Loss of the deubiquitylase BAP1 alters class I histone deacetylase expression and sensitivity of mesothelioma cells to HDAC inhibitors

Oncotarget

Volumn 6, Issue 15, 2015, Pages 13757-13771

  Sacco, Joseph J ^a   Kenyani, Jenna ^a   Butt, Zohra ^a   Carter, Rachel ^a   Chew, Hui Yi ^a,b   Cheeseman, Liam P ^a,c   Darling, Sarah ^a   Denny, Michael ^a   Urbé, Sylvie ^a   Clague, Michael J ^a   Coulson, Judy M ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

BRCA1 associated protein 1; Histone deacetylase 2; MPM; Stratified medicine; Vorinostat

Indexed keywords

BRCA1 ASSOCIATED PROTEIN 1; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; SMALL INTERFERING RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; BAP1 PROTEIN, HUMAN; HDAC1 PROTEIN, HUMAN; HDAC2 PROTEIN, HUMAN; UBIQUITIN THIOLESTERASE;

ARTICLE; CARCINOID; CONTROLLED STUDY; CORRELATIONAL STUDY; DOWN REGULATION; DRUG SENSITIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ACTIVATION; GENETIC TRANSCRIPTION; HISTONE UBIQUITINATION; LOSS OF FUNCTION MUTATION; LUNG CANCER CELL LINE; NON SMALL CELL LUNG CANCER; PLEURA MESOTHELIOMA; PROTEIN EXPRESSION; SMALL CELL LUNG CANCER; APOPTOSIS; BIOSYNTHESIS; DEFICIENCY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; LUNG NEOPLASMS; MESOTHELIOMA; METABOLISM; PATHOLOGY; TUMOR CELL LINE; UBIQUITINATION;

APOPTOSIS; CELL LINE, TUMOR; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITORS; HUMANS; LUNG NEOPLASMS; MESOTHELIOMA; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

EID: 84979868471     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.3765     Document Type: Article

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