A cytochrome P450-independent mechanism of acetaminophen-induced injury in cultured mouse hepatocytes

Journal of Pharmacology and Experimental Therapeutics

Volumn 354, Issue 2, 2015, Pages 230-237

  Miyakawa, Kazuhisa ^a   Albee, Ryan ^b   Letzig, Lynda G ^c   Lehner, Andreas F ^a   Scott, Michael A ^a   Buchweitz, John P ^a   James, Laura P ^c   Ganey, Patricia E ^b   Roth, Robert A ^b  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c UNIVERSITY OF ARKANSAS AT LITTLE ROCK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINOBENZOTRIAZOLE; 4 AMINOPHENOL; 4 NITROPHENYL PHOSPHATE; BIOLOGICAL MARKER; CYTOCHROME P450; DRUG METABOLITE; PARACETAMOL; ANALGESIC AGENT;

ANIMAL CELL; ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; ENZYME ACTIVATION; IN VITRO STUDY; LIVER CELL DAMAGE; LIVER TOXICITY; MOUSE; NONHUMAN; PRIMARY CELL CULTURE; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL CULTURE; DOSE RESPONSE; DRUG EFFECTS; LIVER CELL; MALE; METABOLISM; PHYSIOLOGY;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; CELL DEATH; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPATOCYTES; MALE; MICE; MICE, INBRED C57BL;

EID: 84941554009     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.115.223537     Document Type: Article

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