Glucocorticoid signaling in the heart: A cardiomyocyte perspective

Journal of Steroid Biochemistry and Molecular Biology

Volumn 153, Issue , 2015, Pages 27-34

  Oakley, Robert H ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cardiomyocytes; Glucocorticoid receptor; Glucocorticoids; Mineralocorticoid receptor; Transgenic mice

Indexed keywords

ALDOSTERONE; ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; ATRIAL MYOSIN; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; COLLAGEN; CONNECTIVE TISSUE GROWTH FACTOR; DEXAMETHASONE; DIPEPTIDYL CARBOXYPEPTIDASE; DOXYCYCLINE; FIBRONECTIN; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR BETA; MINERALOCORTICOID ANTAGONIST; MINERALOCORTICOID RECEPTOR; MYOSIN HEAVY CHAIN BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PLASMINOGEN ACTIVATOR INHIBITOR 1; REACTIVE OXYGEN METABOLITE; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; SODIUM CALCIUM EXCHANGE PROTEIN; STRESS HORMONE; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIMENTIN;

ALDOSTERONE BLOOD LEVEL; ALTERNATIVE RNA SPLICING; AORTA CONSTRICTION; ARTICLE; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; CHROMATIN ASSEMBLY AND DISASSEMBLY; DISEASE COURSE; DNA POLYMORPHISM; ECHOCARDIOGRAPHY; FETUS HEART; GENE CONTROL; GENE EXPRESSION; HEART; HEART DEVELOPMENT; HEART DISEASE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART MUSCLE METABOLISM; HEART PERFORMANCE; HEART PROTECTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE EXTRASYSTOLE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE TACHYCARDIA; HORMONE ACTION; HUMAN; ISCHEMIC HEART DISEASE; MOUSE MODEL; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGICAL PROCESS; PREMATURITY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SUDDEN CARDIAC DEATH; SYSTOLIC DYSFUNCTION; TISSUE INJURY; TRANSCRIPTION INITIATION SITE; TRANSGENIC MOUSE; TRANSLATION INITIATION; VASCULAR SMOOTH MUSCLE CELL; WATER ABSORPTION; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CYTOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; GLUCOCORTICOIDS; HEART; HEART DISEASES; HUMANS; MICE; MICE, TRANSGENIC; MYOCARDIUM; MYOCYTES, CARDIAC; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; SIGNAL TRANSDUCTION;

EID: 84941261196     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2015.03.009     Document Type: Review

References (87)

1. R.H. Oakley, and J.A. Cidlowski The biology of the glucocorticoid receptor: new signaling mechanisms in health and disease J. Allergy Clin. Immunol. 132 5 2013 1033 1044
2. R.M. Evans The steroid and thyroid hormone receptor superfamily Science 240 4854 1988 889 895
3. P.J. Barnes Anti-inflammatory actions of glucocorticoids: molecular mechanisms Clin. Sci. (Lond.) 94 6 1998 557 572
4. R.M. Sapolsky, L.M. Romero, and A.U. Munck How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions Endocr. Rev. 21 1 2000 55 89
5. J.M. Busillo, and J.A. Cidlowski The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore Trends Endocrinol. Metab. 2013
6. T. Rhen, and J.A. Cidlowski Antiinflammatory action of glucocorticoids-new mechanisms for old drugs N. Engl. J. Med. 353 16 2005 1711 1723
7. J.N. Miner, M.H. Hong, and A. Negro-Vilar New and improved glucocorticoid receptor ligands Expert Opin. Investig. Drugs 14 12 2005 1527 1545
8. E. Braunwald, and M.R. Bristow Congestive heart failure: fifty years of progress Circulation 102 20 Suppl. 4 2000 IV14 23
9. D.J. Brotman, S.H. Golden, and I.S. Wittstein The cardiovascular toll of stress Lancet 370 9592 2007 1089 1100
10. A. Steptoe, and M. Kivimaki Stress and cardiovascular disease Nat. Rev. Cardiol. 9 6 2012 360 370
11. T. Addison On the Constitutional and Local Effects of Disease of the Suprarenal Capsules 1855 Samuel Highley London
12. T. Chung, A. Grossman, and A.J.L. Clark Adrenal insufficiency L.J. Jameson, L.J. Degroot, Endocrinology 6th ed. 2010 Saunders Elsevier Philadelphia 1853 1863
13. J.J. Krug Cardiac arrest secondary to Addison's disease Ann. Emergency Med. 15 6 1986 735 737
14. A.M. Lefer Influence of corticosteroids on mechanical performance of isolated rat papillary muscles Am. J. Physiol. 214 3 1968 518 524
15. J.J. Geelhoed, and et al. Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study Early Hum. Dev. 87 2 2011 97 102
16. C. Otte, and et al. Glucocorticoid receptor gene, low-grade inflammation, and heart failure: the heart and soul study J. Clin. Endocrinol. Metab. 95 6 2010 2885 2891
17. E.L. van den Akker, and et al. Glucocorticoid receptor gene and risk of cardiovascular disease Arch. Intern. Med. 168 1 2008 33 39
18. P.W. Hadoke, J. Iqbal, and B.R. Walker Therapeutic manipulation of glucocorticoid metabolism in cardiovascular disease Br. J. Pharmacol. 156 5 2009 689 712
19. N. Merlet, D. Busseuil, E. Rheaume, and J.C. Tardif Cardiac consequences of anti-inflammatory drugs in experimental models Antiinflamm. Antiallergy Agents Med. Chem. 12 1 2013 24 35
20. U. Nussinovitch, J.F. de Carvalho, R.M. Pereira, and Y. Shoenfeld Glucocorticoids and the cardiovascular system: state of the art Curr. Pharm. Des. 16 32 2010 3574 3585
21. N. Narayanan, C. Yang, and A. Xu Dexamethasone treatment improves sarcoplasmic reticulum function and contractile performance in aged myocardium Mol. Cell. Biochem. 266 1-2 2004 31 36
22. Z.J. Penefsky, and M. Kahn Inotropic effects of dexamethasone in mammalian heart muscle Eur. J. Pharmacol. 15 3 1971 259 266
23. M.K. Rao, A. Xu, and N. Narayanan Glucocorticoid modulation of protein phosphorylation and sarcoplasmic reticulum function in rat myocardium Am. J. Physiol. Heart Circ. Physiol. 281 1 2001 H325 333
24. L. Wang, Z.P. Feng, and H.J. Duff Glucocorticoid regulation of cardiac K+ currents and L-type Ca2+ current in neonatal mice Circ. Res. 85 2 1999 168 173
25. R.M. Whitehurst Jr., M. Zhang, A. Bhattacharjee, and M. Li Dexamethasone-induced hypertrophy in rat neonatal cardiac myocytes involves an elevated L-type Ca(2+) current J. Mol. Cell. Cardiol. 31 8 1999 1551 1558
26. Q.M. Chen, and et al. Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes Mol. Pharmacol. 67 6 2005 1861 1873
27. G. Kewalramani, and et al. AMP-activated protein kinase confers protection against TNF-{alpha}-induced cardiac cell death Cardiovasc. Res. 84 1 2009 42 53
28. J.M. Pearl, and et al. Glucocorticoids reduce ischemia-reperfusion-induced myocardial apoptosis in immature hearts Ann. Thorac. Surg. 74 3 2002 830 836 discussion 836-837.
29. R. Ren, R.H. Oakley, D. Cruz-Topete, and J.A. Cidlowski Dual role for glucocorticoids in cardiomyocyte hypertrophy and apoptosis Endocrinology 2012
30. B. Xu, J. Strom, and Q.M. Chen Dexamethasone induces transcriptional activation of Bcl-xL gene and inhibits cardiac injury by myocardial ischemia Eur. J. Pharmacol. 2011
31. L. Migliazza, and et al. Prenatal dexamethasone rescues heart hypoplasia in fetal rats with congenital diaphragmatic hernia J. Pediatr. Surg. 35 12 2000 1757 1761
32. M. Mizuno, and et al. Antenatal glucocorticoid therapy accelerates ATP production with creatine kinase increase in the growth-enhanced fetal rat heart Circ. J. 74 1 2010 171 180
33. M.P. Bal, and et al. Neonatal glucocorticosteroid treatment causes systolic dysfunction and compensatory dilation in early life: studies in 4-week-old prepubertal rats Pediatr. Res. 58 1 2005 46 52
34. W.B. de Vries, and et al. Alterations in adult rat heart after neonatal dexamethasone therapy Pediatr. Res. 52 6 2002 900 906
35. L.W. Doyle, G.W. Ford, N.M. Davis, and C. Callanan Antenatal corticosteroid therapy and blood pressure at 14 years of age in preterm children Clin. Sci. (Lond.) 98 2 2000 137 142
36. D.J. Brotman, and et al. Effects of short-term glucocorticoids on cardiovascular biomarkers J. Clin. Endocrinol. Metab. 90 6 2005 3202 3208
37. N.S. La Mear, S.S. MacGilvray, and T.F. Myers Dexamethasone-induced myocardial hypertrophy in neonatal rats Biol. Neonate 72 3 1997 175 180
38. K. Lister, D.J. Autelitano, A. Jenkins, R.D. Hannan, and K.E. Sheppard Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: a possible role for SGK1 Cardiovasc. Res. 70 3 2006 555 565
39. P.C. Souverein, and et al. Use of oral glucocorticoids and risk of cardiovascular and cerebrovascular disease in a population based case-control study Heart 90 8 2004 859 865
40. L. Wei, T.M. MacDonald, and B.R. Walker Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease Ann. Intern. Med. 141 10 2004 764 770
41. + metabolism Proc. Natl. Acad. Sci. U. S. A. 95 16 1998 9424 9429
42. T.J. Cole, and et al. Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation Genes Dev. 9 13 1995 1608 1621
43. R. Kumar, and E.B. Thompson Gene regulation by the glucocorticoid receptor: structure:function relationship J. Steroid Biochem. Mol. Biol. 94 5 2005 383 394
44. I. Grad, and D. Picard The glucocorticoid responses are shaped by molecular chaperones Mol. Cell. Endocrinol. 275 1-2 2007 2 12
45. W.B. Pratt, and D.O. Toft Steroid receptor interactions with heat shock protein and immunophilin chaperones Endocr. Rev. 18 3 1997 306 360
46. M. Beato Gene regulation by steroid hormones Cell 56 3 1989 335 344
47. L.P. Freedman Anatomy of the steroid receptor zinc finger region Endocr. Rev. 13 2 1992 129 145
48. M. Surjit, and et al. Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor Cell 145 2 2011 224 241
49. J. Galon, and et al. Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells FASEB J. 16 1 2002 61 71
50. N.Z. Lu, J.B. Collins, S.F. Grissom, and J.A. Cidlowski Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor Mol. Cell. Biol. 27 20 2007 7143 7160
51. S. John, and et al. Chromatin accessibility pre-determines glucocorticoid receptor binding patterns Nat. Genet. 43 3 2011 264 268
52. C.J. Burd, and T.K. Archer Chromatin architecture defines the glucocorticoid response Mol. Cell. Endocrinol. 2013
53. B.D. Jenkins, C.B. Pullen, and B.D. Darimont Novel glucocorticoid receptor coactivator effector mechanisms Trends Endocrinol. Metab. 12 3 2001 122 126
54. D.M. Lonard, and B.W. O'Malley Expanding functional diversity of the coactivators Trends Biochem. Sci. 30 3 2005 126 132
55. M.G. Rosenfeld, and C.K. Glass Coregulator codes of transcriptional regulation by nuclear receptors J. Biol. Chem. 276 40 2001 36865 36868
56. S.H. Meijsing, and et al. DNA binding site sequence directs glucocorticoid receptor structure and activity Science 324 5925 2009 407 410
57. T.E. Reddy, J. Gertz, G.E. Crawford, M.J. Garabedian, and R.M. Myers The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes Mol. Cell. Biol. 32 18 2012 3756 3767
58. K. Ronacher, and et al. Ligand-selective transactivation and transrepression via the glucocorticoid receptor: role of cofactor interaction Mol. Cell. Endocrinol. 299 2 2009 219 231
59. N.H. Uhlenhaut, and et al. Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes Mol. Cell 49 1 2013 158 171
60. R.H. Oakley, and J.A. Cidlowski The glucocorticoid receptor C. Bunce, M.J. Campbell, Nuclear Receptors: Current Concepts and Future Challenges vol. 8 2010 Springer Netherlands 63 89
61. R.H. Oakley, and J.A. Cidlowski Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids J. Biol. Chem. 286 5 2011 3177 3184
62. R.H. Derijk, and et al. A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis J. Rheumatol. 28 11 2001 2383 2388
63. M.J. Schaaf, and J.A. Cidlowski AUUUA motifs in the 3'UTR of human glucocorticoid receptor alpha and beta mRNA destabilize mRNA and decrease receptor protein expression Steroids 67 7 2002 627 636
64. N.Z. Lu, and J.A. Cidlowski Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes Mol. Cell. 18 3 2005 331 342
65. M.R. Yudt, and J.A. Cidlowski Molecular identification and characterization of a and b forms of the glucocorticoid receptor Mol. Endocrinol. 15 7 2001 1093 1103
66. M.J. Young Targeting the mineralocorticoid receptor in cardiovascular disease Expert Opin. Ther. Targets 17 3 2013 321 331
67. K. Chapman, M. Holmes, and J. Seckl 11beta-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action Physiol. Rev. 93 3 2013 1139 1206
68. J.W. Funder Mineralocorticoid receptors: distribution and activation Heart Fail. Rev. 10 1 2005 15 22
69. J.W. Funder Mineralocorticoid receptor antagonists: emerging roles in cardiovascular medicine Integr. Blood Press. Control 6 2013 129 138
70. J.W. Funder Mineralocorticoid receptor activation and oxidative stress Hypertension 50 5 2007 840 841
71. A.S. Mihailidou, T.Y. Loan Le, M. Mardini, and J.W. Funder Glucocorticoids activate cardiac mineralocorticoid receptors during experimental myocardial infarction Hypertension 54 6 2009 1306 1312
72. M.F. Rossier, S. Lenglet, L. Vetterli, M. Python, and A. Maturana Corticosteroids and redox potential modulate spontaneous contractions in isolated rat ventricular cardiomyocytes Hypertension 52 4 2008 721 728
73. Y. Sainte-Marie, and et al. Conditional glucocorticoid receptor expression in the heart induces atrio-ventricular block FASEB J. 21 12 2007 3133 3141
74. E.A. Rog-Zielinska, and et al. Glucocorticoid receptor is required for foetal heart maturation Hum. Mol. Genet. 22 16 2013 3269 3282
75. A.L. Fowden, J. Li, and A.J. Forhead Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance? Proc. Nutr. Soc. 57 1 1998 113 122
76. E.A. Rog-Zielinska, R.V. Richardson, M.A. Denvir, and K.E. Chapman Glucocorticoids and foetal heart maturation; implications for prematurity and foetal programming J. Mol. Endocrinol. 52 2 2014 R125 135
77. G.C. Liggins The role of cortisol in preparing the fetus for birth Reprod. Fertil. Dev. 6 2 1994 141 150
78. X. Miracle, and et al. Guideline for the use of antenatal corticosteroids for fetal maturation J. Perinat. Med. 36 3 2008 191 196
79. J.L. Morrison, and et al. Antenatal steroids and the IUGR fetus: are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses? J. Pregnancy 2012 2012 839656
80. E.A. Rog-Zielinska, and et al. Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1alpha Cell Death Differ. 2014
81. R.H. Oakley, and et al. Essential role of stress hormone signaling in cardiomyocytes for the prevention of heart disease Proc. Natl. Acad. Sci. U. S. A. 110 42 2013 17035 17040
82. R. Agah, and et al. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo J. Clin. Investig. 100 1 1997 169 179
83. B. Greenberg, F. Zannad, and B. Pitt Role of aldosterone blockade for treatment of heart failure and post-acute myocardial infarction Am. J. Cardiol. 97 10A 2006 34F 40F
84. A. Ouvrard-Pascaud, and et al. Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias Circulation 111 23 2005 3025 3033
85. D. Fraccarollo, and et al. Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction Circulation 123 4 2011 400 408
86. A. Lother, and et al. Ablation of mineralocorticoid receptors in myocytes but not in fibroblasts preserves cardiac function Hypertension 57 4 2011 746 754
87. A.J. Rickard, and et al. Cardiomyocyte mineralocorticoid receptors are essential for deoxycorticosterone/salt-mediated inflammation and cardiac fibrosis Hypertension 60 6 2012 1443 1450