMICS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INFLAMMATION; INTERLEUKIN-6; LAPAROTOMY; LIPOPROTEINS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PERIOPERATIVE PERIOD; PLAQUE, ATHEROSCLEROTIC; RUPTURE; SERUM AMYLOID A PROTEIN; SIGNAL TRANSDUCTION;

EID: 84941557933     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.018713     Document Type: Article

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