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Volumn 9, Issue 5, 2015, Pages 633-654

Latest developments in our understanding of the pathogenesis of mesothelioma and the design of targeted therapies

Author keywords

Asbestos; Aspirin; BAP1; Carcinogenesis; HMGB1; Immunotherapy; Mesothelioma; Molecular therapy; Polyclonal tumors

Indexed keywords

AMATUXIMAB; ANETUMAB RAVTANSINE; ARF PROTEIN; ATEZOLIZUMAB; AVELUMAB; BMS 986148; BORTEZOMIB; CANCER VACCINE; CELECOXIB; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLOOXYGENASE 2 INHIBITOR; CYCLOPHOSPHAMIDE; FOCAL ADHESION KINASE 1; FRESOLIMUMAB; IMMUNOMODULATING AGENT; IPILIMUMAB; MERLIN; MESOTHELIN; MICRORNA; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TP41.2; NIVOLUMAB; NONSTEROID ANTIINFLAMMATORY AGENT; ONCOLYTIC VIRUS; PEGARGIMINASE; PEMBROLIZUMAB; PROTEIN TYROSINE KINASE INHIBITOR; TICILIMUMAB; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84941358675     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1586/17476348.2015.1081066     Document Type: Review
Times cited : (50)

References (260)
  • 1
    • 80054885219 scopus 로고    scopus 로고
    • Malignant mesothelioma: Facts, myths, and hypotheses
    • Carbone M, Ly BH, Dodson RF, et al. Malignant mesothelioma: facts, myths, and hypotheses. J Cell Physiol 2012;227(1): 44-58
    • (2012) J Cell Physiol , vol.227 , Issue.1 , pp. 44-58
    • Carbone, M.1    Ly, B.H.2    Dodson, R.F.3
  • 2
    • 84910467774 scopus 로고
    • Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province
    • Wagner JC, Sleggs CA, Marchand P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province. Br J Ind Med 1960;17:260-71
    • (1960) Br J Ind Med , vol.17 , pp. 260-271
    • Wagner, J.C.1    Sleggs, C.A.2    Marchand, P.3
  • 3
    • 84855381356 scopus 로고    scopus 로고
    • Differences among peritoneal and pleural mesothelioma: Data from the Lombardy Region Mesothelioma Register (Italy
    • Mensi C, Bonzini M, Macchione M, et al. Differences among peritoneal and pleural mesothelioma: data from the Lombardy Region Mesothelioma Register (Italy). Med Lav 2011;102(5):409-16
    • (2011) Med Lav , vol.102 , Issue.5 , pp. 409-416
    • Mensi, C.1    Bonzini, M.2    Macchione, M.3
  • 4
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21(14): 2636-44
    • (2003) J Clin Oncol , vol.21 , Issue.14 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3
  • 5
    • 84887882312 scopus 로고    scopus 로고
    • Diffuse mesothelioma of the peritoneum: A pathological study of 64 tumours treated with cytoreductive therapy
    • Lee M, Alexander HR, Burke A. Diffuse mesothelioma of the peritoneum: A pathological study of 64 tumours treated with cytoreductive therapy. Pathology 2013; 45(5):464-73
    • (2013) Pathology , vol.45 , Issue.5 , pp. 464-473
    • Lee, M.1    Alexander, H.R.2    Burke, A.3
  • 6
    • 84964264799 scopus 로고    scopus 로고
    • Diffuse mesothelioma of the peritoneum: Correlation between histological and clinical parameters and survival in 73 patients
    • Liu S, Staats P, Lee M, et al. Diffuse mesothelioma of the peritoneum: Correlation between histological and clinical parameters and survival in 73 patients. Pathology 2014; 46(7):604-9
    • (2014) Pathology , vol.46 , Issue.7 , pp. 604-609
    • Liu, S.1    Staats, P.2    Lee, M.3
  • 7
    • 84939891182 scopus 로고    scopus 로고
    • Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent or progressive diffuse malignant peritoneal mesothelioma: Clinicopathologic characteristics and survival outcome
    • Ihemelandu C, Bijelic L, Sugarbaker PH. Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent or progressive diffuse malignant peritoneal mesothelioma: Clinicopathologic characteristics and survival outcome. Ann Surg Oncol 2015;22(5): 1680-5
    • (2015) Ann Surg Oncol , vol.22 , Issue.5 , pp. 1680-1685
    • Ihemelandu, C.1    Bijelic, L.2    Sugarbaker, P.H.3
  • 8
    • 0026741321 scopus 로고
    • Latent period for malignant mesothelioma of occupational origin
    • Lanphear BP, Buncher CR. Latent period for malignant mesothelioma of occupational origin. J Occup Med 1992;34(7):718-21
    • (1992) J Occup Med , vol.34 , Issue.7 , pp. 718-721
    • Lanphear, B.P.1    Buncher, C.R.2
  • 9
    • 84867845142 scopus 로고    scopus 로고
    • The ticking time-bomb of asbestos: Its insidious role in the development of malignant mesothelioma
    • Linton A, Vardy J, Clarke S, van Zandwijk N. The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma. Crit Rev Oncol Hematol 2012;84(2): 200-12
    • (2012) Crit Rev Oncol Hematol , vol.84 , Issue.2 , pp. 200-212
    • Linton, A.1    Vardy, J.2    Clarke, S.3    Van Zandwijk, N.4
  • 10
    • 77949328585 scopus 로고    scopus 로고
    • Health experts concerned over India's asbestos industry
    • Burki T. Health experts concerned over India's asbestos industry. Lancet 2010; 375(9715):626-7
    • (2010) Lancet , vol.375 , Issue.9715 , pp. 626-627
    • Burki, T.1
  • 11
    • 84878365444 scopus 로고    scopus 로고
    • Asbestos is not just asbestos: An unrecognised health hazard
    • Baumann F, Ambrosi JP, Carbone M. Asbestos is not just asbestos: An unrecognised health hazard. Lancet Oncol 2013;14(7):576-8
    • (2013) Lancet Oncol , vol.14 , Issue.7 , pp. 576-578
    • Baumann, F.1    Ambrosi, J.P.2    Carbone, M.3
  • 12
    • 0032134431 scopus 로고    scopus 로고
    • Asbestos fibers and interleukin-1 upregulate the formation of reactive nitrogen species in rat pleural mesothelial cells
    • Choe N, Tanaka S, Kagan E. Asbestos fibers and interleukin-1 upregulate the formation of reactive nitrogen species in rat pleural mesothelial cells. Am J Respir Cell Mol Biol 1998;19(2):226-36
    • (1998) Am J Respir Cell Mol Biol , vol.19 , Issue.2 , pp. 226-236
    • Choe, N.1    Tanaka, S.2    Kagan, E.3
  • 13
    • 79959243816 scopus 로고    scopus 로고
    • Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases
    • Huang SX, Jaurand MC, Kamp DW, et al. Role of mutagenicity in asbestos fiber-induced carcinogenicity and other diseases. J Toxicol Environ Health B Crit Rev 2011;14(1-4):179-245
    • (2011) J Toxicol Environ Health B Crit Rev , vol.14 , Issue.1-4 , pp. 179-245
    • Huang, S.X.1    Jaurand, M.C.2    Kamp, D.W.3
  • 14
    • 84880273681 scopus 로고    scopus 로고
    • Molecular pathogenesis of malignant mesothelioma
    • Sekido Y. Molecular pathogenesis of malignant mesothelioma. Carcinogenesis 2013;34(7):1413-19
    • (2013) Carcinogenesis , vol.34 , Issue.7 , pp. 1413-1419
    • Sekido, Y.1
  • 15
    • 77955446834 scopus 로고    scopus 로고
    • Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation
    • Yang H, Rivera Z, Jube S, et al. Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc Natl Acad Sci USA 2010;107(28):12611-16
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.28 , pp. 12611-12616
    • Yang, H.1    Rivera, Z.2    Jube, S.3
  • 16
    • 84863599924 scopus 로고    scopus 로고
    • Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma
    • Jube S, Rivera ZS, Bianchi ME, et al. Cancer cell secretion of the DAMP protein HMGB1 supports progression in malignant mesothelioma. Cancer Res 2012;72(13): 3290-301
    • (2012) Cancer Res , vol.72 , Issue.13 , pp. 3290-3301
    • Jube, S.1    Rivera, Z.S.2    Bianchi, M.E.3
  • 17
    • 84886661068 scopus 로고    scopus 로고
    • Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-alpha signaling
    • Qi F, Okimoto G, Jube S, et al. Continuous exposure to chrysotile asbestos can cause transformation of human mesothelial cells via HMGB1 and TNF-alpha signaling. Am J Pathol 2013; 183(5):1654-66
    • (2013) Am J Pathol , vol.183 , Issue.5 , pp. 1654-1666
    • Qi, F.1    Okimoto, G.2    Jube, S.3
  • 18
    • 33745892099 scopus 로고    scopus 로고
    • TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis
    • Yang H, Bocchetta M, Kroczynska B, et al. TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci USA 2006;103(27):10397-402
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.27 , pp. 10397-10402
    • Yang, H.1    Bocchetta, M.2    Kroczynska, B.3
  • 19
    • 0035835437 scopus 로고    scopus 로고
    • Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey
    • Roushdy-Hammady I, Siegel J, Emri S, et al. Genetic-susceptibility factor and malignant mesothelioma in the Cappadocian region of Turkey. Lancet 2001;357(9254):444-5
    • (2001) Lancet , vol.357 , Issue.9254 , pp. 444-445
    • Roushdy-Hammady, I.1    Siegel, J.2    Emri, S.3
  • 20
    • 33744913033 scopus 로고    scopus 로고
    • Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey
    • Dogan AU, Baris YI, Dogan M, et al. Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey. Cancer Res 2006; 66(10):5063-8
    • (2006) Cancer Res , vol.66 , Issue.10 , pp. 5063-5068
    • Dogan, A.U.1    Baris, Y.I.2    Dogan, M.3
  • 21
    • 79955877144 scopus 로고    scopus 로고
    • Pleural mesothelioma in New Caledonia: Associations with environmental risk factors
    • Baumann F, Maurizot P, Mangeas M, et al. Pleural mesothelioma in New Caledonia: Associations with environmental risk factors. Environ Health Perspect 2011;119(5): 695-700
    • (2011) Environ Health Perspect , vol.119 , Issue.5 , pp. 695-700
    • Baumann, F.1    Maurizot, P.2    Mangeas, M.3
  • 22
    • 80052019417 scopus 로고    scopus 로고
    • Erionite exposure in North Dakota and Turkish villages with mesothelioma
    • Carbone M, Baris YI, Bertino P, et al. Erionite exposure in North Dakota and Turkish villages with mesothelioma. Proc Natl Acad Sci USA 2011;108(33):13618-23
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.33 , pp. 13618-13623
    • Carbone, M.1    Baris, Y.I.2    Bertino, P.3
  • 23
    • 84938266924 scopus 로고    scopus 로고
    • The presence of asbestos in the natural environment is likely related to mesothelioma in young individuals and women from Southern Nevada
    • Baumann F, Buck BJ, Metcalf RV, et al. The Presence of Asbestos in the Natural Environment is Likely Related to Mesothelioma in Young Individuals and Women from Southern Nevada. J Thorac Oncol 2015;10(5):731-7
    • (2015) J Thorac Oncol , vol.10 , Issue.5 , pp. 731-737
    • Baumann, F.1    Buck, B.J.2    Metcalf, R.V.3
  • 24
    • 80053385701 scopus 로고    scopus 로고
    • Germline BAP1 mutations predispose to malignant mesothelioma
    • Testa JR, Cheung M, Pei J, et al. Germline BAP1 mutations predispose to malignant mesothelioma. Nat Genet 2011;43(10): 1022-5
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 1022-1025
    • Testa, J.R.1    Cheung, M.2    Pei, J.3
  • 26
    • 40149090140 scopus 로고    scopus 로고
    • Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: Results in 663 patients
    • Flores RM, Pass HI, Seshan VE, et al. Extrapleural pneumonectomy versus pleurectomy/decortication in the surgical management of malignant pleural mesothelioma: results in 663 patients. J Thorac Cardiovasc Surg 2008;135(3): 620-6
    • (2008) J Thorac Cardiovasc Surg , vol.135 , Issue.3 , pp. 620-626
    • Flores, R.M.1    Pass, H.I.2    Seshan, V.E.3
  • 27
    • 70349743978 scopus 로고    scopus 로고
    • Surgical options in malignant pleural mesothelioma: Extrapleural pneumonectomy or pleurectomy/decortication
    • Flores RM. Surgical options in malignant pleural mesothelioma: Extrapleural pneumonectomy or pleurectomy/decortication. Semin Thorac Cardiovasc Surg 2009;21(2):149-53
    • (2009) Semin Thorac Cardiovasc Surg , vol.21 , Issue.2 , pp. 149-153
    • Flores, R.M.1
  • 28
    • 84881661548 scopus 로고    scopus 로고
    • Radical pleurectomy and photodynamic therapy for malignant pleural mesothelioma
    • Friedberg JS. Radical pleurectomy and photodynamic therapy for malignant pleural mesothelioma. Ann Cardiothorac Surg 2012;1(4):472-80
    • (2012) Ann Cardiothorac Surg , vol.1 , Issue.4 , pp. 472-480
    • Friedberg, J.S.1
  • 29
    • 84926483527 scopus 로고    scopus 로고
    • Real-time treatment light dose guidance of Pleural PDT: An update
    • Epub ahead of print]
    • Zhu TC, Kim MM, Jacques SL, et al. Real-time treatment light dose guidance of Pleural PDT: An update. Proc SPIE Int Soc Opt Eng 9308 2015. [Epub ahead of print]
    • (2015) Proc SPIE Int Soc Opt Eng 9308
    • Zhu, T.C.1    Kim, M.M.2    Jacques, S.L.3
  • 30
    • 0031300337 scopus 로고    scopus 로고
    • Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma
    • Pass HI, Temeck BK, Kranda K, et al. Phase III randomized trial of surgery with or without intraoperative photodynamic therapy and postoperative immunochemotherapy for malignant pleural mesothelioma. Ann Surg Oncol 1997;4(8): 628-33
    • (1997) Ann Surg Oncol , vol.4 , Issue.8 , pp. 628-633
    • Pass, H.I.1    Temeck, B.K.2    Kranda, K.3
  • 31
    • 79957735482 scopus 로고    scopus 로고
    • Photodynamic therapy and the evolution of a lung-sparing surgical treatment for mesothelioma
    • Friedberg JS, Mick R, Culligan M, et al. Photodynamic therapy and the evolution of a lung-sparing surgical treatment for mesothelioma. Ann Thorac Surg 2011; 91(6):1738-45
    • (2011) Ann Thorac Surg , vol.91 , Issue.6 , pp. 1738-1745
    • Friedberg, J.S.1    Mick, R.2    Culligan, M.3
  • 32
    • 84860249120 scopus 로고    scopus 로고
    • Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma
    • 1658-65.discussion
    • Friedberg JS, Culligan MJ, Mick R, et al. Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma. Ann Thorac Surg 2012; 93(5):1658-65.discussion 1665-1657
    • (2012) Ann Thorac Surg , vol.93 , Issue.5 , pp. 1665-1657
    • Friedberg, J.S.1    Culligan, M.J.2    Mick, R.3
  • 33
    • 84930924639 scopus 로고    scopus 로고
    • Intrapleural photodynamic therapy for mesothelioma: What place and which future?
    • Munck C, Mordon SR, Scherpereel A, et al. Intrapleural Photodynamic Therapy for Mesothelioma: What Place and Which Future? Ann Thorac Surg 2015;99(6): 2237-45
    • (2015) Ann Thorac Surg , vol.99 , Issue.6 , pp. 2237-2245
    • Munck, C.1    Mordon, S.R.2    Scherpereel, A.3
  • 34
    • 20444417438 scopus 로고    scopus 로고
    • Induction chemotherapy, extrapleural pneumonectomy, and radiotherapy in the treatment of malignant pleural mesothelioma: The Memorial Sloan-Kettering experience
    • Flores RM. Induction chemotherapy, extrapleural pneumonectomy, and radiotherapy in the treatment of malignant pleural mesothelioma: The Memorial Sloan-Kettering experience. Lung Cancer 2005;49(Suppl 1):S71-4
    • (2005) Lung Cancer , vol.49 , pp. S71-S74
    • Flores, R.M.1
  • 35
    • 27244447448 scopus 로고    scopus 로고
    • Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: An intergroup study of the european organisation for research and treatment of cancer lung cancer group and the national cancer institute of Canada
    • van Meerbeeck JP, Gaafar R, Manegold C, et al. Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: An intergroup study of the european organisation for research and treatment of cancer lung cancer group and the national cancer institute of Canada. J Clin Oncol 2005;23(28):6881-9
    • (2005) J Clin Oncol , vol.23 , Issue.28 , pp. 6881-6889
    • Van Meerbeeck, J.P.1    Gaafar, R.2    Manegold, C.3
  • 36
    • 40249088552 scopus 로고    scopus 로고
    • Advances in the systemic therapy of malignant pleural mesothelioma
    • Fennell DA, Gaudino G, O'Byrne KJ, et al. Advances in the systemic therapy of malignant pleural mesothelioma. Nat Clin Pract Oncol 2008;5(3):136-47
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.3 , pp. 136-147
    • Fennell, D.A.1    Gaudino, G.2    O'Byrne, K.J.3
  • 37
    • 74649084445 scopus 로고    scopus 로고
    • Second-line treatment for malignant pleural mesothelioma
    • Ceresoli GL, Zucali PA, Gianoncelli L, et al. Second-line treatment for malignant pleural mesothelioma. Cancer Treat Rev 2010;36(1):24-32
    • (2010) Cancer Treat Rev , vol.36 , Issue.1 , pp. 24-32
    • Ceresoli, G.L.1    Zucali, P.A.2    Gianoncelli, L.3
  • 38
    • 84924766219 scopus 로고    scopus 로고
    • Evaluation of clonal origin of malignant mesothelioma
    • Comertpay S, Pastorino S, Tanji M, et al. Evaluation of clonal origin of malignant mesothelioma. J Transl Med 2014;12:301
    • (2014) J Transl Med , vol.12 , pp. 301
    • Comertpay, S.1    Pastorino, S.2    Tanji, M.3
  • 39
    • 0035944823 scopus 로고    scopus 로고
    • Familial malignant mesothelioma
    • Saracci R, Simonato L. Familial malignant mesothelioma. Lancet 2001;358(9295): 1813-14
    • (2001) Lancet , vol.358 , Issue.9295 , pp. 1813-1814
    • Saracci, R.1    Simonato, L.2
  • 40
    • 84865461263 scopus 로고    scopus 로고
    • BAP1 cancer syndrome: Malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs
    • Carbone M, Ferris LK, Baumann F, et al. BAP1 cancer syndrome: malignant mesothelioma, uveal and cutaneous melanoma, and MBAITs. J Transl Med 2012;10:179
    • (2012) J Transl Med , vol.10 , pp. 179
    • Carbone, M.1    Ferris, L.K.2    Baumann, F.3
  • 41
    • 80053386896 scopus 로고    scopus 로고
    • Germline mutations in BAP1 predispose to melanocytic tumors
    • Wiesner T, Obenauf AC, Murali R, et al. Germline mutations in BAP1 predispose to melanocytic tumors. Nat Genet 2011; 43(10):1018-21
    • (2011) Nat Genet , vol.43 , Issue.10 , pp. 1018-1021
    • Wiesner, T.1    Obenauf, A.C.2    Murali, R.3
  • 42
    • 84920876186 scopus 로고    scopus 로고
    • BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations
    • Piris A, Mihm MC Jr, Hoang MP. BAP1 and BRAFV600E expression in benign and malignant melanocytic proliferations. Hum Pathol 2015;46(2): 239-45
    • (2015) Hum Pathol , vol.46 , Issue.2 , pp. 239-245
    • Piris, A.1    Mihm, M.C.2    Hoang, M.P.3
  • 43
    • 84856023369 scopus 로고    scopus 로고
    • Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers
    • Abdel-Rahman MH, Pilarski R, Cebulla CM, et al. Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. J Med Genet 2011;48(12):856-9
    • (2011) J Med Genet , vol.48 , Issue.12 , pp. 856-859
    • Abdel-Rahman, M.H.1    Pilarski, R.2    Cebulla, C.M.3
  • 44
    • 84878846119 scopus 로고    scopus 로고
    • Germline BAP1 mutations predispose to renal cell carcinomas
    • Popova T, Hebert L, Jacquemin V, et al. Germline BAP1 mutations predispose to renal cell carcinomas. Am J Hum Genet 2013;92(6):974-80
    • (2013) Am J Hum Genet , vol.92 , Issue.6 , pp. 974-980
    • Popova, T.1    Hebert, L.2    Jacquemin, V.3
  • 45
    • 84888353882 scopus 로고    scopus 로고
    • Exome sequencing identifies frequent inactivating mutations in BAP1 ARID1A and PBRM1 in intrahepatic cholangiocarcinomas
    • Jiao Y, Pawlik TM, Anders RA, et al. Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas. Nat Genet 2013; 45(12):1470-3
    • (2013) Nat Genet , vol.45 , Issue.12 , pp. 1470-1473
    • Jiao, Y.1    Pawlik, T.M.2    Anders, R.A.3
  • 46
    • 84923048216 scopus 로고    scopus 로고
    • A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma
    • Epub ahead of print
    • Wadt KA, Aoude LG, Johansson P, et al. A recurrent germline BAP1 mutation and extension of the BAP1 tumor predisposition spectrum to include basal cell carcinoma. Clin Genet 2014; Epub ahead of print
    • (2014) Clin Genet
    • Wadt, K.A.1    Aoude, L.G.2    Johansson, P.3
  • 48
    • 84938286152 scopus 로고    scopus 로고
    • High incidence of somatic BAP1 alterations in sporadic malignant mesothelioma
    • Nasu M, Emi M, Pastorino S, et al. High Incidence of Somatic BAP1 Alterations in Sporadic Malignant Mesothelioma. J Thorac Oncol 2015;10(4):565-76
    • (2015) J Thorac Oncol , vol.10 , Issue.4 , pp. 565-576
    • Nasu, M.1    Emi, M.2    Pastorino, S.3
  • 49
    • 84860248968 scopus 로고    scopus 로고
    • Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma
    • Yoshikawa Y, Sato A, Tsujimura T, et al. Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma. Cancer Sci 2012;103(5):868-74
    • (2012) Cancer Sci , vol.103 , Issue.5 , pp. 868-874
    • Yoshikawa, Y.1    Sato, A.2    Tsujimura, T.3
  • 50
    • 84920940180 scopus 로고    scopus 로고
    • Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma
    • Guo G, Chmielecki J, Goparaju C, et al. Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma. Cancer Res 2015;75(2): 264-9
    • (2015) Cancer Res , vol.75 , Issue.2 , pp. 264-269
    • Guo, G.1    Chmielecki, J.2    Goparaju, C.3
  • 51
    • 84938287128 scopus 로고    scopus 로고
    • Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: A retrospective study
    • Lo Iacono M, Monica V, Righi L, et al. Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma: A retrospective study. J Thorac Oncol 2015;10(3):492-9
    • (2015) J Thorac Oncol , vol.10 , Issue.3 , pp. 492-499
    • Lo Iacono, M.1    Monica, V.2    Righi, L.3
  • 52
    • 84896044958 scopus 로고    scopus 로고
    • BAP1 protein is a progression factor in malignant pleural mesothelioma
    • Arzt L, Quehenberger F, Halbwedl I, et al. BAP1 protein is a progression factor in malignant pleural mesothelioma. Pathol Oncol Res 2014;20(1):145-51
    • (2014) Pathol Oncol Res , vol.20 , Issue.1 , pp. 145-151
    • Arzt, L.1    Quehenberger, F.2    Halbwedl, I.3
  • 53
    • 84978646172 scopus 로고    scopus 로고
    • Loss of expression of BAP1 predicts longer survival in mesothelioma
    • Farzin M, Toon CW, Clarkson A, et al. Loss of expression of BAP1 predicts longer survival in mesothelioma. Pathology 2015; 47(4):302-7
    • (2015) Pathology , vol.47 , Issue.4 , pp. 302-307
    • Farzin, M.1    Toon, C.W.2    Clarkson, A.3
  • 54
    • 85003053479 scopus 로고    scopus 로고
    • Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival
    • Baumann F, Flores E, Napolitano A, et al. Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival. Carcinogenesis 2015; 36(1):76-81
    • (2015) Carcinogenesis , vol.36 , Issue.1 , pp. 76-81
    • Baumann, F.1    Flores, E.2    Napolitano, A.3
  • 55
    • 15144342687 scopus 로고    scopus 로고
    • BAP1: A novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
    • Jensen DE, Proctor M, Marquis ST, et al. BAP1: A novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression. Oncogene 1998;16(9): 1097-112
    • (1998) Oncogene , vol.16 , Issue.9 , pp. 1097-1112
    • Jensen, D.E.1    Proctor, M.2    Marquis, S.T.3
  • 56
    • 52049085265 scopus 로고    scopus 로고
    • BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization
    • Ventii KH, Devi NS, Friedrich KL, et al. BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer Res 2008;68(17):6953-62
    • (2008) Cancer Res , vol.68 , Issue.17 , pp. 6953-6962
    • Ventii, K.H.1    Devi, N.S.2    Friedrich, K.L.3
  • 57
    • 77952429798 scopus 로고    scopus 로고
    • Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB
    • Scheuermann JC, de Ayala Alonso AG, Oktaba K, et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature 2010;465(7295):243-7
    • (2010) Nature , vol.465 , Issue.7295 , pp. 243-247
    • Scheuermann, J.C.1    De Ayala Alonso, A.G.2    Oktaba, K.3
  • 58
    • 64649106796 scopus 로고    scopus 로고
    • Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor
    • Misaghi S, Ottosen S, Izrael-Tomasevic A, et al. Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor Mol Cell Biol 2009;29(8):2181-92.
    • (2009) Mol Cell Biol , vol.29 , Issue.8 , pp. 2181-2192
    • Misaghi, S.1    Ottosen, S.2    Izrael-Tomasevic, A.3
  • 59
    • 71749110779 scopus 로고    scopus 로고
    • The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1
    • Machida YJ, Machida Y, Vashisht AA, et al. The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem 2009;284(49): 34179-88
    • (2009) J Biol Chem , vol.284 , Issue.49 , pp. 34179-34188
    • Machida, Y.J.1    Machida, Y.2    Vashisht, A.A.3
  • 60
    • 79955934205 scopus 로고    scopus 로고
    • An emerging model for BAP1's role in regulating cell cycle progression
    • Eletr ZM, Wilkinson KD. An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys 2011;60(1-2):3-11
    • (2011) Cell Biochem Biophys , vol.60 , Issue.1-2 , pp. 3-11
    • Eletr, Z.M.1    Wilkinson, K.D.2
  • 61
    • 77957853061 scopus 로고    scopus 로고
    • The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression
    • Yu H, Mashtalir N, Daou S, et al. The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol 2010;30(21):5071-85
    • (2010) Mol Cell Biol , vol.30 , Issue.21 , pp. 5071-5085
    • Yu, H.1    Mashtalir, N.2    Daou, S.3
  • 62
    • 84905995383 scopus 로고    scopus 로고
    • Germline mutations in BAP1 impair its function in DNA double-strand break repair
    • Ismail IH, Davidson R, Gagne JP, et al. Germline mutations in BAP1 impair its function in DNA double-strand break repair. Cancer Res 2014;74(16):4282-94
    • (2014) Cancer Res , vol.74 , Issue.16 , pp. 4282-4294
    • Ismail, I.H.1    Davidson, R.2    Gagne, J.P.3
  • 63
    • 84891912266 scopus 로고    scopus 로고
    • Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair
    • Yu H, Pak H, Hammond-Martel I, et al. Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repair. Proc Natl Acad Sci USA 2014; 111(1):285-90
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.1 , pp. 285-290
    • Yu, H.1    Pak, H.2    Hammond-Martel, I.3
  • 64
    • 84856023489 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma
    • Landreville S, Agapova OA, Matatall KA, et al. Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma. Clin Cancer Res 2012;18(2): 408-16
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 408-416
    • Landreville, S.1    Agapova, O.A.2    Matatall, K.A.3
  • 65
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006;5(9): 769-84
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 66
    • 0035184066 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma
    • Cao XX, Mohuiddin I, Ece F, et al. Histone deacetylase inhibitor downregulation of bcl-xl gene expression leads to apoptotic cell death in mesothelioma. Am J Respir Cell Mol Biol 2001;25(5):562-8
    • (2001) Am J Respir Cell Mol Biol , vol.25 , Issue.5 , pp. 562-568
    • Cao, X.X.1    Mohuiddin, I.2    Ece, F.3
  • 67
    • 0346725822 scopus 로고    scopus 로고
    • Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: Role of Bcl-xL down-regulation
    • Neuzil J, Swettenham E, Gellert N. Sensitization of mesothelioma to TRAIL apoptosis by inhibition of histone deacetylase: role of Bcl-xL down-regulation. Biochem Biophys Res Commun 2004; 314(1):186-91
    • (2004) Biochem Biophys Res Commun , vol.314 , Issue.1 , pp. 186-191
    • Neuzil, J.1    Swettenham, E.2    Gellert, N.3
  • 68
    • 1842481018 scopus 로고    scopus 로고
    • Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells
    • Nguyen DM, Schrump WD, Chen GA, et al. Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells. Clin Cancer Res 2004;10(5):1813-25
    • (2004) Clin Cancer Res , vol.10 , Issue.5 , pp. 1813-1825
    • Nguyen, D.M.1    Schrump, W.D.2    Chen, G.A.3
  • 69
    • 65649105510 scopus 로고    scopus 로고
    • A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL
    • Symanowski J, Vogelzang N, Zawel L, et al. A histone deacetylase inhibitor LBH589 downregulates XIAP in mesothelioma cell lines which is likely responsible for increased apoptosis with TRAIL. J Thorac Oncol 2009;4(2):149-60
    • (2009) J Thorac Oncol , vol.4 , Issue.2 , pp. 149-160
    • Symanowski, J.1    Vogelzang, N.2    Zawel, L.3
  • 70
    • 65249096105 scopus 로고    scopus 로고
    • Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma
    • Vandermeers F, Hubert P, Delvenne P, et al. Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma. Clin Cancer Res 2009;15(8):2818-28
    • (2009) Clin Cancer Res , vol.15 , Issue.8 , pp. 2818-2828
    • Vandermeers, F.1    Hubert, P.2    Delvenne, P.3
  • 71
    • 84979868471 scopus 로고    scopus 로고
    • Loss of the deubiquitylase BAP1 alters class i histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors
    • Epub ahead of print
    • Sacco JJ, Kenyani J, Butt Z, et al. Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors. Oncotarget 2015; Epub ahead of print
    • (2015) Oncotarget
    • Sacco, J.J.1    Kenyani, J.2    Butt, Z.3
  • 72
    • 21244464349 scopus 로고    scopus 로고
    • Phase i study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
    • Kelly WK, O'Connor OA, Krug LM, et al. Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J Clin Oncol 2005;23(17):3923-31
    • (2005) J Clin Oncol , vol.23 , Issue.17 , pp. 3923-3931
    • Kelly, W.K.1    O'Connor, O.A.2    Krug, L.M.3
  • 73
    • 84933526775 scopus 로고    scopus 로고
    • Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): A phase 3, double-blind, randomised, placebo-controlled trial
    • Krug LM, Kindler HL, Calvert H, et al. Vorinostat in patients with advanced malignant pleural mesothelioma who have progressed on previous chemotherapy (VANTAGE-014): A phase 3, double-blind, randomised, placebo-controlled trial. Lancet Oncol 2015;16(4):447-56
    • (2015) Lancet Oncol , vol.16 , Issue.4 , pp. 447-456
    • Krug, L.M.1    Kindler, H.L.2    Calvert, H.3
  • 74
    • 61549123363 scopus 로고    scopus 로고
    • Phase II study of belinostat (PXD101), a histone deacetylase inhibitor, for second line therapy of advanced malignant pleural mesothelioma
    • Ramalingam SS, Belani CP, Ruel C, et al. Phase II study of belinostat (PXD101), a histone deacetylase inhibitor, for second line therapy of advanced malignant pleural mesothelioma. J Thorac Oncol 2009;4(1): 97-101
    • (2009) J Thorac Oncol , vol.4 , Issue.1 , pp. 97-101
    • Ramalingam, S.S.1    Belani, C.P.2    Ruel, C.3
  • 75
    • 84866467141 scopus 로고    scopus 로고
    • Loss of the tumor suppressor BAP1 causes myeloid transformation
    • Dey A, Seshasayee D, Noubade R, et al. Loss of the tumor suppressor BAP1 causes myeloid transformation. Science 2012; 337(6101):1541-6
    • (2012) Science , vol.337 , Issue.6101 , pp. 1541-1546
    • Dey, A.1    Seshasayee, D.2    Noubade, R.3
  • 76
    • 84963936069 scopus 로고    scopus 로고
    • Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma
    • Epub ahead of print]
    • Napolitano A, Pellegrini L, Dey A, et al. Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma. Oncogene 2015. [Epub ahead of print]
    • (2015) Oncogene
    • Napolitano, A.1    Pellegrini, L.2    Dey, A.3
  • 77
    • 84907000329 scopus 로고    scopus 로고
    • Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma
    • Cornelissen R, Lievense LA, Maat AP, et al. Ratio of intratumoral macrophage phenotypes is a prognostic factor in epithelioid malignant pleural mesothelioma. PLoS One 2014;9(9):e106742
    • (2014) PLoS One , vol.9 , Issue.9 , pp. e106742
    • Cornelissen, R.1    Lievense, L.A.2    Maat, A.P.3
  • 78
    • 24944522720 scopus 로고    scopus 로고
    • A mouse model recapitulating molecular features of human mesothelioma
    • Altomare DA, Vaslet CA, Skele KL, et al. A mouse model recapitulating molecular features of human mesothelioma. Cancer Res 2005;65(18):8090-5
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8090-8095
    • Altomare, D.A.1    Vaslet, C.A.2    Skele, K.L.3
  • 79
    • 0028818921 scopus 로고
    • High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas
    • Bianchi AB, Mitsunaga SI, Cheng JQ, et al. High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc Natl Acad Sci USA 1995;92(24):10854-8
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.24 , pp. 10854-10858
    • Bianchi, A.B.1    Mitsunaga, S.I.2    Cheng, J.Q.3
  • 80
    • 84865720268 scopus 로고    scopus 로고
    • New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment
    • Ladanyi M, Zauderer MG, Krug LM, et al. New strategies in pleural mesothelioma: BAP1 and NF2 as novel targets for therapeutic development and risk assessment. Clin Cancer Res 2012;18(17): 4485-90
    • (2012) Clin Cancer Res , vol.18 , Issue.17 , pp. 4485-4490
    • Ladanyi, M.1    Zauderer, M.G.2    Krug, L.M.3
  • 81
    • 67651230554 scopus 로고    scopus 로고
    • Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling
    • Lopez-Lago MA, Okada T, Murillo MM, et al. Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling. Mol Cell Biol 2009; 29(15):4235-49
    • (2009) Mol Cell Biol , vol.29 , Issue.15 , pp. 4235-4249
    • Lopez-Lago, M.A.1    Okada, T.2    Murillo, M.M.3
  • 82
    • 84964076211 scopus 로고    scopus 로고
    • S0722: Everolimus in treating patients with pleural malignant mesothelioma that cannot be removed by surgery. Available from
    • S0722: Everolimus in treating patients with pleural malignant mesothelioma that cannot be removed by surgery. Available from: www.clinicaltrials.gov/ct2/show/NCT00770120
  • 83
    • 84922246665 scopus 로고    scopus 로고
    • SWOG S0722: Phase II study of mTOR inhibitor everolimus (RAD001) in advanced malignant pleural mesothelioma (MPM)
    • Ou SH, Moon J, Garland LL, et al. SWOG S0722: phase II study of mTOR inhibitor everolimus (RAD001) in advanced malignant pleural mesothelioma (MPM). J Thorac Oncol 2015;10(2):387-91
    • (2015) J Thorac Oncol , vol.10 , Issue.2 , pp. 387-391
    • Ou, S.H.1    Moon, J.2    Garland, L.L.3
  • 85
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo A, Ma L, Teruya-Feldstein J, et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008;118(9):3065-74
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 3065-3074
    • Carracedo, A.1    Ma, L.2    Teruya-Feldstein, J.3
  • 86
    • 84907189396 scopus 로고    scopus 로고
    • MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma
    • Kanteti R, Dhanasingh I, Kawada I, et al. MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesothelioma. PLoS ONE 2014;9(9):e105919
    • (2014) PLoS ONE , vol.9 , Issue.9 , pp. e105919
    • Kanteti, R.1    Dhanasingh, I.2    Kawada, I.3
  • 89
    • 84900539635 scopus 로고    scopus 로고
    • Multipoint targeting of the PI3K/mTOR pathway in mesothelioma
    • Zhou S, Liu L, Li H, et al. Multipoint targeting of the PI3K/mTOR pathway in mesothelioma. Br J Cancer 2014;110(10): 2479-88
    • (2014) Br J Cancer , vol.110 , Issue.10 , pp. 2479-2488
    • Zhou, S.1    Liu, L.2    Li, H.3
  • 90
    • 21744435478 scopus 로고    scopus 로고
    • The role of focal-adhesion kinase in cancer - A new therapeutic opportunity
    • McLean GW, Carragher NO, Avizienyte E, et al. The role of focal-adhesion kinase in cancer-a new therapeutic opportunity. Nat Rev Cancer 2005;5(7):505-15
    • (2005) Nat Rev Cancer , vol.5 , Issue.7 , pp. 505-515
    • McLean, G.W.1    Carragher, N.O.2    Avizienyte, E.3
  • 91
    • 33749188461 scopus 로고    scopus 로고
    • Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK
    • Poulikakos PI, Xiao GH, Gallagher R, et al. Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK. Oncogene 2006;25(44):5960-8
    • (2006) Oncogene , vol.25 , Issue.44 , pp. 5960-5968
    • Poulikakos, P.I.1    Xiao, G.H.2    Gallagher, R.3
  • 95
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan D. The hippo signaling pathway in development and cancer. Dev Cell 2010; 19(4):491-505
    • (2010) Dev Cell , vol.19 , Issue.4 , pp. 491-505
    • Pan, D.1
  • 96
    • 55849132186 scopus 로고    scopus 로고
    • The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP
    • Striedinger K, VandenBerg SR, Baia GS, et al. The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP. Neoplasia 2008;10(11): 1204-12
    • (2008) Neoplasia , vol.10 , Issue.11 , pp. 1204-1212
    • Striedinger, K.1    VandenBerg, S.R.2    Baia, G.S.3
  • 97
    • 56049125036 scopus 로고    scopus 로고
    • YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
    • Yokoyama T, Osada H, Murakami H, et al. YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. Carcinogenesis 2008;29(11):2139-46
    • (2008) Carcinogenesis , vol.29 , Issue.11 , pp. 2139-2146
    • Yokoyama, T.1    Osada, H.2    Murakami, H.3
  • 98
    • 84870807773 scopus 로고    scopus 로고
    • YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes
    • Mizuno T, Murakami H, Fujii M, et al. YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene 2012;31(49):5117-22
    • (2012) Oncogene , vol.31 , Issue.49 , pp. 5117-5122
    • Mizuno, T.1    Murakami, H.2    Fujii, M.3
  • 99
    • 84862605178 scopus 로고    scopus 로고
    • Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
    • Liu-Chittenden Y, Huang B, Shim JS, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev 2012;26(12):1300-5
    • (2012) Genes Dev , vol.26 , Issue.12 , pp. 1300-1305
    • Liu-Chittenden, Y.1    Huang, B.2    Shim, J.S.3
  • 100
    • 84865708583 scopus 로고    scopus 로고
    • Role of hedgehog signaling in malignant pleural mesothelioma
    • Shi Y, Moura U, Opitz I, et al. Role of hedgehog signaling in malignant pleural mesothelioma. Clin Cancer Res 2012; 18(17):4646-56
    • (2012) Clin Cancer Res , vol.18 , Issue.17 , pp. 4646-4656
    • Shi, Y.1    Moura, U.2    Opitz, I.3
  • 101
    • 0036312569 scopus 로고    scopus 로고
    • Alterations of the p16(INK4) locus in human malignant mesothelial tumors
    • Hirao T, Bueno R, Chen CJ, et al. Alterations of the p16(INK4) locus in human malignant mesothelial tumors. Carcinogenesis 2002;23(7):1127-30
    • (2002) Carcinogenesis , vol.23 , Issue.7 , pp. 1127-1130
    • Hirao, T.1    Bueno, R.2    Chen, C.J.3
  • 102
    • 0028907620 scopus 로고
    • Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer
    • Sekido Y, Pass HI, Bader S, et al. Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res 1995;55(6): 1227-31
    • (1995) Cancer Res , vol.55 , Issue.6 , pp. 1227-1231
    • Sekido, Y.1    Pass, H.I.2    Bader, S.3
  • 103
    • 33748444562 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic changes in malignant mesothelioma
    • Musti M, Kettunen E, Dragonieri S, et al. Cytogenetic and molecular genetic changes in malignant mesothelioma. Cancer Genet Cytogenet 2006;170(1):9-15
    • (2006) Cancer Genet Cytogenet , vol.170 , Issue.1 , pp. 9-15
    • Musti, M.1    Kettunen, E.2    Dragonieri, S.3
  • 104
    • 79955442548 scopus 로고    scopus 로고
    • Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis
    • Altomare DA, Menges CW, Xu J, et al. Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS ONE 2011; 6(4):e18828
    • (2011) PLoS ONE , vol.6 , Issue.4 , pp. e18828
    • Altomare, D.A.1    Menges, C.W.2    Xu, J.3
  • 105
    • 84874625850 scopus 로고    scopus 로고
    • A potential therapeutic strategy for malignant mesothelioma with gene medicine
    • Tada Y, Shimada H, Hiroshima K, Tagawa M. A potential therapeutic strategy for malignant mesothelioma with gene medicine. Biomed Res Int 2013;2013:572609
    • (2013) Biomed Res Int , vol.2013 , pp. 572609
    • Tada, Y.1    Shimada, H.2    Hiroshima, K.3    Tagawa, M.4
  • 106
    • 0032543305 scopus 로고    scopus 로고
    • Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression
    • Frizelle SP, Grim J, Zhou J, et al. Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression. Oncogene 1998;16(24): 3087-95
    • (1998) Oncogene , vol.16 , Issue.24 , pp. 3087-3095
    • Frizelle, S.P.1    Grim, J.2    Zhou, J.3
  • 107
    • 40549094291 scopus 로고    scopus 로고
    • Inhibition of both mesothelioma cell growth and Cdk4 activity following treatment with a TATp16INK4a peptide
    • Frizelle SP, Kratzke MG, Carreon RR, et al. Inhibition of both mesothelioma cell growth and Cdk4 activity following treatment with a TATp16INK4a peptide. Anticancer research 2008;28(1A):1-7
    • (2008) Anticancer Research , vol.28 , Issue.1 A , pp. 1-7
    • Frizelle, S.P.1    Kratzke, M.G.2    Carreon, R.R.3
  • 108
    • 79955459524 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases in malignant mesothelioma as a rationale for combination targeted therapy
    • Brevet M, Shimizu S, Bott MJ, et al. Coactivation of receptor tyrosine kinases in malignant mesothelioma as a rationale for combination targeted therapy. J Thorac Oncol 2011;6(5):864-74
    • (2011) J Thorac Oncol , vol.6 , Issue.5 , pp. 864-874
    • Brevet, M.1    Shimizu, S.2    Bott, M.J.3
  • 109
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009;9(1):28-39
    • (2009) Nat Rev Cancer , vol.9 , Issue.1 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 110
    • 79955020053 scopus 로고    scopus 로고
    • Antiangiogenic therapies for malignant pleural mesothelioma
    • Yano S, Li Q, Wang W, et al. Antiangiogenic therapies for malignant pleural mesothelioma. Front Biosci (Landmark Ed) 2011;16:740-8
    • (2011) Front Biosci (Landmark Ed , vol.16 , pp. 740-748
    • Yano, S.1    Li, Q.2    Wang, W.3
  • 111
    • 0035068834 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma
    • Strizzi L, Catalano A, Vianale G, et al. Vascular endothelial growth factor is an autocrine growth factor in human malignant mesothelioma. J Pathol 2001;193(4):468-75
    • (2001) J Pathol , vol.193 , Issue.4 , pp. 468-475
    • Strizzi, L.1    Catalano, A.2    Vianale, G.3
  • 113
    • 84883149018 scopus 로고    scopus 로고
    • Phase II study of pemetrexed and carboplatin plus bevacizumab as first-line therapy in malignant pleural mesothelioma
    • Ceresoli GL, Zucali PA, Mencoboni M, et al. Phase II study of pemetrexed and carboplatin plus bevacizumab as first-line therapy in malignant pleural mesothelioma. Br J cancer 2013;109(3):552-8
    • (2013) Br J Cancer , vol.109 , Issue.3 , pp. 552-558
    • Ceresoli, G.L.1    Zucali, P.A.2    Mencoboni, M.3
  • 114
    • 84865181805 scopus 로고    scopus 로고
    • A multicenter phase II study of cisplatin, pemetrexed, and bevacizumab in patients with advanced malignant mesothelioma
    • Dowell JE, Dunphy FR, Taub RN, et al. A multicenter phase II study of cisplatin, pemetrexed, and bevacizumab in patients with advanced malignant mesothelioma. Lung Cancer 2012;77(3):567-71
    • (2012) Lung Cancer , vol.77 , Issue.3 , pp. 567-571
    • Dowell, J.E.1    Dunphy, F.R.2    Taub, R.N.3
  • 115
    • 84864055587 scopus 로고    scopus 로고
    • Multicenter, double-blind, placebo-controlled, randomized phase II trial of gemcitabine/cisplatin plus bevacizumab or placebo in patients with malignant mesothelioma
    • Kindler HL, Karrison TG, Gandara DR, et al. Multicenter, double-blind, placebo-controlled, randomized phase II trial of gemcitabine/cisplatin plus bevacizumab or placebo in patients with malignant mesothelioma. J Clin Oncol 2012;30(20):2509-15
    • (2012) J Clin Oncol , vol.30 , Issue.20 , pp. 2509-2515
    • Kindler, H.L.1    Karrison, T.G.2    Gandara, D.R.3
  • 116
    • 84866158896 scopus 로고    scopus 로고
    • Cediranib in patients with malignant mesothelioma: A phase II trial of the University of Chicago Phase II Consortium
    • University of Chicago
    • Campbell NP, Kunnavakkam R, Leighl N, et al. Cediranib in patients with malignant mesothelioma: A phase II trial of the University of Chicago Phase II Consortium. Lung Cancer 2012;78(1):76-80
    • (2012) Lung Cancer , vol.78 , Issue.1 , pp. 76-80
    • Campbell, N.P.1    Kunnavakkam, R.2    Leighl, N.3
  • 117
    • 80054880979 scopus 로고    scopus 로고
    • Phase II study of cediranib in patients with malignant pleural mesothelioma: SWOG S0509
    • Garland LL, Chansky K, Wozniak AJ, et al. Phase II study of cediranib in patients with malignant pleural mesothelioma: SWOG S0509. J Thorac Oncol 2011;6(11):1938-45
    • (2011) J Thorac Oncol , vol.6 , Issue.11 , pp. 1938-1945
    • Garland, L.L.1    Chansky, K.2    Wozniak, A.J.3
  • 118
    • 80054897151 scopus 로고    scopus 로고
    • Brief report: A phase II study of sunitinib in malignant pleural mesothelioma. The NCIC Clinical Trials Group
    • Laurie SA, Gupta A, Chu Q, et al. Brief report: A phase II study of sunitinib in malignant pleural mesothelioma. the NCIC Clinical Trials Group. J Thorac Oncol 2011;6(11):1950-4
    • (2011) J Thorac Oncol , vol.6 , Issue.11 , pp. 1950-1954
    • Laurie, S.A.1    Gupta, A.2    Chu, Q.3
  • 119
    • 84865687005 scopus 로고    scopus 로고
    • A phase II study of intermittent sunitinib malate as second-line therapy in progressive malignant pleural mesothelioma
    • Nowak AK, Millward MJ, Creaney J, et al. A phase II study of intermittent sunitinib malate as second-line therapy in progressive malignant pleural mesothelioma. J Thorac Oncol 2012;7(9):1449-56
    • (2012) J Thorac Oncol , vol.7 , Issue.9 , pp. 1449-1456
    • Nowak, A.K.1    Millward, M.J.2    Creaney, J.3
  • 120
    • 84874112681 scopus 로고    scopus 로고
    • Sunitinib combined with pemetrexed and cisplatin: Results of a phase i dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma
    • Camidge DR, Blais N, Jonker DJ, et al. Sunitinib combined with pemetrexed and cisplatin: results of a phase I dose-escalation and pharmacokinetic study in patients with advanced solid malignancies, with an expanded cohort in non-small cell lung cancer and mesothelioma. Cancer Chemother Pharmacol 2013;71(2):307-19
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.2 , pp. 307-319
    • Camidge, D.R.1    Blais, N.2    Jonker, D.J.3
  • 121
    • 77958167230 scopus 로고    scopus 로고
    • A phase II study of sorafenib in malignant mesothelioma: Results of Cancer and Leukemia Group B 30307
    • Dubey S, Janne PA, Krug L, et al. A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307. J Thorac Oncol 2010;5(10):1655-61
    • (2010) J Thorac Oncol , vol.5 , Issue.10 , pp. 1655-1661
    • Dubey, S.1    Janne, P.A.2    Krug, L.3
  • 122
    • 84879501497 scopus 로고    scopus 로고
    • Phase 2 study of sorafenib in malignant mesothelioma previously treated with platinum-containing chemotherapy
    • Papa S, Popat S, Shah R, et al. Phase 2 study of sorafenib in malignant mesothelioma previously treated with platinum-containing chemotherapy. J Thorac Oncol 2013;8(6):783-7
    • (2013) J Thorac Oncol , vol.8 , Issue.6 , pp. 783-787
    • Papa, S.1    Popat, S.2    Shah, R.3
  • 123
    • 84860525842 scopus 로고    scopus 로고
    • Vatalanib in malignant mesothelioma: A phase II trial by the Cancer and Leukemia Group B (CALGB 30107
    • Jahan T, Gu L, Kratzke R, et al. Vatalanib in malignant mesothelioma: A phase II trial by the Cancer and Leukemia Group B (CALGB 30107). Lung Cancer 2012;76(3): 393-6
    • (2012) Lung Cancer , vol.76 , Issue.3 , pp. 393-396
    • Jahan, T.1    Gu, L.2    Kratzke, R.3
  • 124
    • 84861404077 scopus 로고    scopus 로고
    • Mesothelioma cell proliferation through autocrine activation of PDGF-betabeta receptor
    • Honda M, Kanno T, Fujita Y, et al. Mesothelioma cell proliferation through autocrine activation of PDGF-betabeta receptor. Cell Physiol Biochem 2012; 29(5-6):667-74
    • (2012) Cell Physiol Biochem , vol.29 , Issue.5-6 , pp. 667-674
    • Honda, M.1    Kanno, T.2    Fujita, Y.3
  • 125
    • 24144456982 scopus 로고    scopus 로고
    • Serum PDGF-AB in pleural mesothelioma
    • Filiberti R, Marroni P, Neri M, et al. Serum PDGF-AB in pleural mesothelioma. Tumour Biol 2005;26(5):221-6
    • (2005) Tumour Biol , vol.26 , Issue.5 , pp. 221-226
    • Filiberti, R.1    Marroni, P.2    Neri, M.3
  • 126
    • 0026046037 scopus 로고
    • Human malignant mesothelioma cell lines express PDGF beta-receptors whereas cultured normal mesothelial cells express predominantly PDGF alpha-receptors
    • Versnel MA, Claesson-Welsh L, Hammacher A, et al. Human malignant mesothelioma cell lines express PDGF beta-receptors whereas cultured normal mesothelial cells express predominantly PDGF alpha-receptors. Oncogene 1991; 6(11):2005-11
    • (1991) Oncogene , vol.6 , Issue.11 , pp. 2005-2011
    • Versnel, M.A.1    Claesson-Welsh, L.2    Hammacher, A.3
  • 127
    • 0030053330 scopus 로고    scopus 로고
    • Regulation of differential expression of platelet-derived growth factor alpha-and beta-receptor mRNA in normal and malignant human mesothelial cell lines
    • Langerak AW, van der Linden-van Beurden CA, Versnel MA. Regulation of differential expression of platelet-derived growth factor alpha-and beta-receptor mRNA in normal and malignant human mesothelial cell lines. Biochim Biophys Acta 1996;1305(1-2): 63-70
    • (1996) Biochim Biophys Acta , vol.1305 , Issue.1-2 , pp. 63-70
    • Langerak, A.W.1    Van Der Linden-Van Beurden, C.A.2    Versnel, M.A.3
  • 128
    • 0030041140 scopus 로고    scopus 로고
    • Expression of platelet-derived growth factor (PDGF) and PDGF receptors in human malignant mesothelioma in vitro and in vivo
    • Langerak AW, De Laat PA, Van Der Linden-Van Beurden CA, et al. Expression of platelet-derived growth factor (PDGF) and PDGF receptors in human malignant mesothelioma in vitro and in vivo. J Pathol 1996;178(2):151-60
    • (1996) J Pathol , vol.178 , Issue.2 , pp. 151-160
    • Langerak, A.W.1    De Laat, P.A.2    Van Der Linden-Van Beurden, C.A.3
  • 129
    • 33751294371 scopus 로고    scopus 로고
    • Negative results of an Italian Group for Mesothelioma (G.I. Me.) pilot study of single-agent imatinib mesylate in malignant pleural mesothelioma
    • Porta C, Mutti L, Tassi G. Negative results of an Italian Group for Mesothelioma (G.I. Me.) pilot study of single-agent imatinib mesylate in malignant pleural mesothelioma. Cancer Chemother Pharmacol 2007;59(1): 149-50
    • (2007) Cancer Chemother Pharmacol , vol.59 , Issue.1 , pp. 149-150
    • Porta, C.1    Mutti, L.2    Tassi, G.3
  • 130
    • 24744463358 scopus 로고    scopus 로고
    • Limited efficacy of imatinib mesylate in malignant mesothelioma: A phase II trial
    • Mathy A, Baas P, Dalesio O, van Zandwijk N. Limited efficacy of imatinib mesylate in malignant mesothelioma: A phase II trial. Lung Cancer 2005;50(1):83-6
    • (2005) Lung Cancer , vol.50 , Issue.1 , pp. 83-86
    • Mathy, A.1    Baas, P.2    Dalesio, O.3    Van Zandwijk, N.4
  • 131
    • 84898004711 scopus 로고    scopus 로고
    • Phase i trial of cisplatin, pemetrexed, and imatinib mesylate in chemonaive patients with unresectable malignant pleural mesothelioma
    • Tsao AS, Harun N, Lee JJ, et al. Phase I trial of cisplatin, pemetrexed, and imatinib mesylate in chemonaive patients with unresectable malignant pleural mesothelioma. Clin Lung Cancer 2014; 15(3):197-201
    • (2014) Clin Lung Cancer , vol.15 , Issue.3 , pp. 197-201
    • Tsao, A.S.1    Harun, N.2    Lee, J.J.3
  • 132
    • 84858789713 scopus 로고    scopus 로고
    • Phase II study of dasatinib in patients with previously treated malignant mesothelioma (cancer and leukemia group B 30601): A brief report
    • Dudek AZ, Pang H, Kratzke RA, et al. Phase II study of dasatinib in patients with previously treated malignant mesothelioma (cancer and leukemia group B 30601): A brief report. J Thorac Oncol 2012;7(4): 755-9
    • (2012) J Thorac Oncol , vol.7 , Issue.4 , pp. 755-759
    • Dudek, A.Z.1    Pang, H.2    Kratzke, R.A.3
  • 133
    • 34347273808 scopus 로고    scopus 로고
    • Phase II study of erlotinib in patients with malignant pleural mesothelioma: A Southwest Oncology Group Study
    • Garland LL, Rankin C, Gandara DR, et al. Phase II study of erlotinib in patients with malignant pleural mesothelioma: A Southwest Oncology Group Study. J Clin Oncol 2007;25(17):2406-13
    • (2007) J Clin Oncol , vol.25 , Issue.17 , pp. 2406-2413
    • Garland, L.L.1    Rankin, C.2    Gandara, D.R.3
  • 134
    • 16844372990 scopus 로고    scopus 로고
    • Gefitinib in patients with malignant mesothelioma: A phase II study by the Cancer and Leukemia Group B
    • Govindan R, Kratzke RA, Herndon JE 2nd, et al. Gefitinib in patients with malignant mesothelioma: A phase II study by the Cancer and Leukemia Group B. Clin Cancer Res 2005;11(6):2300-4
    • (2005) Clin Cancer Res , vol.11 , Issue.6 , pp. 2300-2304
    • Govindan, R.1    Kratzke, R.A.2    Herndon, J.E.3
  • 135
    • 50249155473 scopus 로고    scopus 로고
    • Erlotinib plus bevacizumab in previously treated patients with malignant pleural mesothelioma
    • Jackman DM, Kindler HL, Yeap BY, et al. Erlotinib plus bevacizumab in previously treated patients with malignant pleural mesothelioma. Cancer 2008;113(4):808-14
    • (2008) Cancer , vol.113 , Issue.4 , pp. 808-814
    • Jackman, D.M.1    Kindler, H.L.2    Yeap, B.Y.3
  • 136
    • 0035349924 scopus 로고    scopus 로고
    • Basic fibroblast growth factor in mesothelioma pleural effusions: Correlation with patient survival and angiogenesis
    • Strizzi L, Vianale G, Catalano A, et al. Basic fibroblast growth factor in mesothelioma pleural effusions: Correlation with patient survival and angiogenesis. Int J Oncol 2001;18(5):1093-8
    • (2001) Int J Oncol , vol.18 , Issue.5 , pp. 1093-1098
    • Strizzi, L.1    Vianale, G.2    Catalano, A.3
  • 137
    • 84925368747 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio-and chemotherapy
    • Schelch K, Hoda MA, Klikovits T, et al. Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio-and chemotherapy. Am J Respir Crit Care Med 2014;190(7): 763-72
    • (2014) Am J Respir Crit Care Med , vol.190 , Issue.7 , pp. 763-772
    • Schelch, K.1    Hoda, M.A.2    Klikovits, T.3
  • 138
    • 21844469713 scopus 로고    scopus 로고
    • Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: Mechanism and the role of oxidative stress
    • Stapelberg M, Gellert N, Swettenham E, et al. Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. J Biol Chem 2005;280(27):25369-76
    • (2005) J Biol Chem , vol.280 , Issue.27 , pp. 25369-25376
    • Stapelberg, M.1    Gellert, N.2    Swettenham, E.3
  • 139
    • 0037850880 scopus 로고    scopus 로고
    • NK4 (HGFantagonist/angiogenesis inhibitor) in cancer biology and therapeutics
    • Matsumoto K, Nakamura T. NK4 (HGFantagonist/angiogenesis inhibitor) in cancer biology and therapeutics. Cancer Sci 2003; 94(4):321-7
    • (2003) Cancer Sci , vol.94 , Issue.4 , pp. 321-327
    • Matsumoto, K.1    Nakamura, T.2
  • 140
    • 84920606724 scopus 로고    scopus 로고
    • Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells
    • Leon LG, Gemelli M, Sciarrillo R, et al. Synergistic activity of the c-Met and tubulin inhibitor tivantinib (ARQ197) with pemetrexed in mesothelioma cells. Curr Drug Targets 2014;15(14):1331-40
    • (2014) Curr Drug Targets , vol.15 , Issue.14 , pp. 1331-1340
    • Leon, L.G.1    Gemelli, M.2    Sciarrillo, R.3
  • 141
    • 33845761445 scopus 로고    scopus 로고
    • In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion
    • Szlosarek PW, Klabatsa A, Pallaska A, et al. In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. Clin Cancer Res 2006;12(23):7126-31
    • (2006) Clin Cancer Res , vol.12 , Issue.23 , pp. 7126-7131
    • Szlosarek, P.W.1    Klabatsa, A.2    Pallaska, A.3
  • 143
    • 84924962270 scopus 로고    scopus 로고
    • Dysregulation of microRNA biogenesis and gene silencing in cancer
    • re3
    • Hata A, Lieberman J. Dysregulation of microRNA biogenesis and gene silencing in cancer. Sci Signal 2015;8(368):re3
    • (2015) Sci Signal , vol.8 , pp. 368
    • Hata, A.1    Lieberman, J.2
  • 144
    • 67449086733 scopus 로고    scopus 로고
    • CDKN2A NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma-A miRNA microarray analysis
    • Guled M, Lahti L, Lindholm PM, et al. CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma-A miRNA microarray analysis. Genes Chromosomes Cancer 2009;48(7):615-23
    • (2009) Genes Chromosomes Cancer , vol.48 , Issue.7 , pp. 615-623
    • Guled, M.1    Lahti, L.2    Lindholm, P.M.3
  • 145
    • 77249135944 scopus 로고    scopus 로고
    • MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications
    • Busacca S, Germano S, De Cecco L, et al. MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. Am J Respir Cell Mol Biol 2010;42(3):312-19
    • (2010) Am J Respir Cell Mol Biol , vol.42 , Issue.3 , pp. 312-319
    • Busacca, S.1    Germano, S.2    De Cecco, L.3
  • 146
    • 84888785695 scopus 로고    scopus 로고
    • Restoring expression of miR-16: A novel approach to therapy for malignant pleural mesothelioma
    • Reid G, Pel ME, Kirschner MB, et al. Restoring expression of miR-16: A novel approach to therapy for malignant pleural mesothelioma. Ann Oncol 2013;24(12): 3128-35
    • (2013) Ann Oncol , vol.24 , Issue.12 , pp. 3128-3135
    • Reid, G.1    Pel, M.E.2    Kirschner, M.B.3
  • 147
    • 82755161993 scopus 로고    scopus 로고
    • Minicells: Versatile vectors for targeted drug or si/shRNA cancer therapy
    • MacDiarmid JA, Brahmbhatt H. Minicells: versatile vectors for targeted drug or si/shRNA cancer therapy. Curr Opin Biotechnol 2011;22(6):909-16
    • (2011) Curr Opin Biotechnol , vol.22 , Issue.6 , pp. 909-916
    • MacDiarmid, J.A.1    Brahmbhatt, H.2
  • 148
    • 35348874294 scopus 로고    scopus 로고
    • Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma
    • Sartore-Bianchi A, Gasparri F, Galvani A, et al. Bortezomib inhibits nuclear factor-kappaB dependent survival and has potent in vivo activity in mesothelioma. Clin Cancer Res 2007;13(19):5942-51
    • (2007) Clin Cancer Res , vol.13 , Issue.19 , pp. 5942-5951
    • Sartore-Bianchi, A.1    Gasparri, F.2    Galvani, A.3
  • 149
    • 84881091484 scopus 로고    scopus 로고
    • Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052
    • O'Brien ME, Gaafar RM, Popat S, et al. Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052). Eur J Cancer 2013;49(13): 2815-22
    • (2013) Eur J Cancer , vol.49 , Issue.13 , pp. 2815-2822
    • O'Brien, M.E.1    Gaafar, R.M.2    Popat, S.3
  • 150
    • 80053020945 scopus 로고    scopus 로고
    • Ranpirnase interferes with NF-kappaB pathway and MMP9 activity inhibiting malignant mesothelioma cell invasiveness and xenograft growth
    • Nasu M, Carbone M, Gaudino G, et al. Ranpirnase Interferes with NF-kappaB Pathway and MMP9 Activity, Inhibiting Malignant Mesothelioma Cell Invasiveness and Xenograft Growth. Genes Cancer 2011; 2(5):576-84
    • (2011) Genes Cancer , vol.2 , Issue.5 , pp. 576-584
    • Nasu, M.1    Carbone, M.2    Gaudino, G.3
  • 152
    • 84963994012 scopus 로고    scopus 로고
    • Eds Available from
    • Corporation A. Annual Report 2009. (Eds) 2009. Available from: www.alfacell.com/annualreport2009.pdf
    • (2009) Annual Report 2009
    • Corporation, A.1
  • 153
    • 33746278685 scopus 로고    scopus 로고
    • Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma
    • de Melo M, Gerbase MW, Curran J, Pache JC. Phosphorylated extracellular signal-regulated kinases are significantly increased in malignant mesothelioma. J Histochem Cytochem 2006;54(8):855-61
    • (2006) J Histochem Cytochem , vol.54 , Issue.8 , pp. 855-861
    • De Melo, M.1    Gerbase, M.W.2    Curran, J.3    Pache, J.C.4
  • 154
    • 0030447748 scopus 로고    scopus 로고
    • Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor
    • Zanella CL, Posada J, Tritton TR, Mossman BT. Asbestos causes stimulation of the extracellular signal-regulated kinase 1 mitogen-activated protein kinase cascade after phosphorylation of the epidermal growth factor receptor. Cancer Res 1996; 56(23):5334-8
    • (1996) Cancer Res , vol.56 , Issue.23 , pp. 5334-5338
    • Zanella, C.L.1    Posada, J.2    Tritton, T.R.3    Mossman, B.T.4
  • 155
    • 84882640239 scopus 로고    scopus 로고
    • Calretinin is essential for mesothelioma cell growth/survival in vitro a potential new target for malignant mesothelioma therapy?
    • Blum W, Schwaller B. Calretinin is essential for mesothelioma cell growth/survival in vitro: A potential new target for malignant mesothelioma therapy? Int J Cancer 2013; 133(9):2077-88
    • (2013) Int J Cancer , vol.133 , Issue.9 , pp. 2077-2088
    • Blum, W.1    Schwaller, B.2
  • 156
    • 25444496522 scopus 로고    scopus 로고
    • Wnt2 as a new therapeutic target in malignant pleural mesothelioma
    • Mazieres J, You L, He B, et al. Wnt2 as a new therapeutic target in malignant pleural mesothelioma. Int J Cancer 2005;117(2): 326-32
    • (2005) Int J Cancer , vol.117 , Issue.2 , pp. 326-332
    • Mazieres, J.1    You, L.2    He, B.3
  • 157
    • 58949093514 scopus 로고    scopus 로고
    • Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma
    • Okamoto J, Mikami I, Tominaga Y, et al. Inhibition of Hsp90 leads to cell cycle arrest and apoptosis in human malignant pleural mesothelioma. J Thorac Oncol 2008;3(10): 1089-95
    • (2008) J Thorac Oncol , vol.3 , Issue.10 , pp. 1089-1095
    • Okamoto, J.1    Mikami, I.2    Tominaga, Y.3
  • 158
    • 84879799563 scopus 로고    scopus 로고
    • Understanding, recognizing, and managing toxicities of targeted anticancer therapies
    • Dy GK, Adjei AA. Understanding, recognizing, and managing toxicities of targeted anticancer therapies. CA Cancer J Clin 2013;63(4):249-79
    • (2013) CA Cancer J Clin , vol.63 , Issue.4 , pp. 249-279
    • Dy, G.K.1    Adjei, A.A.2
  • 159
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144(5):646-74
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 160
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer 2012;12(4):252-64
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 161
    • 84902522051 scopus 로고    scopus 로고
    • B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis
    • Mansfield AS, Roden AC, Peikert T, et al. B7-H1 expression in malignant pleural mesothelioma is associated with sarcomatoid histology and poor prognosis. J Thorac Oncol 2014;9(7):1036-40
    • (2014) J Thorac Oncol , vol.9 , Issue.7 , pp. 1036-1040
    • Mansfield, A.S.1    Roden, A.C.2    Peikert, T.3
  • 162
    • 84925004185 scopus 로고    scopus 로고
    • Analysis of expression of programmed cell death 1 ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM)
    • Cedres S, Ponce-Aix S, Zugazagoitia J, et al. Analysis of expression of programmed cell death 1 ligand 1 (PD-L1) in malignant pleural mesothelioma (MPM). PLoS One 2015;10(3):e0121071
    • (2015) PLoS One , vol.10 , Issue.3 , pp. e0121071
    • Cedres, S.1    Ponce-Aix, S.2    Zugazagoitia, J.3
  • 163
    • 84884703526 scopus 로고    scopus 로고
    • Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: An open-label, single-arm, phase 2 trial
    • Calabro L, Morra A, Fonsatti E, et al. Tremelimumab for patients with chemotherapy-resistant advanced malignant mesothelioma: An open-label, single-arm, phase 2 trial. Lancet Oncol 2013;14(11): 1104-11
    • (2013) Lancet Oncol , vol.14 , Issue.11 , pp. 1104-1111
    • Calabro, L.1    Morra, A.2    Fonsatti, E.3
  • 164
    • 84926418972 scopus 로고    scopus 로고
    • Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study
    • Calabro L, Morra A, Fonsatti E, et al. Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study. Lancet Respir Med 2015;3(4):301-9
    • (2015) Lancet Respir Med , vol.3 , Issue.4 , pp. 301-309
    • Calabro, L.1    Morra, A.2    Fonsatti, E.3
  • 168
    • 84983084740 scopus 로고    scopus 로고
    • A potential immune therapy for mesothelioma
    • Epub ahead of print
    • A potential immune therapy for mesothelioma. Cancer Discov 2015; Epub ahead of print
    • (2015) Cancer Discov
  • 169
    • 84885717570 scopus 로고    scopus 로고
    • Immunological effects of the TGFbeta-blocking antibody GC1008 in malignant pleural mesothelioma patients
    • Stevenson JP, Kindler HL, Papasavvas E, et al. Immunological effects of the TGFbeta-blocking antibody GC1008 in malignant pleural mesothelioma patients. Oncoimmunology 2013;2(8):e26218
    • (2013) Oncoimmunology , vol.2 , Issue.8 , pp. e26218
    • Stevenson, J.P.1    Kindler, H.L.2    Papasavvas, E.3
  • 170
    • 84902124061 scopus 로고    scopus 로고
    • Discovery of mesothelin and exploiting it as a target for immunotherapy
    • Pastan I, Hassan R. Discovery of mesothelin and exploiting it as a target for immunotherapy. Cancer Res 2014;74(11): 2907-12
    • (2014) Cancer Res , vol.74 , Issue.11 , pp. 2907-2912
    • Pastan, I.1    Hassan, R.2
  • 171
    • 84860506230 scopus 로고    scopus 로고
    • Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients
    • Servais EL, Colovos C, Rodriguez L, et al. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res 2012;18(9):2478-89
    • (2012) Clin Cancer Res , vol.18 , Issue.9 , pp. 2478-2489
    • Servais, E.L.1    Colovos, C.2    Rodriguez, L.3
  • 172
    • 1542365125 scopus 로고    scopus 로고
    • Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion
    • Rump A, Morikawa Y, Tanaka M, et al. Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion. J Biol Chem 2004;279(10): 9190-8
    • (2004) J Biol Chem , vol.279 , Issue.10 , pp. 9190-9198
    • Rump, A.1    Morikawa, Y.2    Tanaka, M.3
  • 173
    • 33750998782 scopus 로고    scopus 로고
    • Mesothelin-MUC16 binding is a high affinity N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors
    • Gubbels JA, Belisle J, Onda M, et al. Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Mol Cancer 2006;5(1):50
    • (2006) Mol Cancer , vol.5 , Issue.1 , pp. 50
    • Gubbels, J.A.1    Belisle, J.2    Onda, M.3
  • 174
    • 37449006756 scopus 로고    scopus 로고
    • Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin
    • Hassan R, Ebel W, Routhier EL, et al. Preclinical evaluation of MORAb-009, a chimeric antibody targeting tumor-associated mesothelin. Cancer Immun 2007;7:20
    • (2007) Cancer Immun , vol.7 , pp. 20
    • Hassan, R.1    Ebel, W.2    Routhier, E.L.3
  • 175
    • 77952551039 scopus 로고    scopus 로고
    • Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy
    • Hassan R, Schweizer C, Lu KF, et al. Inhibition of mesothelin-CA-125 interaction in patients with mesothelioma by the anti-mesothelin monoclonal antibody MORAb-009: Implications for cancer therapy. Lung Cancer 2010;68(3):455-9
    • (2010) Lung Cancer , vol.68 , Issue.3 , pp. 455-459
    • Hassan, R.1    Schweizer, C.2    Lu, K.F.3
  • 176
    • 78650339895 scopus 로고    scopus 로고
    • Phase i clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers
    • Hassan R, Cohen SJ, Phillips M, et al. Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers. Clin Cancer Res 2010;16(24):6132-8
    • (2010) Clin Cancer Res , vol.16 , Issue.24 , pp. 6132-6138
    • Hassan, R.1    Cohen, S.J.2    Phillips, M.3
  • 177
    • 84918827048 scopus 로고    scopus 로고
    • Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma
    • Hassan R, Kindler HL, Jahan T, et al. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res 2014;20(23):5927-36
    • (2014) Clin Cancer Res , vol.20 , Issue.23 , pp. 5927-5936
    • Hassan, R.1    Kindler, H.L.2    Jahan, T.3
  • 179
    • 0036848812 scopus 로고    scopus 로고
    • Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro
    • Hassan R, Lerner MR, Benbrook D, et al. Antitumor activity of SS(dsFv)PE38 and SS1(dsFv)PE38, recombinant antimesothelin immunotoxins against human gynecologic cancers grown in organotypic culture in vitro. Clin Cancer Res 2002;8(11):3520-6
    • (2002) Clin Cancer Res , vol.8 , Issue.11 , pp. 3520-3526
    • Hassan, R.1    Lerner, M.R.2    Benbrook, D.3
  • 180
    • 3242689904 scopus 로고    scopus 로고
    • Cytotoxic activity of the recombinant anti-mesothelin immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas
    • Li Q, Verschraegen CF, Mendoza J, Hassan R. Cytotoxic activity of the recombinant anti-mesothelin immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas. Anticancer research 2004;24(3a):1327-35
    • (2004) Anticancer Research , vol.24 , Issue.3 A , pp. 1327-1335
    • Li, Q.1    Verschraegen, C.F.2    Mendoza, J.3    Hassan, R.4
  • 181
    • 34548858453 scopus 로고    scopus 로고
    • Phase i study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. Infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers
    • Hassan R, Bullock S, Premkumar A, et al. Phase I study of SS1P, a recombinant anti-mesothelin immunotoxin given as a bolus I.V. infusion to patients with mesothelin-expressing mesothelioma, ovarian, and pancreatic cancers. Clin Cancer Res 2007;13(17):5144-9
    • (2007) Clin Cancer Res , vol.13 , Issue.17 , pp. 5144-5149
    • Hassan, R.1    Bullock, S.2    Premkumar, A.3
  • 182
    • 69349100450 scopus 로고    scopus 로고
    • Phase i trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P
    • Kreitman RJ, Hassan R, Fitzgerald DJ, Pastan I. Phase I trial of continuous infusion anti-mesothelin recombinant immunotoxin SS1P. Clin Cancer Res 2009; 15(16):5274-9
    • (2009) Clin Cancer Res , vol.15 , Issue.16 , pp. 5274-5279
    • Kreitman, R.J.1    Hassan, R.2    Fitzgerald, D.J.3    Pastan, I.4
  • 183
    • 84925032574 scopus 로고    scopus 로고
    • Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin megakaryocyte potentiating factor, and cancer antigen
    • Hassan R, Sharon E, Thomas A, et al. Phase 1 study of the antimesothelin immunotoxin SS1P in combination with pemetrexed and cisplatin for front-line therapy of pleural mesothelioma and correlation of tumor response with serum mesothelin, megakaryocyte potentiating factor, and cancer antigen Cancer 2014;120(21):3311-19
    • (2014) Cancer , vol.120 , Issue.21 , pp. 3311-3319
    • Hassan, R.1    Sharon, E.2    Thomas, A.3
  • 184
    • 84886382139 scopus 로고    scopus 로고
    • Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression
    • 208ra147
    • Hassan R, Miller AC, Sharon E, et al. Major cancer regressions in mesothelioma after treatment with an anti-mesothelin immunotoxin and immune suppression. Sci Transl Med 2013;5(208):208ra147
    • (2013) Sci Transl Med , vol.5 , pp. 208
    • Hassan, R.1    Miller, A.C.2    Sharon, E.3
  • 186
    • 84905643817 scopus 로고    scopus 로고
    • In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer
    • Hollevoet K, Mason-Osann E, Liu XF, et al. In vitro and in vivo activity of the low-immunogenic antimesothelin immunotoxin RG7787 in pancreatic cancer. Mol Cancer Ther 2014;13(8):2040-9
    • (2014) Mol Cancer Ther , vol.13 , Issue.8 , pp. 2040-2049
    • Hollevoet, K.1    Mason-Osann, E.2    Liu, X.F.3
  • 187
    • 84918775119 scopus 로고    scopus 로고
    • Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers
    • Alewine C, Xiang L, Yamori T, et al. Efficacy of RG7787, a next-generation mesothelin-targeted immunotoxin, against triple-negative breast and gastric cancers. Mol Cancer Ther 2014;13(11):2653-61
    • (2014) Mol Cancer Ther , vol.13 , Issue.11 , pp. 2653-2661
    • Alewine, C.1    Xiang, L.2    Yamori, T.3
  • 188
    • 84924353446 scopus 로고    scopus 로고
    • Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity
    • Pasetto M, Antignani A, Ormanoglu P, et al. Whole-genome RNAi screen highlights components of the endoplasmic reticulum/Golgi as a source of resistance to immunotoxin-mediated cytotoxicity. Proc Natl Acad USA 2015;112(10):E1135-42
    • (2015) Proc Natl Acad USA , vol.112 , Issue.10 , pp. E1135-E1142
    • Pasetto, M.1    Antignani, A.2    Ormanoglu, P.3
  • 189
    • 84918771947 scopus 로고    scopus 로고
    • An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models
    • Scales SJ, Gupta N, Pacheco G, et al. An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models. Mol Cancer Ther 2014;13(11): 2630-40
    • (2014) Mol Cancer Ther , vol.13 , Issue.11 , pp. 2630-2640
    • Scales, S.J.1    Gupta, N.2    Pacheco, G.3
  • 190
    • 84902687265 scopus 로고    scopus 로고
    • Anetumab ravtansine: A novel mesothelin-targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect
    • Golfier S, Kopitz C, Kahnert A, et al. Anetumab ravtansine: A novel mesothelin-targeting antibody-drug conjugate cures tumors with heterogeneous target expression favored by bystander effect. Mol Cancer Ther 2014;13(6):1537-48
    • (2014) Mol Cancer Ther , vol.13 , Issue.6 , pp. 1537-1548
    • Golfier, S.1    Kopitz, C.2    Kahnert, A.3
  • 193
    • 84894100387 scopus 로고    scopus 로고
    • Novel immunocytokine IL12-SS1 (Fv) inhibits mesothelioma tumor growth in nude mice
    • Kim H, Gao W, Ho M. Novel immunocytokine IL12-SS1 (Fv) inhibits mesothelioma tumor growth in nude mice. PLoS One 2013;8(11):e81919
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e81919
    • Kim, H.1    Gao, W.2    Ho, M.3
  • 194
    • 84895924146 scopus 로고    scopus 로고
    • A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma
    • Yuan J, Kashiwagi S, Reeves P, et al. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol 2014;7:15
    • (2014) J Hematol Oncol , vol.7 , pp. 15
    • Yuan, J.1    Kashiwagi, S.2    Reeves, P.3
  • 195
    • 84856519280 scopus 로고    scopus 로고
    • A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: Phase i studies of safety and immune induction
    • Le DT, Brockstedt DG, Nir-Paz R, et al. A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction. Clin Cancer Res 2012;18(3):858-68
    • (2012) Clin Cancer Res , vol.18 , Issue.3 , pp. 858-868
    • Le, D.T.1    Brockstedt, D.G.2    Nir-Paz, R.3
  • 197
    • 84929431322 scopus 로고    scopus 로고
    • Safety and survival with GVAX pancreas prime and listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer
    • Le DT, Wang-Gillam A, Picozzi V, et al. Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes-Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer. J Clin Oncol 2015; 33(12):1325-33
    • (2015) J Clin Oncol , vol.33 , Issue.12 , pp. 1325-1333
    • Le, D.T.1    Wang-Gillam, A.2    Picozzi, V.3
  • 199
    • 84876678061 scopus 로고    scopus 로고
    • Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer
    • Yamasaki S, Miura Y, Davydova J, et al. Intravenous genetic mesothelin vaccine based on human adenovirus 40 inhibits growth and metastasis of pancreatic cancer. Int J Cancer 2013;133(1):88-97
    • (2013) Int J Cancer , vol.133 , Issue.1 , pp. 88-97
    • Yamasaki, S.1    Miura, Y.2    Davydova, J.3
  • 200
    • 78549253550 scopus 로고    scopus 로고
    • Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor
    • Zhao Y, Moon E, Carpenito C, et al. Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor. Cancer Res 2010;70(22):9053-61
    • (2010) Cancer Res , vol.70 , Issue.22 , pp. 9053-9061
    • Zhao, Y.1    Moon, E.2    Carpenito, C.3
  • 201
    • 79960403269 scopus 로고    scopus 로고
    • Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor
    • Moon EK, Carpenito C, Sun J, et al. Expression of a functional CCR2 receptor enhances tumor localization and tumor eradication by retargeted human T cells expressing a mesothelin-specific chimeric antibody receptor. Clin Cancer Res 2011; 17(14):4719-30
    • (2011) Clin Cancer Res , vol.17 , Issue.14 , pp. 4719-4730
    • Moon, E.K.1    Carpenito, C.2    Sun, J.3
  • 202
    • 84857794017 scopus 로고    scopus 로고
    • Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor
    • Lanitis E, Poussin M, Hagemann IS, et al. Redirected antitumor activity of primary human lymphocytes transduced with a fully human anti-mesothelin chimeric receptor. Mol Ther 2012;20(3):633-43
    • (2012) Mol Ther , vol.20 , Issue.3 , pp. 633-643
    • Lanitis, E.1    Poussin, M.2    Hagemann, I.S.3
  • 203
    • 84879097325 scopus 로고    scopus 로고
    • Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases
    • Riese MJ, Wang LC, Moon EK, et al. Enhanced effector responses in activated CD8+ T cells deficient in diacylglycerol kinases. Cancer Res 2013;73(12):3566-77
    • (2013) Cancer Res , vol.73 , Issue.12 , pp. 3566-3577
    • Riese, M.J.1    Wang, L.C.2    Moon, E.K.3
  • 204
    • 84996572349 scopus 로고    scopus 로고
    • Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies
    • Beatty GL, Haas AR, Maus MV, et al. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunol Res 2014;2(2):112-20
    • (2014) Cancer Immunol Res , vol.2 , Issue.2 , pp. 112-120
    • Beatty, G.L.1    Haas, A.R.2    Maus, M.V.3
  • 205
    • 84905993539 scopus 로고    scopus 로고
    • Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors
    • Moon EK, Wang LC, Dolfi DV, et al. Multifactorial T-cell hypofunction that is reversible can limit the efficacy of chimeric antigen receptor-transduced human T cells in solid tumors. Clin Cancer Res 2014; 20(16):4262-73
    • (2014) Clin Cancer Res , vol.20 , Issue.16 , pp. 4262-4273
    • Moon, E.K.1    Wang, L.C.2    Dolfi, D.V.3
  • 206
    • 84908891854 scopus 로고    scopus 로고
    • Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity
    • Adusumilli PS, Cherkassky L, Villena-Vargas J, et al. Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity. Sci Transl Med 2014;6(261):261ra151
    • (2014) Sci Transl Med , vol.6 , Issue.261 , pp. 261ra151
    • Adusumilli, P.S.1    Cherkassky, L.2    Villena-Vargas, J.3
  • 209
    • 34547660192 scopus 로고    scopus 로고
    • Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells
    • May RJ, Dao T, Pinilla-Ibarz J, et al. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res 2007;13(15 Pt 1):4547-55
    • (2007) Clin Cancer Res , vol.13 , Issue.15 , pp. 4547-4555
    • May, R.J.1    Dao, T.2    Pinilla-Ibarz, J.3
  • 210
    • 4644289323 scopus 로고    scopus 로고
    • Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    • Oka Y, Tsuboi A, Taguchi T, et al. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc Natl Acad Sci USA 2004;101(38):13885-90
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.38 , pp. 13885-13890
    • Oka, Y.1    Tsuboi, A.2    Taguchi, T.3
  • 211
    • 77955553483 scopus 로고    scopus 로고
    • WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer
    • Krug LM, Dao T, Brown AB, et al. WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesothelioma and non-small cell lung cancer. Cancer Immunol Immunother 2010;59(10):1467-79
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.10 , pp. 1467-1479
    • Krug, L.M.1    Dao, T.2    Brown, A.B.3
  • 215
    • 84872582630 scopus 로고    scopus 로고
    • Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor
    • Tamanaka T, Oka Y, Fujiki F, et al. Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor. Anticancer Res 2012;32(12): 5201-9
    • (2012) Anticancer Res , vol.32 , Issue.12 , pp. 5201-5209
    • Tamanaka, T.1    Oka, Y.2    Fujiki, F.3
  • 216
    • 84874141705 scopus 로고    scopus 로고
    • Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor
    • Asai H, Fujiwara H, An J, et al. Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor. PLoS One 2013;8(2):e56820
    • (2013) PLoS One , vol.8 , Issue.2 , pp. e56820
    • Asai, H.1    Fujiwara, H.2    An, J.3
  • 218
    • 84881312673 scopus 로고    scopus 로고
    • Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma
    • Kakarla S, Chow KK, Mata M, et al. Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Mol Ther 2013;21(8):1611-20
    • (2013) Mol Ther , vol.21 , Issue.8 , pp. 1611-1620
    • Kakarla, S.1    Chow, K.K.2    Mata, M.3
  • 219
    • 84882636722 scopus 로고    scopus 로고
    • Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells
    • Schuberth PC, Hagedorn C, Jensen SM, et al. Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells. J Transl Med 2013;11:187
    • (2013) J Transl Med , vol.11 , pp. 187
    • Schuberth, P.C.1    Hagedorn, C.2    Jensen, S.M.3
  • 220
    • 84996565577 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity
    • Wang LC, Lo A, Scholler J, et al. Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity. Cancer Immunol Res 2014;2(2):154-66
    • (2014) Cancer Immunol Res , vol.2 , Issue.2 , pp. 154-166
    • Wang, L.C.1    Lo, A.2    Scholler, J.3
  • 222
    • 84909594602 scopus 로고    scopus 로고
    • Vaccine-elicited CD8+ T cells cure mesothelioma by overcoming tumor-induced immunosuppressive environment
    • Tan Z, Zhou J, Cheung AK, et al. Vaccine-elicited CD8+ T cells cure mesothelioma by overcoming tumor-induced immunosuppressive environment. Cancer Res 2014;74(21): 6010-21
    • (2014) Cancer Res , vol.74 , Issue.21 , pp. 6010-6021
    • Tan, Z.1    Zhou, J.2    Cheung, A.K.3
  • 225
    • 84877937399 scopus 로고    scopus 로고
    • Fowlpox-based survivin vaccination for malignant mesothelioma therapy
    • Bertino P, Panigada M, Soprana E, et al. Fowlpox-based survivin vaccination for malignant mesothelioma therapy. Int J Cancer 2013;133(3):612-23
    • (2013) Int J Cancer , vol.133 , Issue.3 , pp. 612-623
    • Bertino, P.1    Panigada, M.2    Soprana, E.3
  • 226
    • 84944452759 scopus 로고    scopus 로고
    • Preclinical development of HIvax: Human survivin Highly Immunogenic vaccines
    • Epub ahead of print
    • Hoffmann PR, Panigada M, Soprana E, et al. Preclinical development of HIvax: human survivin Highly Immunogenic vaccines. Hum Vaccin Immunother 2015; Epub ahead of print
    • (2015) Hum Vaccin Immunother
    • Hoffmann, P.R.1    Panigada, M.2    Soprana, E.3
  • 227
    • 84866931227 scopus 로고    scopus 로고
    • CSPG4 as a target of antibody-based immunotherapy for malignant mesothelioma
    • Rivera Z, Ferrone S, Wang X, et al. CSPG4 as a target of antibody-based immunotherapy for malignant mesothelioma. Clin Cancer Res 2012; 18(19):5352-63
    • (2012) Clin Cancer Res , vol.18 , Issue.19 , pp. 5352-5363
    • Rivera, Z.1    Ferrone, S.2    Wang, X.3
  • 228
    • 3242815209 scopus 로고    scopus 로고
    • Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts
    • 436-43.discussion
    • Beseth BD, Cameron RB, Leland P, et al. Interleukin-4 receptor cytotoxin as therapy for human malignant pleural mesothelioma xenografts. Ann Thorac Surg 2004;78(2): 436-43.discussion 436-443
    • (2004) Ann Thorac Surg , vol.78 , Issue.2 , pp. 436-443
    • Beseth, B.D.1    Cameron, R.B.2    Leland, P.3
  • 229
    • 84875219857 scopus 로고    scopus 로고
    • Gene therapy for malignant mesothelioma: Current prospects and challenges
    • Tagawa M, Tada Y, Shimada H, Hiroshima K. Gene therapy for malignant mesothelioma: Current prospects and challenges. Cancer Gene Ther 2013;20(3): 150-6
    • (2013) Cancer Gene Ther , vol.20 , Issue.3 , pp. 150-156
    • Tagawa, M.1    Tada, Y.2    Shimada, H.3    Hiroshima, K.4
  • 230
    • 84897476768 scopus 로고    scopus 로고
    • Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy
    • Zamarin D, Holmgaard RB, Subudhi SK, et al. Localized oncolytic virotherapy overcomes systemic tumor resistance to immune checkpoint blockade immunotherapy. Sci Transl Med 2014; 6(226):226ra232
    • (2014) Sci Transl Med , vol.6 , Issue.226 , pp. 226ra232
    • Zamarin, D.1    Holmgaard, R.B.2    Subudhi, S.K.3
  • 231
    • 84962219179 scopus 로고    scopus 로고
    • Virotherapy with a semliki forest virus-based vector encoding IL12 Synergizes with PD-1/PDL1 Blockade
    • Quetglas JI, Labiano S, Aznar MA, et al. Virotherapy with a Semliki Forest Virus-Based Vector Encoding IL12 Synergizes with PD-1/PDL1 Blockade. Cancer Immunol Res 2015; 3(5):449-54
    • (2015) Cancer Immunol Res , vol.3 , Issue.5 , pp. 449-454
    • Quetglas, J.I.1    Labiano, S.2    Aznar, M.A.3
  • 232
    • 77954814628 scopus 로고    scopus 로고
    • Oncolytic measles viruses encoding interferon beta and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy
    • Li H, Peng KW, Dingli D, et al. Oncolytic measles viruses encoding interferon beta and the thyroidal sodium iodide symporter gene for mesothelioma virotherapy. Cancer Gene Ther 2010;17(8):550-8
    • (2010) Cancer Gene Ther , vol.17 , Issue.8 , pp. 550-558
    • Li, H.1    Peng, K.W.2    Dingli, D.3
  • 233
    • 49649111732 scopus 로고    scopus 로고
    • Measles virus induces oncolysis of mesothelioma cells and allows dendritic cells to cross-prime tumor-specific CD8 response
    • Gauvrit A, Brandler S, Sapede-Peroz C, et al. Measles virus induces oncolysis of mesothelioma cells and allows dendritic cells to cross-prime tumor-specific CD8 response. Cancer Res 2008;68(12):4882-92
    • (2008) Cancer Res , vol.68 , Issue.12 , pp. 4882-4892
    • Gauvrit, A.1    Brandler, S.2    Sapede-Peroz, C.3
  • 235
    • 84859376777 scopus 로고    scopus 로고
    • Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: Assessment of safety and immunologic responses in patients
    • Pesonen S, Diaconu I, Kangasniemi L, et al. Oncolytic immunotherapy of advanced solid tumors with a CD40L-expressing replicating adenovirus: Assessment of safety and immunologic responses in patients. Cancer Res 2012;72(7):1621-31
    • (2012) Cancer Res , vol.72 , Issue.7 , pp. 1621-1631
    • Pesonen, S.1    Diaconu, I.2    Kangasniemi, L.3
  • 236
    • 79960556047 scopus 로고    scopus 로고
    • Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma
    • Kawasaki Y, Tamamoto A, Takagi-Kimura M, et al. Replication-competent retrovirus vector-mediated prodrug activator gene therapy in experimental models of human malignant mesothelioma. Cancer Gene Ther 2011;18(8):571-8
    • (2011) Cancer Gene Ther , vol.18 , Issue.8 , pp. 571-578
    • Kawasaki, Y.1    Tamamoto, A.2    Takagi-Kimura, M.3
  • 237
    • 33744827944 scopus 로고    scopus 로고
    • Imaging and therapy of malignant pleural mesothelioma using replication-competent herpes simplex viruses
    • Adusumilli PS, Stiles BM, Chan MK, et al. Imaging and therapy of malignant pleural mesothelioma using replication-competent herpes simplex viruses. J Gene Med 2006; 8(5):603-15
    • (2006) J Gene Med , vol.8 , Issue.5 , pp. 603-615
    • Adusumilli, P.S.1    Stiles, B.M.2    Chan, M.K.3
  • 240
    • 84863012595 scopus 로고    scopus 로고
    • Molecular pathways: Targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma
    • Carbone M, Yang H. Molecular pathways: targeting mechanisms of asbestos and erionite carcinogenesis in mesothelioma. Clin Cancer Res 2012;18(3):598-604
    • (2012) Clin Cancer Res , vol.18 , Issue.3 , pp. 598-604
    • Carbone, M.1    Yang, H.2
  • 241
    • 84870551811 scopus 로고    scopus 로고
    • NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma
    • Chow MT, Tschopp J, Moller A, Smyth MJ. NLRP3 promotes inflammation-induced skin cancer but is dispensable for asbestos-induced mesothelioma. Immunol Cell Biol 2012; 90(10):983-6
    • (2012) Immunol Cell Biol , vol.90 , Issue.10 , pp. 983-986
    • Chow, M.T.1    Tschopp, J.2    Moller, A.3    Smyth, M.J.4
  • 242
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs PAMPs and alarmins: All we need to know about danger
    • Bianchi ME. DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 2007;81(1):1-5
    • (2007) J Leukoc Biol , vol.81 , Issue.1 , pp. 1-5
    • Bianchi, M.E.1
  • 243
    • 34249812086 scopus 로고    scopus 로고
    • Masquerader: High mobility group box-1 and cancer
    • Ellerman JE, Brown CK, de Vera M, et al. Masquerader: high mobility group box-1 and cancer. Clin Cancer Res 2007; 13(10):2836-48
    • (2007) Clin Cancer Res , vol.13 , Issue.10 , pp. 2836-2848
    • Ellerman, J.E.1    Brown, C.K.2    De Vera, M.3
  • 244
    • 1342330958 scopus 로고    scopus 로고
    • Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention
    • Catalano A, Graciotti L, Rinaldi L, et al. Preclinical evaluation of the nonsteroidal anti-inflammatory agent celecoxib on malignant mesothelioma chemoprevention. Int J Cancer 2004;109(3):322-8
    • (2004) Int J Cancer , vol.109 , Issue.3 , pp. 322-328
    • Catalano, A.1    Graciotti, L.2    Rinaldi, L.3
  • 245
    • 78650825618 scopus 로고    scopus 로고
    • Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials
    • Rothwell PM, Fowkes FG, Belch JF, et al. Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials. Lancet 2011;377(9759):31-41
    • (2011) Lancet , vol.377 , Issue.9759 , pp. 31-41
    • Rothwell, P.M.1    Fowkes, F.G.2    Belch, J.F.3
  • 246
    • 84983464535 scopus 로고    scopus 로고
    • Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression
    • Yang H, Pellegrini L, Napolitano A, et al. Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression. Cell death & disease 2015;6: E1786
    • (2015) Cell Death & Disease , vol.6 , pp. e1786
    • Yang, H.1    Pellegrini, L.2    Napolitano, A.3
  • 247
    • 33845864424 scopus 로고    scopus 로고
    • Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice
    • Sitia G, Iannacone M, Muller S, et al. Treatment with HMGB1 inhibitors diminishes CTL-induced liver disease in HBV transgenic mice. J Leukoc Biol 2007; 81(1):100-7
    • (2007) J Leukoc Biol , vol.81 , Issue.1 , pp. 100-107
    • Sitia, G.1    Iannacone, M.2    Muller, S.3
  • 248
    • 70449727077 scopus 로고    scopus 로고
    • Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
    • Lamkanfi M, Mueller JL, Vitari AC, et al. Glyburide inhibits the Cryopyrin/Nalp3 inflammasome. J Cell Biol 2009; 187(1):61-70
    • (2009) J Cell Biol , vol.187 , Issue.1 , pp. 61-70
    • Lamkanfi, M.1    Mueller, J.L.2    Vitari, A.C.3
  • 249
    • 84876667356 scopus 로고    scopus 로고
    • Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma
    • Tabata C, Shibata E, Tabata R, et al. Serum HMGB1 as a prognostic marker for malignant pleural mesothelioma. BMC Cancer 2013;13:205
    • (2013) BMC Cancer , vol.13 , pp. 205
    • Tabata, C.1    Shibata, E.2    Tabata, R.3
  • 250
    • 84883232281 scopus 로고    scopus 로고
    • Serum HMGB1 as a diagnostic marker for malignant peritoneal mesothelioma
    • Tabata C, Kanemura S, Tabata R, et al. Serum HMGB1 as a diagnostic marker for malignant peritoneal mesothelioma. J Clin Gastroenterol 2013;47(8):684-8
    • (2013) J Clin Gastroenterol , vol.47 , Issue.8 , pp. 684-688
    • Tabata, C.1    Kanemura, S.2    Tabata, R.3
  • 251
    • 58949092008 scopus 로고    scopus 로고
    • Diagnostic and prognostic value of soluble mesothelin-related proteins in patients with malignant pleural mesothelioma in comparison with benign asbestosis and lung cancer
    • Schneider J, Hoffmann H, Dienemann H, et al. Diagnostic and prognostic value of soluble mesothelin-related proteins in patients with malignant pleural mesothelioma in comparison with benign asbestosis and lung cancer. J Thorac Oncol 2008;3(11):1317-24
    • (2008) J Thorac Oncol , vol.3 , Issue.11 , pp. 1317-1324
    • Schneider, J.1    Hoffmann, H.2    Dienemann, H.3
  • 252
    • 84862991636 scopus 로고    scopus 로고
    • Serum mesothelin for diagnosing malignant pleural mesothelioma: An individual patient data meta-analysis
    • Hollevoet K, Reitsma JB, Creaney J, et al. Serum mesothelin for diagnosing malignant pleural mesothelioma: An individual patient data meta-analysis. J Clin Oncol 2012; 30(13):1541-9
    • (2012) J Clin Oncol , vol.30 , Issue.13 , pp. 1541-1549
    • Hollevoet, K.1    Reitsma, J.B.2    Creaney, J.3
  • 253
    • 26444506232 scopus 로고    scopus 로고
    • Asbestos exposure, pleural mesothelioma, and serum osteopontin levels
    • Pass HI, Lott D, Lonardo F, et al. Asbestos exposure, pleural mesothelioma, and serum osteopontin levels. N Engl J Med 2005; 353(15):1564-73
    • (2005) N Engl J Med , vol.353 , Issue.15 , pp. 1564-1573
    • Pass, H.I.1    Lott, D.2    Lonardo, F.3
  • 254
    • 84867191409 scopus 로고    scopus 로고
    • Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma
    • Pass HI, Levin SM, Harbut MR, et al. Fibulin-3 as a blood and effusion biomarker for pleural mesothelioma. N Engl J Med 2012;367(15):1417-27
    • (2012) N Engl J Med , vol.367 , Issue.15 , pp. 1417-1427
    • Pass, H.I.1    Levin, S.M.2    Harbut, M.R.3
  • 255
    • 0032579462 scopus 로고    scopus 로고
    • Vitamin A and cancer prevention II: Comparison of the effects of retinol and beta-carotene
    • de Klerk NH, Musk AW, Ambrosini GL, et al. Vitamin A and cancer prevention II: Comparison of the effects of retinol and beta-carotene. Int J Cancer 1998;75(3): 362-7
    • (1998) Int J Cancer , vol.75 , Issue.3 , pp. 362-367
    • De Klerk, N.H.1    Musk, A.W.2    Ambrosini, G.L.3
  • 256
    • 77955272046 scopus 로고    scopus 로고
    • Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia
    • Alfonso HS, Reid A, de Klerk NH, et al. Retinol supplementation and mesothelioma incidence in workers earlier exposed to blue asbestos (Crocidolite) at Wittenoom, Western Australia. Eur J Cancer Prev 2010; 19(5):355-9
    • (2010) Eur J Cancer Prev , vol.19 , Issue.5 , pp. 355-359
    • Alfonso, H.S.1    Reid, A.2    De Klerk, N.H.3
  • 257
    • 84862117879 scopus 로고    scopus 로고
    • The antioxidants vitamins A and e and selenium do not reduce the incidence of asbestos-induced disease in a mouse model of mesothelioma
    • Robinson C, Woo S, Walsh A, et al. The antioxidants vitamins A and E and selenium do not reduce the incidence of asbestos-induced disease in a mouse model of mesothelioma. Nutr Cancer 2012;64(2): 315-22
    • (2012) Nutr Cancer , vol.64 , Issue.2 , pp. 315-322
    • Robinson, C.1    Woo, S.2    Walsh, A.3
  • 258
    • 84908447518 scopus 로고    scopus 로고
    • Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort
    • Robinson C, Alfonso H, Woo S, et al. Effect of NSAIDS and COX-2 inhibitors on the incidence and severity of asbestos-induced malignant mesothelioma: Evidence from an animal model and a human cohort. Lung Cancer 2014;86(1): 29-34
    • (2014) Lung Cancer , vol.86 , Issue.1 , pp. 29-34
    • Robinson, C.1    Alfonso, H.2    Woo, S.3
  • 259
    • 84905460215 scopus 로고    scopus 로고
    • Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans
    • Robinson C, Alfonso H, Woo S, et al. Statins do not alter the incidence of mesothelioma in asbestos exposed mice or humans. PLoS ONE 2014;9(8):e103025
    • (2014) PLoS ONE , vol.9 , Issue.8 , pp. e103025
    • Robinson, C.1    Alfonso, H.2    Woo, S.3
  • 260
    • 84887970737 scopus 로고    scopus 로고
    • Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats
    • Nagai H, Okazaki Y, Chew SH, et al. Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats. Cancer Prev Res (Phila) 2013;6(11):1222-30
    • (2013) Cancer Prev Res (Phila , vol.6 , Issue.11 , pp. 1222-1230
    • Nagai, H.1    Okazaki, Y.2    Chew, S.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.