P-Aminophenol-induced liver toxicity: Tentative evidence of a role for acetaminophen

Journal of Biochemical and Molecular Toxicology

Volumn 15, Issue 1, 2001, Pages 34-40

  Song, Hong ^a   Chen, Theresa S ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Acetaminophen; Glutathione; Liver toxicity; P Aminophenol

Indexed keywords

4 AMINOPHENOL; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ANALGESIC AGENT; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CYSTEINE; DRUG METABOLITE; GLUCURONIDE; GLUTATHIONE; IDITOL DEHYDROGENASE; PARACETAMOL; REDUCING AGENT; SULFATE; THIOL DERIVATIVE;

ACETYLATION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG POTENTIATION; ENZYME BLOOD LEVEL; GLUTATHIONE METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INDUSTRY; LIVER; LIVER TOXICITY; MALE; MEASUREMENT; MOUSE; NEPHROTOXICITY; NONHUMAN; RAT; TIME;

ACETAMINOPHEN; ACETYLATION; ALANINE TRANSAMINASE; AMINOPHENOLS; ANIMALS; ASCORBIC ACID; BUTHIONINE SULFOXIMINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTEINE; CYSTINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GLUTATHIONE; GLUTATHIONE DISULFIDE; HEPATITIS, TOXIC; L-IDITOL 2-DEHYDROGENASE; LIVER; MALE; MICE; MICE, INBRED C57BL;

EID: 0035141087     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0461(2001)15:1<34::AID-JBT4>3.0.CO;2-U     Document Type: Article

References (33)

1. The nephrotoxicity of p-aminophenol. I. The effect on microsomal cytochromes, glutathione and covalent binding in kidney and liver
2. Nephrotoxicity of p-aminophenol, a metabolite of acetaminophen, in the Fischer 344 rat
3. Mouse and rat differences in p-aminophenol toxicity
4. Effects of analgesics and related compounds on renal metabolism in rats
5. Nephrotoxicity of 4-aminophenol glutathione conjugate
6. Paracetamol (acetamiophen) poisoning
7. Liver necrosis from paracetamol
8. N-Acetyl-p-benzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen
9. Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione
10. Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters
11. p-Aminophenol nephrotoxicity: Biosynthesis of toxic glutathione conjugates
12. Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism
13. Species differences in hepatic glutathione depletion, covalent binding and hepatic necrosis after acetaminophen
14. Metabolism and cytotoxicity of acetaminophen in hepatocytes isolated from resistant and susceptible species
15. Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite
16. Species variation in toxication and detoxication of acetaminophen in vivo: A comparative study of biliary and urinary excretion of acetaminophen metabolites
17. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
18. Sorbital dehydrogenase and hepatocellular injury: An experimental and clinical study
19. Tissue sulfhydryl groups
20. The determination of glutathione, cyst(e)ine, and other thiols and disulfides in biological samples using high-performance liquid chromatography with dual electrochemical detection
21. Life span profiles of glutathione and acetaminophen detoxification
22. Routine methods in toxicology and therapeutic drug monitoring by high-performance liquid chromatography. I. Rapid method for determination of acetaminophen in plasma, including a STAT procedure
23. Different mechanism of saturation of acetaminophen sulfate conjugation in mice and rats
24. Diurnal variation in mouse and rat liver sulfhydryl
25. Circadian rhythm in acetaminophen toxicity: Role of nonprotein sulfhydryls
26. Effects of biliary cannulation and buthionine sulphoximine pretreatment on the nephrotoxicity of para-aminophenol in the Fischer 344 rats
27. Effect of L-ascorbic acid on acetaminophen-induced hepatotoxicity and covalent binding in hamsters: Evidence that in vitro covalent binding differs from that in vivo
28. 3-Hydroxyacetaminophen: A microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen
29. Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine
30. Studies on the effects of L-ascorbic acid on acetaminophen-induced hepatotoxicty. I. Inhibition of the covalent binding of acetaminophen metabolites to hepatic microsomes in vitro
31. Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats
32. Effects of microsomal enzyme induction on paracetamol metabolism in man
33. Biliary excretion of acetaminophen-glutathione as an index of toxic activation of acetaminophen: Effect of chemicals that alter acetaminophen hepatotoxicity