Tetracycline-grafted PLGA nanoparticles as bone-targeting drug delivery system

International Journal of Nanomedicine

Volumn 10, Issue , 2015, Pages 5671-5685

  Wang, Hua ^a   Liu, Jun ^b   Tao, Shan ^b   Chai, Guihong ^b   Wang, Jianwei ^c   Hu, Fu Qiang ^b   Yuan, Hong ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Bone targeting; Nanoparticles; Osteoporosis; Poly(lactic co glycolic acid); Simvastatin; Tetracycline

Indexed keywords

NANOPARTICLE; PHOSPHATE BUFFERED SALINE; SIMVASTATIN; SOLVENT; TETRACYCLINE GRAFTED POLYGLACTIN NANOPARTICLE; UNCLASSIFIED DRUG; FLUORESCEIN; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOCOMPATIBILITY; BONE DENSITY; BONE DEVELOPMENT; BONE TISSUE; CELL DIFFERENTIATION; CHEMICAL STRUCTURE; CONJUGATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG STRUCTURE; DRUG TARGETING; DRUG TRANSPORT; EMULSION; FEMALE; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; MINERALIZATION; MOUSE; NEWBORN; NONHUMAN; OSTEOPOROSIS; OVARIECTOMY; PARTICLE SIZE; PHARMACODYNAMICS; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE PROPERTY; 3T3 CELL LINE; ANIMAL; BONE; CHEMISTRY; DRUG EFFECTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSTITUTE FOR CANCER RESEARCH MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SPRAGUE DAWLEY RAT;

3T3 CELLS; ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG DELIVERY SYSTEMS; FEMALE; FLUORESCEIN; LACTIC ACID; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MICE, INBRED ICR; NANOPARTICLES; OSTEOGENESIS; OSTEOPOROSIS; PARTICLE SIZE; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SOLVENTS; SURFACE PROPERTIES; TETRACYCLINE;

EID: 84941217890     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S88798     Document Type: Article

References (32)

1. Mundy G, Garrett R, Harris S, et al. Stimulation of bone formation in vitro and in rodents by statins. Science. 1999;286(5446):1946–1949.
2. Blum CB. Comparison of properties of four inhibitors of 3-hdroxy-3methyglutary-coenzyme A reductase. Am J Cardiol. 1994;73:3D–11D.
3. Montagnani A, Gonnelli S, Cepollaro C, et al. Effect of simvastatin treatment on bone mineral density and bone turnover in hypercholesterolemic postmenopausal women: a 1-year longitudinal study. Bone. 2003;32:427–433.
4. Tikiz C, Tikiz H, Taneli F, Gumuser G, Tuzun C. Effects of simvastatin on bone mineral density and remodeling parameters in postmenopausal osteopenic subjects: 1-year follow-up study. Clin Rheumatol. 2005;24:447–452.
5. Skoglund B, Forslund C, Aspenberg P. Simvastatin improves fracture healing in mice. J Bone Miner Res. 2002;17:2004–2008.
6. Guyton JR. Benefit versus risk in statin treatment. Am J Cardiol. 2006;97:95C–97C.
7. Shekunov BY, Chattopadhyay P, Seitzinger J, Huff R. Nanoparticles of poorly water-soluble drugs prepared by supercritical fluid extraction of emulsions. Pharm Res. 2006;23(1):196–204.
8. Kwon GS, Kataoka K. Block copolymer micelles as long-circulating drug vehicles. Adv Drug Deliv Rev. 1995;16(2):295–309.
9. Kataoka K, Harada A, Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv Drug Deliv Rev. 2001;47(1):113–131.
10. Hans ML, Lowman AM. Biodegradable nanoparticles for drug delivery and targeting. Curr Opin Solid State Mater Sci. 2002;6(4):319–327.
11. De Jong WH, Borm PJ. Drug delivery and nanoparticles: applications and hazards. Int J Nanomedicine. 2008;3(2):133.
12. Wang G, Uludag H. Recent developments in nanoparticle-based drug delivery and targeting systems with emphasis on protein-based nanoparticles. Expert Opin Drug Deliv. 2008;5:499–515.
13. Danhier F, Ansorena E, Silva JM, Coco R, Le Breton A, Préat V. PLGA-based nanoparticles: an overview of biomedical applications. J Control Release. 2012;161(2):505–522.
14. Ho ML, Fu YC, Wang GJ, et al. Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite. J Control Release. 2008;128(2):142–148.
15. Perrin RA. Binding of tetracycline to bone. Nature. 1965;208(11):787–788.
16. Mazaleyrat JP, Boutboul A, Lebars Y, Gaucher A, Wakselman M. Practical resolution of an atropoisomeric [alpha],[alpha]-disubstituted glycine with l-phenylalanine cyclohexylamide as chiral auxiliary. Tetrahedron Asymmetry. 1998;9(15):2701–2713.
17. Gaucher A, Zuliani Y, Cabaret D, Wakselman M, Mazaleyrat JP. Synthesis and resolution of β 2, 2-HBin, the first enantiomerically stable β-amino acid with chirality only due to axial dissymmetry. Tetrahedron Asymmetry. 2001;12(18):2571–2580.
18. Nath SD, Son S, Sadiasa A, Min YK, Lee BT. Preparation and characterization of PLGA microspheres by the electrospraying method for delivering simvastatin for bone regeneration. Int J Pharm. 2013;443(1–2):87–94.
19. Ho MH, Chiang CP, Liu YF, et al. Highly efficient release of lovastatin from poly(lactic-co-glycolic acid) nanoparticles enhances bone repair in rats. J Orthop Res. 2011;29(10):1504–1510.
20. Tiwari R, Pathak K. Nanostructured lipid carrier versus solid lipid nanoparticles of simvastatin: comparative analysis of characteristics, pharmacokinetics and tissue uptake. Int J Pharm. 2011;415(1):232–243.
21. Wang CZ, Fu YC, Jian SC, et al. Synthesis and characterization of cationic polymeric nanoparticles as simvastatin carriers for enhancing the osteogenesis of bone marrow mesenchymal stem cells. J Colloid Interface Sci. 2014;432:190–199.
22. Yang F, Zhao S, Zhang F, He FM, Yang GL. Simvastatin-loaded porous implant surfaces stimulate preosteoblasts differentiation: an in vitro study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111(5):551–556.
23. Park JB, Zhang H, Lin CY, et al. Simvastatin maintains osteoblastic viability while promoting differentiation by partially regulating the expressions of estrogen receptors α. J Surg Res. 2012;174(2):278–283.
24. Gregory CA, Gunn WG, Peister A, Prockop DJ. An Alizarin red-based assay of mineralization by adherent cells in culture: comparison with cetylpyridinium chloride extraction. Anal Biochem. 2004;329(1):77–84.
25. Maeda T, Matsunuma A, Kawane T, Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun. 2001;280(3):874–877.
26. Ho ML, Fu YC, Wang GJ, et al. Controlled release carrier of BSA made by W/O/W emulsion method containing PLGA and hydroxyapatite. J Control Release. 2008;128:142–148.
27. Fu YC, Fu TF, Wang HJ, et al. Aspartic acid-based modified PLGA–PEG nanoparticles for bone targeting: In vitro and in vivo evaluation. Acta Biomater. 2014;10(11):4583–4596.
28. Waynforth HB. Experimental and Surgical Technique in the Rat. Academic Press, London: Academic Press; 1980.
29. Wang JW, Xu SW, Yang DS, Lv RK. Locally applied simvastatin promotes fracture healing in ovariectomized rat. Osteoporos Int. 2007;18(12):1641–1650.
30. Ito T, Takemasa M, Makino K, Otsuka M. Preparation of calcium phosphate nanocapsules including simvastatin/deoxycholic acid assembly, and their therapeutic effect in osteoporosis model mice. J Pharm Pharmacol. 2013;65(4):494–502.
31. Maeda T, Matsunuma A, Kurahashi I, Yanagawa T, Yoshida H, Horiuchi N. Induction of osteoblast differentiation indices by statins in MC3T3-E1 cells. J Cell Biochem. 2004;92(3):458–471.
32. Wong L, Bendayan R, Rauth AM, Li YQ, Wu XY. Chemotherapy with anticancer drugs encapsulated in solid lipid nanoparticles. Adv Drug Deliv Rev. 2007;59(6):491–504.