Losses of both products of the cdkn2a/arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Altomare, Deborah A ^a   Menges, Craig W ^a   Xu, Jinfei ^a   Pei, Jianming ^a   Zhang, Lili ^a   Tadevosyan, Ara ^a   Neumann Domer, Erin ^a   Liu, Zemin ^a   Carbone, Michele ^b   Chudoba, Ilse ^c   Klein Szanto, Andres J ^a   Testa, Joseph R ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^c MetaSystems   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; CDKN2A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARF GENE; ARTICLE; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CONTROLLED STUDY; EXON; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE LOCUS; GENOMIC INSTABILITY; INK4A GENE; INK4B GENE; MALIGNANT MESOTHELIOMA; MOUSE; NONHUMAN; P53 GENE; SURVIVAL RATE; TUMOR SUPPRESSOR GENE; ALLELE; ANIMAL; CHROMOSOME; GENE SILENCING; GENETICS; HUMAN; MESOTHELIOMA; METABOLISM; PATHOLOGY; PRECANCER;

MUS;

ALLELES; ANIMALS; ASBESTOS; CHROMOSOMES, MAMMALIAN; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GENE SILENCING; GENETIC LOCI; HUMANS; MESOTHELIOMA; MICE; PRECANCEROUS CONDITIONS; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 79955442548     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018828     Document Type: Article

References (13)

1. Kamijo T, Zindy F, Roussel MF, Quelle DE, Downing JR, et al. (1997) Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell 91: 649-659.
2. Kamijo T, Bodner S, van de Kamp E, Randle DH, Sherr CJ, (1999) Tumor spectrum in ARF-deficient mice. Cancer Res 59: 2217-2222.
3. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, et al. (2001) Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413: 86-91.
4. Serrano M, Lee H-W, Chin L, Cordon-Cardo C, Beach D, et al. (1996) Role of the INK4a locus in tumor suppression and cell mortality. Cell 85: 27-37.
5. Altomare DA, Vaslet CA, Skele KL, De Rienzo A, Devarajan K, et al. (2005) A mouse model recapitulating molecular features of human mesothelioma. Cancer Res 65: 8090-8095.
6. Altomare DA, Menges CW, Pei J, Zhang L, Skele-Stump KL, et al. (2009) Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc Natl Acad Sci U S A 106: 3430-3435.
7. Heintz NH, Janssen-Heininger YM, Mossman BT, (2010) Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am J Respir Cell Mol Biol 42: 133-139.
8. Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA, (2004) The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene 23: 379-385.
9. Jongsma J, van Montfort E, Vooijs M, Zevenhoven J, Krimpenfort P, et al. (2008) A conditional mouse model for malignant mesothelioma. Cancer Cell 12: 261-271.
10. Poulikakos PI, Xiao GH, Gallagher R, Jablonski S, Jhanwar SC, et al. (2006) Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK. Oncogene 25.
11. Fleury-Feith J, Lecomte C, Renier A, Matrat M, Kheuang L, et al. (2003) Hemizygosity of Nf2 is associated with increased susceptibility to asbestos-induced peritoneal tumours. Oncogene 22: 3799-3805.
12. Hopkins-Donaldson S, Belyanskaya LL, Simões-Wüst AP, Sigrist B, Kurtz S, et al. (2006) p53-induced apoptosis occurs in the absence of p14(ARF) in malignant pleural mesothelioma. Neoplasia 8: 551-559.
13. Testa JRGL, Salazar H, Liu Z, Handel LM, Godwin AK, Hamilton TC, (1994) Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity. Cancer Res 54: 2778-2784.