Inflammatory response to cardiac surgery: Cardiopulmonary bypass versus non-cardiopulmonary bypass surgery

Best Practice and Research: Clinical Anaesthesiology

Volumn 18, Issue 3, 2004, Pages 425-438

  Larmann, Jan ^a   Theilmeier, Gregor ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Anti inflammatory strategies; Cardiac surgery; Cardiopulmonary bypass; Inflammation; Off pump coronary artery bypass

Indexed keywords

ALLOPURINOL; ALPHA TOCOPHEROL; APROTININ; ASCORBIC ACID; COMPLEMENT COMPONENT C5 INHIBITOR; DEFEROXAMINE; HEPARIN; METHYLPREDNISOLONE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

CARDIOPULMONARY BYPASS; CELL SEPARATION; COMPLEMENT SYSTEM; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY RECANALIZATION; CYTOKINE RELEASE; ENDOTOXEMIA; ENZYME ACTIVITY; GENETIC POLYMORPHISM; HEART INFARCTION; HEMOFILTRATION; HUMAN; INTERMETHOD COMPARISON; LEUKOCYTE ACTIVATION; OXIDATIVE STRESS; POSTOPERATIVE INFLAMMATION; PRIORITY JOURNAL; REVIEW; STERNOTOMY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOCYTE ACTIVATION; VASCULAR ENDOTHELIUM;

ANIMALS; CARDIAC SURGICAL PROCEDURES; CARDIOPULMONARY BYPASS; ENDOTHELIUM, VASCULAR; HUMANS; INFLAMMATION; LYMPHOCYTE ACTIVATION; PLATELET ACTIVATION; POSTOPERATIVE COMPLICATIONS;

EID: 3242696860     PISSN: 15216896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bpa.2003.12.004     Document Type: Review

References (100)

1. Gibbon Jr. J.H. Application of a mechanical heart and lung apparatus to cardiac surgery Minnesota Medicine 37 1954 171-185
2. Benetti F.J. Naselli G. Wood M. et al. Direct myocardial revascularization without extracorporeal circulation. Experience in 700 patients Chest 100 1991 312-316
3. Caputo M. Yeatman M. Narayan P. et al. Effect of off-pump coronary surgery with right ventricular assist device on organ function and inflammatory response: a randomized controlled trial Annals of Thoracic Surgery 74 2002 2088-2095
4. Cooley D.A. Con: beating-heart surgery for coronary revascularization: is it the most important development since the introduction of the heart-lung machine? Annals of Thoracic Surgery 70 2000 1779-1781
5. Gundry S.R. Romano M.A. Shattuck O.H. et al. Seven-year follow-up of coronary artery bypasses performed with and without cardiopulmonary bypass Journal of Thoracic and Cardiovascular Surgery 115 1998 1273-1277
6. Mack M.J. Pro: beating-heart surgery for coronary revascularization: is it the most important development since the introduction of the heart-lung machine? Annals of Thoracic Surgery 70 2000 1774-1778
7. Giomarelli P. Scolletta S. Borrelli E. et al. Myocardial and lung injury after cardiopulmonary bypass: role of interleukin (IL)-10 Annals of Thoracic Surgery 76 2003 117-123
8. Ascione R. Lloyd C.T. Underwood M.J. et al. On-pump versus off-pump coronary revascularization: evaluation of renal function Annals of Thoracic Surgery 68 1999 493-498
9. Czerny M. Baumer H. Kilo J. et al. Inflammatory response and myocardial injury following coronary artery bypass grafting with or without cardiopulmonary bypass European Journal of Cardiothoracic Surgery 17 2000 737-742
10. Puskas J.D. Williams W.H. Duke P.G. et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting Journal of Thoracic and Cardiovascular Surgery 125 2003 797-808
11. Riddington D.W. Venkatesh B. Boivin C.M. et al. Intestinal permeability, gastric intramucosal pH, and systemic endotoxemia in patients undergoing cardiopulmonary bypass Journal of the American Medical Association 275 1996 1007-1012
12. Holmes J.H. Connolly N.C. Paull D.L. et al. Magnitude of the inflammatory response to cardiopulmonary bypass and its relation to adverse clinical outcomes Inflammatory Research 51 2002 579-586
13. Roach G.W. Kanchuger M. Mangano C.M. et al. Adverse cerebral outcomes after coronary bypass surgery. Multicenter Study of Perioperative Ischemia Research Group and the Ischemia Research and Education Foundation Investigators New England Journal of Medicine 335 1996 1857-1863
14. Morse D.S. Adams D. Magnani B. Platelet and neutrophil activation during cardiac surgical procedures: impact of cardiopulmonary bypass Annals of Thoracic Surgery 65 1998 691-695
15. Rothenburger M. Trosch F. Markewitz A. et al. Leukocyte activation and phagocytotic activity in cardiac surgery and infection Cardiovascular Surgery 10 2002 470-475
16. Chenoweth D.E. Cooper S.W. Hugli T.E. et al. Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins New England Journal of Medicine 304 1981 497-503
17. Despotis G.J. Joist J.H. Anticoagulation and anticoagulation reversal with cardiac surgery involving cardiopulmonary bypass: an update Journal of Cardiothoracic and Vascular Anesthesia 13 1999 18-29
18. Kharazmi A. Andersen L.W. Baek L. et al. Endotoxemia and enhanced generation of oxygen radicals by neutrophils from patients undergoing cardiopulmonary bypass Journal of Thoracic Cardiovascular Surgery 98 1989 381-385
19. Gu Y.J. Mariani M.A. van Oeveren W. et al. Reduction of the inflammatory response in patients undergoing minimally invasive coronary artery bypass grafting Annals of Thoracic Surgery 65 1998 420-424
20. Luscinskas F.W. Gimbrone Jr. M.A. Endothelial-dependent mechanisms in chronic inflammatory leukocyte recruitment Annual Review of Medicine 47 1996 413-421
21. Gimbrone Jr. M.A. Nagel T. Topper J.N. Biomechanical activation: an emerging paradigm in endothelial adhesion biology Journal of Clinical Investigation 99 1997 1809-1813
22. Topper J.N. Cai J. Falb D. et al. Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclo-oxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress Proceedings of the National Academy of Sciences of the USA 93 1996 10417-10422
23. Tsao P.S. Lewis N.P. Alpert S. et al. Exposure to shear stress alters endothelial adhesiveness. Role of nitric oxide Circulation 92 1995 3513-3519
24. Dekker R.J. van Soest S. Fontijn R.D. et al. Prolonged fluid shear stress induces a distinct set of endothelial cell genes, most specifically lung Kruppel-like factor (KLF2) Blood 100 2002 1689-1698
25. Inoue N. Ramasamy S. Fukai T. et al. Shear stress modulates expression of Cu/Zn superoxide dismutase in human aortic endothelial cells Circulation Research 79 1996 32-37
26. Jordan J.E. Zhao Z.Q. Vinten-Johansen J. The role of neutrophils in myocardial ischemia-reperfusion injury Cardiovascular Research 43 1999 860-878
27. Terada L.S. Oxidative stress and endothelial activation Critical Care Medicine 30 2002 S186-S191
28. Ferrari R. Alfieri O. Curello S. et al. Occurrence of oxidative stress during reperfusion of the human heart Circulation 81 1990 201-211
29. Rossi F. The O2-forming NADPH oxidase of the phagocytes: nature, mechanisms of activation and function Biochimica Biophysica Acta 853 1986 65-89
30. Curello S. Ceconi C. de Giuli F. et al. Oxidative stress during reperfusion of human hearts: potential sources of oxygen free radicals Cardiovascular Research 29 1995 118-125
31. Tarpey M.M. Fridovich I. Methods of detection of vascular reactive species: nitric oxide, superoxide, hydrogen peroxide, and peroxynitrite Circulation Research 89 2001 224-236
32. Clermont G. Vergely C. Jazayeri S. et al. Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass Anesthesiology 96 2002 80-87
33. Cavarocchi N.C. England M.D. Schaff H.V. et al. Oxygen free radical generation during cardiopulmonary bypass: correlation with complement activation Circulation 74 1986 III130-III133
34. Fong Y. Moldawer L.L. Marano M. et al. Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man Journal of Immunology 142 1989 2321-2324
35. Wan S. LeClerc J.L. Vincent J.L. Cytokine responses to cardiopulmonary bypass: lessons learned from cardiac transplantation Annals of Thoracic Surgery 63 1997 269-276
36. Iglesias J. Marik P.E. Levine J.S. Elevated serum levels of the type I and type II receptors for tumor necrosis factor-alpha as predictive factors for ARF in patients with septic shock American Journal of Kidney Disease 41 2003 62-75
37. Zimmermann A.K. Simon P. Seeburger J. et al. Cytokine gene expression in monocytes of patients undergoing cardiopulmonary bypass surgery evaluated by real-time PCR Journal of Cellular and Molecular Medicine 7 2003 146-156
38. Brix-Christensen V. Vestergaard C. Chew M. et al. Plasma cytokines do not reflect expression of pro- and anti-inflammatory cytokine mRNA at organ level after cardiopulmonary bypass in neonatal pigs Acta Anaesthesiologica Scandinavica 47 2003 525-531
39. Hennein H.A. Ebba H. Rodriguez J.L. et al. Relationship of the proinflammatory cytokines to myocardial ischemia and dysfunction after uncomplicated coronary revascularization Journal of Thoracic Cardiovascular Surgery 108 1994 626-635
40. Steinberg J.B. Kapelanski D.P. Olson J.D. et al. Cytokine and complement levels in patients undergoing cardiopulmonary bypass Journal of Thoracic Cardiovascular Surgery 106 1993 1008-1016
41. Okubo N. Hatori N. Ochi M. et al. Comparison of m-RNA expression for inflammatory mediators in leukocytes between on-pump and off-pump coronary artery bypass grafting Annals of Thoracic and Cardiovascular Surgery 9 2003 43-49
42. Schulze C. Conrad N. Schutz A. et al. Reduced expression of systemic proinflammatory cytokines after off-pump versus conventional coronary artery bypass grafting Thoracic and Cardiovascular Surgery 48 2000 364-369
43. Wan S. Izzat M.B. Lee T.W. et al. Avoiding cardiopulmonary bypass in multivessel CABG reduces cytokine response and myocardial injury Annals of Thoracic Surgery 68 1999 52-56
44. Sablotzki A. Dehne M.G. Friedrich I. et al. Different expression of cytokines in survivors and non-survivors from MODS following cardiovascular surgery European Journal of Medical Research 8 2003 71-76
45. Stuber F. Petersen M. Bokelmann F. et al. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis Critical Care Medicine 24 1996 381-384
46. Schroeder S. Borger N. Wrigge H. et al. A tumor necrosis factor gene polymorphism influences the inflammatory response after cardiac operation Annals of Thoracic Surgery 75 2003 534-537
47. Jirik F.R. Podor T.J. Hirano T. et al. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells Journal of Immunology 142 1989 144-147
48. Taggart D.P. Sundaram S. McCartney C. et al. Endotoxemia, complement, and white blood cell activation in cardiac surgery: a randomized trial of laxatives and pulsatile perfusion Annals of Thoracic Surgery 57 1994 376-382
49. Rocke D.A. Gaffin S.L. Wells M.T. et al. Endotoxemia associated with cardiopulmonary bypass Journal of Thoracic and Cardiovascular Surgery 93 1987 832-837
50. Bouter H. Schippers E.F. Luelmo S.A. et al. No effect of preoperative selective gut decontamination on endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study Critical Care Medicine 30 2002 38-43
51. Tao W. Zwischenberger J.B. Nguyen T.T. et al. Gut mucosal ischemia during normothermic cardiopulmonary bypass results from blood flow redistribution and increased oxygen demand Journal of Thoracic and Cardiovascular Surgery 110 1995 819-828
52. Ohri S.K. Bjarnason I. Pathi V. et al. Cardiopulmonary bypass impairs small intestinal transport and increases gut permeability Annals of Thoracic Surgery 55 1993 1080-1086
53. Andersen L.W. Landow L. Baek L. et al. Association between gastric intramucosal pH and splanchnic endotoxin, antibody to endotoxin, and tumor necrosis factor-alpha concentrations in patients undergoing cardiopulmonary bypass Critical Care Medicine 21 1993 210-217
54. Aydin N.B. Gercekoglu H. Aksu B. et al. Endotoxemia in coronary artery bypass surgery: a comparison of the off-pump technique and conventional cardiopulmonary bypass Journal of Thoracic Cardiovascular Surgery 125 2003 843-848
55. te V.H. Jansen P.G. Oudemans-van Straaten H.M. et al. Myocardial performance in elderly patients after cardiopulmonary bypass is suppressed by tumor necrosis factor Journal of Thoracic and Cardiovascular Surgery 110 1995 1663-1669
56. Lequier L.L. Nikaidoh H. Leonard S.R. et al. Preoperative and postoperative endotoxemia in children with congenital heart disease Chest 117 2000 1706-1712
57. Smedly L.A. Tonnesen M.G. Sandhaus R.A. et al. Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase Journal of Clinical Investigation 77 1986 1233-1243
58. Edmunds Jr. L.H. Inflammatory response to cardiopulmonary bypass Annals of Thoracic Surgery 66 1998 S12-S16
59. Vergnolle N. Derian C.K. D'Andrea M.R. et al. Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4 Journal of Immunology 169 2002 1467-1473
60. Martin W. Carter R. Tweddel A. et al. Respiratory dysfunction and white cell activation following cardiopulmonary bypass: comparison of membrane and bubble oxygenators European Journal of Cardiothoracic Surgery 10 1996 774-783
61. Kuijper P.H. Gallardo Torres H.I. Lammers J.W. et al. Platelet and fibrin deposition at the damaged vessel wall: cooperative substrates for neutrophil adhesion under flow conditions Blood 89 1997 166-175
62. Theilmeier G. Lenaerts T. Remacle C. et al. Circulating activated platelets assist THP-1 monocytoid/endothelial cell interaction under shear stress Blood 94 1999 2725-2734
63. Rinder C.S. Bonan J.L. Rinder H.M. et al. Cardiopulmonary bypass induces leukocyte-platelet adhesion Blood 79 1992 1201-1205
64. Bruins P. te Velthuis H. Eerenberg-Belmer A.J. et al. Heparin-protamine complexes and C-reactive protein induce activation of the classical complement pathway: studies in patients undergoing cardiac surgery and in vitro Thrombosis Haemostasis 84 2000 237-243
65. Fosse E. Mollnes T.E. Ingvaldsen B. Complement activation during major operations with or without cardiopulmonary bypass Journal of Thoracic and Cardiovascular Surgery 93 1987 860-866
66. Matata B.M. Sosnowski A.W. Galinanes M. Off-pump bypass graft operation significantly reduces oxidative stress and inflammation Annals of Thoracic Surgery 69 2000 785-791
67. Johnson D. Thomson D. Mycyk T. et al. Depletion of neutrophils by filter during aortocoronary bypass surgery transiently improves postoperative cardiorespiratory status Chest 107 1995 1253-1259
68. Scholz M. Simon A. Matheis G. et al. Leukocyte filtration fails to limit functional neutrophil activity during cardiac surgery Inflammatory Research 51 2002 363-368
69. Chiba Y. Morioka K. Muraoka R. et al. Effects of depletion of leukocytes and platelets on cardiac dysfunction after cardiopulmonary bypass Annals of Thoracic Surgery 65 1998 107-113
70. Olivencia-Yurvati A.H. Ferrara C.A. Tierney N. et al. Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass Perfusion 18 supplement 1 2003 23-31
71. Replogle R.L. Gazzaniga A.B. Gross R.E. Use of corticosteroids during cardiopulmonary bypass: possible lysosome stabilization Circulation 33 1966 I86-I92
72. Kawamura T. Inada K. Nara N. et al. Influence of methylprednisolone on cytokine balance during cardiac surgery Critical Care Medicine 27 1999 545-548
73. Kilger E. Weis F. Briegel J. et al. Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery Critical Care Medicine 31 2003 1068-1074
74. El Azab S.R. Rosseel P.M. De Lange J.J. et al. Dexamethasone decreases the pro- to anti-inflammatory cytokine ratio during cardiac surgery British Journal of Anaesthesia 88 2002 496-501
75. Engelman R.M. Rousou J.A. Flack III J.E. et al. Influence of steroids on complement and cytokine generation after cardiopulmonary bypass Annals of Thoracic Surgery 60 1995 801-804
76. Chaney M.A. Corticosteroids and cardiopulmonary bypass: a review of clinical investigations Chest 121 2002 921-931
77. Schroeder V.A. Pearl J.M. Schwartz S.M. et al. Combined steroid treatment for congenital heart surgery improves oxygen delivery and reduces postbypass inflammatory mediator expression Circulation 107 2003 2823-2828
78. Engelman R.M. Rousou J.A. Flack III J.E. et al. Fast-track recovery of the coronary bypass patient Annals of Thoracic Surgery 58 1994 1742-1746
79. van Oeveren W. Jansen N.J. Bidstrup B.P. et al. Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass Annals of Thoracic Surgery 44 1987 640-645
80. Mojcik C.F. Levy J.H. Aprotinin and the systemic inflammatory response after cardiopulmonary bypass Annals of Thoracic Surgery 71 2001 745-754
81. Levi M. Cromheecke M.E. de Jonge E. et al. Pharmacological strategies to decrease excessive blood loss in cardiac surgery: a meta-analysis of clinically relevant endpoints Lancet 354 1999 1940-1947
82. Drossos G. Lazou A. Panagopoulos P. et al. Deferoxamine cardioplegia reduces superoxide radical production in human myocardium Annals of Thoracic Surgery 59 1995 169-172
83. Julia P.L. Buckberg G.D. Acar C. et al. Studies of controlled reperfusion after ischemia. XXI. Reperfusate composition: superiority of blood cardioplegia over crystalloid cardioplegia in limiting reperfusion damage-importance of endogenous oxygen free radical scavengers in red blood cells Journal of Thoracic Cardiovascular Surgery 101 1991 303-313
84. Angdin M. Settergren G. Starkopf J. et al. Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass Journal of Cardiothoracic and Vascular Anesthesia 17 2003 314-320
85. Sisto T. Paajanen H. Metsa-Ketela T. et al. Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting Annals of Thoracic Surgery 59 1995 1519-1523
86. Ovrum E. Brosstad F. Am H.E. et al. Effects on coagulation and fibrinolysis with reduced versus full systemic heparinization and heparin-coated cardiopulmonary bypass Circulation 92 1995 2579-2584
87. Gu Y.J. van Oeveren W. Akkerman C. et al. Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass Annals of Thoracic Surgery 55 1993 917-922
88. Thomas T.C. Rollins S.A. Rother R.P. et al. Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv Molecular Immunology 33 1996 1389-1401
89. Rinder C.S. Rinder H.M. Smith B.R. et al. Blockade of C5a and C5b-9 generation inhibits leukocyte and platelet activation during extracorporeal circulation Journal of Clinical Investigation 96 1995 1564-1572
90. Fitch J.C. Rollins S. Matis L. et al. Pharmacology and biological efficacy of a recombinant, humanized, single-chain antibody C5 complement inhibitor in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass Circulation 100 1999 2499-2506
91. Journois D. Pouard P. Greeley W.J. et al. Hemofiltration during cardiopulmonary bypass in pediatric cardiac surgery. Effects on hemostasis, cytokines, and complement components Anesthesiology 81 1994 1181-1189
92. Huang H. Yao T. Wang W. et al. Continuous ultrafiltration attenuates the pulmonary injury that follows open heart surgery with cardiopulmonary bypass Annals of Thoracic Surgery 76 2003 136-140
93. Cleveland Jr. J.C. Shroyer A.L. Chen A.Y. et al. Off-pump coronary artery bypass grafting decreases risk-adjusted mortality and morbidity Annals of Thoracic Surgery 72 2001 1282-1288
94. Parolari A. Alamanni F. Cannata A. et al. Off-pump versus on-pump coronary artery bypass: meta-analysis of currently available randomized trials Annals of Thoracic Surgery 76 2003 37-40
95. Nossuli T.O. Lakshminarayanan V. Baumgarten G. et al. A chronic mouse model of myocardial ischemia - Reperfusion: essential in cytokine studies American Journal of Physiology: Heart and Circulatory Physiology 278 2000 H1049-H1055
96. van Dijk D. Nierich A.P. Jansen E.W.L. et al. Early outcome after off-pump versus on-pump coronary bypass surgery: results from a randomized study Circulation 104 2001 1761-1766
97. Angelini G.D. Taylor F.C. Reeves B.C. et al. Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials Lancet 359 2002 1194-1199
98. Ascione R. Caputo M. Calori G. et al. Predictors of atrial fibrillation after conventional and beating heart coronary surgery: a prospective, randomized study Circulation 102 2000 1530-1535
99. Ivanov J. Weisel R.D. David T.E. et al. Fifteen-year trends in risk severity and operative mortality in elderly patients undergoing coronary artery bypass graft surgery Circulation 97 1998 673-680
100. Beauford R.B. Goldstein D.J. Sardari F.F. et al. Multivessel off-pump revascularization in octogenarians: early and midterm outcomes Annals of Thoracic Surgery 76 2003 12-17