메뉴 건너뛰기




Volumn 34, Issue 7, 2013, Pages 1413-1419

Molecular pathogenesis of malignant mesothelioma

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; MAMMALIAN TARGET OF RAPAMYCIN; MERLIN; NEUROFIBROMATOSIS TYPE 2 PROTEIN; PROTEIN; PROTEIN TYROSINE KINASE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

EID: 84880273681     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgt166     Document Type: Article
Times cited : (216)

References (73)
  • 1
    • 26444458845 scopus 로고    scopus 로고
    • Advances in malignant mesothelioma
    • Robinson, B.W. et al. (2005) Advances in malignant mesothelioma. N. Engl. J. Med., 353, 1591-1603.
    • (2005) N. Engl. J. Med. , vol.353 , pp. 1591-1603
    • Robinson, B.W.1
  • 2
    • 65349131853 scopus 로고    scopus 로고
    • Malignant pleural mesothelioma
    • Tsao, A.S. et al. (2009) Malignant pleural mesothelioma. J. Clin. Oncol., 27, 2081-2090.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2081-2090
    • Tsao, A.S.1
  • 3
    • 69149105448 scopus 로고    scopus 로고
    • Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group
    • Husain, A.N. et al. (2009) Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. Arch. Pathol. Lab. Med., 133, 1317-1331.
    • (2009) Arch. Pathol. Lab. Med. , vol.133 , pp. 1317-1331
    • Husain, A.N.1
  • 4
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang, N.J. et al. (2003) Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J. Clin. Oncol., 21, 2636-2644.
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1
  • 5
    • 79955562300 scopus 로고    scopus 로고
    • Review on clinical trials of targeted treatments in malignant mesothelioma
    • Jakobsen, J.N. et al. (2011) Review on clinical trials of targeted treatments in malignant mesothelioma. Cancer Chemother. Pharmacol., 68, 1-15.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , pp. 1-15
    • Jakobsen, J.N.1
  • 6
    • 84858017101 scopus 로고    scopus 로고
    • Molecular changes in mesothelioma with an impact on prognosis and treatment
    • Jean, D. et al. (2012) Molecular changes in mesothelioma with an impact on prognosis and treatment. Arch. Pathol. Lab. Med., 136, 277-293.
    • (2012) Arch. Pathol. Lab. Med. , vol.136 , pp. 277-293
    • Jean, D.1
  • 7
    • 2942547767 scopus 로고    scopus 로고
    • Malignant pleural mesothelioma
    • Pass, H.I. et al. (2004) Malignant pleural mesothelioma. Curr. Probl. Cancer, 28, 93-174.
    • (2004) Curr. Probl. Cancer , vol.28 , pp. 93-174
    • Pass, H.I.1
  • 8
    • 0033823647 scopus 로고    scopus 로고
    • Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells
    • Liu, W. et al. (2000) Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells. Am. J. Respir. Cell Mol. Biol., 23, 371-378.
    • (2000) Am. J. Respir. Cell Mol. Biol. , vol.23 , pp. 371-378
    • Liu, W.1
  • 9
    • 74549195498 scopus 로고    scopus 로고
    • Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways
    • Heintz, N.H. et al. (2010) Asbestos, lung cancers, and mesotheliomas: from molecular approaches to targeting tumor survival pathways. Am. J. Respir. Cell Mol. Biol., 42, 133-139.
    • (2010) Am. J. Respir. Cell Mol. Biol. , vol.42 , pp. 133-139
    • Heintz, N.H.1
  • 10
    • 65549136242 scopus 로고    scopus 로고
    • Mechanisms of asbestos-induced carcinogenesis
    • Toyokuni, S. (2009) Mechanisms of asbestos-induced carcinogenesis. Nagoya J. Med. Sci., 71, 1-10.
    • (2009) Nagoya J. Med. Sci. , vol.71 , pp. 1-10
    • Toyokuni, S.1
  • 11
    • 33745892099 scopus 로고    scopus 로고
    • TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestosinduced oncogenesis
    • Yang, H. et al. (2006) TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestosinduced oncogenesis. Proc. Natl Acad. Sci. USA, 103, 10397-10402.
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 10397-10402
    • Yang, H.1
  • 12
    • 77955446834 scopus 로고    scopus 로고
    • Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation
    • Yang, H. et al. (2010) Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation. Proc. Natl Acad. Sci. USA, 107, 12611-12616.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 12611-12616
    • Yang, H.1
  • 13
    • 80053969591 scopus 로고    scopus 로고
    • DNA repair systems in malignant mesothelioma
    • Toumpanakis, D. et al. (2011) DNA repair systems in malignant mesothelioma. Cancer Lett., 312, 143-149.
    • (2011) Cancer Lett. , vol.312 , pp. 143-149
    • Toumpanakis, D.1
  • 14
    • 71549141637 scopus 로고    scopus 로고
    • Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets
    • Røe, O.D. et al. (2010) Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets. Lung Cancer, 67, 57-68.
    • (2010) Lung Cancer , vol.67 , pp. 57-68
    • Røe, O.D.1
  • 15
    • 77952317021 scopus 로고    scopus 로고
    • Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma
    • Donaldson, K. et al. (2010) Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part. Fibre Toxicol., 7, 5.
    • (2010) Part. Fibre Toxicol , vol.7 , Issue.5
    • Donaldson, K.1
  • 16
    • 70449556649 scopus 로고    scopus 로고
    • Inhaled carbon nanotubes reach the subpleural tissue in mice
    • Ryman-Rasmussen, J.P. et al. (2009) Inhaled carbon nanotubes reach the subpleural tissue in mice. Nat. Nanotechnol., 4, 747-751.
    • (2009) Nat. Nanotechnol. , vol.4 , pp. 747-751
    • Ryman-Rasmussen, J.P.1
  • 17
    • 83755178438 scopus 로고    scopus 로고
    • Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis
    • Nagai, H. et al. (2011) Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis. Proc. Natl Acad. Sci. USA, 108, E1330-E1338.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108
    • Nagai, H.1
  • 18
    • 79955459524 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases in malignant mesothelioma as a rationale for combination targeted therapy
    • Brevet, M. et al. (2011) Coactivation of receptor tyrosine kinases in malignant mesothelioma as a rationale for combination targeted therapy. J. Thorac. Oncol., 6, 864-874.
    • (2011) J. Thorac. Oncol. , vol.6 , pp. 864-874
    • Brevet, M.1
  • 19
    • 80054897151 scopus 로고    scopus 로고
    • Brief report: a phase II study of sunitinib in malignant pleural mesothelioma
    • Laurie, S.A. et al. (2011) Brief report: a phase II study of sunitinib in malignant pleural mesothelioma. the NCIC Clinical Trials Group. J. Thorac. Oncol., 6, 1950-1954.
    • (2011) The NCIC Clinical Trials Group. J. Thorac. Oncol. , vol.6 , pp. 1950-1954
    • Laurie, S.A.1
  • 20
    • 77958167230 scopus 로고    scopus 로고
    • A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307
    • Dubey, S. et al. (2010) A phase II study of sorafenib in malignant mesothelioma: results of Cancer and Leukemia Group B 30307. J. Thorac. Oncol., 5, 1655-1661.
    • (2010) J. Thorac. Oncol. , vol.5 , pp. 1655-1661
    • Dubey, S.1
  • 21
    • 77950916911 scopus 로고    scopus 로고
    • Combined treatment with cisplatin and sirolimus to enhance cell death in human mesothelioma
    • Hartman, M.L. et al. (2010) Combined treatment with cisplatin and sirolimus to enhance cell death in human mesothelioma. J. Thorac. Cardiovasc. Surg., 139, 1233-1240.
    • (2010) J. Thorac. Cardiovasc. Surg. , vol.139 , pp. 1233-1240
    • Hartman, M.L.1
  • 22
    • 45149094559 scopus 로고    scopus 로고
    • Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids
    • Barbone, D. et al. (2008) Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. J. Biol. Chem., 283, 13021-13030.
    • (2008) J. Biol. Chem. , vol.283 , pp. 13021-13030
    • Barbone, D.1
  • 23
    • 78650997009 scopus 로고    scopus 로고
    • Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma
    • Varghese, S. et al. (2011) Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma. Cancer, 117, 361-371.
    • (2011) Cancer , vol.117 , pp. 361-371
    • Varghese, S.1
  • 24
    • 79952269646 scopus 로고    scopus 로고
    • A phosphotyrosine proteomic screen identifies multiple tyrosine kinase signaling pathways aberrantly activated in malignant mesothelioma
    • Menges, C.W. et al. (2010) A phosphotyrosine proteomic screen identifies multiple tyrosine kinase signaling pathways aberrantly activated in malignant mesothelioma. Genes Cancer, 1, 493-505.
    • (2010) Genes Cancer , vol.1 , pp. 493-505
    • Menges, C.W.1
  • 25
    • 80054880979 scopus 로고    scopus 로고
    • Phase II study of cediranib in patients with malignant pleural mesothelioma: SWOG S0509
    • Garland, L.L. et al. (2011) Phase II study of cediranib in patients with malignant pleural mesothelioma: SWOG S0509. J. Thorac. Oncol., 6, 1938-1945.
    • (2011) J. Thorac. Oncol. , vol.6 , pp. 1938-1945
    • Garland, L.L.1
  • 26
    • 84866158896 scopus 로고    scopus 로고
    • Cediranib in patients with malignant mesothelioma: a phase II trial of the University of Chicago Phase II Consortium
    • Campbell, N.P. et al. (2012) Cediranib in patients with malignant mesothelioma: a phase II trial of the University of Chicago Phase II Consortium. Lung Cancer, 78, 76-80.
    • (2012) Lung Cancer , vol.78 , pp. 76-80
    • Campbell, N.P.1
  • 27
    • 33748444562 scopus 로고    scopus 로고
    • Cytogenetic and molecular genetic changes in malignant mesothelioma
    • Musti, M. et al. (2006) Cytogenetic and molecular genetic changes in malignant mesothelioma. Cancer Genet. Cytogenet., 170, 9-15.
    • (2006) Cancer Genet. Cytogenet. , vol.170 , pp. 9-15
    • Musti, M.1
  • 28
    • 0029155471 scopus 로고
    • Codeletion of p15 and p16 in primary malignant mesothelioma
    • Xio, S. et al. (1995) Codeletion of p15 and p16 in primary malignant mesothelioma. Oncogene, 11, 511-515.
    • (1995) Oncogene , vol.11 , pp. 511-515
    • Xio, S.1
  • 29
    • 0038515139 scopus 로고    scopus 로고
    • Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas
    • Illei, P.B. et al. (2003) Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas. Clin. Cancer Res., 9, 2108-2113.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 2108-2113
    • Illei, P.B.1
  • 30
    • 84871773204 scopus 로고    scopus 로고
    • Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis
    • Wu, D. et al. (2013) Diagnostic usefulness of p16/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis. Am. J. Clin. Pathol., 139, 39-46.
    • (2013) Am. J. Clin. Pathol. , vol.139 , pp. 39-46
    • Wu, D.1
  • 31
    • 84355162843 scopus 로고    scopus 로고
    • Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues
    • Takeda, M. et al. (2012) Genomic gains and losses in malignant mesothelioma demonstrated by FISH analysis of paraffin-embedded tissues. J. Clin. Pathol., 65, 77-82.
    • (2012) J. Clin. Pathol. , vol.65 , pp. 77-82
    • Takeda, M.1
  • 32
    • 44349092440 scopus 로고    scopus 로고
    • Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas
    • Chiosea, S. et al. (2008) Diagnostic importance of 9p21 homozygous deletion in malignant mesotheliomas. Mod. Pathol., 21, 742-747.
    • (2008) Mod. Pathol. , vol.21 , pp. 742-747
    • Chiosea, S.1
  • 33
    • 47049096400 scopus 로고    scopus 로고
    • 9p21 Deletion in the diagnosis of malignant mesothelioma in serous effusions additional to immunocytochemistry, DNAICM, and AgNOR analysis
    • Onofre, F.B. et al. (2008) 9p21 Deletion in the diagnosis of malignant mesothelioma in serous effusions additional to immunocytochemistry, DNAICM, and AgNOR analysis. Cancer, 114, 204-215.
    • (2008) Cancer , vol.114 , pp. 204-215
    • Onofre, F.B.1
  • 34
    • 84880265119 scopus 로고    scopus 로고
    • Morphology of 9p21 homozygous deletionpositive pleural mesothelioma cells analyzed using fluorescence in situ hybridization and virtual microscope system in effusion cytology
    • doi:101002/cncy.21269.
    • Matsumoto, S. et al. (2013) Morphology of 9p21 homozygous deletionpositive pleural mesothelioma cells analyzed using fluorescence in situ hybridization and virtual microscope system in effusion cytology. Cancer Cytopathol. doi:10.1002/cncy.21269.
    • (2013) Cancer Cytopathol
    • Matsumoto, S.1
  • 35
    • 77954926304 scopus 로고    scopus 로고
    • Pro-tumorigenic effects of miR-31 loss in mesothelioma
    • Ivanov, S.V. et al. (2010) Pro-tumorigenic effects of miR-31 loss in mesothelioma. J. Biol. Chem., 285, 22809-22817.
    • (2010) J. Biol. Chem. , vol.285 , pp. 22809-22817
    • Ivanov, S.V.1
  • 36
    • 79959694149 scopus 로고    scopus 로고
    • The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma
    • Bott, M. et al. (2011) The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. Nat. Genet., 43, 668-672.
    • (2011) Nat. Genet. , vol.43 , pp. 668-672
    • Bott, M.1
  • 37
    • 63049127084 scopus 로고    scopus 로고
    • Functional inactivation of NF2/merlin in human mesothelioma
    • Thurneysen, C. et al. (2009) Functional inactivation of NF2/merlin in human mesothelioma. Lung Cancer, 64, 140-147.
    • (2009) Lung Cancer , vol.64 , pp. 140-147
    • Thurneysen, C.1
  • 38
    • 0001387683 scopus 로고    scopus 로고
    • Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: evidence for a twohit mechanism of NF2 inactivation
    • Cheng, J.Q. et al. (1999) Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: evidence for a twohit mechanism of NF2 inactivation. Genes. Chromosomes Cancer, 24, 238-242.
    • (1999) Genes. Chromosomes Cancer , vol.24 , pp. 238-242
    • Cheng, J.Q.1
  • 39
    • 79551570342 scopus 로고    scopus 로고
    • LATS2 is a tumor suppressor gene of malignant mesothelioma
    • Murakami, H. et al. (2011) LATS2 is a tumor suppressor gene of malignant mesothelioma. Cancer Res., 71, 873-883.
    • (2011) Cancer Res. , vol.71 , pp. 873-883
    • Murakami, H.1
  • 40
    • 84860248968 scopus 로고    scopus 로고
    • Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma
    • Yoshikawa, Y. et al. (2012) Frequent inactivation of the BAP1 gene in epithelioid-type malignant mesothelioma. Cancer Sci., 103, 868-874.
    • (2012) Cancer Sci. , vol.103 , pp. 868-874
    • Yoshikawa, Y.1
  • 41
    • 62549148264 scopus 로고    scopus 로고
    • Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice
    • Altomare, D.A. et al. (2009) Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. Proc. Natl Acad. Sci. USA, 106, 3420-3425.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3420-3425
    • Altomare, D.A.1
  • 42
    • 79955442548 scopus 로고    scopus 로고
    • Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis
    • Altomare, D.A. et al. (2011) Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis. PLoS One, 6, e18828.
    • (2011) PLoS One , vol.6
    • Altomare, D.A.1
  • 43
    • 77649104601 scopus 로고    scopus 로고
    • Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma
    • Hu, Q. et al. (2010) Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma. Lab. Invest., 90, 360-373.
    • (2010) Lab. Invest. , vol.90 , pp. 360-373
    • Hu, Q.1
  • 44
    • 43949098268 scopus 로고    scopus 로고
    • New insights into the biology of peritoneal mesothelial cells: the roles of epithelial-to-mesenchymal transition and cellular senescence
    • Witowski, J. et al. (2008) New insights into the biology of peritoneal mesothelial cells: the roles of epithelial-to-mesenchymal transition and cellular senescence. Nephron. Exp. Nephrol., 108, e69-e73.
    • (2008) Nephron. Exp. Nephrol. , vol.108
    • Witowski, J.1
  • 45
    • 0028907620 scopus 로고
    • Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer
    • Sekido, Y. et al. (1995) Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancer. Cancer Res., 55,1227-1231.
    • (1995) Cancer Res. , vol.55 , pp. 1227-1231
    • Sekido, Y.1
  • 46
    • 0028818921 scopus 로고
    • High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas
    • Bianchi, A.B. et al. (1995) High frequency of inactivating mutations in the neurofibromatosis type 2 gene (NF2) in primary malignant mesotheliomas. Proc. Natl Acad. Sci. USA, 92, 10854-10858.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10854-10858
    • Bianchi, A.B.1
  • 47
    • 84864063110 scopus 로고    scopus 로고
    • Merlin: the wizard requires protein stability to function as a tumor suppressor
    • Morrow, K.A. et al. (2012) Merlin: the wizard requires protein stability to function as a tumor suppressor. Biochim. Biophys. Acta, 1826, 400-406.
    • (2012) Biochim. Biophys. Acta , vol.1826 , pp. 400-406
    • Morrow, K.A.1
  • 48
    • 67449086733 scopus 로고    scopus 로고
    • CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis
    • Guled, M. et al. (2009) CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis. Genes. Chromosomes Cancer, 48, 615-623.
    • (2009) Genes. Chromosomes Cancer , vol.48 , pp. 615-623
    • Guled, M.1
  • 49
    • 24944522720 scopus 로고    scopus 로고
    • A mouse model recapitulating molecular features of human mesothelioma
    • Altomare, D.A. et al. (2005) A mouse model recapitulating molecular features of human mesothelioma. Cancer Res., 65, 8090-8095.
    • (2005) Cancer Res. , vol.65 , pp. 8090-8095
    • Altomare, D.A.1
  • 50
    • 39849089040 scopus 로고    scopus 로고
    • A conditional mouse model for malignant mesothelioma
    • Jongsma, J. et al. (2008) A conditional mouse model for malignant mesothelioma. Cancer Cell, 13, 261-271.
    • (2008) Cancer Cell , vol.13 , pp. 261-271
    • Jongsma, J.1
  • 51
    • 76749108011 scopus 로고    scopus 로고
    • Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus
    • Li, W. et al. (2010) Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus. Cell, 140, 477-490.
    • (2010) Cell , vol.140 , pp. 477-490
    • Li, W.1
  • 52
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante, M. et al. (2012) mTOR signaling in growth control and disease. Cell, 149, 274-293.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1
  • 53
    • 67651230554 scopus 로고    scopus 로고
    • Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling
    • López-Lago, M.A. et al. (2009) Loss of the tumor suppressor gene NF2, encoding merlin, constitutively activates integrin-dependent mTORC1 signaling. Mol. Cell. Biol., 29, 4235-4249.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4235-4249
    • López-Lago, M.A.1
  • 54
    • 67651230548 scopus 로고    scopus 로고
    • NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth
    • James, M.F. et al. (2009) NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth. Mol. Cell. Biol., 29, 4250-4261.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4250-4261
    • James, M.F.1
  • 55
    • 77957883342 scopus 로고    scopus 로고
    • The hippo signaling pathway in development and cancer
    • Pan, D. (2010) The hippo signaling pathway in development and cancer. Dev. Cell, 19, 491-505.
    • (2010) Dev. Cell , vol.19 , pp. 491-505
    • Pan, D.1
  • 56
    • 56049125036 scopus 로고    scopus 로고
    • YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation
    • Yokoyama, T. et al. (2008) YAP1 is involved in mesothelioma development and negatively regulated by Merlin through phosphorylation. Carcinogenesis, 29, 2139-2146.
    • (2008) Carcinogenesis , vol.29 , pp. 2139-2146
    • Yokoyama, T.1
  • 57
    • 84870807773 scopus 로고    scopus 로고
    • YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes
    • Mizuno, T. et al. (2012) YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene, 31, 5117-5122.
    • (2012) Oncogene , vol.31 , pp. 5117-5122
    • Mizuno, T.1
  • 58
    • 84860354807 scopus 로고    scopus 로고
    • TGF-ß synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth
    • Fujii, M. et al. (2012) TGF-ß synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J. Exp. Med., 209, 479-494.
    • (2012) J. Exp. Med. , vol.209 , pp. 479-494
    • Fujii, M.1
  • 59
    • 79955934205 scopus 로고    scopus 로고
    • An emerging model for BAP1's role in regulating cell cycle progression
    • Eletr, Z.M. et al. (2011) An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem. Biophys., 60, 3-11.
    • (2011) Cell Biochem. Biophys. , vol.60 , pp. 3-11
    • Eletr, Z.M.1
  • 60
    • 80053385701 scopus 로고    scopus 로고
    • Germline BAP1 mutations predispose to malignant mesothelioma
    • Testa, J.R. et al. (2011) Germline BAP1 mutations predispose to malignant mesothelioma. Nat. Genet., 43, 1022-1025.
    • (2011) Nat. Genet. , vol.43 , pp. 1022-1025
    • Testa, J.R.1
  • 61
    • 78649700287 scopus 로고    scopus 로고
    • Frequent mutation of BAP1 in metastasizing uveal melanomas
    • Harbour, J.W. et al. (2010) Frequent mutation of BAP1 in metastasizing uveal melanomas. Science, 330, 1410-1413.
    • (2010) Science , vol.330 , pp. 1410-1413
    • Harbour, J.W.1
  • 62
    • 80053386896 scopus 로고    scopus 로고
    • Germline mutations in BAP1 predispose to melanocytic tumors
    • Wiesner, T. et al. (2011) Germline mutations in BAP1 predispose to melanocytic tumors. Nat. Genet., 43, 1018-1021.
    • (2011) Nat. Genet. , vol.43 , pp. 1018-1021
    • Wiesner, T.1
  • 63
    • 84862988411 scopus 로고    scopus 로고
    • BAP1 loss defines a new class of renal cell carcinoma
    • Peña-Llopis, S. et al. (2012) BAP1 loss defines a new class of renal cell carcinoma. Nat. Genet., 44, 751-759.
    • (2012) Nat. Genet. , vol.44 , pp. 751-759
    • Peña-Llopis, S.1
  • 64
    • 33846258311 scopus 로고    scopus 로고
    • Promoter methylation of RASSF1A, RARbeta and DAPK predict poor prognosis of patients with malignant mesothelioma
    • Fischer, J.R. et al. (2006) Promoter methylation of RASSF1A, RARbeta and DAPK predict poor prognosis of patients with malignant mesothelioma. Lung Cancer, 54, 109-116.
    • (2006) Lung Cancer , vol.54 , pp. 109-116
    • Fischer, J.R.1
  • 65
    • 58249128191 scopus 로고    scopus 로고
    • Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome
    • Christensen, B.C. et al. (2009) Epigenetic profiles distinguish pleural mesothelioma from normal pleura and predict lung asbestos burden and clinical outcome. Cancer Res., 69, 227-234.
    • (2009) Cancer Res. , vol.69 , pp. 227-234
    • Christensen, B.C.1
  • 66
    • 71549131914 scopus 로고    scopus 로고
    • Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma
    • Goto, Y. et al. (2009) Epigenetic profiles distinguish malignant pleural mesothelioma from lung adenocarcinoma. Cancer Res., 69, 9073-9082.
    • (2009) Cancer Res. , vol.69 , pp. 9073-9082
    • Goto, Y.1
  • 67
    • 77955042687 scopus 로고    scopus 로고
    • Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma
    • Christensen, B.C. et al. (2010) Integrated profiling reveals a global correlation between epigenetic and genetic alterations in mesothelioma. Cancer Res., 70, 5686-5694.
    • (2010) Cancer Res. , vol.70 , pp. 5686-5694
    • Christensen, B.C.1
  • 68
    • 84855433971 scopus 로고    scopus 로고
    • Polycomb repressor complex-2 is a novel target for mesothelioma therapy
    • Kemp, C.D. et al. (2012) Polycomb repressor complex-2 is a novel target for mesothelioma therapy. Clin. Cancer Res., 18, 77-90.
    • (2012) Clin. Cancer Res. , vol.18 , pp. 77-90
    • Kemp, C.D.1
  • 69
    • 77249135944 scopus 로고    scopus 로고
    • MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications
    • Busacca, S. et al. (2010) MicroRNA signature of malignant mesothelioma with potential diagnostic and prognostic implications. Am. J. Respir. Cell Mol. Biol., 42, 312-319.
    • (2010) Am. J. Respir. Cell Mol. Biol. , vol.42 , pp. 312-319
    • Busacca, S.1
  • 70
    • 77950285052 scopus 로고    scopus 로고
    • Hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma
    • Pass, H.I. et al. (2010) hsa-miR-29c* is linked to the prognosis of malignant pleural mesothelioma. Cancer Res., 70, 1916-1924.
    • (2010) Cancer Res. , vol.70 , pp. 1916-1924
    • Pass, H.I.1
  • 71
    • 79959261969 scopus 로고    scopus 로고
    • Factors that impact susceptibility to fiber-induced health effects
    • Below, J.E. et al. (2011) Factors that impact susceptibility to fiber-induced health effects. J. Toxicol. Environ. Health. B. Crit. Rev., 14, 246-266.
    • (2011) J. Toxicol. Environ. Health. B. Crit. Rev. , vol.14 , pp. 246-266
    • Below, J.E.1
  • 72
    • 33846509979 scopus 로고    scopus 로고
    • A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes
    • Carbone, M. et al. (2007) A mesothelioma epidemic in Cappadocia: scientific developments and unexpected social outcomes. Nat. Rev. Cancer, 7, 147-154.
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 147-154
    • Carbone, M.1
  • 73
    • 42149162212 scopus 로고    scopus 로고
    • Transcriptome sequencing of malignant pleural mesothelioma tumors
    • Sugarbaker, D.J. et al. (2008) Transcriptome sequencing of malignant pleural mesothelioma tumors. Proc. Natl Acad. Sci. USA, 105, 3521-3526.
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 3521-3526
    • Sugarbaker, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.