Fish oil and flax seed oil supplemented diets increase FFAR4 expression in the rat colon

Inflammation Research

Volumn 64, Issue 10, 2015, Pages 809-815

  Cheshmehkani, Ameneh ^a   Senatorov, Ilya S ^a   Kandi, Praveen ^a   Singh, Monalisa ^a   Britt, April ^a   Hayslett, Renée ^a   Moniri, Nader H ^a  

^a MERCER UNIVERSITY   (United States)

Author keywords

Fish oil; Flaxseed oil; Free fatty acid receptor 4; GPR120; Polyunsaturated fatty acids

Indexed keywords

ACTIN; DOCOSAHEXAENOIC ACID; FATTY ACID; FISH OIL; FREE FATTY ACID RECEPTOR 4; G PROTEIN COUPLED RECEPTOR 120; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; ICOSAPENTAENOIC ACID; LINOLENIC ACID; LINSEED OIL; OMEGA 3 FATTY ACID; SOYBEAN OIL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; GLUCOSE BLOOD LEVEL; O3FAR1 PROTEIN, RAT; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ASSESSMENT; DIET SUPPLEMENTATION; DIETARY INTAKE; FAT INTAKE; FISH; GLUCOSE BLOOD LEVEL; INGESTION; INSULIN SENSITIVITY; LINSEED; MALE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; SPRAGUE DAWLEY RAT; SYSTEMATIC REVIEW; TRANSVERSE COLON; ANIMAL; BIOSYNTHESIS; COLON; DIET; DIETARY SUPPLEMENT; DRUG EFFECTS; METABOLISM;

ANIMALS; BLOOD GLUCOSE; COLON; DIET; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FISH OILS; GLUCAGON-LIKE PEPTIDE 1; LINSEED OIL; MALE; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84941414976     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-015-0864-3     Document Type: Article

References (28)

1. Yates CM, Calder PC, Ed Rainger G. Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease. Pharmacol Ther. 2014;141:272–82.
2. Hokari R, Matsunaga H, Miura S. Effect of dietary fat on intestinal inflammatory diseases. J Gastroenterol Hepatol. 2013;S4:33–6.
3. Cabré E, Mañosa M, Gassull MA. Omega-3 fatty acids and inflammatory bowel diseases—a systematic review. Br J Nutr. 2012;107:240–52.
4. Kantha SS. Dietary effects of fish oils on human health: a review of recent studies. Yale J Biol Med. 1987;60:37–44.
5. Hawkey CJ, Mahida YR, Hawthorne AB. Therapeutic interventions in gastrointestinal disease based on an understanding of inflammatory mediators. Agents Actions. (1992) C22–6.
6. Brown AJ, Jupe S, Briscoe CP. A family of fatty acid binding receptors. DNA Cell Biol. 2005;24:54–61.
7. Hirasawa A, Tsumaya K, Awaji T, Katsuma S, Adachi T, Yamada M, Sugimoto Y, Miyazaki S, Tsujimoto G. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120. Nat Med. 2005;11:90–4.
8. Oh DY, Talukdar S, Bae EJ, Imamura T, Morinaga H, Fan W, Li P, Lu WJ, Watkins SM, Olefsky JM. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects. Cell. 2010;142:687–98.
9. Burns RN, Moniri NH. Agonism with the omega-3 fatty acids alpha-linolenic acid and docosahexaenoic acid mediates phosphorylation of both the short and long isoforms of the human GPR120 receptor. Biochem Biophys Res Commun. 2010;396:1030–5.
10. Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, et al. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012;483:350–4.
11. Gotoh C, Hong YH, Iga T, Hishikawa D, Suzuki Y, Song SH, Choi KC, Adachi T, Hirasawa A, Tsujimoto G, Sasaki S, Roh SG. The regulation of adipogenesis through GPR120. Biochem Biophys Res Commun. 2007;9:591–7.
12. Enos RT, Velázquez KT, McClellan JL, Cranford TL, Walla MD, Murphy EA. Reducing the dietary omega-6:omega-3 utilizing α-linolenic acid; not a sufficient therapy for attenuating high-fat-diet-induced obesity development nor related detrimental metabolic and adipose tissue inflammatory outcomes. PLoS One. 2014;14:e94897.
13. Paulsen SJ, Larsen LK, Hansen G, Chelur S, Larsen PJ, Vrang N. Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion. PLoS One. 2014;10:e88227.
14. Cornall LM, Mathai ML, Hryciw DH, McAinch AJ. Diet-induced obesity up-regulates the abundance of GPR43 and GPR120 in a tissue specific manner. Cell Physiol Biochem. 2011;28:949–58.
15. Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939–51.
16. Kris-Etherton PM, Taylor DS, Yu-Poth S, Huth P, Moriarty K, Fishell V, et al. Polyunsaturated fatty acids in the food chain in the United States. Am J Clin Nutr. 2000;71:179S–88S.
17. 357 in the C-terminal tail. Biochem Pharmacol. 2014;87:650–9.
18. Tanaka T, Yano T, Adachi T, Koshimizu TA, Hirasawa A, Tsujimoto G. Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells. Naunyn Schmiedebergs Arch Pharmacol. 2008;377:515–22.
19. Xiong Y, Swaminath G, Cao Q, Yang L, Guo Q, Salomonis H, et al. Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. Mol Cell Endocrinol. 2013;369:119–29.
20. Widmayer P, Goldschmid H, Henkel H, Küper M, Königsrainer A, Breer H. High-fat feeding affects the number of GPR120 cells and enteroendocrine cells in the mouse stomach. Front Physiol. 2015;6(53):1–6.
21. Duca FA, Swartz TD, Sakar Y, Covasa M. Decreased intestinal nutrient response in diet-induced obese rats: role of gut peptides and nutrient receptors. Int J Obes (Lond). 2013;37:375–81.
22. Lim GE, Xu M, Sun J, Jin T, Brubaker PL. The Rho guanosine 5′-triphosphatase, cell division cycle 42, is required for insulin-induced actin remodeling and glucogan-like peptide-1 secretion in the intestinal endocrine L cell. Endocrinology. 2009;150:5249–61.
23. Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z, Tschopp J, Zhou R. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013;38:1154–63.
24. Mobraten K, Haug TM, Kleiveland CR, Lea T. Omega-3 and omega-6 PUFAs induce the same GPR120-mediated signalling events, but with different kinetics and intensity in Caco-2 cells. Lipids Health Dis. 2013;12:101.
25. Li X, Yu Y, Funk CD. Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4). FASEB J. 2013;27:4987–97.
26. 2 and plays an anti-inflammatory role in macrophages. Immunology. 2014;143:81–95.
27. Wellhauser L, Belsham DD. Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons. J Neuroinflammation. 2014;11:60.
28. Tsukahara T, Watanabe K, Watanabe T, Yamagami H, Sogawa M, Tanigawa T, et al. Tumor necrosis factor α decreases glucagon-like peptide-2 expression by up-regulating G-protein-coupled receptor 120 in Crohn disease. Am J Pathol. 2015;185:185–96.