MicroRNA Let-7i negatively regulates cardiac inflammation and fibrosis

Hypertension

Volumn 66, Issue 4, 2015, Pages 776-785

  Wang, Xia ^a   Wang, Hong Xia ^a   Li, Yu Lin ^b   Zhang, Cong Cong ^b   Zhou, Chun Yu ^a   Wang, Lei ^c   Xia, Yun Long ^c   Du, Jie ^b   Li, Hui Hua ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

angiotensin II; collagen; inflammation; interleukin 6; microRNAs

Indexed keywords

AGENTS AFFECTING NUCLEIC ACID METABOLISM; AGOMIR; ANGIOTENSIN II; ANTISENSE OLIGONUCLEOTIDE; BIOLOGICAL MARKER; COLLAGEN DERIVATIVE; COLLAGEN TYPE I ALPHA 2; COLLAGEN TYPE III ALPHA 1; COLLAGEN TYPE IV ALPHA 1; COLLAGEN TYPE V ALPHA 2; INTERLEUKIN 6; MESSENGER RNA; MICRORNA; MICRORNA LET 7I; UNCLASSIFIED DRUG; MIRNLET7 MICRORNA, MOUSE; RNA;

ANIMAL CELL; ANIMAL TISSUE; ANTISENSE THERAPY; ARTICLE; CARDIAC REMODELING; CARDITIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FIBROBLAST CULTURE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HEART CELL CULTURE; HEART DISEASE; HEART FIBROBLAST; HEART MUSCLE FIBROSIS; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CARDIOMYOPATHY; CELL PROLIFERATION; DISEASE MODEL; FIBROSIS; GENETICS; METABOLISM; MYOCARDITIS; PATHOLOGY; PROTEIN MICROARRAY;

ANIMALS; CARDIOMYOPATHIES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; FIBROSIS; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICRORNAS; MYOCARDITIS; PROTEIN ARRAY ANALYSIS; RNA;

EID: 84941205685     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05548     Document Type: Article

References (38)

1. Haudek SB, Cheng J, Du J, Wang Y, Hermosillo-Rodriguez J, Trial J, Taffet GE, Entman ML, Monocytic fibroblast precursors mediate fibrosis in angiotensin-II-induced cardiac hypertrophy. J Mol Cell Cardiol 2010 49 499 507. doi: 10.1016/j.yjmcc.2010.05.005
2. Jia L, Li Y, Xiao C, Du J, Angiotensin II induces inflammation leading to cardiac remodeling. Front Biosci (Landmark Ed) 2012 17 221 231
3. Ma F, Li Y, Jia L, Han Y, Cheng J, Li H, Qi Y, Du J, Macrophage-stimulated cardiac fibroblast production of IL-6 is essential for TGF β/Smad activation and cardiac fibrosis induced by angiotensin II. PLoS One 2012 7 e35144. doi: 10.1371/journal.pone.0035144
4. Chen K, Chen J, Li D, Zhang X, Mehta JL, Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: modulation by PPAR-gamma ligand pioglitazone. Hypertension 2004 44 655 661. doi: 10.1161/01.HYP.0000144400.49062.6b
5. Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG, Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-Talk regulates collagen production in cardiac fibroblasts. J Biol Chem 2003 278 24461 24468. doi: 10.1074/jbc.M212659200
6. Bartel DP, MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004 116 281 297
7. Duisters RF, Tijsen AJ, Schroen B, Leenders JJ, Lentink V, van der Made I, Herias V, van Leeuwen RE, Schellings MW, Barenbrug P, Maessen JG, Heymans S, Pinto YM, Creemers EE, MiR-133 and miR-30 regulate connective tissue growth factor: Implications for a role of microRNAs in myocardial matrix remodeling. Circ Res 2009 104 170 178. doi: 10.1161/CIRCRESAHA.108.182535
8. van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA, Olson EN, Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A 2008 105 13027 13032. doi: 10.1073/pnas.0805038105
9. Thum T, Gross C, Fiedler J, MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008 456 980 984. doi: 10.1038/nature07511
10. Patrick DM, Montgomery RL, Qi X, Obad S, Kauppinen S, Hill JA, van Rooij E, Olson EN, Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest 2010 120 3912 3916. doi: 10.1172/JCI43604
11. Carè A, Catalucci D, Felicetti F, MicroRNA-133 controls cardiac hypertrophy. Nat Med 2007 13 613 618. doi: 10.1038/nm1582
12. Huang ZP, Chen J, Seok HY, Zhang Z, Kataoka M, Hu X, Wang DZ, MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress. Circ Res 2013 112 1234 1243. doi: 10.1161/CIRCRESAHA.112.300682
13. Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M, MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ Res 2007 100 416 424. doi: 10.1161/01.RES.0000257913.42552.23
14. Schipper ME, van Kuik J, de Jonge N, Dullens HF, de Weger RA, Changes in regulatory microRNA expression in myocardium of heart failure patients on left ventricular assist device support. J Heart Lung Transplant 2008 27 1282 1285. doi: 10.1016/j.healun.2008.09.005
15. Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J, MicroRNAs in the human heart: a clue to fetal gene reprogramming in heart failure. Circulation 2007 116 258 267. doi: 10.1161/CIRCULATIONAHA.107.687947
16. van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA, Olson EN, A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006 103 18255 18260. doi: 10.1073/pnas.0608791103
17. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN, Control of stress-dependent cardiac growth and gene expression by a microRNA. Science 2007 316 575 579. doi: 10.1126/science.1139089
18. Masur SK, Dewal HS, Dinh TT, Erenburg I, Petridou S, Myofibroblasts differentiate from fibroblasts when plated at low density. Proc Natl Acad Sci U S A 1996 93 4219 4223
19. Yang B, Lin H, Xiao J, Lu Y, Luo X, Li B, Zhang Y, Xu C, Bai Y, Wang H, Chen G, Wang Z, The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 2007 13 486 491. doi: 10.1038/nm1569
20. Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell 2007 129 303 317. doi: 10.1016/j.cell.2007.03.030
21. Small EM, Frost RJ, Olson EN, MicroRNAs add a new dimension to cardiovascular disease. Circulation 2010 121 1022 1032. doi: 10.1161/CIRCULATIONAHA.109.889048
22. Chiu SC, Chung HY, Cho DY, Chan TM, Liu MC, Huang HM, Li TY, Lin JY, Chou PC, Fu RH, Yang WK, Harn HJ, Lin SZ, Therapeutic potential of microRNA let-7: tumor suppression or impeding normal stemness. Cell Transplant 2014 23 459 469. doi: 10.3727/096368914X678418
23. Bao MH, Feng X, Zhang YW, Lou XY, Cheng Y, Zhou HH, Let-7 in cardiovascular diseases, heart development and cardiovascular differentiation from stem cells. Int J Mol Sci 2013 14 23086 23102. doi: 10.3390/ijms141123086
24. Yang Y, Ago T, Zhai P, Abdellatif M, Sadoshima J, Thioredoxin 1 negatively regulates angiotensin II-induced cardiac hypertrophy through upregulation of miR-98/let-7. Circ Res 2011 108 305 313. doi: 10.1161/CIRCRESAHA.110.228437
25. Satoh M, Minami Y, Takahashi Y, Tabuchi T, Nakamura M, A cellular microRNA, let-7i, is a novel biomarker for clinical outcome in patients with dilated cardiomyopathy. J Card Fail 2011 17 923 929. doi: 10.1016/j.cardfail.2011.07.012
26. Satoh M, Tabuchi T, Minami Y, Takahashi Y, Itoh T, Nakamura M, Expression of let-7i is associated with toll-like receptor 4 signal in coronary artery disease: effect of statins on let-7i and toll-like receptor 4 signal. Immunobiology 2012 217 533 539. doi: 10.1016/j.imbio.2011.08.005
27. Varga ZV, Zvara A, Faragó N, Kocsis GF, Pipicz M, Gáspár R, Bencsik P, Görbe A, Csonka C, Puskás LG, Thum T, Csont T, Ferdinandy P, MicroRNAs associated with ischemia-reperfusion injury and cardioprotection by ischemic pre- and postconditioning: protectomiRs. Am J Physiol Heart Circ Physiol 2014 307 H216 H227. doi: 10.1152/ajpheart.00812.2013
28. Ikeda S, Kong SW, Lu J, Bisping E, Zhang H, Allen PD, Golub TR, Pieske B, Pu WT, Altered microRNA expression in human heart disease. Physiol Genomics 2007 31 367 373. doi: 10.1152/physiolgenomics.00144.2007
29. Luo X, Zhang H, Xiao J, Wang Z, Regulation of human cardiac ion channel genes by microRNAs: theoretical perspective and pathophysiological implications. Cell Physiol Biochem 2010 25 571 586. doi: 10.1159/000315076
30. Ghosh AK, Nagpal V, Covington JW, Michaels MA, Vaughan DE, Molecular basis of cardiac endothelial-To-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT. Cell Signal 2012 24 1031 1036. doi: 10.1016/j.cellsig.2011.12.024
31. Deddens JC, Colijn JM, Oerlemans MI, Pasterkamp G, Chamuleau SA, Doevendans PA, Sluijter JP, Circulating microRNAs as novel biomarkers for the early diagnosis of acute coronary syndrome. J Cardiovasc Transl Res 2013 6 884 898. doi: 10.1007/s12265-013-9493-9
32. Huang JC, Babak T, Corson TW, Chua G, Khan S, Gallie BL, Hughes TR, Blencowe BJ, Frey BJ, Morris QD, Using expression profiling data to identify human microRNA targets. Nat Methods 2007 4 1045 1049. doi: 10.1038/nmeth1130
33. Long C, Jiang L, Wei F, Ma C, Zhou H, Yang S, Liu X, Liu Z, Integrated miRNA-mRNA analysis revealing the potential roles of miRNAs in chordomas. PLoS One 2013 8 e66676. doi: 10.1371/journal.pone.0066676
34. Johnson SM, Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D, Slack FJ, RAS is regulated by the let-7 microRNA family. Cell 2005 120 635 647. doi: 10.1016/j.cell.2005.01.014
35. Mayr C, Hemann MT, Bartel DP, Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 2007 315 1576 1579. doi: 10.1126/science.1137999
36. Sampson VB, Rong NH, Han J, Yang Q, Aris V, Soteropoulos P, Petrelli NJ, Dunn SP, Krueger LJ, MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells. Cancer Res 2007 67 9762 9770. doi: 10.1158/0008-5472.CAN-07-2462
37. Iliopoulos D, Hirsch HA, Struhl K, An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 2009 139 693 706. doi: 10.1016/j.cell.2009.10.014
38. Ji J, Zhao L, Budhu A, Forgues M, Jia HL, Qin LX, Ye QH, Yu J, Shi X, Tang ZY, Wang XW, Let-7g targets collagen type I alpha2 and inhibits cell migration in hepatocellular carcinoma. J Hepatol 2010 52 690 697. doi: 10.1016/j.jhep.2009.12.025