Neonatal glucocorticosteroid treatment causes systolic dysfunction and compensatory dilatation in early life: Studies in 4-week-old prepubertal rats

Pediatric Research

Volumn 58, Issue 1, 2005, Pages 46-52

  Bal, Miriam P ^a,b,c   De Vries, Willem B ^b   Van Der Leij, Feike R ^c   Van Oosterhout, Matthijs P M ^b   Berger, Rolf M F ^c   Baan, Jan ^a   Van Der Wall, Ernst E ^a   Van Bel, Frank ^b   Steendijk, Paul ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC LUNG DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HEART FUNCTION; HEART OUTPUT; HEART VENTRICLE ENDDIASTOLIC PRESSURE; LIFE EXPECTANCY; MALE; NEWBORN; NONHUMAN; PRESSURE VOLUME CURVE; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; DEXAMETHASONE; ECHOCARDIOGRAPHY; GLUCOCORTICOIDS; HEART RATE; HEART VENTRICLES; HEMODYNAMIC PROCESSES; HUMANS; LUNG; MALE; PRESSURE; RATS; RATS, WISTAR; SODIUM CHLORIDE; SYSTOLE; TIME FACTORS;

EID: 22044443421     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/01.PDR.0000163617.01673.9A     Document Type: Article

References (42)

1. American Academy of Pediatrics 2002 Postnatal corticosteroids to treat or prevent chronic lung disease in preterm infants. Pediatrics 109:330-338
2. Mammel MC, Green TP, Johnson DE, Thompson TR 1983 Controlled trial of dexamethasone therapy in infants with bronchopulmonary dysplasia. Lancet 1:3356-1358
3. Liley HG, White RT, Benson BJ, Ballard PL 1988 Glucocorticoids both stimulate and inhibit production of pulmonary surfactant protein A in fetal human lung. Proc Natl Acad Sci USA 85:9096-9100
4. Cummings JJ, D'Eugenio DB, Gross SJ 1989 A controlled trial of dexamethasone in preterm infants at high risk for bronchopulmonary dysplasia. N Engl J Med 320:1505-1510
5. Bakker JM, van Bel F, Heijnen CJ 2001 Neonatal glucocorticoids and the developing brain: short-term treatment with life-long consequences? Trends Neurosci 24:649-653
6. Kamphuis PJ, Gardoni F, Kamal A, Croiset G, Bakker JM, Cattabeni F, Gispen WH, Van Bel F, Di Luca M, Wiegant VM 2003 Long-lasting effects of neonatal dexamethasone treatment on spatial learning and hippocampal synaptic plasticity: involvement of the NMDA receptor complex. FASEB J 17:911-913
7. Halliday HL 2001 The effect of postnatal steroids on growth and development. J Perinat Med 29:281-285
8. Barrington KJ 2001 The adverse neuro-developmental effects of postnatal steroids in the preterm infant: a systematic review of RCTs. BMC Pediatr 1:1
9. Yeh TF, Lin YJ, Huang CC, Chen YJ, Lin CH, Lin HC, Hsieh WS, Lien YJ 1998 Early dexamethasone therapy in preterm infants: a follow-up study. Pediatrics 101:E7
10. Doyle L, Davis P 2000 Postnatal corticosteroids in preterm infants: systematic review of effects on mortality and motor function. J Paediatr Child Health 36:101-107
11. La Mear NS, MacGilvray SS, Myers TF 1997 Dexamethasone-induced myocardial hypertrophy in neonatal rats. Biol Neonate 72:175-180
12. Werner JC, Sicard RE, Hansen TW, Solomon E, Cowett RM, Oh W 1992 Hypertrophic cardiomyopathy associated with dexamethasone therapy for bronchopulmonary dysplasia. J Pediatr 120:286-291
13. Israel BA, Sherman FS, Guthrie RD 1993 Hypertrophic cardiomyopathy associated with dexamethasone therapy for chronic lung disease in preterm infants. Am J Perinatol 10:307-310
14. de Vries WB, van der Leij FR, Bakker JM, Kamphuis PJ, van Oosterhout MF, Schipper ME, Smid GB, Bartelds B, van Bel F 2002 Alterations in adult rat heart after neonatal dexamethasone therapy. Pediatr Res 52:900-906
15. Kamphuis PJ, Croiset G, Bakker JM, Wiegant VM, Van Bel F2001 Neonatal dexamethasone treatment results in reduction of life-span in rats. Pediatr Res 49:299A
16. Baan J, van der Velde ET, de Bruin H, Smeenk G, Koops J, van Dijk AD, Temmerman D, Senden J, Buis B 1984 Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation 70:812-823
17. Georgakopoulos D, Mitzner WA, Chen CH, Byrne BJ, Millar HD, Hare JM, Kass DA 1998 In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry. Am J Physiol 274:H1416-H1422
18. Yang B, Larson DF, Beischel J, Kelly R, Shi J, Watson RR 2001 Validation of conductance catheter system for quantification of murine pressure-volume loops. J Invest Surg 14:341-355
19. Feldman MD, Erikson JM, Mao Y, Korcarz CE, Lang RM, Freeman GL 2000 Validation of a mouse conductance system to determine LV volume: comparison to echocardiography and crystals. Am J Physiol Heart Circ Physiol 279:H1698-H1707
20. Steendijk P, Baan J 2000 Comparison of intravenous and pulmonary artery injections of hypertonic saline for the assessment of conductance catheter parallel conductance. Cardiovasc Res 46:82-89
21. Kass DA, Maughan WL, Guo ZM, Kono A, Sunagawa K, Sagawa K 1987 Comparative influence of load versus inotropic states on indexes of ventricular contractility: experimental and theoretical analysis based on pressure-volume relationships. Circulation 76:1422-1436
22. Little WC 1985 The left ventricular dP/dtmax-end-diastolic volume relationship in closed-chest dogs. Circ Res 56:808-815
23. Glower DD, Spratt JA, Snow ND, Kabas JS, Davis JW, Olsen CO, Tyson GS, Sabiston DC Jr, Rankin SJ 1985 Linearity of the Frank-Starling relationship in the intact heart: the concept of preload recruitable stroke work. Circulation 71:994-1009
24. Steendijk P, Baan J Jr, Van Der Velde ET, Baan J 1998 Effects of critical coronary stenosis on global systolic left ventricular function quantified by pressure-volume relations during dobutamine stress in the canine heart. J Am Coll Cardiol 32:816-826
25. Arts T, Bovendeerd PH, Prinzen FW, Reneman RS 1991 Relation between left ventricular cavity pressure and volume and systolic fiber stress and strain in the wall. Biophys J 59:93-102
26. Huttenbach Y, Ostrowski ML, Thaller D, Kim HS 2001 Cell proliferation in the growing human heart: MIB-1 immunostaining in pretenn and term infants at autopsy. Cardiovasc Pathol 10:119-123
27. Mayhew TM, Pharaoh A, Austin A, Pagan DG 1997 Stereological estimates of nuclear number in human ventricular cardiomyocytes before and after birth obtained using physical disectors. J Anat 191:107-115
28. Li F, Wang X, Capasso JM, Gerdes AM 1996 Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol 28:1737-1746
29. Rudolph AM, Roman C, Gournay V 1999 Perinatal myocardial DNA and protein changes in the lamb: effect of cortisol in the fetus. Pediatr Res 46:141-146
30. Dodic M, Peers A, Coghlan JP, Wintour M 1999 Can excess glucocorticoid predispose to cardiovascular and metabolic disease in middle age? Trends Endocrinol Metab 10:86-91
31. Hasan Q, Tan ST, Xu B, Davis PF 2003 Effects of five commonly used glucocorticoids on haemangioma in vitro. Clin Exp Pharmacol Physiol 30:140-144
32. Lansink M, Koolwijk P, van Hinsbergh V, Kooistra T 1998 Effect of steroid hormones and retinoids on the formation of capillary-like tubular structures of human microvascular endothelial cells in fibrin matrices is related to urokinase expression. Blood 92:927-938
33. Olivetti G, Quaini F, Lagrasta C, Cigola E, Ricci R, Maestri R, Anversa P 1995 Cellular basis of ventricular remodeling after myocardial infarction in rats. Cardioscience 6:101-106
34. Zecca E, Papacci P, Maggio L, Gallini F, Elia S, De Rosa G, Romagnoli C 2001 Cardiac adverse effects of early dexamethasone treatment in preterm infants: a randomized clinical trial. J Clin Pharmacol 41:1075-1081
35. Skelton R, Gill AB, Parsons JM 1998 Cardiac effects of short course dexamethasone in preterm infants. Arch Dis Child Fetal Neonatal Ed 78:F133-F137
36. van der Heide-Jalving M, Kamphuis PJ, van der Laan MJ, Bakker JM, Wiegant VM, Heijnen CJ, Veen S, van Bel F 2003 Short- and long-term effects of neonatal glucocorticoid therapy: is hydrocortisone an alternative to dexamethasone? Acta Paediatr 92:827-835
37. Flagel SB, Vazquez DM, Watson SJ, Jr, Neal CR Jr 2002 Effects of tapering neonatal dexamethasone on rat growth, neurodevelopment, and stress response. Am J Physiol Regul Integr Comp Physiol 282:R55-R63
38. Segar JL, Lumbers ER, Nuyt AM, Smith OJ, Robillard JE 1998 Effect of antenatal glucocorticoids on sympathetic nerve activity at birth in preterm sheep. Am J Physiol 274:R160-R167
39. Robinson RB 1996 Autonomic receptor-effector coupling during post-natal development. Cardiovasc Res 31:E68-E76
40. Muangmingsuk S, Ingram P, Gupta MP, Arcilla RA, Gupta M 2000 Dexamethasone induced cardiac hypertrophy in newborn rats is accompanied by changes in myosin heavy chain phenotype and gene transcription. Mol Cell Biochem 209:165-173
41. Sicard RE, Werner JC 1992 Dexamethasone induces a transient relative cardiomegaly in neonatal rats. Pediatr Res 31:359-363
42. Jong WM, Zuurbier CJ, De Winter RJ, Van Den Heuvel DA, Reitsma PH, Ten Cate H, Ince C 2002 Fentanyl-fluanisone-midazolam combination results in more stable hemodynamics than does urethane alpha-chloralose and 2,2,2- tribromoethanol in mice. Contemp Top Lab Anim Sci 41:28-32