Preparation of calcium phosphate nanocapsules including simvastatin/deoxycholic acid assembly, and their therapeutic effect in osteoporosis model mice

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 4, 2013, Pages 494-502

  Ito, Tomoko ^a,c   Takemasa, Manami ^b   Makino, Kimiko ^b   Otsuka, Makoto ^a  

^a MUSASHINO UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c Shinyamanote Hospital   (Japan)

Author keywords

calcium phosphate; deoxycholic acid; micelles; osteoporosis; simvastatin

Indexed keywords

CALCIUM PHOSPHATE; DEOXYCHOLIC ACID; NANOCAPSULE; SIMVASTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; BONE MINERAL; BONE STRENGTH; CONTROLLED STUDY; DRUG COATING; DRUG CYTOTOXICITY; DRUG DOSAGE FORM COMPARISON; DRUG SOLUBILITY; FEMALE; MOUSE; NONHUMAN; OSTEOPOROSIS; TOXICITY TESTING; TREATMENT RESPONSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; CALCIUM PHOSPHATES; CELL LINE; DEOXYCHOLIC ACID; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; HYPOLIPIDEMIC AGENTS; MICE; MICE, INBRED STRAINS; MICELLES; NANOCAPSULES; OSTEOPOROSIS, POSTMENOPAUSAL; RANDOM ALLOCATION; SIMVASTATIN; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS;

EID: 84875245788     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12008     Document Type: Article

References (19)

1. Mundy G, et al,. Stimulation of bone formation in vitro and in rodents by statins. Science 1999; 286: 1946-1949.
2. Du Z, et al,. Effects of Simvastatin on bone healing around titanium implants in osteoporotic rats. Clin Oral Implants Res 2009; 20: 145-150.
3. Du Z, et al,. Serum bone formation marker correlation with improved osseointegration in osteoporotic rats treated with simvastatin. Clin Oral Implants Res 2011; doi: 10.1111/j.1600-0501.2011.02341.x [Epub ahead of print].
4. Ito T, et al,. Preparation of injectable auto-forming alginate gel containing simvastatin with amorphous calcium phosphate as a controlled release medium and their therapeutic effect in osteoporosis model rat. J Mater Sci Mater Med 2012; 23: 1291-1297.
5. Otsuka M, et al,. Dissolution medium responsive simvastatin release from biodegradable apatite cements drug delivery system-the therapeutically effect and their histology in osteoporosis rats. Key Eng Mater 2012; 493-494 (Bioceramics 23): 684-688.
6. Carey MC, Small DM,. Micelle formation by bile salts: physical-chemical and thermodynamic considerations. Arch Intern Med 1972; 130: 506-527.
7. Dorozhkin SV, Epple M,. Biological and medical significance of calcium phosphates. Angew Chem Int Ed Engl 2002; 41: 3130-3146.
8. Ginebra MP, et al,. Calcium phosphate cements as bone drug delivery systems: a review. J Control Release 2006; 113: 102-110.
9. Baron R,. Molecular mechanisms of bone resorption by the osteoclast. Anat Rec 1989; 224: 317-324.
10. Teitelbaum SL,. Bone resorption by osteoclasts. Science 2000; 289: 1504-1508.
11. Redey SA, et al,. Osteoclast adhesion and activity on synthetic hydroxyapatite, carbonated hydroxyapatite, and natural calcium carbonate: relationship to surface energies. J Biomed Mater Res A 1999; 45: 140-147.
12. Kokubo T, Takadama H,. How useful is SBF in predicting in vivo bone bioactivity? Biomaterials 2006; 27: 2907-2915.
13. Dong DC, Winnik MA,. The Py scale of solvent polarities. Can J Chem 1984; 62: 2560-2565.
14. Sakiyama H, et al,. Establishment and characterization of macrophage-like cell lines expressing osteoclast-specific markers. J Bone Miner Metab 2001; 19: 220-227.
15. Kokubo T, et al,. Solutions able to reproduce in vivo surface-structure changes in bioactive glass-ceramic A-W. J Biomed Mater Res 1990; 24: 721-734.
16. Ohtsuki C, et al,. Mechanism of apatite formation on CaO-SiO2-P2O5 glasses in a simulated body fluid. J Non-Cryst Solids 1992; 143: 84-92.
17. Tanahashi M, Matsuda T,. Surface functional group dependence on apatite formation on self-assembled monolayers in a simulated body fluid. J Biomed Mater Res 1997; 34: 305-315.
18. Yamashita M, et al,. Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling. Regul Pept 2010; 162: 99-108.
19. Tang QO, et al,. Statins: under investigation for increasing bone mineral density and augmenting fracture healing. Expert Opin Investig Drugs 2008; 17: 1435-1463.