The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A2 via GPR120 receptor to produce prostaglandin E2 and plays an anti-inflammatory role in macrophages

Immunology

Volumn 143, Issue 1, 2014, Pages 81-95

  Liu, Yueqin ^a   Chen, Li Yuan ^a   Sokolowska, Milena ^a   Eberlein, Michael ^a,b   Alsaaty, Sara ^a   Martinez Anton, Asuncion ^a   Logun, Carolea ^a   Qi, Hai Yan ^a   Shelhamer, James H ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

Cytokines; Inflammation; Lipid mediators; Signal transduction

Indexed keywords

ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; BETA ARRESTIN 2; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; DOCOSAHEXAENOIC ACID; FISH OIL; G PROTEIN COUPLED RECEPTOR 120; GW 9508; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE RELEASE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; SIGNAL TRANSDUCTION;

CYTOKINES; INFLAMMATION; LIPID MEDIATORS; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CYTOPLASM; DINOPROSTONE; DOCOSAHEXAENOIC ACIDS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FISH OILS; HUMANS; INFLAMMATION; MACROPHAGES; METHYLAMINES; MICE; PHOSPHOLIPASES A2; PROPIONATES; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84904904848     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/imm.12296     Document Type: Article

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