Pyruvate reduces 4-aminophenol in vitro toxicity

Toxicology and Applied Pharmacology

Volumn 213, Issue 2, 2006, Pages 179-186

  Harmon, R Christopher ^a   Kiningham, Kinsley K ^a   Valentovic, Monica A ^a  

^a MARSHALL UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Glutathione; Nephrotoxicity; Oxidative stress; p Aminophenol; Pyruvate

Indexed keywords

4 AMINOPHENOL; 4 HYDROXYNONENAL; ADENINE NUCLEOTIDE; ADENOSINE TRIPHOSPHATE; DIMETHYL SULFOXIDE; GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; LACTATE DEHYDROGENASE; PYRUVIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DENSITOMETRY; DOSE RESPONSE; DRUG MECHANISM; IN VITRO STUDY; KIDNEY CORTEX SLICE; MALE; NEPHROTOXICITY; NONHUMAN; PROTEIN DEPLETION; RAT;

AMINOPHENOLS; ANIMALS; DRUG INTERACTIONS; GLUCOSE; GLUTATHIONE; KIDNEY; MALE; MUTAGENS; ORGAN CULTURE TECHNIQUES; OXIDATIVE STRESS; PYRUVIC ACID; RATS; RATS, INBRED F344;

EID: 33646580018     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2005.10.008     Document Type: Article

References (35)

1. Andersen M.E. Determination of glutathione and glutathione disulfide. Methods Enzymol. 113 (1985) 548-555
2. Bandara L.R., Kelly M.D., Lock E.A., and Kennedy S. A potential biomarker of kidney damage identified by proteomics: preliminary findings. Biomarkers 8 3-4 (2003) 272-286
3. Bandara L.R., Kelly M.D., Lock E.A., and Kennedy S. A correlation between proteomic evaluation and conventional measurements in the assessment of renal proximal tubular toxicity. Toxicol. Sci. 73 (2003) 195-206
4. Bunger R., Swindall B., Brodie D., Zdunek H., Stiegler G., and Walter G. Pyruvate attenuation of hypoxia damage in isolated working guinea pig heart. J. Mol. Cell. Cardiol. 18 (1986) 423-438
5. Calder I.C., Funder C.C., Green C.R., Ham K.N., and Tange J.D. Comparative nephrotoxicity of aspirin and phenacetin derivatives. Br. Med. J. 4 (1971) 518-521
6. Cicalese L., Lee K., Schraut W., Watkins S., Borle A., and Stanko R. Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine. Am. J. Surg. 171 (1996) 97-101
7. Deboer L.W., Bekx P.A., Han L., and Steinke L. Pyruvate enhances recovery of rat hearts after ischemia and reperfusion by preventing free radical generation. Am. J. Physiol. 265 (1993) H1571-H1576
8. Gartland K.R., Booner F.W., Timbrell J.A., and Nickolson J.K. Biochemical characterization of para-aminophenol-induced nephrotoxic lesions in the F 344 rat. Arch. Toxicol. 63 (1989) 97-106
9. Green C.R., Ham K.N., and Tange J.T. Kidney lesions induced in rats by p-aminophenol. Br. Med. J. 1 (1969) 162-164
10. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal. Biochem. 106 (1980) 207-212
11. 1 cells. Toxicology 156 (2000) 37-45
12. Haraguchi C.M., Mabuchi T., and Yokota S. Localization of a mitochondrial type of NADP-dependent isocitrate dehydrogenase in kidney and heart of rat: an immunocytochemical and biochemical study. J. Histochem. Cytochem. 51 2 (2003) 215-226
13. Harmon R.C., Terneus M.V., Kiningham K.K., and Valentovic M.A. Time dependent effect of p-aminophenol (PAP) toxicity in renal slices and development of oxidative stress. Toxicol. Appl. Pharmacol. 209 (2005) 86-94
14. Kristo G., Yoshimura Y., Niu J., Keith B.J., Mentzer Jr. R.M., and Lasley R.D. The intermediary metabolite pyruvate attenuates stunning and reduces infarct size in in vivo porcine myocardium. Am. J. Physiol.: Heart Circ. Physiol. 286 (2004) H517-H524
15. Lash L.H., and Jones D.P. Mitochondrial toxicity in renal injury. In: Zalups R.K., and Lash L.H. (Eds). Methods in Renal Toxicology (1996), CRC Press, Boca Raton, FL 299-330
16. Leier I., Jedlitschky G., Buchholz U., Center M., Cole S.P., Deeley R.G., and Keppler D. ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem. J. 314 Pt. 2 (1996) 433-437
17. Lock E.A., Cross T.J., and Schnellmann R.G. Studies on the mechanism of 4-aminophenol induced toxicity to renal proximal tubules. Hum. Exp. Toxicol. 12 (1993) 383-388
18. Mallet R.T. Pyruvate: metabolic protector of cardiac performance. Proc. Soc. Exp. Med. 223 (2000) 136-146
19. Mallet R.T., Squires J.E., Bhatia S., and Sun J. Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium. J. Mol. Cell. Cardiol. 34 9 (2002) 1173-1184
20. Mallet R.T., Sun J., Knott E.M., Sharma A.B., and Olvencia-yurvati A.H. Metabolic cardioprotection by pyruvate: recent progress. Exp. Biol. Med. 230 (2005) 435-443
21. Minigh J.L., and Valentovic M.A. Characterization of myoglobin cytotoxicity in renal cortical slices from Fischer 344 rats. Toxicology 187 (2003) 77-87
22. 1) epithelial cells. Am. J. Physiol. 257 (1989) F11-F17
23. Newton J.F., Kuo C.H., Gemborys M.W., Mudge G.H., and Hook J.B. Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen in the Fischer 344 rat. Toxicol. Appl. Pharmacol. 65 (1982) 336-341
24. Newton J.F., Bailie M.B., and Hook J.B. Acetaminophen nephrotoxicity in the rat. Renal metabolic activation in vitro. Toxicol. Appl. Pharmacol. 70 (1983) 433-444
25. Newton J.F., Kuo C.H., Deshore G.M., Hoefle D., Bernstein J., and Hook J.B. The role of p-aminophenol in acetaminophen induced nephrotoxicity: effect of bis(p-nitrophenyl)phosphate on acetaminophen and p-aminophenol nephrotoxicity and metabolism. Toxicol. Appl. Pharmacol. 69 (1985) 291-306
26. Robertson J.D., Starnes J.W., and Kehrer J.P. Cosubstrates involved in the reduction of cytosolic glutathione disulfide in rat heart. Toxicology 124 1 (1997) 11-19
27. Salahudeen A.K., Clark E.C., and Nath K.A. Hydrogen peroxide induced renal injury. A protective role for pyruvate in vitro and in vivo. J. Clin. Invest. 88 (1991) 1886-1893
28. Shao R., and Tarloff J.B. Lack of correlation between para-aminophenol toxicity in vivo and in vitro in female Sprague Dawley rats. Fundam. Appl. Toxicol. 31 (1996) 268-278
29. Silverman M. Comparison of glucose transport mechanisms at opposing surfaces of the renal proximal tubular cell. Biochem. Cell. Biol. 64 11 (1986) 1092-1098
30. Squires J.E., Sun J., Caffrey J.L., Yoshishige D., and Mallet R.T. Acetoacetate augments beta-adrenergic inotropism of stunned myocardium by an antioxidant mechanism. Am. J. Physiol.: Heart Circ. Physiol. 284 4 (2003) H1340-H1347
31. Tejero Taldo M.I., Caffrey J.L., Sun J., and Mallet R.T. Antioxidant properties of pyruvate mediate its potentiation of beta adrenergic ionotropism in stunned myocardium. J. Mol. Cell. Cardiol. 31 10 (1999) 1863-1872
32. Timbrell J.A. Principles of Biochemical Toxicology. 2nd ed. (1991), Taylor and Francis Inc., Bristol, PA, USA 217-232
33. Valentovic M.A., and Ball J.G. 2-Aminophenol and 4-aminophenol toxicity in renal slices from Sprague Dawley and Fischer 344 rats. J. Toxicol. Environ. Health 55 (1998) 225-240
34. Valentovic M.A., and Minigh J.L. Pyruvate attenuates myoglobin in vitro toxicity. Toxicol. Sci. 74 (2003) 345-351
35. Valentovic M.A., Ball J.G., Anestis D.A., Beers K., Madan E., Hubbard J.L., and Rankin G.O. Acute renal and hepatic toxicity of 2-haloanilines in Fischer 344 rats. Toxicology 75 (1992) 121-131